JP2020517740A - 神経変性疾患を治療するためのｃｄ１４アンタゴニスト抗体 - Google Patents

神経変性疾患を治療するためのｃｄ１４アンタゴニスト抗体 Download PDF

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JP2020517740A
JP2020517740A JP2020507722A JP2020507722A JP2020517740A JP 2020517740 A JP2020517740 A JP 2020517740A JP 2020507722 A JP2020507722 A JP 2020507722A JP 2020507722 A JP2020507722 A JP 2020507722A JP 2020517740 A JP2020517740 A JP 2020517740A
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antibody
sequence
seq
cdr1
cdr2
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JP2020517740A5 (https=
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ルウェリン レドリッチ ギャリー
ルウェリン レドリッチ ギャリー
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インプリシット バイオサイエンス プロプライアタリー リミティド
インプリシット バイオサイエンス プロプライアタリー リミティド
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Publication of JP2020517740A publication Critical patent/JP2020517740A/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/515—Complete light chain, i.e. VL + CL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2020507722A 2017-04-21 2018-04-20 神経変性疾患を治療するためのｃｄ１４アンタゴニスト抗体 Pending JP2020517740A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2023065903A JP2023090751A (ja) 2017-04-21 2023-04-13 神経変性疾患を治療するためのｃｄ１４アンタゴニスト抗体

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
AU2017901462 2017-04-21
AU2017901462A AU2017901462A0 (en) 2017-04-21 Agents for treating or preventing motor neurone disease and uses therefor
AU2018900762 2018-03-08
AU2018900762A AU2018900762A0 (en) 2018-03-08 “agents for treating disease and uses therefor”
PCT/AU2018/050357 WO2018191786A1 (en) 2017-04-21 2018-04-20 Cd 14 antagonist antibodies for treating neurodegenerative diseases

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JP2023065903A Division JP2023090751A (ja) 2017-04-21 2023-04-13 神経変性疾患を治療するためのｃｄ１４アンタゴニスト抗体

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JP2020517740A true JP2020517740A (ja) 2020-06-18
JP2020517740A5 JP2020517740A5 (https=) 2021-05-27

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JP2020507722A Pending JP2020517740A (ja) 2017-04-21 2018-04-20 神経変性疾患を治療するためのｃｄ１４アンタゴニスト抗体
JP2023065903A Pending JP2023090751A (ja) 2017-04-21 2023-04-13 神経変性疾患を治療するためのｃｄ１４アンタゴニスト抗体

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US (2) US20200148780A1 (https=)
EP (1) EP3612566A4 (https=)
JP (2) JP2020517740A (https=)
KR (1) KR20200015477A (https=)
CN (1) CN110831975A (https=)
AU (1) AU2018255489B2 (https=)
IL (2) IL309046B2 (https=)
WO (1) WO2018191786A1 (https=)

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LT3618928T (lt) 2018-07-13 2023-04-11 Alector Llc Anti-sortilino antikūnai ir jų panaudojimo būdai
EP3983441A1 (en) * 2019-06-11 2022-04-20 Alector LLC Anti-sortilin antibodies for use in therapy
CN114450068A (zh) * 2019-07-25 2022-05-06 因普利西特生物科学有限公司 用于治疗急性神经炎性损伤的方法和剂
JP7701931B2 (ja) * 2020-02-13 2025-07-02 プリレニア ニューロセラピューティクス リミテッド プリドピジンおよび他の活性薬剤を使用して筋萎縮性側索を治療するための併用療法
WO2021253335A1 (zh) * 2020-06-18 2021-12-23 深圳迈瑞生物医疗电子股份有限公司 抗可溶性cd14亚型抗体、试剂盒及其应用
CN116367858A (zh) * 2020-09-10 2023-06-30 隐式生物科技有限公司 用于治疗心肌梗塞的治疗方法和试剂
AU2021356298A1 (en) 2020-10-07 2023-05-04 Line 6 Biotechnology, Inc Methods and agents for the treatment of ocular disease
WO2024040194A1 (en) 2022-08-17 2024-02-22 Capstan Therapeutics, Inc. Conditioning for in vivo immune cell engineering
AU2024279278A1 (en) 2023-05-31 2025-12-18 Capstan Therapeutics, Inc. Lipid nanoparticle formulations and compositions
CN117031014A (zh) * 2023-08-14 2023-11-10 陕西脉元生物科技有限公司 抗matr3自身抗体的试剂在制备检测神经系统自身免疫疾病的产品中的应用及试剂盒
WO2025076113A1 (en) 2023-10-05 2025-04-10 Capstan Therapeutics, Inc. Ionizable cationic lipids with conserved spacing and lipid nanoparticles
US20250127728A1 (en) 2023-10-05 2025-04-24 Capstan Therapeutics, Inc. Constrained Ionizable Cationic Lipids and Lipid Nanoparticles
US20250302763A1 (en) 2024-02-22 2025-10-02 Capstan Therapeutics, Inc. Immune engineering amplification
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CN118290585B (zh) * 2024-06-04 2024-08-30 苏州为度生物技术有限公司天津分公司 一种抗人cd14工程抗体及应用
CN120399098B (zh) * 2025-07-03 2025-09-16 上海玄言生物科技有限公司 抗cd14抗体-il-15超级激动剂融合蛋白及其制法和应用

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021523375A (ja) * 2018-05-10 2021-09-02 ザ・メソジスト・ホスピタル 疾病の予後と管理のための方法
JP7371019B2 (ja) 2018-05-10 2023-10-30 ザ・メソジスト・ホスピタル 疾病の予後と管理のための方法

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IL270097B1 (en) 2024-01-01
AU2018255489B2 (en) 2024-06-13
KR20200015477A (ko) 2020-02-12
IL309046A (en) 2024-02-01
US12297287B2 (en) 2025-05-13
US20200148780A1 (en) 2020-05-14
IL270097B2 (en) 2024-05-01
EP3612566A4 (en) 2021-03-03
IL270097A (https=) 2019-12-31
EP3612566A1 (en) 2020-02-26
IL309046B1 (en) 2024-11-01
AU2018255489A1 (en) 2019-11-07
WO2018191786A1 (en) 2018-10-25
IL309046B2 (en) 2025-03-01
JP2023090751A (ja) 2023-06-29
US20220010025A1 (en) 2022-01-13
CN110831975A (zh) 2020-02-21

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