JP2020517696A5 - - Google Patents
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- Publication number
- JP2020517696A5 JP2020517696A5 JP2019558369A JP2019558369A JP2020517696A5 JP 2020517696 A5 JP2020517696 A5 JP 2020517696A5 JP 2019558369 A JP2019558369 A JP 2019558369A JP 2019558369 A JP2019558369 A JP 2019558369A JP 2020517696 A5 JP2020517696 A5 JP 2020517696A5
- Authority
- JP
- Japan
- Prior art keywords
- medicament according
- months
- cancer
- her2 antibody
- adverse events
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003814 drug Substances 0.000 claims description 73
- 206010028980 Neoplasm Diseases 0.000 claims description 37
- 201000011510 cancer Diseases 0.000 claims description 35
- 230000002411 adverse Effects 0.000 claims description 32
- 229960000575 trastuzumab Drugs 0.000 claims description 16
- 239000005557 antagonist Substances 0.000 claims description 15
- 230000002503 metabolic effect Effects 0.000 claims description 15
- GAGWJHPBXLXJQN-UORFTKCHSA-N Capecitabine Chemical compound C1=C(F)C(NC(=O)OCCCCC)=NC(=O)N1[C@H]1[C@H](O)[C@H](O)[C@@H](C)O1 GAGWJHPBXLXJQN-UORFTKCHSA-N 0.000 claims description 12
- GAGWJHPBXLXJQN-UHFFFAOYSA-N Capecitabine Natural products C1=C(F)C(NC(=O)OCCCCC)=NC(=O)N1C1C(O)C(O)C(C)O1 GAGWJHPBXLXJQN-UHFFFAOYSA-N 0.000 claims description 12
- 239000002246 antineoplastic agent Substances 0.000 claims description 12
- 229960004117 capecitabine Drugs 0.000 claims description 12
- 229940127089 cytotoxic agent Drugs 0.000 claims description 12
- 229960002087 pertuzumab Drugs 0.000 claims description 12
- 239000008194 pharmaceutical composition Substances 0.000 claims description 12
- 230000004083 survival effect Effects 0.000 claims description 8
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 claims description 7
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 claims description 7
- 229960001612 trastuzumab emtansine Drugs 0.000 claims description 7
- 206010006187 Breast cancer Diseases 0.000 claims description 6
- 208000026310 Breast neoplasm Diseases 0.000 claims description 6
- AOCCBINRVIKJHY-UHFFFAOYSA-N Carmofur Chemical compound CCCCCCNC(=O)N1C=C(F)C(=O)NC1=O AOCCBINRVIKJHY-UHFFFAOYSA-N 0.000 claims description 4
- GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 claims description 4
- 229960003261 carmofur Drugs 0.000 claims description 4
- 230000000694 effects Effects 0.000 claims description 4
- 229960002949 fluorouracil Drugs 0.000 claims description 4
- 229950003135 margetuximab Drugs 0.000 claims description 4
- 208000037819 metastatic cancer Diseases 0.000 claims description 4
- 208000011575 metastatic malignant neoplasm Diseases 0.000 claims description 4
- 229960001674 tegafur Drugs 0.000 claims description 4
- WFWLQNSHRPWKFK-ZCFIWIBFSA-N tegafur Chemical compound O=C1NC(=O)C(F)=CN1[C@@H]1OCCC1 WFWLQNSHRPWKFK-ZCFIWIBFSA-N 0.000 claims description 4
- 229940124597 therapeutic agent Drugs 0.000 claims description 4
- 230000001225 therapeutic effect Effects 0.000 claims description 4
- -1 Dokishi off Rurijin Chemical compound 0.000 claims description 3
- 230000037396 body weight Effects 0.000 claims description 3
- 206010004593 Bile duct cancer Diseases 0.000 claims description 2
- 206010005003 Bladder cancer Diseases 0.000 claims description 2
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims description 2
- 102100039788 GTPase NRas Human genes 0.000 claims description 2
- 101000744505 Homo sapiens GTPase NRas Proteins 0.000 claims description 2
- 101000984753 Homo sapiens Serine/threonine-protein kinase B-raf Proteins 0.000 claims description 2
- 206010049694 Left Ventricular Dysfunction Diseases 0.000 claims description 2
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims description 2
- 208000015634 Rectal Neoplasms Diseases 0.000 claims description 2
- 206010038111 Recurrent cancer Diseases 0.000 claims description 2
- 102100027103 Serine/threonine-protein kinase B-raf Human genes 0.000 claims description 2
- 208000005718 Stomach Neoplasms Diseases 0.000 claims description 2
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims description 2
- 239000000611 antibody drug conjugate Substances 0.000 claims description 2
- 229940049595 antibody-drug conjugate Drugs 0.000 claims description 2
- 208000026900 bile duct neoplasm Diseases 0.000 claims description 2
- 201000009036 biliary tract cancer Diseases 0.000 claims description 2
- 208000020790 biliary tract neoplasm Diseases 0.000 claims description 2
- 239000003153 chemical reaction reagent Substances 0.000 claims description 2
- 208000006990 cholangiocarcinoma Diseases 0.000 claims description 2
- 230000000112 colonic effect Effects 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 201000004101 esophageal cancer Diseases 0.000 claims description 2
- 206010017758 gastric cancer Diseases 0.000 claims description 2
- 230000005764 inhibitory process Effects 0.000 claims description 2
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims description 2
- 206010038038 rectal cancer Diseases 0.000 claims description 2
- 201000001275 rectum cancer Diseases 0.000 claims description 2
- 238000011272 standard treatment Methods 0.000 claims description 2
- 201000011549 stomach cancer Diseases 0.000 claims description 2
- 230000002195 synergetic effect Effects 0.000 claims description 2
- 230000004614 tumor growth Effects 0.000 claims description 2
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims description 2
- 201000005112 urinary bladder cancer Diseases 0.000 claims description 2
- 229940079593 drug Drugs 0.000 claims 12
- 230000000340 anti-metabolite Effects 0.000 claims 3
- 229940100197 antimetabolite Drugs 0.000 claims 3
- 239000002256 antimetabolite Substances 0.000 claims 3
- 238000002203 pretreatment Methods 0.000 claims 2
- KIZQNNOULOCVDM-UHFFFAOYSA-M 2-hydroxyethyl(trimethyl)azanium;hydroxide Chemical compound [OH-].C[N+](C)(C)CCO KIZQNNOULOCVDM-UHFFFAOYSA-M 0.000 claims 1
- 206010019851 Hepatotoxicity Diseases 0.000 claims 1
- 230000007686 hepatotoxicity Effects 0.000 claims 1
- 231100000304 hepatotoxicity Toxicity 0.000 claims 1
- 229960005558 mertansine Drugs 0.000 claims 1
- 238000000034 method Methods 0.000 description 62
- 238000002648 combination therapy Methods 0.000 description 10
- 231100000334 hepatotoxic Toxicity 0.000 description 1
- 230000003082 hepatotoxic effect Effects 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023126666A JP2023145689A (ja) | 2017-04-28 | 2023-08-03 | Ｈｅｒ２陽性がんの処置 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762491872P | 2017-04-28 | 2017-04-28 | |
| US62/491,872 | 2017-04-28 | ||
| PCT/US2018/029899 WO2018201016A1 (en) | 2017-04-28 | 2018-04-27 | Treatment of her2 positive cancers |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023126666A Division JP2023145689A (ja) | 2017-04-28 | 2023-08-03 | Ｈｅｒ２陽性がんの処置 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020517696A JP2020517696A (ja) | 2020-06-18 |
| JP2020517696A5 true JP2020517696A5 (https=) | 2021-09-09 |
| JP7328151B2 JP7328151B2 (ja) | 2023-08-16 |
Family
ID=62165692
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019558369A Active JP7328151B2 (ja) | 2017-04-28 | 2018-04-27 | Ｈｅｒ２陽性がんの処置 |
| JP2023126666A Pending JP2023145689A (ja) | 2017-04-28 | 2023-08-03 | Ｈｅｒ２陽性がんの処置 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023126666A Pending JP2023145689A (ja) | 2017-04-28 | 2023-08-03 | Ｈｅｒ２陽性がんの処置 |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US11207324B2 (https=) |
| EP (1) | EP3615067A1 (https=) |
| JP (2) | JP7328151B2 (https=) |
| KR (1) | KR102845148B1 (https=) |
| CN (1) | CN111032082B (https=) |
| AU (2) | AU2018258663B2 (https=) |
| BR (1) | BR112019022280A2 (https=) |
| CA (1) | CA3060407A1 (https=) |
| EA (1) | EA201992573A1 (https=) |
| MA (1) | MA49059A (https=) |
| SG (1) | SG11201909676WA (https=) |
| WO (1) | WO2018201016A1 (https=) |
| ZA (1) | ZA201907225B (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3060407A1 (en) | 2017-04-28 | 2018-11-01 | Seattle Genetics, Inc. | Treatment of her2 positive cancers |
| TW202042820A (zh) * | 2019-01-28 | 2020-12-01 | 美商西雅圖遺傳學股份有限公司 | 以妥卡替尼（Ｔｕｃａｔｉｎｉｂ）治療乳癌之方法 |
| AU2019450366B2 (en) * | 2019-06-11 | 2026-01-08 | Board Of Regents, The University Of Texas System | Use of an RXR agonist in treating Her2+ cancers |
| MX2022004699A (es) * | 2019-10-21 | 2022-08-08 | Seagen Inc | Metodos de tratamiento del cancer de mama con sobreexpresion de her2 con tucatinib en combinacion con capecitabina y trastuzumab. |
| AU2020381495A1 (en) * | 2019-11-15 | 2022-05-19 | Seagen Inc. | Methods of treating HER2 positive breast cancer with tucatinib in combination with an anti-HER2 antibody-drug conjugate |
| MX2022014886A (es) * | 2020-05-29 | 2023-01-04 | Seagen Inc | Metodos de tratamiento del cancer positivo para her2 con tucatinib en combinacion con trastuzumab y una quimioterapia a base de oxaliplatino. |
| EP4188384A1 (en) * | 2020-07-29 | 2023-06-07 | Seagen Inc. | Methods of treating her2 positive cancer with tucatinib in combination with trastuzumab, a taxane, and a vegfr-2 antagonist |
| US20230372342A1 (en) * | 2020-09-28 | 2023-11-23 | Seagen Inc. | Methods of treating solid tumors driven by her2 alterations with tucatinib in combination with an anti-her2 antibody |
| IL303350A (en) | 2020-12-04 | 2023-08-01 | Macrogenics Inc | Pharmaceutical compositions of a her2/neu antibody and use of the same |
| US11526994B1 (en) * | 2021-09-10 | 2022-12-13 | Neosoma, Inc. | Labeling, visualization, and volumetric quantification of high-grade brain glioma from MRI images |
| WO2024183622A1 (zh) * | 2023-03-03 | 2024-09-12 | 盛禾(中国)生物制药有限公司 | 一种抗her2抗体在制备治疗癌症的药物中的用途 |
| TW202541808A (zh) | 2023-12-20 | 2025-11-01 | 德商百靈佳殷格翰國際股份有限公司 | 抗癌組合治療 |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4235871A (en) | 1978-02-24 | 1980-11-25 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
| US4501728A (en) | 1983-01-06 | 1985-02-26 | Technology Unlimited, Inc. | Masking of liposomes from RES recognition |
| US4957735A (en) | 1984-06-12 | 1990-09-18 | The University Of Tennessee Research Corporation | Target-sensitive immunoliposomes- preparation and characterization |
| US5019369A (en) | 1984-10-22 | 1991-05-28 | Vestar, Inc. | Method of targeting tumors in humans |
| US4902505A (en) | 1986-07-30 | 1990-02-20 | Alkermes | Chimeric peptides for neuropeptide delivery through the blood-brain barrier |
| US4837028A (en) | 1986-12-24 | 1989-06-06 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| US5004697A (en) | 1987-08-17 | 1991-04-02 | Univ. Of Ca | Cationized antibodies for delivery through the blood-brain barrier |
| US5055303A (en) | 1989-01-31 | 1991-10-08 | Kv Pharmaceutical Company | Solid controlled release bioadherent emulsions |
| US5271961A (en) | 1989-11-06 | 1993-12-21 | Alkermes Controlled Therapeutics, Inc. | Method for producing protein microspheres |
| US5188837A (en) | 1989-11-13 | 1993-02-23 | Nova Pharmaceutical Corporation | Lipsopheres for controlled delivery of substances |
| US5268164A (en) | 1990-04-23 | 1993-12-07 | Alkermes, Inc. | Increasing blood-brain barrier permeability with permeabilizer peptides |
| US5254342A (en) | 1991-09-30 | 1993-10-19 | University Of Southern California | Compositions and methods for enhanced transepithelial and transendothelial transport or active agents |
| AU668384B2 (en) | 1992-03-12 | 1996-05-02 | Alkermes Controlled Therapeutics, Inc. | Controlled release ACTH containing microspheres |
| US5534496A (en) | 1992-07-07 | 1996-07-09 | University Of Southern California | Methods and compositions to enhance epithelial drug transport |
| US5514670A (en) | 1993-08-13 | 1996-05-07 | Pharmos Corporation | Submicron emulsions for delivery of peptides |
| US6350786B1 (en) | 1998-09-22 | 2002-02-26 | Hoffmann-La Roche Inc. | Stable complexes of poorly soluble compounds in ionic polymers |
| WO2005016346A1 (en) | 2003-08-14 | 2005-02-24 | Array Biopharma Inc. | Quinazoline analogs as receptor tyrosine kinase inhibitors |
| BRPI0511754A (pt) | 2004-06-03 | 2008-01-02 | Smithkline Beechman Cork Ltd | uso de um composto ou sais ou solvatos do mesmo |
| ES2364901T3 (es) | 2005-11-15 | 2011-09-16 | Array Biopharma, Inc. | Procesos e intermedios para la preparación de derivados de n4-fenil-quinazolin-4-amina. |
| CA2700673A1 (en) * | 2007-09-24 | 2009-04-02 | Tragara Pharmaceuticals, Inc. | Therapies for treating cancer using combinations of cox-2 inhibitors and anti-her2(erbb2) antibodies or combinations of cox-2 inhibitors and her2(erbb2) receptor tyrosine kinase inhibitors |
| NZ602675A (en) | 2008-03-18 | 2014-03-28 | Genentech Inc | Combinations of an anti-her2 antibody-drug conjugate and chemotherapeutic agents, and methods of use |
| US20120295259A1 (en) * | 2011-05-19 | 2012-11-22 | Laboratory Corporation Of America Holdings | Methods for Determining the Likelihood of Survival and for Predicting Likelihood of Metastasis in Cancer Patients |
| MX358013B (es) * | 2009-11-13 | 2018-08-01 | Amgen Inc | Materiales y metodos para el tratamiento o prevencion de enfermedades asociadas al her-3. |
| BR122020010643B1 (pt) | 2011-10-14 | 2022-05-17 | Array Biopharma Inc | Dispersão sólida, composições farmacêuticas compreendendo a referida dispersão, usos das composições farmacêuticas e processo de preparação de uma dispersão sólida |
| RU2629116C2 (ru) | 2011-10-14 | 2017-08-24 | Эррэй Биофарма Инк. | Полиморфы arry-380, селективного ингибитора erbb2, и фармацевтические составы, содержащие их |
| WO2013142875A1 (en) | 2012-03-23 | 2013-09-26 | Array Biopharma Inc. | Treatment of brain cancer |
| JP6706255B2 (ja) * | 2014-07-17 | 2020-06-03 | バイオキュリティー ファーマシューティカルズ インコーポレイテッド | 放射線、酸化セリウムナノ粒子、及び化学療法剤の併用によるがんの治療 |
| US10702527B2 (en) * | 2015-06-12 | 2020-07-07 | Dana-Farber Cancer Institute, Inc. | Combination therapy of transcription inhibitors and kinase inhibitors |
| US20190119284A1 (en) * | 2016-04-19 | 2019-04-25 | The Regents Of The University Of California | ErbB Inhibitors and Uses Thereof |
| CA3060407A1 (en) | 2017-04-28 | 2018-11-01 | Seattle Genetics, Inc. | Treatment of her2 positive cancers |
| US20210239702A1 (en) | 2018-06-14 | 2021-08-05 | Memorial Sloan Kettering Cancer Center | Methods for predicting responsiveness of lung cancer patients to her2-targeting therapies |
| TW202042820A (zh) | 2019-01-28 | 2020-12-01 | 美商西雅圖遺傳學股份有限公司 | 以妥卡替尼（Ｔｕｃａｔｉｎｉｂ）治療乳癌之方法 |
| MX2022004699A (es) | 2019-10-21 | 2022-08-08 | Seagen Inc | Metodos de tratamiento del cancer de mama con sobreexpresion de her2 con tucatinib en combinacion con capecitabina y trastuzumab. |
| AU2020381495A1 (en) | 2019-11-15 | 2022-05-19 | Seagen Inc. | Methods of treating HER2 positive breast cancer with tucatinib in combination with an anti-HER2 antibody-drug conjugate |
| JP2023517078A (ja) | 2020-03-11 | 2023-04-21 | シージェン インコーポレイテッド | ツカチニブを用いてｈｅｒ２突然変異を有するがんを処置する方法 |
-
2018
- 2018-04-27 CA CA3060407A patent/CA3060407A1/en active Pending
- 2018-04-27 BR BR112019022280A patent/BR112019022280A2/pt unknown
- 2018-04-27 AU AU2018258663A patent/AU2018258663B2/en active Active
- 2018-04-27 CN CN201880043831.3A patent/CN111032082B/zh active Active
- 2018-04-27 EA EA201992573A patent/EA201992573A1/ru unknown
- 2018-04-27 EP EP18724716.8A patent/EP3615067A1/en active Pending
- 2018-04-27 WO PCT/US2018/029899 patent/WO2018201016A1/en not_active Ceased
- 2018-04-27 KR KR1020197035001A patent/KR102845148B1/ko active Active
- 2018-04-27 US US16/607,850 patent/US11207324B2/en active Active
- 2018-04-27 SG SG11201909676W patent/SG11201909676WA/en unknown
- 2018-04-27 JP JP2019558369A patent/JP7328151B2/ja active Active
- 2018-04-27 MA MA049059A patent/MA49059A/fr unknown
-
2019
- 2019-10-30 ZA ZA2019/07225A patent/ZA201907225B/en unknown
-
2021
- 2021-11-18 US US17/530,265 patent/US11666572B2/en active Active
-
2022
- 2022-09-28 AU AU2022241509A patent/AU2022241509B2/en active Active
-
2023
- 2023-04-26 US US18/139,653 patent/US12048698B2/en active Active
- 2023-08-03 JP JP2023126666A patent/JP2023145689A/ja active Pending
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