JP2020515688A5 - - Google Patents

Download PDF

Info

Publication number
JP2020515688A5
JP2020515688A5 JP2019553558A JP2019553558A JP2020515688A5 JP 2020515688 A5 JP2020515688 A5 JP 2020515688A5 JP 2019553558 A JP2019553558 A JP 2019553558A JP 2019553558 A JP2019553558 A JP 2019553558A JP 2020515688 A5 JP2020515688 A5 JP 2020515688A5
Authority
JP
Japan
Prior art keywords
polyaminoglycoside
aminoglycoside
super
branched
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2019553558A
Other languages
English (en)
Japanese (ja)
Other versions
JP2020515688A (ja
JP7403152B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/IB2018/052144 external-priority patent/WO2018178902A1/en
Publication of JP2020515688A publication Critical patent/JP2020515688A/ja
Publication of JP2020515688A5 publication Critical patent/JP2020515688A5/ja
Application granted granted Critical
Publication of JP7403152B2 publication Critical patent/JP7403152B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2019553558A 2017-03-28 2018-03-28 生分解可能な抗菌性スキャフォールドとしての一酸化窒素放出性ポリアミノグリコシドおよびそれに関する方法背景 Active JP7403152B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762477564P 2017-03-28 2017-03-28
US62/477,564 2017-03-28
PCT/IB2018/052144 WO2018178902A1 (en) 2017-03-28 2018-03-28 Nitric oxide-releasing polyaminoglycosides as biodegradable antibacterial scaffolds and methods pertaining thereto

Publications (3)

Publication Number Publication Date
JP2020515688A JP2020515688A (ja) 2020-05-28
JP2020515688A5 true JP2020515688A5 (enExample) 2021-05-06
JP7403152B2 JP7403152B2 (ja) 2023-12-22

Family

ID=63677204

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2019553558A Active JP7403152B2 (ja) 2017-03-28 2018-03-28 生分解可能な抗菌性スキャフォールドとしての一酸化窒素放出性ポリアミノグリコシドおよびそれに関する方法背景

Country Status (7)

Country Link
US (1) US11723914B2 (enExample)
EP (1) EP3600338A4 (enExample)
JP (1) JP7403152B2 (enExample)
CN (1) CN110461338A (enExample)
AU (1) AU2018247167B2 (enExample)
CA (1) CA3055474A1 (enExample)
WO (1) WO2018178902A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018067838A1 (en) 2016-10-07 2018-04-12 The University Of North Carolina At Chapel Hill S-nitrosothiol-mediated hyperbranched polyesters
EP3565848A4 (en) 2017-01-03 2020-09-02 The University of North Carolina at Chapel Hill NITRIC OXIDE RELEASING ALGINATES AS BIODEGRADABLE ANTIBACTERIAL SCAFFOLDS AND RELATED PROCESSES
EP3600338A4 (en) 2017-03-28 2020-10-28 The University of North Carolina at Chapel Hill NITRIC OXIDE RELEASING POLYAMINOGLYCOSIDES AS BIODEGRADABLE ANTIBACTERIAL SCAFFOLDS AND RELATED PROCESSES
CN111491982B (zh) 2017-11-15 2023-04-18 北卡罗来纳大学查佩尔希尔分校 作为抗菌支架的一氧化氮释放型超支化化合物及其相关方法
JP7565588B2 (ja) 2018-03-06 2024-10-11 ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒル 生分解性の抗菌性足場としての一酸化窒素放出性シクロデキストリンおよびそれに関する方法
WO2020139857A1 (en) 2018-12-28 2020-07-02 The University Of North Carolina At Chapel Hill Nitric oxide-releasing antibacterial polymers and scaffolds fabricated therefrom and methods pertaining thereto
CN115232318B (zh) * 2022-08-24 2023-12-26 宁波锋成先进能源材料研究院有限公司 一种非离子高分子表面活性剂及其制备方法和应用

Family Cites Families (92)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4169079A (en) 1977-10-24 1979-09-25 Iwao Tabushi Polystyrene based polymers containing cyclodextrin derivatives, metal complexes of the same, and process for the production of the same
US5574027A (en) 1989-11-22 1996-11-12 Bernstein; Lawrence R. Pharmaceutical compositions of gallium complexes of 3-hydroxy-4-pyrones
US5234933A (en) 1991-10-31 1993-08-10 Board Of Governors Of Wayne State University And Vanderbilt University Cyclic hydroxamic acids
DE4210332C1 (enExample) 1992-03-30 1993-07-15 Gruenenthal Gmbh, 5100 Aachen, De
US5814666A (en) 1992-04-13 1998-09-29 The United States As Represented By The Department Of Health And Human Services Encapsulated and non-encapsulated nitric oxide generators used as antimicrobial agents
US5238832A (en) 1992-06-08 1993-08-24 Board Of Governors Of Wayne State University Aryl aliphatic acids
US5910316A (en) 1992-08-24 1999-06-08 The United States Of America, As Represented By The Department Of Health And Human Services Use of nitric oxide-releasing agents to treat impotency
US5691423A (en) 1992-08-24 1997-11-25 The United States Of America As Represented By The Department Of Health And Human Services Polysaccharide-bound nitric oxide-nucleophile adducts
US5650447A (en) 1992-08-24 1997-07-22 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Nitric oxide-releasing polymers to treat restenosis and related disorders
US5405919A (en) 1992-08-24 1995-04-11 The United States Of America As Represented By The Secretary Of Health And Human Services Polymer-bound nitric oxide/nucleophile adduct compositions, pharmaceutical compositions and methods of treating biological disorders
US5632981A (en) 1992-08-24 1997-05-27 The United States Of America As Represented By The Department Of Health And Human Services Biopolymer-bound nitric oxide-releasing compositions, pharmaceutical compositions incorporating same and methods of treating biological disorders using same
US5525357A (en) 1992-08-24 1996-06-11 The United States Of America As Represented By The Department Of Health And Human Services Polymer-bound nitric oxide/nucleophile adduct compositions, pharmaceutical compositions incorporating same and methods of treating biological disorders using same
US6200558B1 (en) 1993-09-14 2001-03-13 The United States Of America As Represented By The Department Of Health And Human Services Biopolymer-bound nitric oxide-releasing compositions, pharmaceutical compositions incorporating same and methods of treating biological disorders using same
US5840759A (en) 1993-10-08 1998-11-24 The United States Of America As Represented By The Department Of Health And Human Services Use of nitric oxide releasing compounds to protect noncancerous cells from chemotherapeutic agents
US5650442A (en) 1993-10-08 1997-07-22 The United States Of America As Represented By The Department Of Health And Human Services Use of nitric oxide releasing compounds as hypoxic cell radiation sensitizers
EP0726768B1 (en) 1993-11-02 2000-05-17 THE UNITED STATES OF AMERICA, represented by THE SECRETARY, Department of Health and Human Services Use of nitric oxide releasing compounds for the manufacture of a medicament for protection in ischemia reperfusion injury
CA2205564C (en) 1994-11-22 2006-07-11 The United States Of America, Represented By The Secretary, Department Of Health And Human Services Pharmaceutical compositions comprising nitric oxide-releasing biopolymers
US5714511A (en) 1995-07-31 1998-02-03 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Selective prevention of organ injury in sepsis and shock using selection release of nitric oxide in vulnerable organs
US6232434B1 (en) 1996-08-02 2001-05-15 Duke University Medical Center Polymers for delivering nitric oxide in vivo
US5770645A (en) 1996-08-02 1998-06-23 Duke University Medical Center Polymers for delivering nitric oxide in vivo
US20030093143A1 (en) 1999-03-01 2003-05-15 Yiju Zhao Medical device having surface depressions containing nitric oxide releasing compound
CA2266908C (en) 1996-09-27 2010-07-20 Joseph E. Saavedra O2-arylated or o2-glycosylated 1-substituted diazen-1-ium-1,2-diolates and o2-substituted 1-[(2-carboxylato)pyrrolidin-1-yl]diazen-1-ium-1,2-diolates
JP4285775B2 (ja) 1996-09-27 2009-06-24 アメリカ合衆国 O▲上2▼―アリール化またはo▲上2▼―グリコシル化1―置換ジアゼン―1―イウム―1,2―ジオレート類およびo▲上2▼―置換1―[(2―カルボキシラト)ピロリジン―1―イル]ジアゼン―1―イウム―1,2―ジオレート類
NO305033B1 (no) 1997-05-09 1999-03-22 Algipharma As Fremgangsmate for fremstilling av uronsyreblokker fra alginat
EP1000023B1 (en) * 1997-07-03 2011-02-23 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, represented by THE DEPARTMENT OF HEALTH & HUMAN SERVICES Novel nitric oxide-releasing amidine- and enamine-derived diazeniumdiolates, compositions and uses thereof and method of making same
US6180082B1 (en) 1997-11-24 2001-01-30 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Method to enhance tissue accumulation of radiolabeled compounds
US6207855B1 (en) 1998-06-23 2001-03-27 Duke University Medical Center Stable no-delivering compounds
US6261594B1 (en) 1998-11-25 2001-07-17 The University Of Akron Chitosan-based nitric oxide donor compositions
JP4870314B2 (ja) 2000-05-02 2012-02-08 セラヴァンス, インコーポレーテッド シクロデキストリンを含むグリコペプチド抗生物質組成物
JP2002179647A (ja) 2000-12-11 2002-06-26 Kikkoman Corp ニコチアナミン又はニコチアナミン含有物の製造法
AUPR879601A0 (en) * 2001-11-09 2001-12-06 Biota Scientific Management Pty Ltd Novel chemical compounds and their use
AU2003226603A1 (en) 2002-04-19 2003-11-03 Yissum Research Development Company Of The Hebrew University Of Jerusalem Beta-agonist compounds comprising nitric oxide donor groups and reactive oxygen species scavenger groups and their use in the treatment of respiratory disorders
US20040038947A1 (en) 2002-06-14 2004-02-26 The Gov. Of The U.S. Of America As Represented By The Sec. Of The Dept. Of Health & Human Services Method of treating ischemia/reperfusion injury with nitroxyl donors
NO20023581D0 (no) 2002-07-26 2002-07-26 Fmc Biopolymer As Nye mutantstammer av Pseudomonas fluorescens og varianter derav, metoder for produksjon og bruk derav til produksjon avalginat
NO335366B1 (no) 2002-07-26 2014-12-01 Algipharma As Mutantstamme Pf201 av Pseudomonas fluorescens og anvendelse derav i alginatproduksjon,samt fremgangsmåte for fremstilling derav.
BR122012021252B8 (pt) 2002-09-06 2021-05-25 Cerulean Pharma Inc polímeros à base de ciclodextrina para o fornecimento de agentes terapêuticos ligados a eles por covalência
US20050009789A1 (en) 2003-05-13 2005-01-13 The Government Of The Usa As Represented By The Secretary Of The Dept. Of Health And Human Service Cyclooxygenase inhibition with nitroxyl
JP2005047979A (ja) 2003-07-30 2005-02-24 Dainippon Ink & Chem Inc 多分岐ポリマーの製造方法、及び多分岐ポリマー
SG113562A1 (en) 2004-01-12 2005-08-29 Agency Science Tech & Res Polyalkyleneimine-graft-biodegradable polymers for delivery of bioactive agents
EP1846006A4 (en) 2005-01-28 2011-04-20 Pinnacle Pharmaceuticals Inc BETA-CYCLODEXTRIN DERIVATIVES AS ANTIBACTERIAL AGENTS
CA2606565C (en) 2005-05-27 2016-05-10 The University Of North Carolina At Chapel Hill Nitric oxide-releasing particles for nitric oxide therapeutics and biomedical applications
GB0515550D0 (en) 2005-07-29 2005-09-07 Univ Strathclyde Inactivation of staphylococcus species
CA2628055C (en) 2005-10-31 2013-10-01 Government Of The United States Of America, Represented By The Secretary , Department Of Health And Human Services Polysaccharide-derived nitric oxide-releasing carbon-bound diazeniumdiolates
JP2009523584A (ja) 2006-01-24 2009-06-25 ミリメッド・アクティーゼルスカブ Ph依存性薬物放出を有する医療デバイス
US7854923B2 (en) 2006-04-18 2010-12-21 Endomedix, Inc. Biopolymer system for tissue sealing
GB0707096D0 (en) 2007-04-12 2007-05-23 Ntnu Technology Transfer As Method
CN101049513B (zh) 2007-05-13 2010-05-19 刘万顺 水溶性壳聚糖基纤维止血愈创材料及其制备方法和应用
ITMI20071341A1 (it) 2007-07-05 2009-01-06 Fidia Farmaceutici Derivati di acido ialuronico contenenti gruppi in grado di rilasciare no
WO2009049208A1 (en) * 2007-10-12 2009-04-16 The University Of North Carolina At Chapel Hill Use of nitric oxide to enhance the efficacy of silver and other topical wound care agents
HUE034051T2 (en) 2007-11-27 2018-01-29 Algipharma As Use of alginate-containing oligomers to combat biofilms
WO2009087005A2 (en) * 2008-01-10 2009-07-16 Nicox S.A. Composition comprising a nitrooxyderivative of acetaminophen and a anticonvulsant drug for the treatment of neuropathic pain
US20090222088A1 (en) 2008-02-29 2009-09-03 Medtronic Vascular, Inc. Secondary Amine Containing Nitric Oxide Releasing Polymer Composition
US20090232863A1 (en) 2008-03-17 2009-09-17 Medtronic Vascular, Inc. Biodegradable Carbon Diazeniumdiolate Based Nitric Oxide Donating Polymers
CN102083862A (zh) 2008-04-01 2011-06-01 康奈尔大学 有机-可溶性壳聚糖盐和由其制备的壳聚糖衍生生物材料
CN102256989B (zh) * 2008-10-03 2016-01-06 聚糖生物科学有限责任公司 糖基化细菌代谢物的阴离子轭合物
US8158187B2 (en) * 2008-12-19 2012-04-17 Medtronic Vascular, Inc. Dry diazeniumdiolation methods for producing nitric oxide releasing medical devices
WO2010096320A2 (en) 2009-02-18 2010-08-26 Bezwada Biomedical, Llc Controlled release of nitric oxide and drugs from functionalized macromers and oligomers
GB0904941D0 (en) 2009-03-23 2009-05-06 Ntnu Technology Transfer As Composition
WO2010120905A2 (en) 2009-04-15 2010-10-21 Board Of Trustees Of Michigan State University Novel nano-probes for molecular imaging and targeted therapy of diseases
US9539233B2 (en) 2009-05-04 2017-01-10 Aridis Pharmaceuticals Inc. Gallium formulation for the treatment and prevention of infectious diseases
US8815831B2 (en) 2009-06-03 2014-08-26 Algipharma As Treatment of Acinetobacter with alginate oligomers and antibiotics
GB0909529D0 (en) 2009-06-03 2009-07-15 Algipharma Ipr As Alginate oligomers for the inhibition of microbial adherence to surfaces
GB0909557D0 (en) 2009-06-03 2009-07-15 Algipharma Ipr As Anti-microbial alginate oligomers
US9957341B2 (en) 2009-06-09 2018-05-01 William Chambers Biodegradable absorbent material and method of manufacture
CA2671595A1 (en) 2009-07-09 2011-01-09 Ping I. Lee Controlled nitric oxide delivery from aqueous s-nitrosothiol conjugated polymers and their complexes
US8551456B2 (en) 2010-03-05 2013-10-08 University Of Dayton Combination therapy and methods for treating bacterial biofilms
EP2547660B1 (en) 2010-03-19 2015-01-07 The United States Of America, As Represented By The Secretary, Department of Health and Human Services Nitroxyl (hno) releasing compounds and uses thereof in treating diseases
KR101272351B1 (ko) * 2010-04-23 2013-06-07 이화여자대학교 산학협력단 새로운 카나마이신 화합물, 카나마이신 생산 스트렙토마이세스 속 미생물 및 카나마이신의 생산 방법
KR101255337B1 (ko) 2010-10-04 2013-04-16 한국과학기술연구원 온도 감응성 합성 고분자를 이용한 일산화질소 전달체
WO2012116177A2 (en) 2011-02-24 2012-08-30 Colorado State University Research Foundation Materials for modulating biological responses and methods of making
ES2658897T3 (es) * 2011-08-24 2018-03-12 Novan, Inc. Macromoléculas de liberación de óxido nítrico ajustables que tienen múltiples estructuras donantes de óxido nítrico
GB201116010D0 (en) 2011-09-15 2011-10-26 Algipharma As Use of alginate oligomers to enhance the effects of antifungal agents
KR101385280B1 (ko) * 2012-05-23 2014-04-16 한국과학기술원 역상 현탁중합과 전구체를 이용한 가교된 하이퍼브랜치 폴리아미도아민 입자의 제조 방법
US9017653B2 (en) 2012-06-14 2015-04-28 The Board Of Regents Of The University Of Texas System Nitric oxide-releasing compositions and methods
EP2885323B1 (en) 2012-08-17 2023-08-30 The University of North Carolina At Chapel Hill Water soluble nitric oxide-releasing polyglucosamines and uses thereof
WO2014138425A1 (en) 2013-03-08 2014-09-12 Allergan, Inc. Cyclosporine a-steroid conjugates
GB201322777D0 (en) 2013-12-20 2014-02-05 Algipharma As Use of alginate oligomers as blood anticoagulants
US20160346313A1 (en) 2013-12-23 2016-12-01 Norwegian University Of Science And Technology Uses of oligouronates in cancer treatment
KR20160119259A (ko) 2014-02-28 2016-10-12 알지파마 에이에스 낭포성 섬유증 및 cftr 이온 채널의 기능 결함과 관련된 기타 병태의 치료제로서 알기네이트 올리고머의 용도
GB201415381D0 (en) 2014-08-29 2014-10-15 Algipharma As Inhalable powder formulations of alginate oligomers
EP3215140A4 (en) 2014-11-06 2018-05-02 The Arizona Board of Regents On Behalf of the University of Arizona Compositions and methods of diazeniumdiolate-based prodrugs for treating cancer
GB201504878D0 (en) 2015-03-23 2015-05-06 Algipharma As Use of alginate oligomers and CFTR modulators in the treatment of conditions associated with CFTR dysfuntion
US11170451B2 (en) 2015-10-02 2021-11-09 Not So Forgetful, LLC Apparatus and method for providing gift recommendations and social engagement reminders, storing personal information, and facilitating gift and social engagement recommendations for calendar-based social engagements through an interconnected social network
GB201517639D0 (en) 2015-10-06 2015-11-18 Algipharma As Use of alginate oligomers to treat or prevent microbial overgrowth in the intestinal tract
CN106046382B (zh) 2016-05-25 2018-10-09 暨南大学 一种装载一氧化氮的阳离子聚合物及其制备方法和应用
WO2018067838A1 (en) 2016-10-07 2018-04-12 The University Of North Carolina At Chapel Hill S-nitrosothiol-mediated hyperbranched polyesters
EP3565848A4 (en) 2017-01-03 2020-09-02 The University of North Carolina at Chapel Hill NITRIC OXIDE RELEASING ALGINATES AS BIODEGRADABLE ANTIBACTERIAL SCAFFOLDS AND RELATED PROCESSES
EP3600338A4 (en) 2017-03-28 2020-10-28 The University of North Carolina at Chapel Hill NITRIC OXIDE RELEASING POLYAMINOGLYCOSIDES AS BIODEGRADABLE ANTIBACTERIAL SCAFFOLDS AND RELATED PROCESSES
CN111491982B (zh) 2017-11-15 2023-04-18 北卡罗来纳大学查佩尔希尔分校 作为抗菌支架的一氧化氮释放型超支化化合物及其相关方法
JP7565588B2 (ja) 2018-03-06 2024-10-11 ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒル 生分解性の抗菌性足場としての一酸化窒素放出性シクロデキストリンおよびそれに関する方法
US11102301B2 (en) 2018-07-12 2021-08-24 Sap Se PCA-based scoring of the similarity of damage patterns of operational assets
WO2020139857A1 (en) 2018-12-28 2020-07-02 The University Of North Carolina At Chapel Hill Nitric oxide-releasing antibacterial polymers and scaffolds fabricated therefrom and methods pertaining thereto

Similar Documents

Publication Publication Date Title
JP2020515688A5 (enExample)
JP2021503029A5 (enExample)
US6440405B1 (en) Quaternary ammonium functionalized dendrimers and methods of use therefor
Lopez et al. Antibacterial activity and cytotoxicity of PEGylated poly (amidoamine) dendrimers
Felczak et al. Antimicrobial activity of poly (propylene imine) dendrimers
JP2012532185A5 (enExample)
US9399044B2 (en) Antimicrobial cationic polyamines
CN107531898B (zh) 微粒
CA2695611A1 (en) Active targeting polymer micelle encapsulating drug, and pharmaceutical composition
CN106102730A (zh) 作为抗微生物剂的聚阳离子两亲物
Lin et al. Antimicrobial peptide-inspired antibacterial polymeric materials for biosafety
Farah et al. Crosslinked QA‐PEI nanoparticles: synthesis reproducibility, chemical modifications, and stability study
Banerjee et al. Linear polyethyleneimine grafted to a hyperbranched poly (ethylene glycol)-like core: a copolymer for gene delivery
CN114560778B (zh) 双子季铵盐及其制备方法与应用
US9403944B2 (en) Antipathogenic guanidinium copolymer
EP0305470B1 (en) Antiinfective compounds and method of use
JP2008503221A5 (enExample)
RU2422474C2 (ru) Новые карбосилановые дендримеры, их получение и применение
JP2020513041A5 (enExample)
Domb et al. Quaternary ammonium antimicrobial polymers
JPWO2018127819A5 (enExample)
US8093352B2 (en) Polyalkylene oxide polyquaternary ammonium biocides
RU2018107057A (ru) Фрамацевтическая композиция с улучшенной устройчивостью при хранении и способ ее получения
CN111491981B (zh) 具有抗微生物功能的亲水性聚合物
JP2025111445A5 (enExample)