JP2020515638A5 - - Google Patents

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JP2020515638A5
JP2020515638A5 JP2020502542A JP2020502542A JP2020515638A5 JP 2020515638 A5 JP2020515638 A5 JP 2020515638A5 JP 2020502542 A JP2020502542 A JP 2020502542A JP 2020502542 A JP2020502542 A JP 2020502542A JP 2020515638 A5 JP2020515638 A5 JP 2020515638A5
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drug delivery
phospholipid
delivery vehicle
vehicle according
nanoscale drug
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JP2020502542A
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JP7280624B2 (ja
JP2020515638A (ja
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JP2020502542A 2017-04-03 2018-04-02 経血液脳関門的、経粘膜的及び経皮的薬物送達のための変形可能なナノスケールビヒクル(dnv) Active JP7280624B2 (ja)

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JP2023039717A JP2023075276A (ja) 2017-04-03 2023-03-14 経血液脳関門的、経粘膜的及び経皮的薬物送達のための変形可能なナノスケールビヒクル(dnv)

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US201762480924P 2017-04-03 2017-04-03
US62/480,924 2017-04-03
PCT/US2018/025749 WO2018187240A1 (en) 2017-04-03 2018-04-02 Deformable nano-scale vehicles (dnvs) for trans-blood brain barrier, trans-mucosal, and transdermal drug delivery

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JP2023039717A Division JP2023075276A (ja) 2017-04-03 2023-03-14 経血液脳関門的、経粘膜的及び経皮的薬物送達のための変形可能なナノスケールビヒクル(dnv)

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JP2020515638A JP2020515638A (ja) 2020-05-28
JP2020515638A5 true JP2020515638A5 (https=) 2021-05-13
JP7280624B2 JP7280624B2 (ja) 2023-05-24

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JP2020502542A Active JP7280624B2 (ja) 2017-04-03 2018-04-02 経血液脳関門的、経粘膜的及び経皮的薬物送達のための変形可能なナノスケールビヒクル(dnv)
JP2023039717A Pending JP2023075276A (ja) 2017-04-03 2023-03-14 経血液脳関門的、経粘膜的及び経皮的薬物送達のための変形可能なナノスケールビヒクル(dnv)

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US (1) US12514929B2 (https=)
EP (1) EP3606557A4 (https=)
JP (2) JP7280624B2 (https=)
CN (1) CN110662532A (https=)
CA (1) CA3058782A1 (https=)
WO (1) WO2018187240A1 (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017087685A1 (en) 2015-11-20 2017-05-26 The Regents Of The University Of California Deformable nano-scale vehicles (dnvs) for trans-blood brain barrier, trans-mucosal, and transdermal drug delivery
CA3058782A1 (en) 2017-04-03 2018-10-11 The Regents Of The University Of California Deformable nano-scale vehicles (dnvs) for trans-blood brain barrier, trans-mucosal, and transdermal drug delivery
CN110251508A (zh) * 2019-05-07 2019-09-20 苏州大学 Nsc-156529作为t-型钙通道拮抗剂的应用
WO2021207273A1 (en) * 2020-04-07 2021-10-14 The Regents Of The University Of California Manufacturing of synthetic exosomes for cns and non-cns delivery of therapeutics
CN111569061A (zh) * 2020-05-06 2020-08-25 吴延恒 一种用于核酸疫苗增强剂的纳米材料
CN114259486B (zh) * 2020-09-16 2024-04-02 香港科技大学 木犀草素及其药物组合物的应用
CN113975397B (zh) * 2021-10-26 2023-08-22 中南大学湘雅三医院 一种基因/小分子化合物纳米递药系统及其制备方法与应用
CN114948852B (zh) * 2022-05-26 2024-05-17 深圳先进技术研究院 一种用于脑部疾病诊断和治疗的微针系统及其制备方法
CN116392449A (zh) * 2023-04-28 2023-07-07 广州医科大学附属第三医院(广州重症孕产妇救治中心、广州柔济医院) 一种橘红素纳米脂质体冻干制剂及其制备方法
CN117551095B (zh) * 2023-11-09 2025-02-07 中国药科大学 一种玫瑰树碱衍生物及其制备方法与应用

Family Cites Families (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4704355A (en) 1985-03-27 1987-11-03 New Horizons Diagnostics Corporation Assay utilizing ATP encapsulated within liposome particles
WO1991004014A1 (en) 1989-09-21 1991-04-04 Synergen, Inc. Method for transporting compositions across the blood brain barrier
FR2658418B1 (fr) 1990-02-20 1994-09-02 Synthelabo Compositions pharmaceutiques a base de phospholipides.
FR2699818B1 (fr) * 1992-12-24 1995-02-03 Oreal Composition cosmétique ou pharmaceutique contenant en association un polyphénol et un extrait de gingko.
US5858398A (en) 1994-11-03 1999-01-12 Isomed Inc. Microparticular pharmaceutical compositions
US20020048596A1 (en) * 1994-12-30 2002-04-25 Gregor Cevc Preparation for the transport of an active substance across barriers
MXPA00006196A (es) * 1998-10-23 2003-07-21 Idea Ag Metodo para desarrollar, evaluar y utilizar asociaciones de macromoleculas y agregados complejos para obtener mejores tasas de asociacion/desasociacion controlable y carga efectiva.
SI1031347T1 (en) 1999-01-27 2002-10-31 Idea Ag Transnasal transport/immunisation with highly adaptable carriers
GB0118517D0 (en) 2001-07-30 2001-09-19 Mitsubishi Tokyo Pharm Inc Compound
CN1703199B (zh) 2002-10-11 2010-04-28 伊迪亚股份公司 具有增强的可变形性、包含至少三种两亲性物质的聚集物,其用于改善通过半透屏障的转运以及非侵入性药物在体内、具体是通过皮肤的应用
CN1285383C (zh) 2004-07-22 2006-11-22 周翔 亲水亲脂自封闭小体液相核心空化成囊泡的方法及应用
GB0416861D0 (en) 2004-07-29 2004-09-01 Quadrant Drug Delivery Ltd Composition
DE102004057303A1 (de) * 2004-11-26 2006-06-01 Merck Patent Gmbh Stabile Kristallmodifikationen von DOTAP Chlorid
EP1850840A2 (en) * 2005-01-13 2007-11-07 Sirtris Pharmaceuticals, Inc. Novel compositions for preventing and treating neurodegenerative and blood coagulation disorders
JP2006248978A (ja) 2005-03-10 2006-09-21 Mebiopharm Co Ltd 新規なリポソーム製剤
US20110020434A1 (en) * 2005-09-02 2011-01-27 O'halloran Thomas V Nanoparticle arsenic-platinum compositions
CN100453071C (zh) 2006-11-03 2009-01-21 李万忠 白藜芦醇口服多相脂质体及其制备方法
US20090017108A1 (en) 2007-07-11 2009-01-15 Alexander Yuzhakov Liposome compositions for treatment of hepatitis C
US20090082400A1 (en) * 2007-07-31 2009-03-26 Ving Lee Soluble pyrone analogs methods and compositions
JO3076B1 (ar) * 2007-10-17 2017-03-15 Janssen Alzheimer Immunotherap نظم العلاج المناعي المعتمد على حالة apoe
WO2009087568A2 (en) * 2008-01-10 2009-07-16 Universidade De Coimbra Compositions comprising antioxidant and mitoprotective flavonoids with neuroprotective properties
CN101474155B (zh) 2009-01-24 2011-03-16 重庆医科大学 注射用肺靶向载药前体脂质体及其使用方法
TR201908314T4 (tr) 2009-02-20 2019-06-21 2 Bbb Medicines B V Glutatyon bazlı ilaç dağıtım sistemi.
SG174287A1 (en) 2009-03-09 2011-10-28 Univ California Single protein nanocapsules for protein delivery with long-term effect
US20110178456A1 (en) 2009-04-03 2011-07-21 The Regents Of The University Of California Assisting transdermal drug delivery by means of tissue freezing, vacuum pressure and photoheating procedures
CN101874763A (zh) 2009-04-29 2010-11-03 上海家化联合股份有限公司 一种白藜芦醇柔性脂质体及其制备方法
WO2010149785A1 (en) 2009-06-26 2010-12-29 Universiteit Gent Cationic liposomes for the delivery of high molecular weight compounds
RU2012103240A (ru) * 2009-07-02 2013-08-10 Ангиокем Инк. Мультимерные пептидные конъюгаты и их применение
EP2394640A1 (en) * 2010-05-21 2011-12-14 MediGene AG Improved liposomal formulations of lipophilic compounds
JP6073783B2 (ja) 2010-06-25 2017-02-01 シャイアー ヒューマン ジェネティック セラピーズ インコーポレイテッド ヘパランn−スルファターゼのcns送達のための方法および組成物
US10357575B2 (en) 2010-09-24 2019-07-23 Case Western Reserve University Stabilized nanobubbles for diagnostic and therapeutic applications
IT1401882B1 (it) 2010-10-01 2013-08-28 Rosa De Nanoparticelle autoassemblanti per il rilascio di bifosfonati nel trattamento di tumori.
BR112013021731A2 (pt) 2011-02-25 2016-11-01 Univ South Dakota nanopartícula;composição farmacêutica ou cosmética;utilização; método para melhorar a estabilidade de um retinóide;método para melhorar a dispersibilidade de um retinóide; método para proporcinar a libertação sustentada de um retinóide; método para aumentar a penetração na pele de um retinóide;método para aumentar a acumulação de tumor de encapsulamento de droga;método para reduzir a acumulação de drogas em tecidos de rolamento não tumorais; método para reduzir a toxicidade de um retinóide;método para reduzir a irritação da pele classificação de um retinóide aplicado topicamente encapsulante compreendendo uma pluralidade de nanopartículas;método de preparação de uma nanopartícula
EP2688554A2 (en) 2011-03-21 2014-01-29 Gregor Cevc Optimised preparations of highly adaptable aggregates
EP2747768A4 (en) * 2011-08-25 2015-10-21 Cognition Therapeutics Inc COMPOSITIONS AND METHOD FOR THE TREATMENT OF NEURODEEGENERATIVE DISEASES
WO2013059617A1 (en) 2011-10-21 2013-04-25 Ndsu Research Foundation Liposome compositions and methods of use
CN104023793B (zh) 2011-10-31 2017-11-24 马林克罗特有限公司 用于治疗癌症的联合脂质体组合物
EP2874605A1 (en) 2012-07-18 2015-05-27 Onyx Therapeutics, Inc. Liposomal compositions of epoxyketone-based proteasome inhibitors
JP2015524849A (ja) 2012-08-15 2015-08-27 ザ・ユニバーシティ・オブ・シカゴThe University Of Chicago 神経変性疾患に対するエキソソームに基づく治療法
US9943482B2 (en) 2013-02-26 2018-04-17 University Of Louisville Research Foundation, Inc. Milk-derived microvesicle compositions and related methods
CN103446055B (zh) 2013-08-22 2015-02-11 合肥工业大学 三羟基异黄酮脂质纳米体的制备方法
EP3057662A4 (en) 2013-10-17 2017-03-29 Children's Hospital Los Angeles Antibody dependent exosome therapy
WO2015061025A1 (en) 2013-10-22 2015-04-30 Aradigm Corporation Inhaled surfactant-modified liposomal formulations providing both an immediate and sustained release profile
WO2015173133A1 (en) * 2014-05-12 2015-11-19 Chiesi Farmaceutici S.P.A. Formulations and methods of treating alzheimer's disease and other proteinopathies by combination therapy
CN108368487B (zh) 2015-10-01 2022-02-01 渥太华大学 核酸的外泌体包装
CN108779167A (zh) * 2015-10-28 2018-11-09 宾夕法尼亚州大学信托人 鞘内施用腺伴随病毒载体用于基因治疗
WO2017087685A1 (en) 2015-11-20 2017-05-26 The Regents Of The University Of California Deformable nano-scale vehicles (dnvs) for trans-blood brain barrier, trans-mucosal, and transdermal drug delivery
CN105287382A (zh) 2015-12-10 2016-02-03 南昌大学 叶酸-壳聚糖修饰姜黄素纳米脂质体的制备方法
EP3402489B1 (en) 2016-01-15 2021-06-09 Orbsen Therapeutics Limited Sdc-2 exosome compositions and methods of isolation and use
US11073511B2 (en) 2016-02-01 2021-07-27 The Board Of Trustees Of The Leland Stanford Junior University Exosome-Total-Isolation-Chip (ExoTIC) device for isolation of exosome-based biomarkers
US20190112351A1 (en) 2016-04-04 2019-04-18 National Institutes Of Biomedical Innovation, Health And Nutrition Exosome-targeted dna vaccine
US20180028600A1 (en) 2016-07-15 2018-02-01 Korea Institute Of Science And Technology Novel recombinant exosome and use thereof
CN106389137B (zh) 2016-08-29 2019-07-16 杭州素妍化妆品有限公司 一种亚麻籽油脂质体及其制备与应用
US20180067121A1 (en) 2016-09-06 2018-03-08 Nanoco Technologies Ltd. Exosome-conjugated quantum dot nanoparticles and methods of detecting exosomes and cancer using same
US20190231694A1 (en) 2016-10-12 2019-08-01 Agency For Science, Technology And Research Method for lyophilising an exosome
US10800817B2 (en) 2016-12-19 2020-10-13 Morehouse School Of Medicine Compositions and methods for treating diseases by inhibiting exosome release
WO2018118015A1 (en) 2016-12-19 2018-06-28 Morehouse School Of Medicine Compositions and methods for treating diseases by inhibiting exosome release
KR102036051B1 (ko) 2017-02-15 2019-10-24 고려대학교 세종산학협력단 엑소좀 기반의 나노입자 복합체 및 이의 제조방법
CA3058782A1 (en) 2017-04-03 2018-10-11 The Regents Of The University Of California Deformable nano-scale vehicles (dnvs) for trans-blood brain barrier, trans-mucosal, and transdermal drug delivery
US11344627B2 (en) 2017-06-27 2022-05-31 Wisconsin Alumni Research Foundation Dendrimer-exosome hybrid nanoparticles as a delivery platform
WO2019094679A1 (en) 2017-11-10 2019-05-16 The Regents Of The University Of California BRAIN DELIVERY OF THE BACE INHIBITOR SAPPALPHA, ANTIBODIES, OR INHIBITORY RNA's USING SYNTHETIC EXOSOMES (DEFORMABLE NANOVESICLES, DNVs)
WO2019099942A1 (en) 2017-11-17 2019-05-23 Codiak Biosciences, Inc. Compositions of engineered exosomes and methods of loading luminal exosomes payloads
WO2019203706A1 (en) 2018-04-20 2019-10-24 Telefonaktiebolaget Lm Ericsson (Publ) Information decoder for polar codes
WO2019209956A1 (en) 2018-04-25 2019-10-31 University Of Massachusetts Artificial exosome composition and related methods
US20190365653A1 (en) 2018-06-04 2019-12-05 Korea Institute Of Science And Technology Novel recombinant exosome containing hyaluronidase and use thereof
WO2021207273A1 (en) 2020-04-07 2021-10-14 The Regents Of The University Of California Manufacturing of synthetic exosomes for cns and non-cns delivery of therapeutics

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