JP2020515638A5 - - Google Patents

Download PDF

Info

Publication number
JP2020515638A5
JP2020515638A5 JP2020502542A JP2020502542A JP2020515638A5 JP 2020515638 A5 JP2020515638 A5 JP 2020515638A5 JP 2020502542 A JP2020502542 A JP 2020502542A JP 2020502542 A JP2020502542 A JP 2020502542A JP 2020515638 A5 JP2020515638 A5 JP 2020515638A5
Authority
JP
Japan
Prior art keywords
drug delivery
phospholipid
delivery vehicle
vehicle according
nanoscale drug
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2020502542A
Other languages
English (en)
Japanese (ja)
Other versions
JP2020515638A (ja
JP7280624B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2018/025749 external-priority patent/WO2018187240A1/en
Publication of JP2020515638A publication Critical patent/JP2020515638A/ja
Publication of JP2020515638A5 publication Critical patent/JP2020515638A5/ja
Priority to JP2023039717A priority Critical patent/JP2023075276A/ja
Application granted granted Critical
Publication of JP7280624B2 publication Critical patent/JP7280624B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2020502542A 2017-04-03 2018-04-02 経血液脳関門的、経粘膜的及び経皮的薬物送達のための変形可能なナノスケールビヒクル(dnv) Active JP7280624B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2023039717A JP2023075276A (ja) 2017-04-03 2023-03-14 経血液脳関門的、経粘膜的及び経皮的薬物送達のための変形可能なナノスケールビヒクル(dnv)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762480924P 2017-04-03 2017-04-03
US62/480,924 2017-04-03
PCT/US2018/025749 WO2018187240A1 (en) 2017-04-03 2018-04-02 Deformable nano-scale vehicles (dnvs) for trans-blood brain barrier, trans-mucosal, and transdermal drug delivery

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2023039717A Division JP2023075276A (ja) 2017-04-03 2023-03-14 経血液脳関門的、経粘膜的及び経皮的薬物送達のための変形可能なナノスケールビヒクル(dnv)

Publications (3)

Publication Number Publication Date
JP2020515638A JP2020515638A (ja) 2020-05-28
JP2020515638A5 true JP2020515638A5 (https=) 2021-05-13
JP7280624B2 JP7280624B2 (ja) 2023-05-24

Family

ID=63712640

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2020502542A Active JP7280624B2 (ja) 2017-04-03 2018-04-02 経血液脳関門的、経粘膜的及び経皮的薬物送達のための変形可能なナノスケールビヒクル(dnv)
JP2023039717A Pending JP2023075276A (ja) 2017-04-03 2023-03-14 経血液脳関門的、経粘膜的及び経皮的薬物送達のための変形可能なナノスケールビヒクル(dnv)

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2023039717A Pending JP2023075276A (ja) 2017-04-03 2023-03-14 経血液脳関門的、経粘膜的及び経皮的薬物送達のための変形可能なナノスケールビヒクル(dnv)

Country Status (6)

Country Link
US (1) US12514929B2 (https=)
EP (1) EP3606557A4 (https=)
JP (2) JP7280624B2 (https=)
CN (1) CN110662532A (https=)
CA (1) CA3058782A1 (https=)
WO (1) WO2018187240A1 (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017087685A1 (en) 2015-11-20 2017-05-26 The Regents Of The University Of California Deformable nano-scale vehicles (dnvs) for trans-blood brain barrier, trans-mucosal, and transdermal drug delivery
WO2018187240A1 (en) 2017-04-03 2018-10-11 The Regents Of The University Of California Deformable nano-scale vehicles (dnvs) for trans-blood brain barrier, trans-mucosal, and transdermal drug delivery
CN110251508A (zh) * 2019-05-07 2019-09-20 苏州大学 Nsc-156529作为t-型钙通道拮抗剂的应用
WO2021207273A1 (en) * 2020-04-07 2021-10-14 The Regents Of The University Of California Manufacturing of synthetic exosomes for cns and non-cns delivery of therapeutics
CN111569061A (zh) * 2020-05-06 2020-08-25 吴延恒 一种用于核酸疫苗增强剂的纳米材料
CN114259486B (zh) * 2020-09-16 2024-04-02 香港科技大学 木犀草素及其药物组合物的应用
CN113975397B (zh) * 2021-10-26 2023-08-22 中南大学湘雅三医院 一种基因/小分子化合物纳米递药系统及其制备方法与应用
CN114948852B (zh) * 2022-05-26 2024-05-17 深圳先进技术研究院 一种用于脑部疾病诊断和治疗的微针系统及其制备方法
CN116392449A (zh) * 2023-04-28 2023-07-07 广州医科大学附属第三医院(广州重症孕产妇救治中心、广州柔济医院) 一种橘红素纳米脂质体冻干制剂及其制备方法
CN117551095B (zh) * 2023-11-09 2025-02-07 中国药科大学 一种玫瑰树碱衍生物及其制备方法与应用

Family Cites Families (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4704355A (en) 1985-03-27 1987-11-03 New Horizons Diagnostics Corporation Assay utilizing ATP encapsulated within liposome particles
CA2025907A1 (en) 1989-09-21 1991-03-22 Franklin D. Collins Method of transporting compositions across the blood brain barrier
FR2658418B1 (fr) 1990-02-20 1994-09-02 Synthelabo Compositions pharmaceutiques a base de phospholipides.
FR2699818B1 (fr) * 1992-12-24 1995-02-03 Oreal Composition cosmétique ou pharmaceutique contenant en association un polyphénol et un extrait de gingko.
US5858398A (en) 1994-11-03 1999-01-12 Isomed Inc. Microparticular pharmaceutical compositions
US20020048596A1 (en) * 1994-12-30 2002-04-25 Gregor Cevc Preparation for the transport of an active substance across barriers
WO2000024377A1 (en) * 1998-10-23 2000-05-04 Idea Innovative Dermale Applikationen Gmbh Method for developing, testing and using associates of macromolecules and complex aggregates for improved payload and controllable de/association rates
PT1031347E (pt) 1999-01-27 2002-09-30 Idea Ag Transporte/imunizacao transnasal com veiculos muitissimo adaptaveis
GB0118517D0 (en) 2001-07-30 2001-09-19 Mitsubishi Tokyo Pharm Inc Compound
AU2003273977B2 (en) 2002-10-11 2007-07-12 Idea Ag Aggregate with increased deformability, comprising at least three amphipats, for improved transport through semi-permeable barriers and for the non-invasive drug application in vivo, especially through the skin
CN1285383C (zh) 2004-07-22 2006-11-22 周翔 亲水亲脂自封闭小体液相核心空化成囊泡的方法及应用
GB0416861D0 (en) 2004-07-29 2004-09-01 Quadrant Drug Delivery Ltd Composition
DE102004057303A1 (de) * 2004-11-26 2006-06-01 Merck Patent Gmbh Stabile Kristallmodifikationen von DOTAP Chlorid
JP2008527002A (ja) * 2005-01-13 2008-07-24 サートリス ファーマシューティカルズ, インコーポレイテッド 神経変性障害および血液凝固障害を予防および処置するための新規組成物
JP2006248978A (ja) 2005-03-10 2006-09-21 Mebiopharm Co Ltd 新規なリポソーム製剤
US20110020434A1 (en) * 2005-09-02 2011-01-27 O'halloran Thomas V Nanoparticle arsenic-platinum compositions
CN100453071C (zh) * 2006-11-03 2009-01-21 李万忠 白藜芦醇口服多相脂质体及其制备方法
WO2009009115A2 (en) 2007-07-11 2009-01-15 Nevsky Pharmaceutical Development Liposome compositions for treatment of hepatitis c
WO2009018326A2 (en) * 2007-07-31 2009-02-05 Limerick Biopharma, Inc. Soluble pyrone analogs methods and compositions
JO3076B1 (ar) * 2007-10-17 2017-03-15 Janssen Alzheimer Immunotherap نظم العلاج المناعي المعتمد على حالة apoe
WO2009087568A2 (en) * 2008-01-10 2009-07-16 Universidade De Coimbra Compositions comprising antioxidant and mitoprotective flavonoids with neuroprotective properties
CN101474155B (zh) 2009-01-24 2011-03-16 重庆医科大学 注射用肺靶向载药前体脂质体及其使用方法
CA2752373C (en) 2009-02-20 2017-10-10 To-Bbb Holding B.V. Glutathione-based drug delivery system
SG174287A1 (en) 2009-03-09 2011-10-28 Univ California Single protein nanocapsules for protein delivery with long-term effect
US20110178456A1 (en) 2009-04-03 2011-07-21 The Regents Of The University Of California Assisting transdermal drug delivery by means of tissue freezing, vacuum pressure and photoheating procedures
CN101874763A (zh) 2009-04-29 2010-11-03 上海家化联合股份有限公司 一种白藜芦醇柔性脂质体及其制备方法
WO2010149785A1 (en) * 2009-06-26 2010-12-29 Universiteit Gent Cationic liposomes for the delivery of high molecular weight compounds
AU2010268726A1 (en) * 2009-07-02 2012-01-19 Angiochem Inc. Multimeric peptide conjugates and uses thereof
EP2394640A1 (en) * 2010-05-21 2011-12-14 MediGene AG Improved liposomal formulations of lipophilic compounds
NZ605874A (en) 2010-06-25 2015-02-27 Shire Human Genetic Therapies Methods and compositions for cns delivery of heparan n-sulfatase
US10357575B2 (en) 2010-09-24 2019-07-23 Case Western Reserve University Stabilized nanobubbles for diagnostic and therapeutic applications
IT1401882B1 (it) 2010-10-01 2013-08-28 Rosa De Nanoparticelle autoassemblanti per il rilascio di bifosfonati nel trattamento di tumori.
EP2678007A4 (en) 2011-02-25 2015-08-12 Univ South Dakota PROTEIN NANOTRIER FOR TOPICAL ADMINISTRATION
GB2503845A (en) * 2011-03-21 2014-01-08 Gregor Cevc Optimised preparations of highly adaptable aggregates
CA2846611A1 (en) * 2011-08-25 2013-02-28 Cognition Therapeutics, Inc. Compositions and methods for treating neurodegenerative disease
WO2013059617A1 (en) 2011-10-21 2013-04-25 Ndsu Research Foundation Liposome compositions and methods of use
WO2013066903A1 (en) 2011-10-31 2013-05-10 Mallinckrodt Llc Combinational liposome compositions for cancer therapy
WO2014015027A1 (en) 2012-07-18 2014-01-23 Onyx Therapeutics, Inc. Liposomal compositions of epoxyketone-based proteasome inhibitors
AU2013302526B2 (en) 2012-08-15 2018-03-22 The University Of Chicago Exosome-based therapeutics against neurodegenerative disorders
US9943482B2 (en) 2013-02-26 2018-04-17 University Of Louisville Research Foundation, Inc. Milk-derived microvesicle compositions and related methods
CN103446055B (zh) * 2013-08-22 2015-02-11 合肥工业大学 三羟基异黄酮脂质纳米体的制备方法
WO2015058148A1 (en) 2013-10-17 2015-04-23 Children's Hospital Los Angeles Antibody dependent exosome therapy
US9987227B2 (en) 2013-10-22 2018-06-05 Aradigm Corporation Inhaled surfactant-modified liposomal formulations providing both an immediate and sustained release profile
US20150320706A1 (en) * 2014-05-12 2015-11-12 Chiesi Farmaceutici S.P.A. Formulations and methods of treating alzheimer's disease and other proteinopathies by combination therapy
CA2997811C (en) 2015-10-01 2021-09-21 University Of Ottawa Exosome packaging of nucleic acids
HK1257801A1 (zh) * 2015-10-28 2019-11-01 宾夕法尼亚州大学信托人 用於基因治疗的腺伴随病毒载体的鞘内给药
WO2017087685A1 (en) * 2015-11-20 2017-05-26 The Regents Of The University Of California Deformable nano-scale vehicles (dnvs) for trans-blood brain barrier, trans-mucosal, and transdermal drug delivery
CN105287382A (zh) * 2015-12-10 2016-02-03 南昌大学 叶酸-壳聚糖修饰姜黄素纳米脂质体的制备方法
EP3922253A1 (en) 2016-01-15 2021-12-15 Orbsen Therapeutics Limited Sdc-2 exosome compositions and methods of isolation and use
WO2017136430A1 (en) 2016-02-01 2017-08-10 The Board Of Trustees Of The Leland Stanford Junior University Exosome-total-isoloation-chip (exotic) device for isolation of exosome-based biomarkers
US20190112351A1 (en) 2016-04-04 2019-04-18 National Institutes Of Biomedical Innovation, Health And Nutrition Exosome-targeted dna vaccine
US20180028600A1 (en) 2016-07-15 2018-02-01 Korea Institute Of Science And Technology Novel recombinant exosome and use thereof
CN106389137B (zh) 2016-08-29 2019-07-16 杭州素妍化妆品有限公司 一种亚麻籽油脂质体及其制备与应用
US20180067121A1 (en) 2016-09-06 2018-03-08 Nanoco Technologies Ltd. Exosome-conjugated quantum dot nanoparticles and methods of detecting exosomes and cancer using same
US20190231694A1 (en) 2016-10-12 2019-08-01 Agency For Science, Technology And Research Method for lyophilising an exosome
EP3554638B1 (en) 2016-12-19 2022-02-02 Morehouse School of Medicine Compositions and methods for treating diseases by inhibiting exosome release
US10800817B2 (en) 2016-12-19 2020-10-13 Morehouse School Of Medicine Compositions and methods for treating diseases by inhibiting exosome release
KR102036051B1 (ko) 2017-02-15 2019-10-24 고려대학교 세종산학협력단 엑소좀 기반의 나노입자 복합체 및 이의 제조방법
WO2018187240A1 (en) 2017-04-03 2018-10-11 The Regents Of The University Of California Deformable nano-scale vehicles (dnvs) for trans-blood brain barrier, trans-mucosal, and transdermal drug delivery
US11344627B2 (en) 2017-06-27 2022-05-31 Wisconsin Alumni Research Foundation Dendrimer-exosome hybrid nanoparticles as a delivery platform
WO2019094679A1 (en) 2017-11-10 2019-05-16 The Regents Of The University Of California BRAIN DELIVERY OF THE BACE INHIBITOR SAPPALPHA, ANTIBODIES, OR INHIBITORY RNA's USING SYNTHETIC EXOSOMES (DEFORMABLE NANOVESICLES, DNVs)
AU2018367670A1 (en) 2017-11-17 2020-05-07 Lonza Sales Ag Compositions of engineered exosomes and methods of loading luminal exosomes payloads
WO2019203706A1 (en) 2018-04-20 2019-10-24 Telefonaktiebolaget Lm Ericsson (Publ) Information decoder for polar codes
CA3092162A1 (en) 2018-04-25 2019-10-31 University Of Massachusetts Artificial exosome composition and related methods
US20190365653A1 (en) 2018-06-04 2019-12-05 Korea Institute Of Science And Technology Novel recombinant exosome containing hyaluronidase and use thereof
WO2021207273A1 (en) 2020-04-07 2021-10-14 The Regents Of The University Of California Manufacturing of synthetic exosomes for cns and non-cns delivery of therapeutics

Similar Documents

Publication Publication Date Title
JP2020515638A5 (https=)
Sun et al. Osteoblast-targeting-peptide modified nanoparticle for siRNA/microRNA delivery
Chen et al. Blood–brain barrier-and blood–brain tumor barrier-penetrating peptide-derived targeted therapeutics for glioma and malignant tumor brain metastases
JP7772597B2 (ja) 生物学的送達ビヒクルのための組成物及び方法
Kumar et al. Drug-triggered and cross-linked self-assembling nanofibrous hydrogels
Hu et al. Physicochemical properties of nanoparticles regulate translocation across pulmonary surfactant monolayer and formation of lipoprotein corona
JP7280624B2 (ja) 経血液脳関門的、経粘膜的及び経皮的薬物送達のための変形可能なナノスケールビヒクル(dnv)
Zhang et al. Corona-directed nucleic acid delivery into hepatic stellate cells for liver fibrosis therapy
JP2010524849A5 (https=)
Martin-Rapun et al. Targeted nanoparticles for the treatment of Alzheimer's disease
Kong et al. Virucidal nano-perforator of viral membrane trapping viral RNAs in the endosome
JP2022058390A (ja) 治療的送達小胞
CN115379829A (zh) 自下而上组装合成细胞外囊泡
HRP20231606T1 (hr) Spojevi i metode za smanjenje ekspresije tau
JP2014532071A (ja) カーゴの経皮送達を含む標的送達用の多孔性ナノ粒子に担持された脂質二重層(プロトセル)及びその方法
Orthmann et al. Treatment of experimental brain metastasis with MTO-liposomes: impact of fluidity and LRP-targeting on the therapeutic result
JP2019514985A5 (https=)
TW202241388A (zh) 生物遞送系統
Yao et al. Novel nanotherapeutics for cancer immunotherapy by CTLA-4 aptamer-functionalized albumin nanoparticle loaded with antihistamine
CN102574879B (zh) 递送至骨的靶向药物
Ghosh et al. Exosome: the “off-the-shelf” cellular nanocomponent as a potential pathogenic agent, a disease biomarker, and neurotherapeutics
Alencastre et al. Delivery of pharmaceutics to bone: nanotechnologies, high-throughput processing and in silico mathematical models
SI2847204T1 (en) Sterol derivatives and their use for the treatment of diseases involving the transformation of astrocytic cells or the treatment of malignant haemopathies
Ghorai et al. Cell-penetrating and targeted peptides delivery systems as potential pharmaceutical carriers for enhanced delivery across the blood-brain barrier (BBB). Pharmaceutics. 2023; 15: 1999
WO2011025036A1 (ja) 粒子組成物及びこれを有する医薬組成物