JP2020515638A5 - - Google Patents
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- JP2020515638A5 JP2020515638A5 JP2020502542A JP2020502542A JP2020515638A5 JP 2020515638 A5 JP2020515638 A5 JP 2020515638A5 JP 2020502542 A JP2020502542 A JP 2020502542A JP 2020502542 A JP2020502542 A JP 2020502542A JP 2020515638 A5 JP2020515638 A5 JP 2020515638A5
- Authority
- JP
- Japan
- Prior art keywords
- drug delivery
- phospholipid
- delivery vehicle
- vehicle according
- nanoscale drug
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000003904 phospholipids Chemical class 0.000 claims 19
- 239000003981 vehicle Substances 0.000 claims 17
- 238000012377 drug delivery Methods 0.000 claims 16
- KILNVBDSWZSGLL-KXQOOQHDSA-N 1,2-dihexadecanoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCC KILNVBDSWZSGLL-KXQOOQHDSA-N 0.000 claims 10
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 10
- LUKBXSAWLPMMSZ-OWOJBTEDSA-N Trans-resveratrol Chemical compound C1=CC(O)=CC=C1\C=C\C1=CC(O)=CC(O)=C1 LUKBXSAWLPMMSZ-OWOJBTEDSA-N 0.000 claims 9
- 101710150875 TAR DNA-binding protein 43 Proteins 0.000 claims 6
- 102100040347 TAR DNA-binding protein 43 Human genes 0.000 claims 6
- 235000012000 cholesterol Nutrition 0.000 claims 5
- 201000010901 lateral sclerosis Diseases 0.000 claims 5
- 239000003446 ligand Substances 0.000 claims 5
- 150000002632 lipids Chemical class 0.000 claims 5
- 208000005264 motor neuron disease Diseases 0.000 claims 5
- 102000004169 proteins and genes Human genes 0.000 claims 5
- 108090000623 proteins and genes Proteins 0.000 claims 5
- 208000024827 Alzheimer disease Diseases 0.000 claims 4
- 208000004051 Chronic Traumatic Encephalopathy Diseases 0.000 claims 4
- BVTJGGGYKAMDBN-UHFFFAOYSA-N Dioxetane Chemical compound C1COO1 BVTJGGGYKAMDBN-UHFFFAOYSA-N 0.000 claims 4
- 201000011240 Frontotemporal dementia Diseases 0.000 claims 4
- 208000018737 Parkinson disease Diseases 0.000 claims 4
- 208000032319 Primary lateral sclerosis Diseases 0.000 claims 4
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- 206010046298 Upper motor neurone lesion Diseases 0.000 claims 4
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- 208000017004 dementia pugilistica Diseases 0.000 claims 4
- 239000012634 fragment Substances 0.000 claims 4
- -1 mylicetin Chemical compound 0.000 claims 4
- ULSUXBXHSYSGDT-UHFFFAOYSA-N tangeretin Chemical compound C1=CC(OC)=CC=C1C1=CC(=O)C2=C(OC)C(OC)=C(OC)C(OC)=C2O1 ULSUXBXHSYSGDT-UHFFFAOYSA-N 0.000 claims 4
- 230000009529 traumatic brain injury Effects 0.000 claims 4
- 102000013455 Amyloid beta-Peptides Human genes 0.000 claims 3
- 108010090849 Amyloid beta-Peptides Proteins 0.000 claims 3
- 108091023037 Aptamer Proteins 0.000 claims 3
- 229940122361 Bisphosphonate Drugs 0.000 claims 3
- QNVSXXGDAPORNA-UHFFFAOYSA-N Resveratrol Natural products OC1=CC=CC(C=CC=2C=C(O)C(O)=CC=2)=C1 QNVSXXGDAPORNA-UHFFFAOYSA-N 0.000 claims 3
- 102000003802 alpha-Synuclein Human genes 0.000 claims 3
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- 150000004663 bisphosphonates Chemical class 0.000 claims 3
- 239000003112 inhibitor Substances 0.000 claims 3
- MWDZOUNAPSSOEL-UHFFFAOYSA-N kaempferol Natural products OC1=C(C(=O)c2cc(O)cc(O)c2O1)c3ccc(O)cc3 MWDZOUNAPSSOEL-UHFFFAOYSA-N 0.000 claims 3
- 239000002736 nonionic surfactant Substances 0.000 claims 3
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- 229940016667 resveratrol Drugs 0.000 claims 3
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- 239000001100 (2S)-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one Substances 0.000 claims 2
- KSXTUUUQYQYKCR-LQDDAWAPSA-M 2,3-bis[[(z)-octadec-9-enoyl]oxy]propyl-trimethylazanium;chloride Chemical compound [Cl-].CCCCCCCC\C=C/CCCCCCCC(=O)OCC(C[N+](C)(C)C)OC(=O)CCCCCCC\C=C/CCCCCCCC KSXTUUUQYQYKCR-LQDDAWAPSA-M 0.000 claims 2
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- 108010017405 NRH - quinone oxidoreductase2 Proteins 0.000 claims 2
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- 101710189291 Quinone oxidoreductase Proteins 0.000 claims 2
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- NWGKJDSIEKMTRX-AAZCQSIUSA-N Sorbitan monooleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O NWGKJDSIEKMTRX-AAZCQSIUSA-N 0.000 claims 2
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- XHEFDIBZLJXQHF-UHFFFAOYSA-N fisetin Chemical compound C=1C(O)=CC=C(C(C=2O)=O)C=1OC=2C1=CC=C(O)C(O)=C1 XHEFDIBZLJXQHF-UHFFFAOYSA-N 0.000 claims 2
- 229930003935 flavonoid Natural products 0.000 claims 2
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- 230000002401 inhibitory effect Effects 0.000 claims 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 2
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- IYRMWMYZSQPJKC-UHFFFAOYSA-N kaempferol Chemical compound C1=CC(O)=CC=C1C1=C(O)C(=O)C2=C(O)C=C(O)C=C2O1 IYRMWMYZSQPJKC-UHFFFAOYSA-N 0.000 claims 2
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- ZPNJDNPXOOBYAA-UHFFFAOYSA-N n-benzyl-6-(5,11-dimethylpyrido[4,3-b]carbazol-6-yl)hexan-1-amine Chemical compound C12=CC=CC=C2C2=C(C)C3=CN=CC=C3C(C)=C2N1CCCCCCNCC1=CC=CC=C1 ZPNJDNPXOOBYAA-UHFFFAOYSA-N 0.000 claims 2
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- 239000004094 surface-active agent Substances 0.000 claims 2
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- PADQINQHPQKXNL-LSDHHAIUSA-N (+)-dihydrokaempferol Chemical compound C1([C@@H]2[C@H](C(C3=C(O)C=C(O)C=C3O2)=O)O)=CC=C(O)C=C1 PADQINQHPQKXNL-LSDHHAIUSA-N 0.000 claims 1
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- VEMAQVIELLSCKY-UHFFFAOYSA-N 1,2,3,6-tetramethoxynaphtho[2,1-f][1,3]benzodioxole Chemical compound C1=C2OCOC2=CC2=C(C(OC)=C(C(OC)=C3)OC)C3=CC(OC)=C21 VEMAQVIELLSCKY-UHFFFAOYSA-N 0.000 claims 1
- BZGJTNMHBWLFNW-UHFFFAOYSA-N 1-n,1-n-diethyl-4-n-(7-methoxy-2-phenylquinolin-4-yl)pentane-1,4-diamine Chemical compound N=1C2=CC(OC)=CC=C2C(NC(C)CCCN(CC)CC)=CC=1C1=CC=CC=C1 BZGJTNMHBWLFNW-UHFFFAOYSA-N 0.000 claims 1
- VXJCEYHNPBHQOS-UHFFFAOYSA-N 10h-indolo[3,2-b]quinoline-3,8-diamine Chemical compound C1=C(N)C=C2N=C3C4=CC=C(N)C=C4NC3=CC2=C1 VXJCEYHNPBHQOS-UHFFFAOYSA-N 0.000 claims 1
- BOWKECNQMUSQGN-UHFFFAOYSA-N 12,13-dihydro-6-(phenylmethyl)-5h-indolo[2,4-c]carbazole-5,7(6h)-dione Chemical compound O=C1C(C2=C3[CH]C=CC=C3NC2=C2N[C]3C=CC=CC3=C22)=C2C(=O)N1CC1=CC=CC=C1 BOWKECNQMUSQGN-UHFFFAOYSA-N 0.000 claims 1
- SVUOLADPCWQTTE-UHFFFAOYSA-N 1h-1,2-benzodiazepine Chemical compound N1N=CC=CC2=CC=CC=C12 SVUOLADPCWQTTE-UHFFFAOYSA-N 0.000 claims 1
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- BVPWSRPVKLEVKE-UHFFFAOYSA-N 2-amino-4,6-dimethyl-3-oxo-9-n-[7,11,14-trimethyl-2,5,9,12,15-pentaoxo-3,10-di(propan-2-yl)-8-oxa-1,4,11,14-tetrazabicyclo[14.3.0]nonadecan-6-yl]-1-n-[7,11,14-trimethyl-2,5,9,12,15-pentaoxo-3,10-di(propan-2-yl)-8-oxa-1,4,11,14-tetrazabicyclo[14.2.0]octade Chemical compound CC1OC(=O)C(C(C)C)N(C)C(=O)CN(C)C(=O)C2CCCN2C(=O)C(C(C)C)NC(=O)C1NC(=O)C1=C(N=C2C(C(=O)NC3C(=O)NC(C(N4CCC4C(=O)N(C)CC(=O)N(C)C(C(C)C)C(=O)OC3C)=O)C(C)C)=C(N)C(=O)C(C)=C2O2)C2=C(C)C=C1 BVPWSRPVKLEVKE-UHFFFAOYSA-N 0.000 claims 1
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| CN110251508A (zh) * | 2019-05-07 | 2019-09-20 | 苏州大学 | Nsc-156529作为t-型钙通道拮抗剂的应用 |
| JP2023522853A (ja) * | 2020-04-07 | 2023-06-01 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 中枢神経系及び非中枢神経系への治療薬の送達のための合成エキソソームの製造 |
| CN111569061A (zh) * | 2020-05-06 | 2020-08-25 | 吴延恒 | 一种用于核酸疫苗增强剂的纳米材料 |
| CN114259486B (zh) * | 2020-09-16 | 2024-04-02 | 香港科技大学 | 木犀草素及其药物组合物的应用 |
| CN113975397B (zh) * | 2021-10-26 | 2023-08-22 | 中南大学湘雅三医院 | 一种基因/小分子化合物纳米递药系统及其制备方法与应用 |
| CN114948852B (zh) * | 2022-05-26 | 2024-05-17 | 深圳先进技术研究院 | 一种用于脑部疾病诊断和治疗的微针系统及其制备方法 |
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