CN110662532A - 用于跨血脑屏障、透粘膜和经皮药物递送的可变形的纳米级媒介物(dnvs) - Google Patents

用于跨血脑屏障、透粘膜和经皮药物递送的可变形的纳米级媒介物(dnvs) Download PDF

Info

Publication number
CN110662532A
CN110662532A CN201880034533.8A CN201880034533A CN110662532A CN 110662532 A CN110662532 A CN 110662532A CN 201880034533 A CN201880034533 A CN 201880034533A CN 110662532 A CN110662532 A CN 110662532A
Authority
CN
China
Prior art keywords
drug delivery
delivery vehicle
nanoscale drug
nanoscale
dnv
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201880034533.8A
Other languages
English (en)
Chinese (zh)
Inventor
V·约翰
西村一郎
N·苏比阿
J·卡姆帕格纳
P·R·斯皮尔曼
M·P·阿拉姆
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California
Original Assignee
University of California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of California filed Critical University of California
Publication of CN110662532A publication Critical patent/CN110662532A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6905—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
    • A61K47/6911—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a liposome
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/28—Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/548—Phosphates or phosphonates, e.g. bone-seeking
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Dispersion Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CN201880034533.8A 2017-04-03 2018-04-02 用于跨血脑屏障、透粘膜和经皮药物递送的可变形的纳米级媒介物(dnvs) Pending CN110662532A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762480924P 2017-04-03 2017-04-03
US62/480,924 2017-04-03
PCT/US2018/025749 WO2018187240A1 (en) 2017-04-03 2018-04-02 Deformable nano-scale vehicles (dnvs) for trans-blood brain barrier, trans-mucosal, and transdermal drug delivery

Publications (1)

Publication Number Publication Date
CN110662532A true CN110662532A (zh) 2020-01-07

Family

ID=63712640

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201880034533.8A Pending CN110662532A (zh) 2017-04-03 2018-04-02 用于跨血脑屏障、透粘膜和经皮药物递送的可变形的纳米级媒介物(dnvs)

Country Status (6)

Country Link
US (1) US20200030457A1 (enExample)
EP (1) EP3606557A4 (enExample)
JP (2) JP7280624B2 (enExample)
CN (1) CN110662532A (enExample)
CA (1) CA3058782A1 (enExample)
WO (1) WO2018187240A1 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114259486A (zh) * 2020-09-16 2022-04-01 香港科技大学 木犀草素及其药物组合物的应用
WO2023226136A1 (zh) * 2022-05-26 2023-11-30 深圳先进技术研究院 一种用于脑部疾病诊断和治疗的微针系统及其制备方法
CN117551095A (zh) * 2023-11-09 2024-02-13 中国药科大学 一种玫瑰树碱衍生物及其制备方法与应用

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12364661B2 (en) 2015-11-20 2025-07-22 The Regents Of The University Of California Deformable nano-scale vehicles (DNVS) for trans-blood brain barrier, trans-mucosal, and transdermal drug delivery
CN110251508A (zh) * 2019-05-07 2019-09-20 苏州大学 Nsc-156529作为t-型钙通道拮抗剂的应用
CN111569061A (zh) * 2020-05-06 2020-08-25 吴延恒 一种用于核酸疫苗增强剂的纳米材料
CN113975397B (zh) * 2021-10-26 2023-08-22 中南大学湘雅三医院 一种基因/小分子化合物纳米递药系统及其制备方法与应用
CN116392449A (zh) * 2023-04-28 2023-07-07 广州医科大学附属第三医院（广州重症孕产妇救治中心、广州柔济医院） 一种橘红素纳米脂质体冻干制剂及其制备方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1951368A (zh) * 2006-11-03 2007-04-25 李万忠 白藜芦醇口服多相脂质体及其制备方法
CN103446055A (zh) * 2013-08-22 2013-12-18 合肥工业大学 三羟基异黄酮脂质纳米体的制备方法
CN105287382A (zh) * 2015-12-10 2016-02-03 南昌大学 叶酸-壳聚糖修饰姜黄素纳米脂质体的制备方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1551370T3 (da) * 2002-10-11 2008-03-03 Idea Ag Aggregat med foröget deformerbarhed, som omfatter mindst tre amfipater, til forbedret transport gennem semipermeable barrierer og til ikke-invasiv lægemiddeltilförsel in vivo, især gennem huden
DE102004057303A1 (de) * 2004-11-26 2006-06-01 Merck Patent Gmbh Stabile Kristallmodifikationen von DOTAP Chlorid
US20110020434A1 (en) * 2005-09-02 2011-01-27 O'halloran Thomas V Nanoparticle arsenic-platinum compositions
JO3076B1 (ar) * 2007-10-17 2017-03-15 Janssen Alzheimer Immunotherap نظم العلاج المناعي المعتمد على حالة apoe
WO2009087568A2 (en) * 2008-01-10 2009-07-16 Universidade De Coimbra Compositions comprising antioxidant and mitoprotective flavonoids with neuroprotective properties
CN101474155B (zh) * 2009-01-24 2011-03-16 重庆医科大学 注射用肺靶向载药前体脂质体及其使用方法
DK3395372T3 (da) * 2009-02-20 2022-04-19 Enhanx Biopharm Inc System til afgivelse af glutathion-baseret medikament
CN101874763A (zh) * 2009-04-29 2010-11-03 上海家化联合股份有限公司 一种白藜芦醇柔性脂质体及其制备方法
WO2010149785A1 (en) * 2009-06-26 2010-12-29 Universiteit Gent Cationic liposomes for the delivery of high molecular weight compounds
JP5932642B2 (ja) * 2009-07-02 2016-06-08 アンジオケム インコーポレーテッド 多量体ペプチドコンジュゲートおよびその使用
CA2828255A1 (en) * 2011-02-25 2012-08-30 South Dakota State University Protein nanocarriers for topical delivery
DE112012001386T5 (de) * 2011-03-21 2013-12-19 Gregor Cevc Optimierte Präparate von sehr anpassungsfähigen Aggregaten
EP2747768A4 (en) * 2011-08-25 2015-10-21 Cognition Therapeutics Inc COMPOSITIONS AND METHOD FOR THE TREATMENT OF NEURODEEGENERATIVE DISEASES
US10022326B2 (en) * 2012-07-18 2018-07-17 Onyx Therapeutics, Inc. Liposomal compositions of epoxyketone-based proteasome inhibitors
US20150320706A1 (en) * 2014-05-12 2015-11-12 Chiesi Farmaceutici S.P.A. Formulations and methods of treating alzheimer's disease and other proteinopathies by combination therapy
US11135313B2 (en) * 2015-10-28 2021-10-05 The Trustees Of The University Of Pennsylvania Intrathecal administration of adeno-associated-viral vectors for gene therapy
US12364661B2 (en) * 2015-11-20 2025-07-22 The Regents Of The University Of California Deformable nano-scale vehicles (DNVS) for trans-blood brain barrier, trans-mucosal, and transdermal drug delivery
CN106389137B (zh) * 2016-08-29 2019-07-16 杭州素妍化妆品有限公司 一种亚麻籽油脂质体及其制备与应用

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1951368A (zh) * 2006-11-03 2007-04-25 李万忠 白藜芦醇口服多相脂质体及其制备方法
CN103446055A (zh) * 2013-08-22 2013-12-18 合肥工业大学 三羟基异黄酮脂质纳米体的制备方法
CN105287382A (zh) * 2015-12-10 2016-02-03 南昌大学 叶酸-壳聚糖修饰姜黄素纳米脂质体的制备方法

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
CEDAR ET AL.: "Ultra-flexible nanocarriers for enhanced topical delivery of a highlylipophilic antioxidative molecule for skin cancer chemoprevention", 《COLLOIDS AND SURFACES B: BIOINTERFACES》 *
ELINE ET AL.: "An elastic liposomal formulation for RNAi-based topical treatment of skin disorders: Proof-of-concept in the treatment of psoriasis", 《INTERNATIONAL JOURNAL OF PHARMACEUTICS》 *
HUANG ET AL.: "Elastic liposomes as carriers for oral delivery and the brain distribution of (+)-catechin", 《JOURNAL OF DRUG TARGETING》 *
邵堃等: "脑靶向药物纳米递释系统", 《东南大学学报(医学版)》 *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114259486A (zh) * 2020-09-16 2022-04-01 香港科技大学 木犀草素及其药物组合物的应用
CN114259486B (zh) * 2020-09-16 2024-04-02 香港科技大学 木犀草素及其药物组合物的应用
WO2023226136A1 (zh) * 2022-05-26 2023-11-30 深圳先进技术研究院 一种用于脑部疾病诊断和治疗的微针系统及其制备方法
CN117551095A (zh) * 2023-11-09 2024-02-13 中国药科大学 一种玫瑰树碱衍生物及其制备方法与应用
CN117551095B (zh) * 2023-11-09 2025-02-07 中国药科大学 一种玫瑰树碱衍生物及其制备方法与应用

Also Published As

Publication number Publication date
JP7280624B2 (ja) 2023-05-24
JP2020515638A (ja) 2020-05-28
WO2018187240A1 (en) 2018-10-11
EP3606557A4 (en) 2020-12-16
JP2023075276A (ja) 2023-05-30
US20200030457A1 (en) 2020-01-30
CA3058782A1 (en) 2018-10-11
EP3606557A1 (en) 2020-02-12

Similar Documents

Publication Publication Date Title
JP7280624B2 (ja) 経血液脳関門的、経粘膜的及び経皮的薬物送達のための変形可能なナノスケールビヒクル（ｄｎｖ）
Li et al. PH responsiveness of hexosomes and cubosomes for combined delivery of Brucea javanica oil and doxorubicin
EP3787607B1 (en) Carotenoid compositions and uses thereof
JP6894423B2 (ja) 融合性リポソーム被覆多孔質ケイ素ナノ粒子
CN103179952B (zh) 基于纳米颗粒的肿瘤靶向药物递送
US20250295586A1 (en) Deformable nano-scale vehicles (dnvs) for trans-blood brain barrier, trans-mucosal, and transdermal drug delivery
E Ruiz et al. Applications of nanosystems to anticancer drug therapy (Part II. Dendrimers, micelles, lipid-based nanosystems)
Gouveia et al. Non-biologic nanodelivery therapies for rheumatoid arthritis
CN102811707A (zh) 结合生物矿物和金属的脂质体，它们的合成以及其使用方法
Salunkhe et al. Development of lipid based nanoparticulate drug delivery systems and drug carrier complexes for delivery to brain
AU2020205473B2 (en) Polymersomes functionalised with multiple ligands
Darji et al. Recent method to improve stability profile, pharmacokinetic and pharmacodynamic properties in anticancer drugs
Mutreja et al. Lipid nanoparticle-based formulations for high-performance dentistry applications
Chandra et al. An overview: The novel carrier for vesicular drug delivery system
Benedini et al. Nanodevices for facing new challenges of medical treatments: stimuli-responsive drug delivery systems
Hashim et al. Nanomaterials in chemotherapy
Yadav et al. Specialized Drug Delivery Systems
Nigro et al. Evaluation of a PH-sensitive mesoporous silca-based nanosystem as a vehicle for targetedcancer therapy
Alhefzi Design and Optimization of Functional Polymer-Modified Liposome Formulations for Enhanced Delivery of Therapeutics for Cancer and Depression
Bertoni et al. Exploring the Use of Spray Congealing to Produce Solid Dispersions with Enhanced Indomethacin Bioavailability
Chen et al. Nanoscale self-assembly for delivery of therapeutics and imaging agents
Mohammed et al. 16 Potential of Dendrimers as
CA3218313A1 (en) Methods and compositions for treating aging and chronic disease
OA20783A (en) Carotenoid compositions and uses thereof

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
WD01 Invention patent application deemed withdrawn after publication
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20200107