JP2020515635A - 医薬組成物 - Google Patents
医薬組成物 Download PDFInfo
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- JP2020515635A JP2020515635A JP2020501595A JP2020501595A JP2020515635A JP 2020515635 A JP2020515635 A JP 2020515635A JP 2020501595 A JP2020501595 A JP 2020501595A JP 2020501595 A JP2020501595 A JP 2020501595A JP 2020515635 A JP2020515635 A JP 2020515635A
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- vitamin
- skin
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- acid
- lipid
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Abstract
Description
a)パルミチン酸レチノールおよびリボフラビンまたはパルミチン酸レチノールおよびナイアシンアミドまたはパルミチン酸レチノールおよびデクスパンテノールまたはパルミチン酸レチノールおよび葉酸またはパルミチン酸レチノールおよびL−アスコルビン酸またはパルミチン酸レチノールおよび酢酸トコフェロール。
b)リボフラビンおよびナイアシンアミドまたはリボフラビンおよびデクスパンテノールまたはリボフラビンおよび(v)葉酸またはリボフラビンおよびL−アスコルビン酸またはリボフラビンおよび酢酸トコフェロール。
c)ナイアシンアミドおよびデクスパンテノールまたはナイアシンアミドおよび葉酸またはナイアシンアミドおよびL−アスコルビン酸またはナイアシンアミドおよび酢酸トコフェロール(ビタミンE)。
d)デクスパンテノールおよび葉酸またはデクスパンテノールおよびL−アスコルビン酸またはデクスパンテノールおよび酢酸トコフェロール。
e)葉酸およびL−アスコルビン酸または葉酸および酢酸トコフェロール。
f)L−アスコルビン酸および酢酸トコフェロール。
乾燥したリン脂質を、室温で水溶液に分散し、自発的に球状のコロイドを形成した。純度98.7%(hplc;面積%)の7−DHCを、140および150℃のあいだの温度で液化した。プロピレングリコールを液化した7−DHCに加え、得られた混合物を室温で激しく攪拌しながらリン脂質コロイドと混合し、20〜150nmの球を形成し、コロイドの油相に7−DHCを加えたコロイドを得た。HA(純度96.8%の低分子4KDaを2%、純度97.3%の中分子48.3KDaを0.5wt%および純度100の点眼グレードの高分子1.78×106Daを0.5wt%)を、攪拌しながら水に分散/溶解し、それぞれ室温で攪拌しながら添加した。HA混合物を、すでに7−DHCを充填したリン脂質コロイドに加え、室温で20分間撹拌して、均一なヒドロゲルの自発的な形成を得た。顕微鏡分析により、20〜150nmサイズの球状粒子が示された。ヒドロゲルは巨視的であり、HPLC分析によれば、6ヶ月間にわたって同じ濃度の添加された7−DHCを示した。
Claims (15)
- 脂質ベースのコロイド状キャリアシステムにカプセル化された少なくとも1つのビタミンD3またはその前駆体もしくは誘導体、および少なくとも1つのヒアルロン酸またはその誘導体を含む組成物。
- ビタミンD3前駆体が7−DHCまたはその誘導体である請求項1記載の組成物。
- ヒアルロン酸が、低分子量、中分子量および高分子量のヒアルロン酸の混合物である請求項1記載の組成物。
- 脂質ベースのコロイド状キャリアシステムが、リポソーム、ニオソーム、トランスフェロソーム、ミセル、ナノ粒子、マイクロエマルジョンなど、好ましくはリポソーム、ニオソーム、トランスフェロソーム、最も好ましくはリポソームである請求項1記載の組成物。
- ビタミンA、好ましくはパルミチン酸レチノール、少なくとも1つビタミンB、ビタミンC、好ましくはアスコルビン酸およびビタミンE、好ましくは酢酸トコフェロールから選択されるさらに1つまたはそれ以上の成分を含む請求項1〜4のいずれか1項に記載の組成物。
- 少なくとも1つのビタミンBがリボフラビン(ビタミンB2)、ナイアシンアミド(ビタミンB3)、デクスパンテノール(プロビタミンB5)、および/または葉酸(ビタミンB9)である請求項5記載の組成物。
- さらに、(i)パルミチン酸レチノール(ビタミンA)、(ii)リボフラビン(ビタミンB2)、(iii)ナイアシンアミド(ビタミンB3)、(iv)デクスパンテノール(プロビタミンB5)、(v)葉酸(ビタミンB9)、(vi)L−アスコルビン酸(ビタミンC)、および(vii)酢酸トコフェロール(ビタミンE)を含む請求項1記載の組成物。
- さらに少なくとも1つのUV−フィルターを含む請求項1〜7のいずれか1項に記載の組成物。
- さらに、界面活性剤、乳化剤、エモリエント、増粘剤、コンディショニング保存料、緩衝剤、保湿剤、香料から選択される少なくとも1つのアジュバントを含む請求項1〜8のいずれか1項に記載の組成物。
- 界面活性剤がポリカーボネート、ポリビニルピロリドン(PVP)、ポリビドン、オビドンメンブレン、ポビドン、コポビドン、ヒプロメロースまたはオイドラギットEPOである請求項9記載の組成物。
- 界面活性剤が、ポリソルベート10〜150、好ましくはポリソルベートPS20、Alkest TW 20およびTween 20などである請求項9記載の組成物。
- 脂質ベースのコロイド状キャリアシステムが、リン脂質、レシチン、スフォンゴミエリン、リノレン酸、リノール酸、ホスファチジルコリンおよびカプリル酸/カプリン酸トリグリセリドから選択される1つそれ以上の成分から構成されている請求項1〜11のいずれか1項に記載の組成物。
- 請求項1〜12記載の組成物を固体、液体または半固体の形態で、好ましくはエマルジョン、マイクロエマルジョン、水性ディスパージョン、オイル、ミルク、バルサム、フォーム、水性もしくは油性ローション、水性もしくは油性ゲル、クリーム、溶液、含水アルコール溶液、含水グリコール溶液、ハイドロゲル、セラム、軟膏、ムース、ペースト、スプレーまたはエアロゾル、または経皮パッチの形態で含む局所製剤。
- 皮膚疾患、湿疹、酒さ、アトピー性皮膚炎、乾癬などの皮膚炎症、光損傷(太陽により誘発された炎症および発赤皮膚)、皮膚萎縮、皮膚の色素沈着異常(パッチ/スポット)、光線皮膚炎(紅斑:炎症および発赤皮膚)、毛細管拡張症、(クーペローズ)の予防および/または治療、および光線皮膚炎(紅斑)、光線性角化症の予防における、請求項1〜12記載の組成物、または請求項14記載の局所製剤の使用。
- 対象の皮膚の光線損傷の予防および/または治療方法であって、光損傷(太陽により誘発された損傷)の予防および/または治療、特に皮膚萎縮、皮膚の色素沈着異常(パッチ/スポット)、光線皮膚炎(紅斑:炎症および発赤皮膚)、毛細管拡張症、(クーペローズ)の予防および/または治療、および光線皮膚炎(紅斑)、光線性角化症の予防に有効な量で、請求項1〜12記載の組成物または請求項13記載の局所製剤を、対象に投与することを含む方法。
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CN107673324A (zh) * | 2017-11-03 | 2018-02-09 | 桂林电子科技大学 | 一种氮掺杂的碳纳米管的制备方法 |
GR1009780B (el) * | 2019-02-08 | 2020-07-06 | Κωνσταντινα Δημητριου Καρυδη | Συνθεση καλλυντικων σκευασματων με βαση τα εγκλεισμενα σε σωματιδια ή μη υαλουρονικα οξεα επιλεγμενων μοριακων βαρων |
MY201184A (en) * | 2019-09-03 | 2024-02-08 | Malaysian Palm Oil Board | A sustained release hydrogel composition |
CN111249302A (zh) * | 2020-03-12 | 2020-06-09 | 李鑫荣 | 一种透明质酸片段的新应用及稳定制造方法 |
CN115884744A (zh) * | 2020-04-20 | 2023-03-31 | 莱雅公司 | 用于护理皮肤的组合物 |
EP4297743A1 (en) * | 2021-02-25 | 2024-01-03 | Exinov | Emulsion for use in the treatment of rosacea |
WO2023135135A1 (en) * | 2022-01-11 | 2023-07-20 | Gpq S.R.L. | New hyaluronic acid derivatives as innovative fillers |
GB202202031D0 (en) * | 2022-02-16 | 2022-03-30 | Dr Weller Ltd | Compositions for Vitamin D production |
CN114848536A (zh) * | 2022-05-13 | 2022-08-05 | 上海好肌茵生物科技有限公司 | 皮肤光损伤修护组合物、其制备方法以及应用 |
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JP2023002724A (ja) | 2023-01-10 |
JP7169003B2 (ja) | 2022-11-10 |
CA3051787A1 (en) | 2018-09-27 |
AU2018238691B2 (en) | 2023-11-02 |
EA201991766A1 (ru) | 2019-12-30 |
WO2018172511A1 (en) | 2018-09-27 |
AU2018238691A1 (en) | 2019-08-15 |
KR102560269B1 (ko) | 2023-07-28 |
KR20190129059A (ko) | 2019-11-19 |
JP7265298B2 (ja) | 2023-04-26 |
US20220124572A1 (en) | 2022-04-21 |
US20200046627A1 (en) | 2020-02-13 |
EP3600563A1 (en) | 2020-02-05 |
SG11201908652QA (en) | 2019-10-30 |
CN110430923A (zh) | 2019-11-08 |
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