JP2020515611A - 疼痛の処置のための１１，１３−修飾サキシトキシン - Google Patents

疼痛の処置のための１１，１３−修飾サキシトキシン Download PDF

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Publication number
JP2020515611A
JP2020515611A JP2019553573A JP2019553573A JP2020515611A JP 2020515611 A JP2020515611 A JP 2020515611A JP 2019553573 A JP2019553573 A JP 2019553573A JP 2019553573 A JP2019553573 A JP 2019553573A JP 2020515611 A JP2020515611 A JP 2020515611A
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Prior art keywords
alkyl
halo
optionally substituted
aryl
alkoxy
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JP2019553573A
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Japanese (ja)
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JP2020515611A5 (https=
Inventor
ジョン マルケイヒー，
ジョン マルケイヒー，
ハッサン パジョヘシュ，
ハッサン パジョヘシュ，
ジョージ ミルジャニッチ，
ジョージ ミルジャニッチ，
アントン デルウィグ，
アントン デルウィグ，
ジェイコブ ベックリー，
ジェイコブ ベックリー，
グラント マサアキ シブヤ，
グラント マサアキ シブヤ，
ボイス， ジャスティン デュ
ボイス， ジャスティン デュ
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Leland Stanford Junior University
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Leland Stanford Junior University
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Publication of JP2020515611A publication Critical patent/JP2020515611A/ja
Publication of JP2020515611A5 publication Critical patent/JP2020515611A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2019553573A 2017-03-29 2018-03-29 疼痛の処置のための１１，１３−修飾サキシトキシン Pending JP2020515611A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762478519P 2017-03-29 2017-03-29
US62/478,519 2017-03-29
PCT/US2018/025304 WO2018183782A1 (en) 2017-03-29 2018-03-29 11,13-modified saxitoxins for the treatment of pain

Publications (2)

Publication Number Publication Date
JP2020515611A true JP2020515611A (ja) 2020-05-28
JP2020515611A5 JP2020515611A5 (https=) 2021-05-06

Family

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JP2019553573A Pending JP2020515611A (ja) 2017-03-29 2018-03-29 疼痛の処置のための１１，１３−修飾サキシトキシン

Country Status (5)

Country Link
US (1) US11279706B2 (https=)
EP (1) EP3601290B1 (https=)
JP (1) JP2020515611A (https=)
CN (1) CN110914276A (https=)
WO (1) WO2018183782A1 (https=)

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JP2020515610A (ja) * 2017-03-29 2020-05-28 サイトワン セラピューティクス， インコーポレイテッド 疼痛の処置のための１１，１３−修飾サキシトキシン：

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US11279706B2 (en) 2017-03-29 2022-03-22 Siteone Therapeutics, Inc. 11,13-modified saxitoxins for the treatment of pain
EP3860714B1 (en) 2018-10-03 2023-09-06 Siteone Therapeutics, Inc. 11,13-modified saxitoxins for the treatment of pain
BR112022010924A2 (pt) 2019-12-06 2022-09-06 Vertex Pharma Tetra-hidrofuranos substituídos como moduladores de canais de sódio
EP4196482B1 (en) * 2020-08-14 2025-10-01 SiteOne Therapeutics, Inc. Non-hydrated ketone inhibitors of nav1.7 for the treatment of pain
SMT202500481T1 (it) 2021-06-04 2026-01-12 Vertex Pharma N-(idrossialchil(etero)aril)tetraidrofuran carbossammidi come modulatori di canali del sodio
AU2022283934A1 (en) 2021-06-04 2023-11-30 Vertex Pharmaceuticals Incorporated Substituted tetrahydrofuran-2-carboxamides as modulators of sodium channels
CA3221938A1 (en) 2021-06-04 2022-12-08 Vertex Pharmaceuticals Incorporated Substituted tetrahydrofuran analogs as modulators of sodium channels
HRP20260068T1 (hr) 2021-06-04 2026-02-27 Vertex Pharmaceuticals Incorporated Čvrsti farmaceutski oblici i režimi doziranja koji obuhvaćaju (2r,3s,4s,5r)-4-[[3-(3,4-difluor-2-metoksifenil)-4,5-dimetil-5-(trifluormetil)tetrahidrofuran-2-karbonil]amino]piridin-2-karboksamid
WO2022256842A1 (en) 2021-06-04 2022-12-08 Vertex Pharmaceuticals Incorporated Hydroxy and (halo)alkoxy substituted tetrahydrofurans as modulators of sodium channels
US20240400544A1 (en) 2021-06-04 2024-12-05 Vertex Pharmaceuticals Incorporated N-(hydroxyalkyl (hetero)aryl) tetrahydrofuran carboxamide analogs as modulators of sodium channels
CA3257285A1 (en) 2022-04-22 2023-10-26 Vertex Pharmaceuticals Incorporated HETEROARYL COMPOUNDS FOR PAIN RELIEF
WO2023205463A1 (en) 2022-04-22 2023-10-26 Vertex Pharmaceuticals Incorporated Heteroaryl compounds for the treatment of pain
US20230382910A1 (en) 2022-04-22 2023-11-30 Vertex Pharmaceuticals Incorporated Heteroaryl compounds for the treatment of pain
CA3256248A1 (en) 2022-04-22 2023-10-26 Vertex Pharmaceuticals Incorporated HETEROARYL COMPOUNDS FOR PAIN RELIEF
WO2024123815A1 (en) 2022-12-06 2024-06-13 Vertex Pharmaceuticals Incorporated Process for the synthesis of substituted tetrahydrofuran modulators of sodium channels
WO2025090480A1 (en) 2023-10-23 2025-05-01 Vertex Pharmaceuticals Incorporated Heteroaryl compounds for the treatment of pain
WO2025090516A1 (en) 2023-10-23 2025-05-01 Vertex Pharmaceuticals Incorporated Methods of preparing compounds for treating pain and solid forms thereof
WO2025090511A1 (en) 2023-10-23 2025-05-01 Vertex Pharmaceuticals Incorporated Methods of preparing modulators of sodium channels and solid forms of the same for treating pain
WO2025090465A1 (en) 2023-10-23 2025-05-01 Vertex Pharmaceuticals Incorporated Heteroaryl compounds for the treatment of pain
US20250186419A1 (en) 2023-12-07 2025-06-12 Vertex Pharmaceuticals Incorporated Dosing regimens for treating pain
US20260001877A1 (en) 2024-06-28 2026-01-01 Vertex Pharmaceuticals Incorporated Heteroaryl compounds for the treatment of pain
WO2026013449A2 (en) 2024-07-11 2026-01-15 Sea4Us - Biotecnologia E Recursos Marinhos, Sa Oxazolidone-derived compounds and their use in the treatment of chronic and acute pain
WO2026030525A1 (en) 2024-07-31 2026-02-05 Vertex Pharmaceuticals Incorporated Zilvetrigine dosage forms and dosing regimens for treating pain

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2020515610A (ja) * 2017-03-29 2020-05-28 サイトワン セラピューティクス， インコーポレイテッド 疼痛の処置のための１１，１３−修飾サキシトキシン：
JP7090100B2 (ja) 2017-03-29 2022-06-23 サイトワン セラピューティクス， インコーポレイテッド 疼痛の処置のための１１，１３－修飾サキシトキシン：

Also Published As

Publication number Publication date
EP3601290B1 (en) 2021-11-24
EP3601290A1 (en) 2020-02-05
US20200102317A1 (en) 2020-04-02
US11279706B2 (en) 2022-03-22
CN110914276A (zh) 2020-03-24
WO2018183782A1 (en) 2018-10-04

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