JP2020514270A5 - - Google Patents
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- Publication number
- JP2020514270A5 JP2020514270A5 JP2019533585A JP2019533585A JP2020514270A5 JP 2020514270 A5 JP2020514270 A5 JP 2020514270A5 JP 2019533585 A JP2019533585 A JP 2019533585A JP 2019533585 A JP2019533585 A JP 2019533585A JP 2020514270 A5 JP2020514270 A5 JP 2020514270A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- group
- substituted
- aryl
- compound according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 229910052799 carbon Inorganic materials 0.000 claims 25
- 125000003118 aryl group Chemical group 0.000 claims 20
- 229910052739 hydrogen Inorganic materials 0.000 claims 19
- 150000001875 compounds Chemical class 0.000 claims 18
- 125000001072 heteroaryl group Chemical group 0.000 claims 14
- -1 cyano, hydroxyl Chemical group 0.000 claims 11
- 125000006413 ring segment Chemical group 0.000 claims 10
- 125000005843 halogen group Chemical group 0.000 claims 9
- 125000000623 heterocyclic group Chemical group 0.000 claims 8
- 125000001424 substituent group Chemical group 0.000 claims 8
- 125000000217 alkyl group Chemical group 0.000 claims 6
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 241001465754 Metazoa Species 0.000 claims 4
- 125000000753 cycloalkyl group Chemical group 0.000 claims 4
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 4
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 4
- 208000023504 respiratory system disease Diseases 0.000 claims 4
- 125000006376 (C3-C10) cycloalkyl group Chemical group 0.000 claims 3
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 3
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 3
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 3
- 229910052757 nitrogen Inorganic materials 0.000 claims 3
- 229910052760 oxygen Inorganic materials 0.000 claims 3
- 229920006395 saturated elastomer Polymers 0.000 claims 3
- 229910052717 sulfur Inorganic materials 0.000 claims 3
- 241000894006 Bacteria Species 0.000 claims 2
- 241000283690 Bos taurus Species 0.000 claims 2
- 241001581234 Histophilus Species 0.000 claims 2
- 241001293415 Mannheimia Species 0.000 claims 2
- 241000606860 Pasteurella Species 0.000 claims 2
- 241000606856 Pasteurella multocida Species 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 208000015181 infectious disease Diseases 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 2
- 229940051027 pasteurella multocida Drugs 0.000 claims 2
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 125000002541 furyl group Chemical group 0.000 claims 1
- 125000002883 imidazolyl group Chemical group 0.000 claims 1
- 125000002971 oxazolyl group Chemical group 0.000 claims 1
- UUEVFMOUBSLVJW-UHFFFAOYSA-N oxo-[[1-[2-[2-[2-[4-(oxoazaniumylmethylidene)pyridin-1-yl]ethoxy]ethoxy]ethyl]pyridin-4-ylidene]methyl]azanium;dibromide Chemical compound [Br-].[Br-].C1=CC(=C[NH+]=O)C=CN1CCOCCOCCN1C=CC(=C[NH+]=O)C=C1 UUEVFMOUBSLVJW-UHFFFAOYSA-N 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 239000000651 prodrug Substances 0.000 claims 1
- 229940002612 prodrug Drugs 0.000 claims 1
- 125000004309 pyranyl group Chemical group O1C(C=CC=C1)* 0.000 claims 1
- 125000003373 pyrazinyl group Chemical group 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 1
- 125000000168 pyrrolyl group Chemical group 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
- 125000004305 thiazinyl group Chemical group S1NC(=CC=C1)* 0.000 claims 1
- 125000000335 thiazolyl group Chemical group 0.000 claims 1
- 125000001544 thienyl group Chemical group 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022119240A JP2022141920A (ja) | 2016-12-23 | 2022-07-27 | マンヘミア・ヘモリチカ感染症又はヒストフィルス・ソムニ感染症を治療するのに有用な化合物 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16206790 | 2016-12-23 | ||
| EP16206790.4 | 2016-12-23 | ||
| PCT/EP2017/084346 WO2018115421A1 (en) | 2016-12-23 | 2017-12-22 | Compounds useful for treating a mannheimia haemolytica or histophilus somni infection |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022119240A Division JP2022141920A (ja) | 2016-12-23 | 2022-07-27 | マンヘミア・ヘモリチカ感染症又はヒストフィルス・ソムニ感染症を治療するのに有用な化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020514270A JP2020514270A (ja) | 2020-05-21 |
| JP2020514270A5 true JP2020514270A5 (https=) | 2021-01-28 |
| JP7471820B2 JP7471820B2 (ja) | 2024-04-22 |
Family
ID=57609790
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019533585A Active JP7471820B2 (ja) | 2016-12-23 | 2017-12-22 | マンヘミア・ヘモリチカ感染症又はヒストフィルス・ソムニ感染症を治療するのに有用な化合物 |
| JP2022119240A Pending JP2022141920A (ja) | 2016-12-23 | 2022-07-27 | マンヘミア・ヘモリチカ感染症又はヒストフィルス・ソムニ感染症を治療するのに有用な化合物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022119240A Pending JP2022141920A (ja) | 2016-12-23 | 2022-07-27 | マンヘミア・ヘモリチカ感染症又はヒストフィルス・ソムニ感染症を治療するのに有用な化合物 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US11034650B2 (https=) |
| EP (1) | EP3558939A1 (https=) |
| JP (2) | JP7471820B2 (https=) |
| CN (1) | CN110072844B (https=) |
| AR (1) | AR110441A1 (https=) |
| AU (2) | AU2017380070B2 (https=) |
| BR (1) | BR112019013016B1 (https=) |
| MX (2) | MX388647B (https=) |
| WO (1) | WO2018115421A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3558284A2 (en) | 2016-12-23 | 2019-10-30 | Intervet International B.V. | Compounds for the treatment of bovine or swine respiratory disease |
| EP3558939A1 (en) * | 2016-12-23 | 2019-10-30 | Intervet International B.V. | Compounds useful for treating a mannheimia haemolytica or histophilus somni infection |
| WO2019154412A1 (zh) * | 2018-02-10 | 2019-08-15 | 山东亨利医药科技有限责任公司 | 作为抗菌素的化合物 |
| AU2019296380B2 (en) | 2018-06-25 | 2024-02-29 | Intervet International B.V. | Compounds for the treatment of bovine or swine respiratory disease |
| IL281614B2 (en) * | 2018-09-20 | 2024-12-01 | Blacksmith Medicines Inc | Antibacterial compounds |
| JP2024536864A (ja) | 2021-09-28 | 2024-10-08 | ブラックスミス メディシンズ，インク． | Ｌｐｘｃ阻害剤およびその使用 |
| CN116183899B (zh) * | 2023-04-28 | 2023-06-30 | 天津市协和医药科技集团有限公司 | 一种吖啶酯标记抗体保存液的制备方法 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS51106743A (https=) * | 1975-03-13 | 1976-09-21 | Ueno Seiyaku Oyo Kenkyujo Kk | |
| JPS5257164A (en) * | 1975-11-05 | 1977-05-11 | Ueno Seiyaku Oyo Kenkyujo Kk | Production of novel nitrofuran derivatives |
| US6074657A (en) | 1997-03-20 | 2000-06-13 | Pharmacia & Upjohn Company | Administration of an injectable antibiotic in the ear of an animal |
| US20030181398A1 (en) | 2002-03-21 | 2003-09-25 | Brown Scott A. | Method of administering an injectable antibiotic to an animal |
| CA2851462A1 (en) * | 2003-01-08 | 2004-07-29 | University Of Washington | Antibacterial agents |
| JP5539864B2 (ja) * | 2007-06-12 | 2014-07-02 | アカオゲン，インコーポレーテッド | 抗菌剤 |
| CA2796750C (en) * | 2010-04-20 | 2017-09-19 | Taisho Pharmaceutical Co., Ltd. | Novel hydroxamic acid derivative |
| WO2012031298A2 (en) * | 2010-09-03 | 2012-03-08 | Duke University | Ethynylbenzene derivatives |
| JP6006609B2 (ja) * | 2011-10-19 | 2016-10-12 | 大正製薬株式会社 | 新規なヒドロキサム酸誘導体を含有する医薬 |
| EP2847162A1 (en) | 2012-05-09 | 2015-03-18 | Achaogen, Inc. | Antibacterial agents |
| WO2014165075A1 (en) * | 2013-03-12 | 2014-10-09 | Achaogen, Inc. | Antibacterial agents |
| CA2921427A1 (en) * | 2013-08-16 | 2015-02-19 | Duke University | Substituted hydroxamic acid compounds |
| CN105777464B (zh) | 2014-12-26 | 2020-09-29 | 中国科学院上海药物研究所 | 异羟肟酸衍生物及其制备方法和应用 |
| EP3558939A1 (en) | 2016-12-23 | 2019-10-30 | Intervet International B.V. | Compounds useful for treating a mannheimia haemolytica or histophilus somni infection |
| EP3558284A2 (en) * | 2016-12-23 | 2019-10-30 | Intervet International B.V. | Compounds for the treatment of bovine or swine respiratory disease |
-
2017
- 2017-12-22 EP EP17826517.9A patent/EP3558939A1/en active Pending
- 2017-12-22 BR BR112019013016-0A patent/BR112019013016B1/pt active IP Right Grant
- 2017-12-22 MX MX2019007468A patent/MX388647B/es unknown
- 2017-12-22 CN CN201780079642.7A patent/CN110072844B/zh active Active
- 2017-12-22 AR ARP170103659A patent/AR110441A1/es unknown
- 2017-12-22 AU AU2017380070A patent/AU2017380070B2/en active Active
- 2017-12-22 WO PCT/EP2017/084346 patent/WO2018115421A1/en not_active Ceased
- 2017-12-22 JP JP2019533585A patent/JP7471820B2/ja active Active
- 2017-12-22 US US16/472,001 patent/US11034650B2/en active Active
-
2019
- 2019-06-20 MX MX2021015235A patent/MX2021015235A/es unknown
-
2021
- 2021-05-10 US US17/316,034 patent/US12077488B2/en active Active
-
2022
- 2022-02-17 AU AU2022201042A patent/AU2022201042B2/en active Active
- 2022-07-27 JP JP2022119240A patent/JP2022141920A/ja active Pending