JP2020513749A5 - - Google Patents
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- JP2020513749A5 JP2020513749A5 JP2019532979A JP2019532979A JP2020513749A5 JP 2020513749 A5 JP2020513749 A5 JP 2020513749A5 JP 2019532979 A JP2019532979 A JP 2019532979A JP 2019532979 A JP2019532979 A JP 2019532979A JP 2020513749 A5 JP2020513749 A5 JP 2020513749A5
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- JP
- Japan
- Prior art keywords
- sample
- weight
- cellulose
- agent
- molecule
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 238000000034 method Methods 0.000 claims 23
- 239000003795 chemical substances by application Substances 0.000 claims 11
- 150000001875 compounds Chemical class 0.000 claims 6
- 239000000758 substrate Substances 0.000 claims 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 2
- 239000004952 Polyamide Substances 0.000 claims 2
- 239000004721 Polyphenylene oxide Substances 0.000 claims 2
- 239000003054 catalyst Substances 0.000 claims 2
- 229920002678 cellulose Polymers 0.000 claims 2
- 239000001913 cellulose Substances 0.000 claims 2
- 150000004676 glycans Chemical class 0.000 claims 2
- 239000000463 material Substances 0.000 claims 2
- 229920002647 polyamide Polymers 0.000 claims 2
- 229920000570 polyether Polymers 0.000 claims 2
- 229920001282 polysaccharide Polymers 0.000 claims 2
- 239000005017 polysaccharide Substances 0.000 claims 2
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 2
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims 2
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 2
- KIDHWZJUCRJVML-UHFFFAOYSA-N putrescine Chemical compound NCCCCN KIDHWZJUCRJVML-UHFFFAOYSA-N 0.000 claims 2
- 239000003566 sealing material Substances 0.000 claims 2
- 238000012163 sequencing technique Methods 0.000 claims 2
- ATHGHQPFGPMSJY-UHFFFAOYSA-N spermidine Chemical compound NCCCCNCCCN ATHGHQPFGPMSJY-UHFFFAOYSA-N 0.000 claims 2
- PFNFFQXMRSDOHW-UHFFFAOYSA-N spermine Chemical compound NCCCNCCCCNCCCN PFNFFQXMRSDOHW-UHFFFAOYSA-N 0.000 claims 2
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 229920000896 Ethulose Polymers 0.000 claims 1
- 239000001856 Ethyl cellulose Substances 0.000 claims 1
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims 1
- 239000001859 Ethyl hydroxyethyl cellulose Substances 0.000 claims 1
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims 1
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims 1
- 229920001479 Hydroxyethyl methyl cellulose Polymers 0.000 claims 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims 1
- 229930040373 Paraformaldehyde Natural products 0.000 claims 1
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- 108010039918 Polylysine Proteins 0.000 claims 1
- 102000007327 Protamines Human genes 0.000 claims 1
- 108010007568 Protamines Proteins 0.000 claims 1
- 239000005700 Putrescine Substances 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 239000001768 carboxy methyl cellulose Substances 0.000 claims 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims 1
- 230000008878 coupling Effects 0.000 claims 1
- 238000010168 coupling process Methods 0.000 claims 1
- 238000005859 coupling reaction Methods 0.000 claims 1
- 125000004122 cyclic group Chemical group 0.000 claims 1
- 229920001249 ethyl cellulose Polymers 0.000 claims 1
- 235000019325 ethyl cellulose Nutrition 0.000 claims 1
- 235000019326 ethyl hydroxyethyl cellulose Nutrition 0.000 claims 1
- 239000001761 ethyl methyl cellulose Substances 0.000 claims 1
- 235000010944 ethyl methyl cellulose Nutrition 0.000 claims 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims 1
- 238000007481 next generation sequencing Methods 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 150000002894 organic compounds Chemical class 0.000 claims 1
- 239000012476 oxidizable substance Substances 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 229920002866 paraformaldehyde Polymers 0.000 claims 1
- 229920000724 poly(L-arginine) polymer Polymers 0.000 claims 1
- 108010011110 polyarginine Proteins 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- 229920002704 polyhistidine Polymers 0.000 claims 1
- 229920000656 polylysine Polymers 0.000 claims 1
- 230000000379 polymerizing effect Effects 0.000 claims 1
- 229920002714 polyornithine Polymers 0.000 claims 1
- 108010055896 polyornithine Proteins 0.000 claims 1
- 229920013636 polyphenyl ether polymer Polymers 0.000 claims 1
- 229920001451 polypropylene glycol Polymers 0.000 claims 1
- -1 polytetramethylene Polymers 0.000 claims 1
- 229940048914 protamine Drugs 0.000 claims 1
- 239000000565 sealant Substances 0.000 claims 1
- 229940063673 spermidine Drugs 0.000 claims 1
- 229940063675 spermine Drugs 0.000 claims 1
- 229910052723 transition metal Inorganic materials 0.000 claims 1
- 150000003624 transition metals Chemical class 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662436407P | 2016-12-19 | 2016-12-19 | |
| US62/436,407 | 2016-12-19 | ||
| PCT/US2017/067421 WO2018118992A1 (en) | 2016-12-19 | 2017-12-19 | Loading molecules into sample wells for analysis |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020513749A JP2020513749A (ja) | 2020-05-21 |
| JP2020513749A5 true JP2020513749A5 (https=) | 2021-02-04 |
| JP7167024B2 JP7167024B2 (ja) | 2022-11-08 |
Family
ID=61132890
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019532979A Active JP7167024B2 (ja) | 2016-12-19 | 2017-12-19 | 分析するための分子の試料ウェル中へのローディング |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US10731209B2 (https=) |
| EP (1) | EP3555314B1 (https=) |
| JP (1) | JP7167024B2 (https=) |
| KR (1) | KR102591300B1 (https=) |
| CN (1) | CN110088293A (https=) |
| AU (1) | AU2017378985A1 (https=) |
| BR (1) | BR112019012414A2 (https=) |
| CA (1) | CA3046680A1 (https=) |
| MX (1) | MX2019007247A (https=) |
| TW (1) | TW201837184A (https=) |
| WO (1) | WO2018118992A1 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3377656B1 (en) | 2015-11-18 | 2025-07-02 | Pacific Biosciences of California, Inc. | Loading nucleic acids onto substrates |
| KR102709865B1 (ko) | 2017-05-05 | 2024-09-26 | 퀀텀-에스아이 인코포레이티드 | 생물학적 반응에 있어서 개질된 표면 반응성 및 오손방지 특성을 갖는 기재 |
| US11712715B2 (en) | 2019-10-11 | 2023-08-01 | Quantum-Si Incorporated | Surface modification in the vapor phase |
| CN111939844A (zh) * | 2020-09-10 | 2020-11-17 | 中国人民解放军军事科学院军事医学研究院 | 一种dna合成微孔板 |
| US20220098658A1 (en) * | 2020-09-21 | 2022-03-31 | Quantum-Si Incorporated | Methods to minimize photodamage during nucleic acid and peptide sequencing |
| JP2023547110A (ja) | 2020-10-22 | 2023-11-09 | クアンタム－エスアイ インコーポレイテッド | 順次結合電荷蓄積部を備える集積回路および関連技術 |
| JP2023554368A (ja) | 2020-12-15 | 2023-12-27 | クアンタム－エスアイ インコーポレイテッド | 単一分子速度論による分子バーコード分析 |
| WO2022246723A1 (zh) * | 2021-05-27 | 2022-12-01 | 京东方科技集团股份有限公司 | 检测芯片及其制备方法和进样方法 |
| KR20240033032A (ko) * | 2021-07-09 | 2024-03-12 | 세페이드 | 높은 수준의 다중화 반응 용기, 시약 점적 장치 및 관련 방법 |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5705366A (en) * | 1994-09-15 | 1998-01-06 | Johnson & Johnson Clinical Diagnostics, Inc. | Coamplification of target nucleic acids using volume exclusion agent in reaction composition, test kit and test device useful therefor |
| AU4690596A (en) | 1994-12-30 | 1996-07-24 | Chiron Viagene, Inc. | Nucleic acid condensing agents with reduced immunogenicity |
| US6290839B1 (en) * | 1998-06-23 | 2001-09-18 | Clinical Micro Sensors, Inc. | Systems for electrophoretic transport and detection of analytes |
| ATE556149T1 (de) * | 1999-02-23 | 2012-05-15 | Caliper Life Sciences Inc | Manipulation von mikropartikeln in mikrofluidischen systemen |
| US6429258B1 (en) | 1999-05-20 | 2002-08-06 | E. I. Du Pont De Nemours & Company | Polymerization of fluoromonomers |
| US6517776B1 (en) * | 2000-11-03 | 2003-02-11 | Chevron Phillips Chemical Company Lp | UV oxygen scavenging initiation in angular preformed packaging articles |
| US7399590B2 (en) * | 2002-02-21 | 2008-07-15 | Asm Scientific, Inc. | Recombinase polymerase amplification |
| JP2007532116A (ja) | 2004-04-07 | 2007-11-15 | キアジェン ノース アメリカン ホールディングス，インコーポレイティド | １成分型および２成分型のＤＮＡＰｏｌＩＩＩレプリカーゼとその使用 |
| US7288514B2 (en) | 2005-04-14 | 2007-10-30 | The Clorox Company | Polymer-fluorosurfactant associative complexes |
| US8975216B2 (en) | 2006-03-30 | 2015-03-10 | Pacific Biosciences Of California | Articles having localized molecules disposed thereon and methods of producing same |
| CN101495654A (zh) | 2006-04-19 | 2009-07-29 | 阿普里拉股份有限公司 | 无凝胶珠基测序的试剂、方法和文库 |
| US8501406B1 (en) | 2009-07-14 | 2013-08-06 | Pacific Biosciences Of California, Inc. | Selectively functionalized arrays |
| JP6001243B2 (ja) * | 2011-08-11 | 2016-10-05 | 株式会社ブリヂストン | 衝撃吸収体、及び衝撃吸収体の製造方法 |
| AU2013249123A1 (en) | 2012-04-19 | 2014-12-11 | Life Technologies Corporation | Method of performing digital PCR |
| US9797011B2 (en) * | 2013-09-13 | 2017-10-24 | Life Technologies Corporation | Device preparation using condensed nucleic acid particles |
| WO2015074001A1 (en) | 2013-11-17 | 2015-05-21 | Quantum-Si Incorporated | Optical system and assay chip for probing, detecting and analyzing molecules |
| US9587268B2 (en) | 2014-01-29 | 2017-03-07 | Agilent Technologies Inc. | Fast hybridization for next generation sequencing target enrichment |
| US9587263B2 (en) | 2014-03-26 | 2017-03-07 | General Electric Company | Isothermal amplification under low salt condition |
| US10174363B2 (en) | 2015-05-20 | 2019-01-08 | Quantum-Si Incorporated | Methods for nucleic acid sequencing |
| EP3471402B1 (en) | 2014-08-08 | 2023-05-31 | Quantum-Si Incorporated | Integrated device for temporal binning of received photons |
| EP4421188A3 (en) | 2014-08-08 | 2024-10-23 | Quantum-Si Incorporated | Integrated device with external light source for probing, detecting, and analyzing molecules |
| CA2957543A1 (en) | 2014-08-08 | 2016-02-11 | Quantum-Si Incorporated | Optical system and assay chip for probing, detecting and analyzing molecules |
| CN106574266A (zh) * | 2014-08-14 | 2017-04-19 | 雅培分子公司 | 用于下一代测序的文库生成 |
| US10605730B2 (en) | 2015-05-20 | 2020-03-31 | Quantum-Si Incorporated | Optical sources for fluorescent lifetime analysis |
| US10246742B2 (en) | 2015-05-20 | 2019-04-02 | Quantum-Si Incorporated | Pulsed laser and bioanalytic system |
| EP3377656B1 (en) * | 2015-11-18 | 2025-07-02 | Pacific Biosciences of California, Inc. | Loading nucleic acids onto substrates |
| EP3458465B1 (en) | 2016-05-20 | 2024-05-08 | Quantum-Si Incorporated | Labeled nucleotide compositions and methods for nucleic acid sequencing |
| EP4113104A3 (en) | 2016-06-01 | 2023-02-22 | Quantum-si Incorporated | Integrated device for detecting and analyzing molecules |
| TWI755400B (zh) | 2016-06-01 | 2022-02-21 | 美商寬騰矽公司 | 脈衝命名器及基質命名器、識別核苷酸之方法、校準定序儀器之方法、識別發生核苷酸併入事件之時間的方法、非暫時性電腦可讀儲存媒體、及定序儀器 |
| WO2018118997A2 (en) | 2016-12-19 | 2018-06-28 | Quantum-Si Incorporated | Polymerizing enzymes for sequencing reactions |
| KR102709865B1 (ko) | 2017-05-05 | 2024-09-26 | 퀀텀-에스아이 인코포레이티드 | 생물학적 반응에 있어서 개질된 표면 반응성 및 오손방지 특성을 갖는 기재 |
-
2017
- 2017-12-19 BR BR112019012414-4A patent/BR112019012414A2/pt not_active Application Discontinuation
- 2017-12-19 KR KR1020197020659A patent/KR102591300B1/ko active Active
- 2017-12-19 AU AU2017378985A patent/AU2017378985A1/en not_active Abandoned
- 2017-12-19 CA CA3046680A patent/CA3046680A1/en active Pending
- 2017-12-19 CN CN201780078700.4A patent/CN110088293A/zh active Pending
- 2017-12-19 US US15/847,001 patent/US10731209B2/en active Active
- 2017-12-19 TW TW106144669A patent/TW201837184A/zh unknown
- 2017-12-19 WO PCT/US2017/067421 patent/WO2018118992A1/en not_active Ceased
- 2017-12-19 JP JP2019532979A patent/JP7167024B2/ja active Active
- 2017-12-19 MX MX2019007247A patent/MX2019007247A/es unknown
- 2017-12-19 EP EP17837924.4A patent/EP3555314B1/en active Active
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