JP2020513050A5 - - Google Patents

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JP2020513050A5
JP2020513050A5 JP2019553932A JP2019553932A JP2020513050A5 JP 2020513050 A5 JP2020513050 A5 JP 2020513050A5 JP 2019553932 A JP2019553932 A JP 2019553932A JP 2019553932 A JP2019553932 A JP 2019553932A JP 2020513050 A5 JP2020513050 A5 JP 2020513050A5
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JP7149614B2 (ja
JP2020513050A (ja
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Priority claimed from PCT/US2018/025567 external-priority patent/WO2018183960A1/en
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JP2019553932A 2017-03-30 2018-03-30 in vivo画像化のためのプロテアーゼ活性化コントラスト剤 Active JP7149614B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762478639P 2017-03-30 2017-03-30
US62/478,639 2017-03-30
PCT/US2018/025567 WO2018183960A1 (en) 2017-03-30 2018-03-30 Protease-activated contrast agents for in vivo imaging

Publications (3)

Publication Number Publication Date
JP2020513050A JP2020513050A (ja) 2020-04-30
JP2020513050A5 true JP2020513050A5 (enExample) 2021-05-06
JP7149614B2 JP7149614B2 (ja) 2022-10-07

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JP2019553932A Active JP7149614B2 (ja) 2017-03-30 2018-03-30 in vivo画像化のためのプロテアーゼ活性化コントラスト剤

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US (2) US11828752B2 (enExample)
EP (1) EP3601261A4 (enExample)
JP (1) JP7149614B2 (enExample)
KR (1) KR102669535B1 (enExample)
CN (1) CN110678460A (enExample)
WO (1) WO2018183960A1 (enExample)

Families Citing this family (4)

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Publication number Priority date Publication date Assignee Title
CN107406872B (zh) * 2015-01-22 2023-03-28 里兰斯坦福初级大学理事会 用于标记动物组织的化合物、组合物及其应用
WO2022203930A1 (en) * 2021-03-24 2022-09-29 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Fluorogenic cyanine carbamates
CN116199662B (zh) * 2021-11-30 2024-10-11 中国科学院大连化学物理研究所 一种可见光和近红外光罗丹明荧光淬灭剂及其合成和应用
CN116199675B (zh) * 2021-11-30 2024-08-20 中国科学院大连化学物理研究所 一类罗丹明荧光淬灭剂及其合成和应用

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL60888A (en) 1978-06-16 1984-07-31 Yeda Res & Dev Substrates and process for the quantitative assay of enzymes
US5055451A (en) 1986-12-22 1991-10-08 Syntex Inc. Aryloxy and arylacyloxy methyl ketones as thiol protease inhibitors
AU2704395A (en) 1995-06-13 1997-01-09 Sanofi Winthrop, Inc. Calpain inhibitors for the treatment of neurodegenerative di seases
US6544951B2 (en) 1998-07-02 2003-04-08 Idun Pharmaceuticals, Inc. C-terminal modified oxamyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases
US20020052323A1 (en) 2000-08-30 2002-05-02 Jinhai Wang Quinoline-(C=O)-(multiple amino acids)-leaving group compounds for pharmaceutical compositions and reagents
GB0112868D0 (en) 2001-05-25 2001-07-18 Secr Defence Detection system
US7303741B2 (en) 2002-09-23 2007-12-04 General Electric Company Systems and methods for high-resolution in vivo imaging of biochemical activity in a living organism
US20060148014A1 (en) 2004-12-09 2006-07-06 Sergei Agoulnik Tubulin isotype screening in cancer therapy using hemiasterlin analogs
US8968700B2 (en) 2005-08-11 2015-03-03 The Board Of Trustees Of The Leland Stanford Junior University Imaging of protease activity in live cells using activity based probes
MY162041A (en) * 2007-02-28 2017-05-31 Sanofi Aventis Imaging probes
CN101652149B (zh) 2007-02-28 2012-11-14 塞诺菲-安万特股份有限公司 成像探针
CA2695244A1 (en) 2007-08-03 2009-02-12 Sanofi-Aventis Caspase imaging probes
US20090214436A1 (en) 2008-02-18 2009-08-27 Washington University Dichromic fluorescent compounds
WO2009124265A1 (en) 2008-04-03 2009-10-08 The Board Of Trustees Of The Leland Stanford Junior University Probes for in vivo targeting of active cysteine proteases
US9155471B2 (en) 2009-05-27 2015-10-13 Lumicell, Inc'. Methods and systems for spatially identifying abnormal cells
WO2012021800A2 (en) 2010-08-13 2012-02-16 Banyan Biomarkers Caspase inhibitors as therapeutics for neural and organ injury and imaging
WO2012118715A2 (en) 2011-02-28 2012-09-07 The Board Of Trustees Of Leland Stanford Junior University Non-peptidic quenched fluorescent imaging probes
US8709830B2 (en) 2011-03-18 2014-04-29 Biotium, Inc. Fluorescent dyes, fluorescent dye kits, and methods of preparing labeled molecules
WO2013036743A1 (en) 2011-09-09 2013-03-14 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Imaging agents for imaging protease activity and uses thereof
US20140180073A1 (en) 2012-12-24 2014-06-26 Anticancer, Inc. Portable digital imaging system for fluorescence-guided surgery
KR20160037834A (ko) 2013-03-14 2016-04-06 루미셀, 아이엔씨. 의료 이미징 장치 및 사용 방법
WO2014145257A2 (en) 2013-03-15 2014-09-18 The Board Of Trustees Of The Leland Stanford Junior University Activity-based probe compounds, compositions, and methods of use
WO2014171899A1 (en) 2013-04-19 2014-10-23 Agency For Science, Technology And Research Tunable fluorescence using cleavable linkers
US20170050988A1 (en) * 2013-11-25 2017-02-23 Sanofi Dotam derivatives for therapeutic use
CN107406872B (zh) * 2015-01-22 2023-03-28 里兰斯坦福初级大学理事会 用于标记动物组织的化合物、组合物及其应用

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