JP2020513041A5 - - Google Patents
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- Publication number
- JP2020513041A5 JP2020513041A5 JP2020504468A JP2020504468A JP2020513041A5 JP 2020513041 A5 JP2020513041 A5 JP 2020513041A5 JP 2020504468 A JP2020504468 A JP 2020504468A JP 2020504468 A JP2020504468 A JP 2020504468A JP 2020513041 A5 JP2020513041 A5 JP 2020513041A5
- Authority
- JP
- Japan
- Prior art keywords
- mucus
- subject
- alkyl
- nitric oxide
- releasing biopolymer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 claims 64
- 210000003097 mucus Anatomy 0.000 claims 36
- 229920001222 biopolymer Polymers 0.000 claims 23
- 239000003607 modifier Substances 0.000 claims 14
- 125000000217 alkyl group Chemical group 0.000 claims 10
- 229910052739 hydrogen Inorganic materials 0.000 claims 10
- 239000001257 hydrogen Substances 0.000 claims 10
- 150000002431 hydrogen Chemical class 0.000 claims 6
- 239000002840 nitric oxide donor Substances 0.000 claims 6
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 244000052769 pathogen Species 0.000 claims 4
- 241000186359 Mycobacterium Species 0.000 claims 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 3
- 238000012986 modification Methods 0.000 claims 3
- 230000004048 modification Effects 0.000 claims 3
- 229920000715 Mucilage Polymers 0.000 claims 2
- 239000000853 adhesive Substances 0.000 claims 2
- 125000003545 alkoxy group Chemical group 0.000 claims 2
- 230000000844 anti-bacterial effect Effects 0.000 claims 2
- 230000000845 anti-microbial effect Effects 0.000 claims 2
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 claims 2
- 238000000338 in vitro Methods 0.000 claims 2
- 230000003232 mucoadhesive effect Effects 0.000 claims 2
- 230000000510 mucolytic effect Effects 0.000 claims 2
- 239000002953 phosphate buffered saline Substances 0.000 claims 2
- MUMXDRRTIYLYMY-YJKCNMNRSA-N (Z)-[dodecyl-[6-(dodecylazaniumyl)hexyl]amino]-oxido-oxidoiminoazanium Chemical compound CCCCCCCCCCCC[NH2+]CCCCCCN(CCCCCCCCCCCC)[N+](\[O-])=N\[O-] MUMXDRRTIYLYMY-YJKCNMNRSA-N 0.000 claims 1
- 241001673062 Achromobacter xylosoxidans Species 0.000 claims 1
- 241000589513 Burkholderia cepacia Species 0.000 claims 1
- 201000003883 Cystic fibrosis Diseases 0.000 claims 1
- 241000588747 Klebsiella pneumoniae Species 0.000 claims 1
- 241000589517 Pseudomonas aeruginosa Species 0.000 claims 1
- 241000191967 Staphylococcus aureus Species 0.000 claims 1
- 241000122971 Stenotrophomonas Species 0.000 claims 1
- 206010000269 abscess Diseases 0.000 claims 1
- 125000005907 alkyl ester group Chemical group 0.000 claims 1
- 210000000621 bronchi Anatomy 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 230000001717 pathogenic effect Effects 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 238000009097 single-agent therapy Methods 0.000 claims 1
- 125000006850 spacer group Chemical group 0.000 claims 1
- 210000003437 trachea Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762483655P | 2017-04-10 | 2017-04-10 | |
| US62/483,655 | 2017-04-10 | ||
| PCT/IB2018/052522 WO2018189687A1 (en) | 2017-04-10 | 2018-04-10 | Compounds, compositions and methods for inhibiting a pathogen and/or modifying mucus |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020513041A JP2020513041A (ja) | 2020-04-30 |
| JP2020513041A5 true JP2020513041A5 (https=) | 2021-05-20 |
Family
ID=63792445
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020504468A Pending JP2020513041A (ja) | 2017-04-10 | 2018-04-10 | 病原体の阻害および／または粘液の改変のための化合物、組成物、および方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US11324773B2 (https=) |
| EP (1) | EP3592335A4 (https=) |
| JP (1) | JP2020513041A (https=) |
| CN (1) | CN110573143A (https=) |
| WO (1) | WO2018189687A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11534382B2 (en) | 2017-06-19 | 2022-12-27 | Novan, Inc. | Topical compositions and methods of using the same |
| US11285171B2 (en) | 2018-03-01 | 2022-03-29 | Novan, Inc. | Nitric oxide releasing suppositories and methods of use thereof |
| CN115486478A (zh) * | 2022-10-09 | 2022-12-20 | 江苏天美健大自然生物工程有限公司 | 一种蛋白饮料用防腐剂组合物及其制备方法 |
| WO2025049608A1 (en) * | 2023-08-28 | 2025-03-06 | Calroyhealth Sciences, Llc | Compositions and methods to protect and enhance structural and functional integrity of the intestinal glycocalyx |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5234933A (en) | 1991-10-31 | 1993-08-10 | Board Of Governors Of Wayne State University And Vanderbilt University | Cyclic hydroxamic acids |
| DE4210332C1 (https=) | 1992-03-30 | 1993-07-15 | Gruenenthal Gmbh, 5100 Aachen, De | |
| US5238832A (en) | 1992-06-08 | 1993-08-24 | Board Of Governors Of Wayne State University | Aryl aliphatic acids |
| WO1996002245A1 (en) | 1994-07-14 | 1996-02-01 | The Wellcome Foundation Limited | Nitric oxide synthase inhibitors for inhibiting the production of airway mucus |
| US6180082B1 (en) | 1997-11-24 | 2001-01-30 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Method to enhance tissue accumulation of radiolabeled compounds |
| US6261594B1 (en) | 1998-11-25 | 2001-07-17 | The University Of Akron | Chitosan-based nitric oxide donor compositions |
| IT1303793B1 (it) | 1998-11-27 | 2001-02-23 | Promefarm S R L | "composizione farmaceutica comprendente un composto organico donatoredi ossido nitrico (no)" |
| CA2565230A1 (en) * | 2004-05-11 | 2005-11-24 | Pulmonox Technologies Corporation | The use of inhaled gaseous nitric oxide as a mucolytic agent or expectorant |
| EP2209472A1 (en) | 2007-10-12 | 2010-07-28 | The University of North Carolina at Chapel Hill | Use of nitric oxide to enhance the efficacy of silver and other topical wound care agents |
| GB201021186D0 (en) | 2010-12-14 | 2011-01-26 | Novabiotics Ltd | Composition |
| CN106986952B (zh) | 2012-08-17 | 2020-03-10 | 北卡罗来纳大学查珀尔希尔分校 | 水溶性的释放一氧化氮的聚葡糖胺和其用途 |
-
2018
- 2018-04-10 JP JP2020504468A patent/JP2020513041A/ja active Pending
- 2018-04-10 US US16/500,755 patent/US11324773B2/en active Active
- 2018-04-10 WO PCT/IB2018/052522 patent/WO2018189687A1/en not_active Ceased
- 2018-04-10 CN CN201880024184.1A patent/CN110573143A/zh active Pending
- 2018-04-10 EP EP18784598.7A patent/EP3592335A4/en active Pending
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