CN110573143A - 用于抑制病原体和/或改性粘液的化合物、组合物和方法 - Google Patents

用于抑制病原体和/或改性粘液的化合物、组合物和方法 Download PDF

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Publication number
CN110573143A
CN110573143A CN201880024184.1A CN201880024184A CN110573143A CN 110573143 A CN110573143 A CN 110573143A CN 201880024184 A CN201880024184 A CN 201880024184A CN 110573143 A CN110573143 A CN 110573143A
Authority
CN
China
Prior art keywords
mucus
releasing
releasing biopolymer
biopolymer
nitric oxide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201880024184.1A
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English (en)
Chinese (zh)
Inventor
M·H·舍恩菲施
K·赖格哈德
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of North Carolina at Chapel Hill
Original Assignee
University of North Carolina at Chapel Hill
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of North Carolina at Chapel Hill filed Critical University of North Carolina at Chapel Hill
Publication of CN110573143A publication Critical patent/CN110573143A/zh
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0065—Forms with gastric retention, e.g. floating on gastric juice, adhering to gastric mucosa, expanding to prevent passage through the pylorus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
CN201880024184.1A 2017-04-10 2018-04-10 用于抑制病原体和/或改性粘液的化合物、组合物和方法 Pending CN110573143A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762483655P 2017-04-10 2017-04-10
US62/483,655 2017-04-10
PCT/IB2018/052522 WO2018189687A1 (en) 2017-04-10 2018-04-10 Compounds, compositions and methods for inhibiting a pathogen and/or modifying mucus

Publications (1)

Publication Number Publication Date
CN110573143A true CN110573143A (zh) 2019-12-13

Family

ID=63792445

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201880024184.1A Pending CN110573143A (zh) 2017-04-10 2018-04-10 用于抑制病原体和/或改性粘液的化合物、组合物和方法

Country Status (5)

Country Link
US (1) US11324773B2 (https=)
EP (1) EP3592335A4 (https=)
JP (1) JP2020513041A (https=)
CN (1) CN110573143A (https=)
WO (1) WO2018189687A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11534382B2 (en) 2017-06-19 2022-12-27 Novan, Inc. Topical compositions and methods of using the same
US11285171B2 (en) 2018-03-01 2022-03-29 Novan, Inc. Nitric oxide releasing suppositories and methods of use thereof
CN115486478A (zh) * 2022-10-09 2022-12-20 江苏天美健大自然生物工程有限公司 一种蛋白饮料用防腐剂组合物及其制备方法
WO2025049608A1 (en) * 2023-08-28 2025-03-06 Calroyhealth Sciences, Llc Compositions and methods to protect and enhance structural and functional integrity of the intestinal glycocalyx

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005110052A2 (en) * 2004-05-11 2005-11-24 Pulmonox Technologies Corporation The use of inhaled gaseous nitric oxide as a mucolytic agent or expectorant
CN104755505A (zh) * 2012-08-17 2015-07-01 北卡罗来纳大学查珀尔希尔分校 水溶性的释放一氧化氮的聚葡糖胺和其用途

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5234933A (en) 1991-10-31 1993-08-10 Board Of Governors Of Wayne State University And Vanderbilt University Cyclic hydroxamic acids
DE4210332C1 (https=) 1992-03-30 1993-07-15 Gruenenthal Gmbh, 5100 Aachen, De
US5238832A (en) 1992-06-08 1993-08-24 Board Of Governors Of Wayne State University Aryl aliphatic acids
WO1996002245A1 (en) 1994-07-14 1996-02-01 The Wellcome Foundation Limited Nitric oxide synthase inhibitors for inhibiting the production of airway mucus
US6180082B1 (en) 1997-11-24 2001-01-30 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Method to enhance tissue accumulation of radiolabeled compounds
US6261594B1 (en) 1998-11-25 2001-07-17 The University Of Akron Chitosan-based nitric oxide donor compositions
IT1303793B1 (it) 1998-11-27 2001-02-23 Promefarm S R L "composizione farmaceutica comprendente un composto organico donatoredi ossido nitrico (no)"
EP2209472A1 (en) 2007-10-12 2010-07-28 The University of North Carolina at Chapel Hill Use of nitric oxide to enhance the efficacy of silver and other topical wound care agents
GB201021186D0 (en) 2010-12-14 2011-01-26 Novabiotics Ltd Composition

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005110052A2 (en) * 2004-05-11 2005-11-24 Pulmonox Technologies Corporation The use of inhaled gaseous nitric oxide as a mucolytic agent or expectorant
CN104755505A (zh) * 2012-08-17 2015-07-01 北卡罗来纳大学查珀尔希尔分校 水溶性的释放一氧化氮的聚葡糖胺和其用途

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
KATELYN P. REIGHARD，ET AL.: "Disruption and eradication of P. aeruginosa biofilms using nitric oxide-releasing chitosan oligosaccharides", 《BIOFOULING》 *

Also Published As

Publication number Publication date
US20200085858A1 (en) 2020-03-19
US11324773B2 (en) 2022-05-10
EP3592335A4 (en) 2021-01-27
WO2018189687A1 (en) 2018-10-18
JP2020513041A (ja) 2020-04-30
EP3592335A1 (en) 2020-01-15

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Legal Events

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SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
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RJ01 Rejection of invention patent application after publication

Application publication date: 20191213