JP2020511481A5 - - Google Patents
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- JP2020511481A5 JP2020511481A5 JP2019551449A JP2019551449A JP2020511481A5 JP 2020511481 A5 JP2020511481 A5 JP 2020511481A5 JP 2019551449 A JP2019551449 A JP 2019551449A JP 2019551449 A JP2019551449 A JP 2019551449A JP 2020511481 A5 JP2020511481 A5 JP 2020511481A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- amino acid
- acid sequence
- variable domain
- heavy chain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 125000003275 alpha amino acid group Chemical group 0.000 claims 92
- 150000001413 amino acids Chemical class 0.000 claims 48
- 230000002195 synergetic effect Effects 0.000 claims 29
- 238000011282 treatment Methods 0.000 claims 16
- 206010028980 Neoplasm Diseases 0.000 claims 12
- 239000000427 antigen Substances 0.000 claims 11
- 102000036639 antigens Human genes 0.000 claims 11
- 108091007433 antigens Proteins 0.000 claims 11
- 239000012634 fragment Substances 0.000 claims 11
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims 10
- 201000011510 cancer Diseases 0.000 claims 9
- 230000001225 therapeutic effect Effects 0.000 claims 8
- 206010025323 Lymphomas Diseases 0.000 claims 5
- 239000002246 antineoplastic agent Substances 0.000 claims 4
- 238000011284 combination treatment Methods 0.000 claims 4
- 238000002560 therapeutic procedure Methods 0.000 claims 4
- 210000004881 tumor cell Anatomy 0.000 claims 4
- 208000024893 Acute lymphoblastic leukemia Diseases 0.000 claims 3
- 208000014697 Acute lymphocytic leukaemia Diseases 0.000 claims 3
- 201000009030 Carcinoma Diseases 0.000 claims 3
- 101000868279 Homo sapiens Leukocyte surface antigen CD47 Proteins 0.000 claims 3
- 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 claims 3
- 206010039491 Sarcoma Diseases 0.000 claims 3
- 102000044459 human CD47 Human genes 0.000 claims 3
- 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 claims 2
- 208000010833 Chronic myeloid leukaemia Diseases 0.000 claims 2
- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 claims 2
- 208000017604 Hodgkin disease Diseases 0.000 claims 2
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- 208000033761 Myelogenous Chronic BCR-ABL Positive Leukemia Diseases 0.000 claims 2
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- QNRATNLHPGXHMA-XZHTYLCXSA-N (r)-(6-ethoxyquinolin-4-yl)-[(2s,4s,5r)-5-ethyl-1-azabicyclo[2.2.2]octan-2-yl]methanol;hydrochloride Chemical compound Cl.C([C@H]([C@H](C1)CC)C2)CN1[C@@H]2[C@H](O)C1=CC=NC2=CC=C(OCC)C=C21 QNRATNLHPGXHMA-XZHTYLCXSA-N 0.000 claims 1
- AOJJSUZBOXZQNB-VTZDEGQISA-N 4'-epidoxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-VTZDEGQISA-N 0.000 claims 1
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
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- GAGWJHPBXLXJQN-UORFTKCHSA-N Capecitabine Chemical compound C1=C(F)C(NC(=O)OCCCCC)=NC(=O)N1[C@H]1[C@H](O)[C@H](O)[C@@H](C)O1 GAGWJHPBXLXJQN-UORFTKCHSA-N 0.000 claims 1
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- XDXDZDZNSLXDNA-TZNDIEGXSA-N Idarubicin Chemical compound C1[C@H](N)[C@H](O)[C@H](C)O[C@H]1O[C@@H]1C2=C(O)C(C(=O)C3=CC=CC=C3C3=O)=C3C(O)=C2C[C@@](O)(C(C)=O)C1 XDXDZDZNSLXDNA-TZNDIEGXSA-N 0.000 claims 1
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- 201000003793 Myelodysplastic syndrome Diseases 0.000 claims 1
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- ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 claims 1
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- 208000024770 Thyroid neoplasm Diseases 0.000 claims 1
- 102100029948 Tyrosine-protein phosphatase non-receptor type substrate 1 Human genes 0.000 claims 1
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- 229960004316 cisplatin Drugs 0.000 claims 1
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- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 229960000975 daunorubicin Drugs 0.000 claims 1
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- 230000000394 mitotic effect Effects 0.000 claims 1
- 229960001156 mitoxantrone Drugs 0.000 claims 1
- KKZJGLLVHKMTCM-UHFFFAOYSA-N mitoxantrone Chemical compound O=C1C2=C(O)C=CC(O)=C2C(=O)C2=C1C(NCCNCCO)=CC=C2NCCNCCO KKZJGLLVHKMTCM-UHFFFAOYSA-N 0.000 claims 1
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- DWAFYCQODLXJNR-BNTLRKBRSA-L oxaliplatin Chemical compound O1C(=O)C(=O)O[Pt]11N[C@@H]2CCCC[C@H]2N1 DWAFYCQODLXJNR-BNTLRKBRSA-L 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
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- 229910052697 platinum Inorganic materials 0.000 claims 1
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- 201000002510 thyroid cancer Diseases 0.000 claims 1
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- 229940044693 topoisomerase inhibitor Drugs 0.000 claims 1
- 229960000303 topotecan Drugs 0.000 claims 1
- UCFGDBYHRUNTLO-QHCPKHFHSA-N topotecan Chemical compound C1=C(O)C(CN(C)C)=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 UCFGDBYHRUNTLO-QHCPKHFHSA-N 0.000 claims 1
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- JXLYSJRDGCGARV-CFWMRBGOSA-N vinblastine Chemical compound C([C@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-CFWMRBGOSA-N 0.000 claims 1
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- OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762475036P | 2017-03-22 | 2017-03-22 | |
| US201762475032P | 2017-03-22 | 2017-03-22 | |
| US62/475,036 | 2017-03-22 | ||
| US62/475,032 | 2017-03-22 | ||
| US15/871,802 | 2018-01-15 | ||
| US15/871,802 US20180142019A1 (en) | 2016-10-21 | 2018-01-15 | Therapeutic cd47 antibodies |
| PCT/US2018/023860 WO2018175790A1 (en) | 2017-03-22 | 2018-03-22 | Combination therapy for the treatment of solid and hematological cancers |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020511481A JP2020511481A (ja) | 2020-04-16 |
| JP2020511481A5 true JP2020511481A5 (enExample) | 2021-05-06 |
| JP7170331B2 JP7170331B2 (ja) | 2022-11-14 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019551449A Active JP7170331B2 (ja) | 2017-03-22 | 2018-03-22 | 固形及び血液癌の治療のための併用療法 |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP3600393A4 (enExample) |
| JP (1) | JP7170331B2 (enExample) |
| CN (1) | CN111148535A (enExample) |
| AU (1) | AU2018240377A1 (enExample) |
| CA (1) | CA3057139A1 (enExample) |
| SG (1) | SG11201908602UA (enExample) |
| WO (1) | WO2018175790A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2015007446A (es) | 2012-12-12 | 2015-12-07 | Vasculox Inc | Anticuerpos terapeuticos para cd47. |
| US9221908B2 (en) | 2012-12-12 | 2015-12-29 | Vasculox, Inc. | Therapeutic CD47 antibodies |
| MX2018003374A (es) | 2015-09-18 | 2018-11-09 | Arch Oncology Inc | Anticuerpos terapeuticos cd47. |
| WO2018075960A1 (en) | 2016-10-21 | 2018-04-26 | Tioma Therapeutics, Inc. | Therapeutic cd47 antibodies |
| CN113166257B (zh) * | 2018-12-03 | 2023-05-30 | 上海开拓者生物医药有限公司 | Cd47抗体及其制备方法和应用 |
| JP2022532249A (ja) * | 2019-05-16 | 2022-07-13 | アーチ オンコロジー，インコーポレイテッド | インターロイキンタンパク質の類似体と組み合わせて癌を処置するための治療用組成物及び方法 |
| JP7561775B2 (ja) | 2019-06-07 | 2024-10-04 | エーエルエックス オンコロジー インコーポレイテッド | 血清学的アッセイにおいてｃｄ４７に結合する薬物の干渉を低減するための方法及び試薬 |
| AU2020372327A1 (en) * | 2019-10-23 | 2022-06-02 | Arch Oncology, Inc. | Combination therapy for the treatment of solid and hematological cancers |
| KR20220114049A (ko) | 2019-12-17 | 2022-08-17 | 화이자 인코포레이티드 | Cd47, pd-l1에 특이적인 항체, 및 그의 용도 |
| US20230303711A1 (en) * | 2020-07-31 | 2023-09-28 | Bio-Thera Solutions, Ltd. | Anti-cd47 antibody and use thereof |
| JP2023552375A (ja) | 2020-12-06 | 2023-12-15 | エーエルエックス オンコロジー インコーポレイテッド | 血清学的アッセイにおいてｃｄ４７に結合する薬物の干渉を低減するための多量体 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7696325B2 (en) * | 1999-03-10 | 2010-04-13 | Chugai Seiyaku Kabushiki Kaisha | Polypeptide inducing apoptosis |
| CN101133083A (zh) * | 2003-11-11 | 2008-02-27 | 中外制药株式会社 | 人源化的抗cd47抗体 |
| CA2715166C (en) * | 2008-02-11 | 2017-05-16 | Curetech Ltd. | Monoclonal antibodies for tumor treatment |
| BR112012017642A2 (pt) * | 2010-01-21 | 2016-04-12 | Immunogen Inc | composições e métodos para tratamento de câncer de ovário |
| US9045541B2 (en) * | 2012-02-06 | 2015-06-02 | Inhibrx Llc | CD47 antibodies and methods of use thereof |
| AU2013278843A1 (en) * | 2012-06-21 | 2014-03-27 | Compugen Ltd. | LSR antibodies, and uses thereof for treatment of cancer |
| US9221908B2 (en) * | 2012-12-12 | 2015-12-29 | Vasculox, Inc. | Therapeutic CD47 antibodies |
| NZ710695A (en) | 2013-02-06 | 2020-05-29 | Inhibrx Inc | Non-platelet depleting and non-red blood cell depleting cd47 antibodies and methods of use thereof |
| MX2018003374A (es) * | 2015-09-18 | 2018-11-09 | Arch Oncology Inc | Anticuerpos terapeuticos cd47. |
-
2018
- 2018-03-22 JP JP2019551449A patent/JP7170331B2/ja active Active
- 2018-03-22 AU AU2018240377A patent/AU2018240377A1/en not_active Abandoned
- 2018-03-22 CN CN201880028490.2A patent/CN111148535A/zh active Pending
- 2018-03-22 EP EP18771103.1A patent/EP3600393A4/en not_active Withdrawn
- 2018-03-22 CA CA3057139A patent/CA3057139A1/en active Pending
- 2018-03-22 WO PCT/US2018/023860 patent/WO2018175790A1/en not_active Ceased
- 2018-03-22 SG SG11201908602U patent/SG11201908602UA/en unknown
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