JP2020511468A5 - - Google Patents
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- JP2020511468A5 JP2020511468A5 JP2019550653A JP2019550653A JP2020511468A5 JP 2020511468 A5 JP2020511468 A5 JP 2020511468A5 JP 2019550653 A JP2019550653 A JP 2019550653A JP 2019550653 A JP2019550653 A JP 2019550653A JP 2020511468 A5 JP2020511468 A5 JP 2020511468A5
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- YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical compound [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 claims 8
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762472022P | 2017-03-16 | 2017-03-16 | |
| US62/472,022 | 2017-03-16 | ||
| PCT/US2018/022545 WO2018170201A1 (en) | 2017-03-16 | 2018-03-15 | Deuterated analogs of mk2 inhibitors and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020511468A JP2020511468A (ja) | 2020-04-16 |
| JP2020511468A5 true JP2020511468A5 (https=) | 2021-04-22 |
Family
ID=63523341
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019550653A Pending JP2020511468A (ja) | 2017-03-16 | 2018-03-15 | Ｍｋ２阻害剤の重水素化アナログおよびその使用 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US11230551B2 (https=) |
| EP (1) | EP3596085A4 (https=) |
| JP (1) | JP2020511468A (https=) |
| WO (1) | WO2018170201A1 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RS62017B1 (sr) | 2014-09-17 | 2021-07-30 | Celgene Car Llc | Mk2 inhibitori i njihova upotreba |
| US11230551B2 (en) | 2017-03-16 | 2022-01-25 | Celgene Car Llc | Deuterated analogs of MK2 inhibitors and uses thereof |
| JP7282039B2 (ja) | 2017-03-16 | 2023-05-26 | セルジーン シーエーアール エルエルシー | Ｍｋ２阻害剤、その合成、およびそれに至るまでの中間体 |
| JP7200120B2 (ja) | 2017-03-16 | 2023-01-06 | セルジーン シーエーアール エルエルシー | Ｍｋ２阻害剤として有用なヘテロアリール化合物 |
| WO2018170204A1 (en) * | 2017-03-16 | 2018-09-20 | Celgene Car Llc | 9,10,11,12-tetrahydro-8h-[1,4]diazepino[5',6':4,5]thieno[3,2-f]quinolin-8-one compounds and uses thereof |
| US10882867B2 (en) | 2017-03-16 | 2021-01-05 | Celgene Car Llc | Forms and compositions of a MK2 inhibitor |
| KR20230142529A (ko) | 2021-02-01 | 2023-10-11 | 셀진 코포레이션 | Mk2 억제제, 이의 합성, 및 이의 중간체 |
| TW202328141A (zh) * | 2021-08-27 | 2023-07-16 | 大陸商瑞石生物醫藥有限公司 | 喹啉并呋喃衍生物及其用途 |
| MX2024008704A (es) | 2022-01-14 | 2024-07-22 | Shanghai Hansoh Biomedical Co Ltd | Derivado policiclico que contiene piridina, y metodo de preparacion de este y uso de este. |
| WO2024044731A1 (en) * | 2022-08-26 | 2024-02-29 | Matchpoint Therapeutics Inc. | Diazepino-thieno-quinoxaline compounds and their use in therapy |
| CN115925718A (zh) * | 2022-12-27 | 2023-04-07 | 瑞石生物医药有限公司 | 一种四环内酰胺衍生物及其用途 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1087725C (zh) | 1994-03-25 | 2002-07-17 | 同位素技术有限公司 | 用氘代方法增强药物效果 |
| TW200413273A (en) * | 2002-11-15 | 2004-08-01 | Wako Pure Chem Ind Ltd | Heavy hydrogenation method of heterocyclic rings |
| CN1747949A (zh) | 2002-12-20 | 2006-03-15 | 法马西亚公司 | 无环吡唑化合物 |
| WO2005105814A1 (en) | 2004-04-28 | 2005-11-10 | Incyte Corporation | Tetracyclic inhibitors of janus kinases |
| EP2223925A1 (en) * | 2006-10-09 | 2010-09-01 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
| CN101687869A (zh) | 2007-07-16 | 2010-03-31 | 诺瓦提斯公司 | 作为mk2抑制剂的四环内酰胺衍生物 |
| WO2011153553A2 (en) | 2010-06-04 | 2011-12-08 | The Regents Of The University Of California | Methods and compositions for kinase inhibition |
| HK1210696A1 (en) * | 2012-07-11 | 2016-05-06 | Nimbus Iris, Inc. | Irak inhibitors and uses thereof |
| JP2016518316A (ja) | 2013-03-15 | 2016-06-23 | セルジーン アビロミクス リサーチ， インコーポレイテッド | Ｍｋ２阻害剤およびそれらの使用 |
| US9457707B2 (en) * | 2014-09-15 | 2016-10-04 | Nissan North America, Inc. | Vehicle auxiliary lamp unit |
| RS62017B1 (sr) | 2014-09-17 | 2021-07-30 | Celgene Car Llc | Mk2 inhibitori i njihova upotreba |
| JP7200120B2 (ja) * | 2017-03-16 | 2023-01-06 | セルジーン シーエーアール エルエルシー | Ｍｋ２阻害剤として有用なヘテロアリール化合物 |
| WO2018170204A1 (en) | 2017-03-16 | 2018-09-20 | Celgene Car Llc | 9,10,11,12-tetrahydro-8h-[1,4]diazepino[5',6':4,5]thieno[3,2-f]quinolin-8-one compounds and uses thereof |
| JP7282039B2 (ja) | 2017-03-16 | 2023-05-26 | セルジーン シーエーアール エルエルシー | Ｍｋ２阻害剤、その合成、およびそれに至るまでの中間体 |
| US11230551B2 (en) | 2017-03-16 | 2022-01-25 | Celgene Car Llc | Deuterated analogs of MK2 inhibitors and uses thereof |
| US10882867B2 (en) | 2017-03-16 | 2021-01-05 | Celgene Car Llc | Forms and compositions of a MK2 inhibitor |
-
2018
- 2018-03-15 US US16/494,711 patent/US11230551B2/en active Active
- 2018-03-15 EP EP18767095.5A patent/EP3596085A4/en not_active Withdrawn
- 2018-03-15 WO PCT/US2018/022545 patent/WO2018170201A1/en not_active Ceased
- 2018-03-15 JP JP2019550653A patent/JP2020511468A/ja active Pending
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