JP2020510632A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2020510632A5 JP2020510632A5 JP2019542183A JP2019542183A JP2020510632A5 JP 2020510632 A5 JP2020510632 A5 JP 2020510632A5 JP 2019542183 A JP2019542183 A JP 2019542183A JP 2019542183 A JP2019542183 A JP 2019542183A JP 2020510632 A5 JP2020510632 A5 JP 2020510632A5
- Authority
- JP
- Japan
- Prior art keywords
- fret
- complex
- compound
- crbn
- small molecule
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022203130A JP2023055688A (ja) | 2017-02-03 | 2022-12-20 | セレブロンに対する小分子の親和性の測定方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762454654P | 2017-02-03 | 2017-02-03 | |
| US62/454,654 | 2017-02-03 | ||
| PCT/US2018/016609 WO2018144832A1 (en) | 2017-02-03 | 2018-02-02 | Methods for measuring small molecule affinity to cereblon |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022203130A Division JP2023055688A (ja) | 2017-02-03 | 2022-12-20 | セレブロンに対する小分子の親和性の測定方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020510632A JP2020510632A (ja) | 2020-04-09 |
| JP2020510632A5 true JP2020510632A5 (https=) | 2021-03-11 |
| JP7534849B2 JP7534849B2 (ja) | 2024-08-15 |
Family
ID=63037575
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019542183A Active JP7534849B2 (ja) | 2017-02-03 | 2018-02-02 | セレブロンに対する小分子の親和性の測定方法 |
| JP2022203130A Pending JP2023055688A (ja) | 2017-02-03 | 2022-12-20 | セレブロンに対する小分子の親和性の測定方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022203130A Pending JP2023055688A (ja) | 2017-02-03 | 2022-12-20 | セレブロンに対する小分子の親和性の測定方法 |
Country Status (4)
| Country | Link |
|---|---|
| US (2) | US10816544B2 (https=) |
| EP (1) | EP3577459A4 (https=) |
| JP (2) | JP7534849B2 (https=) |
| WO (1) | WO2018144832A1 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017127414A1 (en) | 2016-01-19 | 2017-07-27 | Celgene Corporation | Transgenic mouse expressing human cereblon |
| EP3577459A4 (en) | 2017-02-03 | 2020-12-16 | Celgene Corporation | METHOD OF MEASURING THE AFFINITY OF SMALL MOLECULES FOR CEREBLON |
| WO2020118098A1 (en) * | 2018-12-05 | 2020-06-11 | Vividion Therapeutics, Inc. | Substituted isoindolinones as modulators of cereblon-mediated neo-substrate recruitment |
| JP2023507172A (ja) * | 2019-12-17 | 2023-02-21 | オリオニス バイオサイエンシズ，インコーポレイテッド | タンパク質分解の調節 |
| US20230099031A1 (en) * | 2019-12-17 | 2023-03-30 | Orionis Biosciences, Inc. | Bifunctional agents for protein recruitment and/or degradation |
| WO2021239117A1 (en) * | 2020-05-28 | 2021-12-02 | Cullgen (Shanghai) , Inc. | Modified proteins and protein degraders |
| WO2022272061A1 (en) * | 2021-06-25 | 2022-12-29 | Celgene Corporation | Cereblon binding compounds, compositions thereof, and methods of treatment therewith |
| JP2024143160A (ja) | 2023-03-30 | 2024-10-11 | セイコーエプソン株式会社 | 剛度検出装置 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1134293A3 (en) | 1992-03-04 | 2004-01-07 | The Regents of The University of California | Comparative genomic hybridization (CGH) |
| US20030059811A1 (en) | 2001-06-14 | 2003-03-27 | Hakim Djaballah | Methods of screening for ligands of target molecules |
| WO2010127980A1 (en) * | 2009-05-05 | 2010-11-11 | F. Hoffmann-La Roche Ag | Fret-based binding assay |
| EP2436387B1 (en) | 2009-05-25 | 2018-07-25 | Celgene Corporation | Pharmaceutical composition comprising crbn for use in treating a disease of the cerebral cortex |
| PL3202460T3 (pl) | 2010-02-11 | 2019-12-31 | Celgene Corporation | Pochodne arylometoksyizoindoliny i zawierające je kompozycje oraz sposoby ich zastosowania |
| AU2012249491B2 (en) | 2011-04-29 | 2016-12-15 | Celgene Corporation | Methods for the treatment of cancer and inflammatory diseases using cereblon as a predictor |
| US9587281B2 (en) | 2012-08-14 | 2017-03-07 | Celgene Corporation | Cereblon isoforms and their use as biomarkers for therapeutic treatment |
| WO2014028445A2 (en) | 2012-08-14 | 2014-02-20 | Celgene Corporation | Cereblon isoforms and their use as biomarkers for therapeutic treatment |
| EP2757379A1 (en) * | 2013-01-16 | 2014-07-23 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Method to screen for the teratogenic potential of substances |
| US10272117B2 (en) | 2014-02-24 | 2019-04-30 | Celgene Corporation | Methods of using an activator of cereblon for neural cell expansion and the treatment of central nervous system disorders |
| EP3827836A1 (en) | 2014-06-27 | 2021-06-02 | Celgene Corporation | Compositions and methods for inducing conformational changes in cereblon and other e3 ubiquitin ligases |
| WO2017127414A1 (en) | 2016-01-19 | 2017-07-27 | Celgene Corporation | Transgenic mouse expressing human cereblon |
| EP3577459A4 (en) | 2017-02-03 | 2020-12-16 | Celgene Corporation | METHOD OF MEASURING THE AFFINITY OF SMALL MOLECULES FOR CEREBLON |
-
2018
- 2018-02-02 EP EP18748010.8A patent/EP3577459A4/en active Pending
- 2018-02-02 JP JP2019542183A patent/JP7534849B2/ja active Active
- 2018-02-02 US US15/887,941 patent/US10816544B2/en active Active
- 2018-02-02 WO PCT/US2018/016609 patent/WO2018144832A1/en not_active Ceased
-
2020
- 2020-09-18 US US17/026,105 patent/US11644461B2/en active Active
-
2022
- 2022-12-20 JP JP2022203130A patent/JP2023055688A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2020510632A5 (https=) | ||
| Bhatnagar et al. | Graphene quantum dots FRET based sensor for early detection of heart attack in human | |
| JP7645812B2 (ja) | 生物発光を使用した分析物検出のための組成物及び方法 | |
| EP3696277B2 (en) | Quantitative dna-based imaging and super-resolution imaging | |
| Shen et al. | Immunochromatographic assay for quantitative and sensitive detection of hepatitis B virus surface antigen using highly luminescent quantum dot-beads | |
| Korten et al. | Setting up roadblocks for kinesin-1: mechanism for the selective speed control of cargo carrying microtubules | |
| US10184935B2 (en) | Quantum dot-based optical sensors for rapid detection and quantitative analysis of biomolecules and biological materials | |
| JP2009513798A (ja) | 蛍光性の炭素ナノ粒子 | |
| JP2007526998A5 (https=) | ||
| Wang et al. | Binding mechanism of PicoGreen to DNA characterized by magnetic tweezers and fluorescence spectroscopy | |
| JP2025138758A (ja) | 増強された蛍光バイオアッセイのための超高輝度蛍光ナノコンポジット構造体 | |
| JP6493085B2 (ja) | 蛍光色素内包樹脂粒子溶液の選択方法および濃度調整方法 | |
| CN107923908A (zh) | 具有提高的灵敏度的免疫检定 | |
| JPWO2019182130A1 (ja) | 標識化抗体分散液、ｓｐｆｓ用キット | |
| JP2018533017A5 (https=) | ||
| TW202206813A (zh) | 藉由使用抗原抗體反應而量化固定化金屬基材上之病毒或抗體的螢光計數系統 | |
| US20100248212A1 (en) | Detection conjugate | |
| WO2021039492A1 (ja) | 検体希釈液、標識化抗体分散液、サンドイッチ法 | |
| Hu et al. | Ultra-sensitive detection of prion protein with a long range resonance energy transfer strategy | |
| Cavadas et al. | Unravelling Malaria Antigen Binding to Antibody‐Gold Nanoparticle Conjugates | |
| Ohyanagi et al. | Compact and stable SNAP ligand-conjugated quantum dots as a fluorescent probe for single-molecule imaging of dynein motor protein | |
| CN1745300A (zh) | 用于检测c－反应蛋白和结合c－反应蛋白的成分之间的相互作用的能实施hts的方法和检测系统 | |
| KR20140121653A (ko) | 페리틴 단백질을 함유하는 표적-특이적 프로브 및 이를 이용한 바이오마커의 탐지 | |
| JP2003516526A5 (https=) | ||
| US20240272152A1 (en) | Labeling nanostructure for signal amplification in immunoassays and immunoassays using the labeling nanostructure |