JP2020510632A5 - - Google Patents
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- Publication number
- JP2020510632A5 JP2020510632A5 JP2019542183A JP2019542183A JP2020510632A5 JP 2020510632 A5 JP2020510632 A5 JP 2020510632A5 JP 2019542183 A JP2019542183 A JP 2019542183A JP 2019542183 A JP2019542183 A JP 2019542183A JP 2020510632 A5 JP2020510632 A5 JP 2020510632A5
- Authority
- JP
- Japan
- Prior art keywords
- fret
- complex
- compound
- crbn
- small molecule
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022203130A JP2023055688A (ja) | 2017-02-03 | 2022-12-20 | セレブロンに対する小分子の親和性の測定方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762454654P | 2017-02-03 | 2017-02-03 | |
| US62/454,654 | 2017-02-03 | ||
| PCT/US2018/016609 WO2018144832A1 (en) | 2017-02-03 | 2018-02-02 | Methods for measuring small molecule affinity to cereblon |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022203130A Division JP2023055688A (ja) | 2017-02-03 | 2022-12-20 | セレブロンに対する小分子の親和性の測定方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020510632A JP2020510632A (ja) | 2020-04-09 |
| JP2020510632A5 true JP2020510632A5 (https=) | 2021-03-11 |
| JP7534849B2 JP7534849B2 (ja) | 2024-08-15 |
Family
ID=63037575
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019542183A Active JP7534849B2 (ja) | 2017-02-03 | 2018-02-02 | セレブロンに対する小分子の親和性の測定方法 |
| JP2022203130A Pending JP2023055688A (ja) | 2017-02-03 | 2022-12-20 | セレブロンに対する小分子の親和性の測定方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022203130A Pending JP2023055688A (ja) | 2017-02-03 | 2022-12-20 | セレブロンに対する小分子の親和性の測定方法 |
Country Status (4)
| Country | Link |
|---|---|
| US (2) | US10816544B2 (https=) |
| EP (1) | EP3577459A4 (https=) |
| JP (2) | JP7534849B2 (https=) |
| WO (1) | WO2018144832A1 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11963520B2 (en) | 2016-01-19 | 2024-04-23 | Celgene Corporation | Transgenic mouse expressing human cereblon |
| WO2018144832A1 (en) | 2017-02-03 | 2018-08-09 | Celgene Corporation | Methods for measuring small molecule affinity to cereblon |
| EP3891128A4 (en) * | 2018-12-05 | 2022-08-17 | Vividion Therapeutics, Inc. | SUBSTITUTED ISOINDOLINONES AS MODULATORS OF CEREBLON-MEDIATED NEOSUBSTRATE RECRUITMENT |
| JP2023508891A (ja) * | 2019-12-17 | 2023-03-06 | オリオニス バイオサイエンシズ，インコーポレイテッド | タンパク質の動員および／または分解のための二機能性剤 |
| JP2023507172A (ja) * | 2019-12-17 | 2023-02-21 | オリオニス バイオサイエンシズ，インコーポレイテッド | タンパク質分解の調節 |
| EP4157888A4 (en) * | 2020-05-28 | 2024-07-10 | Cullgen (Shanghai), Inc. | MODIFIED PROTEINS AND PROTEIN DEGRADATION AGENTS |
| EP4359404A4 (en) * | 2021-06-25 | 2025-06-04 | Celgene Corporation | Cereblon-binding compounds, compositions thereof and methods of treatment therewith |
| JP2024143160A (ja) | 2023-03-30 | 2024-10-11 | セイコーエプソン株式会社 | 剛度検出装置 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE205542T1 (de) | 1992-03-04 | 2001-09-15 | Univ California | Vergleichende genomhybridisierung |
| EP1409982A4 (en) * | 2001-06-14 | 2006-05-24 | Anadys Pharmaceuticals Inc | PROCESS FOR SCREENING ON LIGANDS OF TARGET MOLECULES |
| WO2010127980A1 (en) * | 2009-05-05 | 2010-11-11 | F. Hoffmann-La Roche Ag | Fret-based binding assay |
| EP2436387B1 (en) | 2009-05-25 | 2018-07-25 | Celgene Corporation | Pharmaceutical composition comprising crbn for use in treating a disease of the cerebral cortex |
| EP2536706B1 (en) | 2010-02-11 | 2017-06-14 | Celgene Corporation | Arylmethoxy isoindoline derivatives and compositions comprising and methods of using the same |
| CA2834535A1 (en) | 2011-04-29 | 2012-11-01 | Celgene Corporation | Methods for the treatment of cancer and inflammatory diseases using cereblon as a predictor |
| US9587281B2 (en) | 2012-08-14 | 2017-03-07 | Celgene Corporation | Cereblon isoforms and their use as biomarkers for therapeutic treatment |
| WO2014028445A2 (en) | 2012-08-14 | 2014-02-20 | Celgene Corporation | Cereblon isoforms and their use as biomarkers for therapeutic treatment |
| EP2757379A1 (en) * | 2013-01-16 | 2014-07-23 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Method to screen for the teratogenic potential of substances |
| US10272117B2 (en) | 2014-02-24 | 2019-04-30 | Celgene Corporation | Methods of using an activator of cereblon for neural cell expansion and the treatment of central nervous system disorders |
| WO2015200795A1 (en) | 2014-06-27 | 2015-12-30 | Celgene Corporation | Compositions and methods for inducing conformational changes in cereblon other e3 ubiquitin ligases |
| US11963520B2 (en) | 2016-01-19 | 2024-04-23 | Celgene Corporation | Transgenic mouse expressing human cereblon |
| WO2018144832A1 (en) | 2017-02-03 | 2018-08-09 | Celgene Corporation | Methods for measuring small molecule affinity to cereblon |
-
2018
- 2018-02-02 WO PCT/US2018/016609 patent/WO2018144832A1/en not_active Ceased
- 2018-02-02 EP EP18748010.8A patent/EP3577459A4/en active Pending
- 2018-02-02 US US15/887,941 patent/US10816544B2/en active Active
- 2018-02-02 JP JP2019542183A patent/JP7534849B2/ja active Active
-
2020
- 2020-09-18 US US17/026,105 patent/US11644461B2/en active Active
-
2022
- 2022-12-20 JP JP2022203130A patent/JP2023055688A/ja active Pending
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