JP2020509745A5 - - Google Patents
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- Publication number
- JP2020509745A5 JP2020509745A5 JP2019548547A JP2019548547A JP2020509745A5 JP 2020509745 A5 JP2020509745 A5 JP 2020509745A5 JP 2019548547 A JP2019548547 A JP 2019548547A JP 2019548547 A JP2019548547 A JP 2019548547A JP 2020509745 A5 JP2020509745 A5 JP 2020509745A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- antibody
- antigen
- binding fragment
- peptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000427 antigen Substances 0.000 claims description 61
- 108091007433 antigens Proteins 0.000 claims description 61
- 102000036639 antigens Human genes 0.000 claims description 61
- 239000012634 fragment Substances 0.000 claims description 61
- 210000004027 cell Anatomy 0.000 claims description 25
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims description 23
- 108020004707 nucleic acids Proteins 0.000 claims description 16
- 150000007523 nucleic acids Chemical class 0.000 claims description 16
- 102000039446 nucleic acids Human genes 0.000 claims description 16
- 102100025064 Cellular tumor antigen p53 Human genes 0.000 claims description 13
- 238000000034 method Methods 0.000 claims description 13
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 13
- 102100028976 HLA class I histocompatibility antigen, B alpha chain Human genes 0.000 claims description 12
- 108010088652 Histocompatibility Antigens Class I Proteins 0.000 claims description 12
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 8
- 206010028980 Neoplasm Diseases 0.000 claims description 7
- 201000011510 cancer Diseases 0.000 claims description 7
- 150000001413 amino acids Chemical class 0.000 claims description 4
- 230000010056 antibody-dependent cellular cytotoxicity Effects 0.000 claims description 4
- 239000003814 drug Substances 0.000 claims description 4
- 229940079593 drug Drugs 0.000 claims description 4
- 238000000338 in vitro Methods 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 230000002265 prevention Effects 0.000 claims description 3
- 108700028369 Alleles Proteins 0.000 claims description 2
- 101000979117 Curvularia clavata Nonribosomal peptide synthetase Proteins 0.000 claims description 2
- 102100028972 HLA class I histocompatibility antigen, A alpha chain Human genes 0.000 claims description 2
- 108010075704 HLA-A Antigens Proteins 0.000 claims description 2
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims description 2
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims description 2
- 102000043129 MHC class I family Human genes 0.000 claims description 2
- 108091054437 MHC class I family Proteins 0.000 claims description 2
- 230000015572 biosynthetic process Effects 0.000 claims description 2
- 238000012258 culturing Methods 0.000 claims description 2
- 201000010099 disease Diseases 0.000 claims description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 210000002865 immune cell Anatomy 0.000 claims description 2
- 238000006467 substitution reaction Methods 0.000 claims description 2
- 238000002560 therapeutic procedure Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SG10201701883R | 2017-03-08 | ||
| SG10201701883R | 2017-03-08 | ||
| PCT/SG2018/050093 WO2018164637A1 (en) | 2017-03-08 | 2018-03-01 | T cell receptor like antibodies that bind to p53-mhc class i complex |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020190304A Division JP2021072773A (ja) | 2017-03-08 | 2020-11-16 | ｐ５３−ＭＨＣクラスＩ複合体に結合するＴ細胞受容体様抗体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020509745A JP2020509745A (ja) | 2020-04-02 |
| JP2020509745A5 true JP2020509745A5 (enExample) | 2021-04-15 |
Family
ID=63449067
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019548547A Pending JP2020509745A (ja) | 2017-03-08 | 2018-03-01 | ｐ５３−ＭＨＣクラスＩ複合体に結合するＴ細胞受容体様抗体 |
| JP2020190304A Pending JP2021072773A (ja) | 2017-03-08 | 2020-11-16 | ｐ５３−ＭＨＣクラスＩ複合体に結合するＴ細胞受容体様抗体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020190304A Pending JP2021072773A (ja) | 2017-03-08 | 2020-11-16 | ｐ５３−ＭＨＣクラスＩ複合体に結合するＴ細胞受容体様抗体 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20200071406A1 (enExample) |
| EP (2) | EP3592776A4 (enExample) |
| JP (2) | JP2020509745A (enExample) |
| CN (2) | CN110603267A (enExample) |
| SG (2) | SG10202010600SA (enExample) |
| TW (2) | TW202116798A (enExample) |
| WO (1) | WO2018164637A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3592776A4 (en) * | 2017-03-08 | 2021-01-06 | Agency for Science, Technology and Research | T-CELL RECEPTOR LIKE ANTIBODIES THAT BIND TO THE P53 MHC CLASS I COMPLEX |
| CA3126707A1 (en) * | 2019-01-29 | 2020-08-06 | Gritstone Bio, Inc. | Multispecific binding proteins |
| WO2022082030A2 (en) | 2020-10-15 | 2022-04-21 | Gritstone Bio, Inc. | Antigen-binding proteins and related methods of use |
| WO2022155503A1 (en) | 2021-01-14 | 2022-07-21 | Gritstone Bio, Inc. | Multi-specific antibodies and methods of use |
| WO2025217204A1 (en) * | 2024-04-08 | 2025-10-16 | The Johns Hopkins University | Methods and materials for treating p53+ cancers |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2305630C (en) * | 1997-10-02 | 2012-11-06 | Sunol Molecular Corporation | Soluble single-chain t-cell receptor proteins |
| KR101131297B1 (ko) * | 2003-11-10 | 2012-03-30 | 알토 바이오사이언스 코포레이션 | 가용성 티씨알 분자 및 이용 방법 |
| JPWO2005083074A1 (ja) * | 2004-03-01 | 2007-11-22 | 有限会社金沢大学ティ・エル・オー | 腫瘍抗原ペプチド |
| US20090226474A1 (en) * | 2004-05-27 | 2009-09-10 | Weidanz Jon A | Antibodies as T cell receptor mimics, methods of production and uses thereof |
| US20060034850A1 (en) * | 2004-05-27 | 2006-02-16 | Weidanz Jon A | Antibodies as T cell receptor mimics, methods of production and uses thereof |
| JP6699013B2 (ja) * | 2014-12-25 | 2020-05-27 | 国立大学法人三重大学 | Ｗｔ１由来ペプチド認識抗体 |
| EP3286222A4 (en) * | 2015-03-23 | 2018-08-08 | The Johns Hopkins University | Hla-restricted epitopes encoded by somatically mutated genes |
| RU2018102526A (ru) * | 2015-06-24 | 2019-07-25 | Еурека Терапьютикс, Инк. | Конструкции, направленные на комплексы пептида ny-eso-1/мнс, и их применение |
| US11000521B2 (en) * | 2015-08-03 | 2021-05-11 | Institut Pasteur | Dipeptidylpeptidase 4 inhibition enhances lymphocyte trafficking, improving both naturally occurring tumor immunity and immunotherapy |
| GB201515351D0 (en) * | 2015-08-28 | 2015-10-14 | Cancer Res Technology | Antibody |
| EP3592776A4 (en) * | 2017-03-08 | 2021-01-06 | Agency for Science, Technology and Research | T-CELL RECEPTOR LIKE ANTIBODIES THAT BIND TO THE P53 MHC CLASS I COMPLEX |
| JP7374416B2 (ja) * | 2019-05-23 | 2023-11-07 | 株式会社ソミックマネージメントホールディングス | ロータリダンパ |
-
2018
- 2018-03-01 EP EP18763437.3A patent/EP3592776A4/en not_active Withdrawn
- 2018-03-01 EP EP20195355.1A patent/EP3778646A1/en not_active Withdrawn
- 2018-03-01 JP JP2019548547A patent/JP2020509745A/ja active Pending
- 2018-03-01 US US16/491,697 patent/US20200071406A1/en not_active Abandoned
- 2018-03-01 TW TW109134389A patent/TW202116798A/zh unknown
- 2018-03-01 SG SG10202010600SA patent/SG10202010600SA/en unknown
- 2018-03-01 SG SG11201908247R patent/SG11201908247RA/en unknown
- 2018-03-01 TW TW107106855A patent/TW201833133A/zh unknown
- 2018-03-01 WO PCT/SG2018/050093 patent/WO2018164637A1/en not_active Ceased
- 2018-03-01 CN CN201880023533.8A patent/CN110603267A/zh active Pending
- 2018-03-01 CN CN202010923936.7A patent/CN112062860A/zh active Pending
-
2020
- 2020-11-16 JP JP2020190304A patent/JP2021072773A/ja active Pending