JP2020508995A - 癌の処置のためのｓｍａｒｃａ２の阻害 - Google Patents

癌の処置のためのｓｍａｒｃａ２の阻害 Download PDF

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JP2020508995A
JP2020508995A JP2019544887A JP2019544887A JP2020508995A JP 2020508995 A JP2020508995 A JP 2020508995A JP 2019544887 A JP2019544887 A JP 2019544887A JP 2019544887 A JP2019544887 A JP 2019544887A JP 2020508995 A JP2020508995 A JP 2020508995A
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smarca2
activity
cancer
smarca4
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JP2020508995A5 (enExample
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アレクサンドラ ローズ グラシアン，
アレクサンドラ ローズ グラシアン，
アリソン ドリュー，
アリソン ドリュー，
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エピザイム，インコーポレイティド
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    • A—HUMAN NECESSITIES
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    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/4995—Pyrazines or piperazines forming part of bridged ring systems
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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JP2019544887A 2017-02-28 2018-02-28 癌の処置のためのｓｍａｒｃａ２の阻害 Pending JP2020508995A (ja)

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JP2022116375A JP2022136149A (ja) 2017-02-28 2022-07-21 癌の処置のためのｓｍａｒｃａ２の阻害

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US201762464811P 2017-02-28 2017-02-28
US62/464,811 2017-02-28
US201762542241P 2017-08-07 2017-08-07
US62/542,241 2017-08-07
PCT/US2018/020124 WO2018160636A1 (en) 2017-02-28 2018-02-28 Inhibition of smarca2 for treatment of cancer

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US (2) US20200069669A1 (enExample)
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KR (1) KR20190140438A (enExample)
CN (1) CN110366418A (enExample)
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JP2022136149A (ja) * 2017-02-28 2022-09-15 エピザイム，インコーポレイティド 癌の処置のためのｓｍａｒｃａ２の阻害

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MX2020003695A (es) 2017-11-30 2020-08-03 Arrakis Therapeutics Inc Fotosondas de union a acido nucleico y usos de las mismas.
EP3746124A4 (en) 2018-01-30 2021-10-27 Foghorn Therapeutics Inc. COMPOUNDS AND THEIR USES
US12473334B2 (en) 2018-10-17 2025-11-18 Dana-Farber Cancer Institute, Inc. SWI/SNF family chromatin remodeling complexes and uses thereof
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US12509453B2 (en) 2019-01-29 2025-12-30 Foghorn Therapeutics Inc. BRM/BRG1 inhibitors and uses thereof
US12384776B2 (en) 2019-01-29 2025-08-12 Foghorn Therapeutics Inc. Compounds and uses thereof
EP3989967B1 (en) 2019-06-27 2024-08-14 Dana-Farber Cancer Institute, Inc. Compounds, compositions, and methods for protein degradation
CA3150354A1 (en) 2019-09-12 2021-03-18 Muralidhara Ramachandra METHOD FOR IDENTIFYING RESPONDERS TO SMARCA2/4 DEGRADATION AGENTS
WO2021155264A1 (en) 2020-01-29 2021-08-05 Foghorn Therapeutics Inc. Compounds and uses thereof
WO2021155262A1 (en) * 2020-01-29 2021-08-05 Foghorn Therapeutics Inc. Compounds and uses thereof
WO2021236080A1 (en) * 2020-05-20 2021-11-25 Foghorn Therapeutics Inc. Methods of treating cancers
US12383555B2 (en) 2020-05-20 2025-08-12 Foghorn Therapeutics Inc. Methods of treating cancers
MX2023001445A (es) * 2020-08-04 2023-05-08 Aurigene Oncology Ltd Compuestos de piridazina 6-sustituidos como degradadores de smarca2 y/o smarca4.
US12606553B2 (en) 2021-03-09 2026-04-21 Foghorn Therapeutics Inc. Crystalline forms, compositions containing same, and methods of their use
WO2024086577A1 (en) * 2022-10-17 2024-04-25 Foghorn Therapeutics Inc. Methods of reducing or preventing metastases
CN116004644A (zh) * 2023-01-19 2023-04-25 南京中澳转化医学研究院有限公司 Smarca4突变体及其在结直肠癌药物开发中的应用

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