CN110366418A - 抑制smarca2用于治疗癌症 - Google Patents

抑制smarca2用于治疗癌症 Download PDF

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Publication number
CN110366418A
CN110366418A CN201880014651.2A CN201880014651A CN110366418A CN 110366418 A CN110366418 A CN 110366418A CN 201880014651 A CN201880014651 A CN 201880014651A CN 110366418 A CN110366418 A CN 110366418A
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Prior art keywords
smarca2
activity
smarca4
subject
cancer
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CN201880014651.2A
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Chinese (zh)
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亚历山德拉·罗斯·格拉西安
艾利森·德鲁
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Epizm
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Epizm
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
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    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/47—Quinolines; Isoquinolines
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    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
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    • A61K31/4995—Pyrazines or piperazines forming part of bridged ring systems
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    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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CN201880014651.2A 2017-02-28 2018-02-28 抑制smarca2用于治疗癌症 Pending CN110366418A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762464811P 2017-02-28 2017-02-28
US62/464,811 2017-02-28
US201762542241P 2017-08-07 2017-08-07
US62/542,241 2017-08-07
PCT/US2018/020124 WO2018160636A1 (en) 2017-02-28 2018-02-28 Inhibition of smarca2 for treatment of cancer

Publications (1)

Publication Number Publication Date
CN110366418A true CN110366418A (zh) 2019-10-22

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CN201880014651.2A Pending CN110366418A (zh) 2017-02-28 2018-02-28 抑制smarca2用于治疗癌症

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US (2) US20200069669A1 (enExample)
EP (1) EP3589289A4 (enExample)
JP (2) JP2020508995A (enExample)
KR (1) KR20190140438A (enExample)
CN (1) CN110366418A (enExample)
AU (2) AU2018227774A1 (enExample)
BR (1) BR112019017851A2 (enExample)
CA (1) CA3054682A1 (enExample)
CL (1) CL2019002427A1 (enExample)
IL (1) IL268676A (enExample)
MX (2) MX2019010149A (enExample)
SG (2) SG10202109335TA (enExample)
WO (1) WO2018160636A1 (enExample)

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CN116529250A (zh) * 2020-08-04 2023-08-01 奥里吉恩肿瘤学有限公司 作为smarca2和/或smarca4降解剂的6-取代的哒嗪化合物

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KR20190140438A (ko) * 2017-02-28 2019-12-19 에피자임, 인코포레이티드 암 치료를 위한 smarca2의 저해
MX2020003695A (es) 2017-11-30 2020-08-03 Arrakis Therapeutics Inc Fotosondas de union a acido nucleico y usos de las mismas.
EP3746124A4 (en) 2018-01-30 2021-10-27 Foghorn Therapeutics Inc. COMPOUNDS AND THEIR USES
US12473334B2 (en) 2018-10-17 2025-11-18 Dana-Farber Cancer Institute, Inc. SWI/SNF family chromatin remodeling complexes and uses thereof
EP3883580A4 (en) * 2018-11-21 2023-01-04 Foghorn Therapeutics Inc. Methods of treating cancers
US12509453B2 (en) 2019-01-29 2025-12-30 Foghorn Therapeutics Inc. BRM/BRG1 inhibitors and uses thereof
US12384776B2 (en) 2019-01-29 2025-08-12 Foghorn Therapeutics Inc. Compounds and uses thereof
EP3989967B1 (en) 2019-06-27 2024-08-14 Dana-Farber Cancer Institute, Inc. Compounds, compositions, and methods for protein degradation
CA3150354A1 (en) 2019-09-12 2021-03-18 Muralidhara Ramachandra METHOD FOR IDENTIFYING RESPONDERS TO SMARCA2/4 DEGRADATION AGENTS
WO2021155264A1 (en) 2020-01-29 2021-08-05 Foghorn Therapeutics Inc. Compounds and uses thereof
WO2021155262A1 (en) * 2020-01-29 2021-08-05 Foghorn Therapeutics Inc. Compounds and uses thereof
WO2021236080A1 (en) * 2020-05-20 2021-11-25 Foghorn Therapeutics Inc. Methods of treating cancers
US12383555B2 (en) 2020-05-20 2025-08-12 Foghorn Therapeutics Inc. Methods of treating cancers
US12606553B2 (en) 2021-03-09 2026-04-21 Foghorn Therapeutics Inc. Crystalline forms, compositions containing same, and methods of their use
WO2024086577A1 (en) * 2022-10-17 2024-04-25 Foghorn Therapeutics Inc. Methods of reducing or preventing metastases

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Publication number Priority date Publication date Assignee Title
CN116529250A (zh) * 2020-08-04 2023-08-01 奥里吉恩肿瘤学有限公司 作为smarca2和/或smarca4降解剂的6-取代的哒嗪化合物
CN116004644A (zh) * 2023-01-19 2023-04-25 南京中澳转化医学研究院有限公司 Smarca4突变体及其在结直肠癌药物开发中的应用

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