JP2020507608A5 - - Google Patents
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- Publication number
- JP2020507608A5 JP2020507608A5 JP2019544029A JP2019544029A JP2020507608A5 JP 2020507608 A5 JP2020507608 A5 JP 2020507608A5 JP 2019544029 A JP2019544029 A JP 2019544029A JP 2019544029 A JP2019544029 A JP 2019544029A JP 2020507608 A5 JP2020507608 A5 JP 2020507608A5
- Authority
- JP
- Japan
- Prior art keywords
- pyrrolino
- compound
- pharmaceutically acceptable
- group
- prodrug
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims description 73
- 239000000203 mixture Substances 0.000 claims description 58
- 239000000651 prodrug Substances 0.000 claims description 48
- 229940002612 prodrug Drugs 0.000 claims description 48
- 150000003839 salts Chemical class 0.000 claims description 48
- 239000012453 solvate Substances 0.000 claims description 44
- 125000000217 alkyl group Chemical group 0.000 claims description 20
- 239000011885 synergistic combination Substances 0.000 claims description 20
- 229940045799 anthracyclines and related substance Drugs 0.000 claims description 13
- 238000000034 method Methods 0.000 claims description 13
- 239000008194 pharmaceutical composition Substances 0.000 claims description 9
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 8
- 230000004663 cell proliferation Effects 0.000 claims description 7
- 239000003937 drug carrier Substances 0.000 claims description 6
- UHYFCDBUKBJSFA-JYFLSIMMSA-N 13-deoxycarminomycin Chemical compound O([C@H]1C[C@](CC2=C(O)C=3C(=O)C4=CC=CC(O)=C4C(=O)C=3C(O)=C21)(O)CC)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 UHYFCDBUKBJSFA-JYFLSIMMSA-N 0.000 claims description 4
- XAMIMZAWZUSOPA-JIGXQNLBSA-N 13-deoxydaunorubicin Chemical compound O([C@H]1C[C@](CC2=C(O)C=3C(=O)C4=CC=CC(OC)=C4C(=O)C=3C(O)=C21)(O)CC)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 XAMIMZAWZUSOPA-JIGXQNLBSA-N 0.000 claims description 4
- -1 13-deoxyepirubicin Chemical compound 0.000 claims description 4
- 241000124008 Mammalia Species 0.000 claims description 3
- 230000035755 proliferation Effects 0.000 claims description 2
- 239000002904 solvent Substances 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims 2
- 230000010261 cell growth Effects 0.000 claims 1
- 230000001629 suppression Effects 0.000 claims 1
- 0 *CC[C@@](C[C@@]1*)(Cc2c1c(O)c(C(c(c(*)ccc1*)c1C1=O)=*)c1c2*)O Chemical compound *CC[C@@](C[C@@]1*)(Cc2c1c(O)c(C(c(c(*)ccc1*)c1C1=O)=*)c1c2*)O 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15/434,617 US10450340B2 (en) | 2017-02-16 | 2017-02-16 | 3′-deamino-3′-(2″-pyrroline-1″-yl)-5-imino-13-deoxyanthracyclines and methods of preparation |
| US15/434,617 | 2017-02-16 | ||
| PCT/US2018/000090 WO2018151872A1 (en) | 2017-02-16 | 2018-02-16 | 3'deamino-3'-(2"-pyrroline-1"-yl)-5-imino-13-deoxyanthracyclines and methods of preparation |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020507608A JP2020507608A (ja) | 2020-03-12 |
| JP2020507608A5 true JP2020507608A5 (https=) | 2021-04-01 |
| JP7159177B2 JP7159177B2 (ja) | 2022-10-24 |
Family
ID=61692048
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019544029A Active JP7159177B2 (ja) | 2017-02-16 | 2018-02-16 | ３’デアミノ－３’－（２”－ピロリン－１”－イル）－５－イミノ－１３－デオキシアントラサイクリンおよび調製方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US10450340B2 (https=) |
| EP (1) | EP3582788A1 (https=) |
| JP (1) | JP7159177B2 (https=) |
| KR (1) | KR20190117609A (https=) |
| CN (1) | CN110573165B (https=) |
| AU (1) | AU2018220520A1 (https=) |
| BR (1) | BR112019017166A2 (https=) |
| CA (1) | CA3053417A1 (https=) |
| IL (1) | IL268680B (https=) |
| MX (1) | MX388090B (https=) |
| WO (1) | WO2018151872A1 (https=) |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5843903A (en) | 1995-11-27 | 1998-12-01 | The Administrators Of The Tulane Educational Fund | Targeted cytotoxic anthracycline analogs |
| US5948896A (en) | 1997-08-13 | 1999-09-07 | Gem Pharmaceuticals | Processes for preparing 13-deoxy anthracycline derivatives |
| US5942605A (en) | 1998-03-03 | 1999-08-24 | Gem Pharmaceuticals, Inc. | 5-imino-13-deoxy anthracycline derivatives, their uses, and processes for preparing them |
| US7244829B2 (en) | 2004-11-08 | 2007-07-17 | Gem Pharmaceuticals, Llc | Compositions and processes for preparing 13-deoxy-anthracyclines |
| JP2007261976A (ja) | 2006-03-28 | 2007-10-11 | Meiji Seika Kaisha Ltd | 抗腫瘍性アンスラサイクリン系抗生物質の製造法 |
| US7776832B2 (en) | 2006-04-21 | 2010-08-17 | Gem Pharmaceuticals, Llc | Anticancer treatment with a combination of taxanes and 13-deoxyanthracyclines |
| US9904704B2 (en) | 2014-04-22 | 2018-02-27 | Openx Software Limited | System and method for controlling audience data and tracking |
-
2017
- 2017-02-16 US US15/434,617 patent/US10450340B2/en active Active
-
2018
- 2018-02-16 MX MX2019009733A patent/MX388090B/es unknown
- 2018-02-16 KR KR1020197026451A patent/KR20190117609A/ko not_active Abandoned
- 2018-02-16 WO PCT/US2018/000090 patent/WO2018151872A1/en not_active Ceased
- 2018-02-16 JP JP2019544029A patent/JP7159177B2/ja active Active
- 2018-02-16 CA CA3053417A patent/CA3053417A1/en active Pending
- 2018-02-16 BR BR112019017166A patent/BR112019017166A2/pt not_active Application Discontinuation
- 2018-02-16 CN CN201880025418.4A patent/CN110573165B/zh not_active Expired - Fee Related
- 2018-02-16 EP EP18712287.4A patent/EP3582788A1/en not_active Withdrawn
- 2018-02-16 AU AU2018220520A patent/AU2018220520A1/en not_active Abandoned
-
2019
- 2019-08-13 IL IL268680A patent/IL268680B/en unknown
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