JP2020506715A5 - - Google Patents

Info

Publication number

JP2020506715A5

JP2020506715A5 JP2019543805A JP2019543805A JP2020506715A5 JP 2020506715 A5 JP2020506715 A5 JP 2020506715A5 JP 2019543805 A JP2019543805 A JP 2019543805A JP 2019543805 A JP2019543805 A JP 2019543805A JP 2020506715 A5 JP2020506715 A5 JP 2020506715A5

Authority

JP

Japan

Prior art keywords

seq

sequence shown

specific binding

amino acid

binding molecule

Prior art date

2018-02-08

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 230000009870 specific binding Effects 0.000 claims 27
• 125000003275 alpha amino acid group Chemical group 0.000 claims 26
• 239000003795 chemical substances by application Substances 0.000 claims 7
• 150000007523 nucleic acids Chemical class 0.000 claims 7
• 102000039446 nucleic acids Human genes 0.000 claims 7
• 108020004707 nucleic acids Proteins 0.000 claims 7
• 239000002773 nucleotide Substances 0.000 claims 6
• 125000003729 nucleotide group Chemical group 0.000 claims 6
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 5
• 239000012634 fragment Substances 0.000 claims 5
• 108010047041 Complementarity Determining Regions Proteins 0.000 claims 4
• 238000002360 preparation method Methods 0.000 claims 4
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 3
• 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 3
• 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 3
• 201000010099 disease Diseases 0.000 claims 3
• 239000003814 drug Substances 0.000 claims 3
• 238000000034 method Methods 0.000 claims 3
• 208000030459 obsessive-compulsive personality disease Diseases 0.000 claims 3
• 208000007656 osteochondritis dissecans Diseases 0.000 claims 3
• 239000008194 pharmaceutical composition Substances 0.000 claims 3
• 208000019901 Anxiety disease Diseases 0.000 claims 2
• 208000023275 Autoimmune disease Diseases 0.000 claims 2
• 201000011152 Pemphigus Diseases 0.000 claims 2
• 210000001744 T-lymphocyte Anatomy 0.000 claims 2
• 210000004027 cell Anatomy 0.000 claims 2
• 208000035475 disorder Diseases 0.000 claims 2
• 229940079593 drug Drugs 0.000 claims 2
• 230000001404 mediated effect Effects 0.000 claims 2
• 208000019906 panic disease Diseases 0.000 claims 2
• 201000001976 pemphigus vulgaris Diseases 0.000 claims 2
• 208000030507 AIDS Diseases 0.000 claims 1
• 206010000234 Abortion spontaneous Diseases 0.000 claims 1
• 208000026872 Addison Disease Diseases 0.000 claims 1
• 208000036640 Asperger disease Diseases 0.000 claims 1
• 201000006062 Asperger syndrome Diseases 0.000 claims 1
• 201000001320 Atherosclerosis Diseases 0.000 claims 1
• 208000023328 Basedow disease Diseases 0.000 claims 1
• 208000009137 Behcet syndrome Diseases 0.000 claims 1
• 208000020925 Bipolar disease Diseases 0.000 claims 1
• 206010009900 Colitis ulcerative Diseases 0.000 claims 1
• 206010048768 Dermatosis Diseases 0.000 claims 1
• 208000011688 Generalised anxiety disease Diseases 0.000 claims 1
• 208000009329 Graft vs Host Disease Diseases 0.000 claims 1
• 208000015023 Graves' disease Diseases 0.000 claims 1
• 208000030836 Hashimoto thyroiditis Diseases 0.000 claims 1
• 206010020710 Hyperphagia Diseases 0.000 claims 1
• 201000001916 Hypochondriasis Diseases 0.000 claims 1
• 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
• 206010033664 Panic attack Diseases 0.000 claims 1
• 206010039710 Scleroderma Diseases 0.000 claims 1
• 208000021386 Sjogren Syndrome Diseases 0.000 claims 1
• 206010041250 Social phobia Diseases 0.000 claims 1
• 208000000323 Tourette Syndrome Diseases 0.000 claims 1
• 208000016620 Tourette disease Diseases 0.000 claims 1
• 206010052779 Transplant rejections Diseases 0.000 claims 1
• 208000012981 Traumatic Stress disease Diseases 0.000 claims 1
• 201000006704 Ulcerative Colitis Diseases 0.000 claims 1
• 206010046851 Uveitis Diseases 0.000 claims 1
• 208000026345 acute stress disease Diseases 0.000 claims 1
• 230000004596 appetite loss Effects 0.000 claims 1
• 201000004982 autoimmune uveitis Diseases 0.000 claims 1
• 208000022266 body dysmorphic disease Diseases 0.000 claims 1
• 239000000969 carrier Substances 0.000 claims 1
• 208000025302 chronic primary adrenal insufficiency Diseases 0.000 claims 1
• 230000007547 defect Effects 0.000 claims 1
• 206010012601 diabetes mellitus Diseases 0.000 claims 1
• 239000003085 diluting agent Substances 0.000 claims 1
• 238000009472 formulation Methods 0.000 claims 1
• 208000029364 generalized anxiety disease Diseases 0.000 claims 1
• 208000013403 hyperactivity Diseases 0.000 claims 1
• 208000019017 loss of appetite Diseases 0.000 claims 1
• 235000021266 loss of appetite Nutrition 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 208000015994 miscarriage Diseases 0.000 claims 1
• 239000000203 mixture Substances 0.000 claims 1
• 239000000546 pharmaceutical excipient Substances 0.000 claims 1
• 208000005987 polymyositis Diseases 0.000 claims 1
• 208000022530 polyphagia Diseases 0.000 claims 1
• 238000000746 purification Methods 0.000 claims 1
• 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
• 201000000980 schizophrenia Diseases 0.000 claims 1
• 208000017520 skin disease Diseases 0.000 claims 1
• 208000000995 spontaneous abortion Diseases 0.000 claims 1
• 201000000596 systemic lupus erythematosus Diseases 0.000 claims 1
• 208000002271 trichotillomania Diseases 0.000 claims 1