JP2020505434A5 - - Google Patents
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- Publication number
- JP2020505434A5 JP2020505434A5 JP2019542201A JP2019542201A JP2020505434A5 JP 2020505434 A5 JP2020505434 A5 JP 2020505434A5 JP 2019542201 A JP2019542201 A JP 2019542201A JP 2019542201 A JP2019542201 A JP 2019542201A JP 2020505434 A5 JP2020505434 A5 JP 2020505434A5
- Authority
- JP
- Japan
- Prior art keywords
- hydrogen
- crmp2
- formula
- compound
- compound according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 16
- 102100024426 Dihydropyrimidinase-related protein 2 Human genes 0.000 claims 14
- 101001053503 Homo sapiens Dihydropyrimidinase-related protein 2 Proteins 0.000 claims 14
- 229910052739 hydrogen Inorganic materials 0.000 claims 14
- 239000001257 hydrogen Substances 0.000 claims 14
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 14
- 239000000126 substance Substances 0.000 claims 6
- 125000000539 amino acid group Chemical group 0.000 claims 4
- 101000654386 Homo sapiens Sodium channel protein type 9 subunit alpha Proteins 0.000 claims 3
- 102100031367 Sodium channel protein type 9 subunit alpha Human genes 0.000 claims 3
- 230000000694 effects Effects 0.000 claims 3
- 230000002401 inhibitory effect Effects 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 239000012453 solvate Substances 0.000 claims 3
- JUYQSMXGDBGGSX-UHFFFAOYSA-N 2-piperidin-1-yl-1h-benzimidazole Chemical group C1CCCCN1C1=NC2=CC=CC=C2N1 JUYQSMXGDBGGSX-UHFFFAOYSA-N 0.000 claims 2
- 101100539164 Caenorhabditis elegans ubc-9 gene Proteins 0.000 claims 2
- 208000002193 Pain Diseases 0.000 claims 2
- 208000003251 Pruritus Diseases 0.000 claims 2
- 238000003032 molecular docking Methods 0.000 claims 2
- 230000010741 sumoylation Effects 0.000 claims 2
- 208000019695 Migraine disease Diseases 0.000 claims 1
- 230000001154 acute effect Effects 0.000 claims 1
- 230000002757 inflammatory effect Effects 0.000 claims 1
- 206010027599 migraine Diseases 0.000 claims 1
- 208000004296 neuralgia Diseases 0.000 claims 1
- 208000021722 neuropathic pain Diseases 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 0 CC(*(C*1cccc(N)c1)C1C(*)=CC=CC1)C(CCC1)CCC1*(*CC1CCOCC1)=O Chemical compound CC(*(C*1cccc(N)c1)C1C(*)=CC=CC1)C(CCC1)CCC1*(*CC1CCOCC1)=O 0.000 description 10
- STKUOACLYKVISM-UHFFFAOYSA-N O=C(C1CCOCC1)N(CC1)CCC1c1nc(cccc2)c2[n]1Cc1cc(F)ccc1 Chemical compound O=C(C1CCOCC1)N(CC1)CCC1c1nc(cccc2)c2[n]1Cc1cc(F)ccc1 STKUOACLYKVISM-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762454475P | 2017-02-03 | 2017-02-03 | |
| US62/454,475 | 2017-02-03 | ||
| US201762506298P | 2017-05-15 | 2017-05-15 | |
| US62/506,298 | 2017-05-15 | ||
| PCT/US2018/016687 WO2018144900A1 (en) | 2017-02-03 | 2018-02-02 | Small molecule antagonists of sumo related modification of crmp2 and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020505434A JP2020505434A (ja) | 2020-02-20 |
| JP2020505434A5 true JP2020505434A5 (https=) | 2021-04-15 |
| JP7092776B2 JP7092776B2 (ja) | 2022-06-28 |
Family
ID=63041159
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019542201A Active JP7092776B2 (ja) | 2017-02-03 | 2018-02-02 | ｃｒｍｐ２のＳＵＭＯ関連修飾の小分子拮抗物質及びその使用 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US11208397B2 (https=) |
| EP (1) | EP3576734A4 (https=) |
| JP (1) | JP7092776B2 (https=) |
| CN (1) | CN110381941A (https=) |
| AU (1) | AU2018215466B2 (https=) |
| CA (1) | CA3052195A1 (https=) |
| WO (1) | WO2018144900A1 (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2025129167A1 (en) * | 2023-12-15 | 2025-06-19 | The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services | Inhibitors of the surface expression of the voltage-gated sodium ion channel 1.7 (nav1.7) and their therapeutic uses |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3989816A (en) | 1975-06-19 | 1976-11-02 | Nelson Research & Development Company | Vehicle composition containing 1-substituted azacycloheptan-2-ones |
| US4444762A (en) | 1980-04-04 | 1984-04-24 | Nelson Research & Development Company | Vehicle composition containing 1-substituted azacyclopentan-2-ones |
| US7205404B1 (en) | 1999-03-05 | 2007-04-17 | Metabasis Therapeutics, Inc. | Phosphorus-containing prodrugs |
| JP2003512372A (ja) * | 1999-10-18 | 2003-04-02 | スミスクライン ビーチャム パブリック リミテッド カンパニー | テトラヒドロベンゾインドロン誘導体、それらの製造および５−ｈｔ７受容体アンタゴニストとしてのそれらの使用 |
| EP2240464A4 (en) * | 2008-02-12 | 2011-09-14 | Yuhan Corp | PROCESS FOR THE PREPARATION OF 2-METHYL-2'-PHENYLPROPIONIC ACID DERIVATIVES AND NOVEL INTERMEDIATE PRODUCTS |
| EP2681200A4 (en) | 2011-03-03 | 2015-05-27 | Zalicus Pharmaceuticals Ltd | INHIBITORS OF BENZIMIDAZOLE TYPE OF SODIUM CHANNEL |
| CN102627631B (zh) * | 2012-03-31 | 2013-07-24 | 中国药科大学 | 苯并杂环类化合物、其制备方法及其医药用途 |
| US9828348B2 (en) * | 2013-11-08 | 2017-11-28 | Purdue Pharma L.P. | Benzimidazole derivatives and use thereof |
| EP3119415A4 (en) | 2014-03-07 | 2017-11-29 | The Arizona Board of Regents on behalf of the University of Arizona | Non-narcotic crmp2 peptides targeting sodium channels for chronic pain |
| JP2018052817A (ja) * | 2015-01-21 | 2018-04-05 | 大日本住友製薬株式会社 | 新規ベンズイミダゾール誘導体およびその医薬用途 |
| EP3359151A4 (en) * | 2015-10-07 | 2019-08-14 | Arizona Board of Regents on behalf of the University of Arizona | CRMP2 SUMOYLATION INHIBITORS AND USES THEREOF |
-
2018
- 2018-02-02 AU AU2018215466A patent/AU2018215466B2/en active Active
- 2018-02-02 CN CN201880015053.7A patent/CN110381941A/zh active Pending
- 2018-02-02 JP JP2019542201A patent/JP7092776B2/ja active Active
- 2018-02-02 CA CA3052195A patent/CA3052195A1/en active Pending
- 2018-02-02 WO PCT/US2018/016687 patent/WO2018144900A1/en not_active Ceased
- 2018-02-02 EP EP18748594.1A patent/EP3576734A4/en not_active Withdrawn
- 2018-02-02 US US16/483,644 patent/US11208397B2/en active Active
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