JP2020505049A - 複数トランスジーン組み換えアデノウイルス - Google Patents

複数トランスジーン組み換えアデノウイルス Download PDF

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JP2020505049A
JP2020505049A JP2019541188A JP2019541188A JP2020505049A JP 2020505049 A JP2020505049 A JP 2020505049A JP 2019541188 A JP2019541188 A JP 2019541188A JP 2019541188 A JP2019541188 A JP 2019541188A JP 2020505049 A JP2020505049 A JP 2020505049A
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recombinant adenovirus
seq
nucleotides
deletion
site
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JP2020505049A5 (cg-RX-API-DMAC10.html
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アール． リード，トニー
アール． リード，トニー
ティー． オロンスキー，ブライアン
ティー． オロンスキー，ブライアン
ラーソン，クリストファー
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エピセントアールエックス，インコーポレイテッド
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • C12N15/86—Viral vectors
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10321—Viruses as such, e.g. new isolates, mutants or their genomic sequences
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    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10332—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
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    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10341—Use of virus, viral particle or viral elements as a vector
    • C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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    • C12N2840/00—Vectors comprising a special translation-regulating system
    • C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
    • C12N2840/203—Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES

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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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JP2019541188A 2017-01-30 2018-01-30 複数トランスジーン組み換えアデノウイルス Pending JP2020505049A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762452342P 2017-01-30 2017-01-30
US62/452,342 2017-01-30
US201762520945P 2017-06-16 2017-06-16
US62/520,945 2017-06-16
PCT/US2018/016032 WO2018140973A1 (en) 2017-01-30 2018-01-30 Multiple transgene recombinant adenovirus

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JP2020505049A true JP2020505049A (ja) 2020-02-20
JP2020505049A5 JP2020505049A5 (cg-RX-API-DMAC10.html) 2021-03-11

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US (1) US20190352616A1 (cg-RX-API-DMAC10.html)
EP (1) EP3574090A4 (cg-RX-API-DMAC10.html)
JP (1) JP2020505049A (cg-RX-API-DMAC10.html)
KR (1) KR20190128634A (cg-RX-API-DMAC10.html)
CN (1) CN110741080A (cg-RX-API-DMAC10.html)
AU (1) AU2018213417A1 (cg-RX-API-DMAC10.html)
BR (1) BR112019015600A2 (cg-RX-API-DMAC10.html)
CA (1) CA3052090A1 (cg-RX-API-DMAC10.html)
IL (1) IL268291A (cg-RX-API-DMAC10.html)
MX (1) MX2019008921A (cg-RX-API-DMAC10.html)
SG (1) SG11201906973TA (cg-RX-API-DMAC10.html)
WO (1) WO2018140973A1 (cg-RX-API-DMAC10.html)

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SG11201507393TA (en) 2013-03-14 2015-10-29 Salk Inst For Biological Studi Oncolytic adenovirus compositions
ES2899913T3 (es) 2014-09-24 2022-03-15 Salk Inst For Biological Studi Virus tumorales oncolíticos y métodos de uso
WO2017147265A1 (en) 2016-02-23 2017-08-31 Salk Institute For Biological Studies High throughput assay for measuring adenovirus replication kinetics
EP3390645B1 (en) 2016-02-23 2022-09-14 Salk Institute for Biological Studies Exogenous gene expression in therapeutic adenovirus for minimal impact on viral kinetics
AU2017375633C1 (en) 2016-12-12 2023-04-27 Salk Institute For Biological Studies Tumor-targeting synthetic adenoviruses and uses thereof
EA201990822A1 (ru) 2017-04-12 2020-01-09 Эписентарикс, Инк. Иммуномодулирующие слитые белки
MX2019014059A (es) * 2017-05-24 2020-07-28 Epicentrx Inc Adenovirus antiangiogenico.
BR112020019942A2 (pt) 2018-04-09 2021-01-26 Salk Institute For Biological Studies composições de adenovírus oncolítico com propriedades de replicação aprimoradas
WO2022007800A1 (zh) * 2020-07-06 2022-01-13 嘉兴安宇生物科技有限公司 一种非洲猪瘟的重组腺病毒疫苗及其构建方法
CN113249342B (zh) * 2021-05-25 2023-12-01 江苏万戎生物医药科技有限公司 一款多重机制协同和增效免疫治疗的嵌合型广谱溶瘤腺病毒及其在肿瘤治疗中的应用
EP4349975A4 (en) * 2021-05-25 2025-04-16 Voncolytic Therapeutics Co., Ltd. Chimeric broad-spectrum oncolytic adenovirus with multiple mechanisms synergizing with and enhancing efficacy of immunotherapy, and application thereof in tumor treatment
WO2024015876A1 (en) 2022-07-13 2024-01-18 Epicentrx, Inc. Adenoviral vectors encapsulated in cationic liposomes, and preparation and use thereof

Citations (2)

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JP2012519014A (ja) * 2009-03-02 2012-08-23 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 腫瘍選択的ｅ１ａおよびｅ１ｂ変異体
JP2014500004A (ja) * 2010-09-24 2014-01-09 オンコス セラピュティックス オサケ ユキチュア 抗ｃｔｌａ−４モノクローナル抗体をコードする腫瘍溶解性アデノウイルスベクター

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KR100896483B1 (ko) * 2007-07-13 2009-05-08 연세대학교 산학협력단 Ｉｌ-12 및 4-1ｂｂｌ을 발현하는 종양 선택적 살상 재조합아데노바이러스 및 수지상 세포를 유효성분으로 포함하는항종양용 약제학적 조성물
EP2550359B1 (en) * 2010-03-23 2017-08-09 Intrexon Corporation Vectors conditionally expressing therapeutic proteins, host cells comprising the vectors, and uses thereof
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CN103614416B (zh) * 2013-09-30 2016-09-07 中国人民解放军第二军医大学东方肝胆外科医院 一种携带人穿膜肽p53与GM-CSF基因的重组溶瘤腺病毒及其用途
ES2899913T3 (es) * 2014-09-24 2022-03-15 Salk Inst For Biological Studi Virus tumorales oncolíticos y métodos de uso
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JP2014500004A (ja) * 2010-09-24 2014-01-09 オンコス セラピュティックス オサケ ユキチュア 抗ｃｔｌａ−４モノクローナル抗体をコードする腫瘍溶解性アデノウイルスベクター

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PONNAZHAGAN, S. ET AL.: "Adeno-associated virus 2-mediated antiangiogenic cancer gene therapy: long-term efficacy of a vector", CANCER RES., vol. Vol. 64(5), JPN7021005109, 2004, pages 1781 - 1787, ISSN: 0004841908 *
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WO2018140973A1 (en) 2018-08-02
US20190352616A1 (en) 2019-11-21
CA3052090A1 (en) 2018-08-02
KR20190128634A (ko) 2019-11-18
IL268291A (en) 2019-09-26
SG11201906973TA (en) 2019-08-27
MX2019008921A (es) 2019-11-08
AU2018213417A1 (en) 2019-08-15
BR112019015600A2 (pt) 2020-03-17
CN110741080A (zh) 2020-01-31
EP3574090A4 (en) 2021-01-06
EP3574090A1 (en) 2019-12-04

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