JP2020504285A - 試薬ノズルシッパー混合システム及び試薬ノズルシッパー混合方法 - Google Patents
試薬ノズルシッパー混合システム及び試薬ノズルシッパー混合方法 Download PDFInfo
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Abstract
Description
分析システムで対象分析物を支持するフローセルと、
試薬を吸引して、前記試薬を混合し、混合済み試薬を行先容器に排出する流体システムと、
前記流体システムと流体連通し、細長い本体及びノズル挿入部を含むノズルシッパーと、
を備えるシステムであり、
前記細長い本体は、前記本体の端部間で延びる中央ルーメンを有し、
前記ノズル挿入部は、遠位端部に配置され、
前記ノズル挿入部を通じて、前記ノズルシッパーは、試薬を前記容器から吸引し、前記混合済み試薬を前記行先容器に排出して戻す、システム。
ノズル及びルーメンは、前記ノズル挿入部を通じて前記シッパー内に前記試薬を吸引するときに前記ルーメンで混合する渦度を高める寸法である、実施形態1のシステム。
ルーメンは約0.5ミリメートルの公称内径を有し、前記ノズル挿入部は約0.25ミリメートルの公称内径を有する、実施形態1のシステム。
前記ノズルシッパーの前記遠位端部は、前記ノズルシッパーの中心軸線に対してオフセットする頂点を含むくさび形状を有する、実施形態1のシステム。
前記ノズル挿入部は、前記ノズルシッパーの前記遠位端部の前記くさび形状と対応する形状である遠位端部を有する、実施形態4のシステム。
前記くさび形状は、前記頂点で交わる4つのファセットを含む、実施形態4のシステム。
前記ノズルシッパーは、前記容器の底面から2ミリメートルの公称距離まで延在する長さを有する、実施形態1のシステム。
それぞれの試薬を吸引する複数の他のシッパーを備え、
前記他のシッパーはノズル挿入部を含まない、実施形態1のシステム。
前記ノズルシッパーは、混合された容器を、少なくとも約5,000μL/分の流量で、少なくとも約1,600ミリメートル/秒まで加速させる、実施形態1のシステム。
分析システムで対象分析物を支持するフローセルと、
それぞれの容器に配置される複数の試薬と、
試薬を吸引して、前記試薬を混合し、混合済み前記試薬を行先容器に排出する流体システムと、
前記流体システムと流体連通し、細長い本体及びノズルを含むノズルシッパーと、
前記流体システムに動作可能に結合される制御回路と、
を備えるシステムであり、
前記細長い本体は、前記本体の端部間で延びる中央ルーメンを有し、
前記ノズルは、遠位端部に存在し、
前記制御回路は、前記流体システムに動作的に結合し前記流体システムに命令して、
前記複数の試薬を1つずつ吸引させ、
前記ノズルを通じて試薬の前記複数の試薬を前記行先容器内へ排出させ、
前記ノズルを通じて前記行先容器から前記複数の試薬を混合するために吸引させ、
前記ノズルを通じて混合済み前記試薬を前記容器に排出して戻させる、
システム。
前記ノズルは、前記ノズルシッパーの前記遠位端部に挿入部を含む、実施形態10のシステム。
前記行先容器はシーケンシングされる分析物を含む、実施形態10のシステム。
前記ルーメンは0.5ミリメートルの公称内径を有し、前記ノズルは0.25ミリメートルの公称内径を有する、実施形態10のシステム。
前記ノズルシッパーの前記遠位端部は、前記ノズルシッパーの中心軸線に対してオフセットする頂点を含むくさび形状を有する、実施形態10のシステム。
前記ノズルは、前記ノズルシッパーの前記遠位端部の前記くさび形状と対応する形状である遠位端部を有する、実施形態14のシステム。
ポンプを作動させて、分析される分析物を包含する複数の試薬を行先容器から吸引するステップと、
前記複数の試薬を前記ポンプに流体連通するノズルシッパーを通じて吸引して前記複数の試薬を混合するステップと、
前記ポンプを作動させて、混合済み前記試薬を前記行先容器内に排出するステップと、
を含む方法であり、
前記ノズルシッパーは中央ルーメンとノズルとを有する細長い本体を含み、
前記中央ルーメンは前記細長い本体の端部間で延び、
前記ノズルは遠位端部に存在する、方法。
前記ノズル及びルーメンは、前記ノズルを通じて前記シッパー内に前記試薬を吸引するときに前記ルーメンで混合する渦度を高める寸法である、実施形態16の方法。
前記ルーメンは0.5ミリメートルの公称内径を有し、前記ノズルは0.25ミリメートルの公称内径を有する挿入部を含む、実施形態16の方法。
前記ノズルシッパーの前記遠位端部は、前記ノズルシッパーの中心軸線に対してオフセットする頂点を含むくさび形状を有する、実施形態16の方法。
前記試薬は、異なる特定の重さの少なくとも3つの試薬を含む、実施形態16の方法。
Claims (21)
- 分析システムで対象分析物を支持するフローセルと流体的に接続される流路と、
試薬容器から試薬を吸引して、前記試薬を混合し、混合済み試薬を行先容器に排出し、前記混合済み試薬を前記行先容器から前記流路に搬送する流体システムと、
前記流体システムと流体連通し、細長い本体及びノズル挿入部を含むノズルシッパーと、
を備えるシステムであり、
前記細長い本体は、前記本体の端部間で延びる中央ルーメンを有し、
前記ノズル挿入部は、前記中央ルーメンの遠位端部に配置され、
前記ノズルシッパーは、前記混合済み試薬を前記容器から吸引し、前記混合済み試薬を前記ノズル挿入部経由で前記行先容器に排出して戻す、システム。 - ノズル及びルーメンは、前記ノズルシッパーから前記ノズル挿入部を通じて前記行先容器内に前記試薬を放出するときに前記行先容器で混合する渦度を高める寸法である、請求項1に記載のシステム。
- ルーメンは約0.5ミリメートルの公称内径を有し、前記ノズル挿入部は約0.25ミリメートルの公称内径を有する管状の挿入部である、請求項1に記載のシステム。
- 前記ノズルシッパーの前記遠位端部は、前記ノズルシッパーの中心軸線に対してオフセットする頂点で交わる複数ファセットを含むくさび形状を有する、請求項1に記載のシステム。
- 前記ノズル挿入部は、前記ノズルシッパーの前記遠位端部の前記くさび形状と対応する形状である遠位端部を有する、請求項4に記載のシステム。
- 前記くさび形状は、前記頂点で交わる4つのファセットを含む、請求項4に記載のシステム。
- 前記ノズルシッパーは、前記行先容器の底面から2ミリメートルの公称距離まで延在する、請求項1に記載のシステム。
- それぞれの試薬を吸引する複数の他のシッパーを備え、
前記他のシッパーはノズル挿入部を持たない、請求項1に記載のシステム。 - 前記ノズルシッパーは、混合される容器を、少なくとも約5,000μL/分の流量で、少なくとも約1,600ミリメートル/秒の流速まで加速させる、請求項1に記載のシステム。
- 分析システムで対象分析物を支持するフローセルと、
試薬を吸引して、前記試薬を混合し、混合済み試薬を行先容器に排出し、前記混合済み試薬を前記行先容器から前記フローセルに搬送する流体システムと、
前記流体システムと流体連通し、細長い本体及びノズルを含むノズルシッパーと、
前記流体システムに動作可能に結合される制御回路と、
を備えるシステムであり、
前記細長い本体は、前記本体の端部間で延びる中央ルーメンを有し、
前記ノズルは、前記細長い本体の遠位端部に配置され、
前記ノズルは前記中央ルーメンの公称内径を減少させ、
前記制御回路は、前記流体システムを制御して前記流体システムに、
前記試薬のセットを1つずつ吸引させ、
前記ノズルを通じて前記試薬のセット内の前記試薬を前記行先容器内へ排出させ、
前記ノズルを通じて前記行先容器から前記試薬のセットを混合するために吸引させ、
前記ノズルを通じて混合済み試薬の前記セットを前記行先容器に排出して戻させる、
システム。 - 前記ノズルは、前記ノズルシッパーの前記遠位端部で前記中央ルーメンに挿入される挿入部を含む、請求項10に記載のシステム。
- 前記行先容器はシーケンシングされる分析物を包含する、請求項10に記載のシステム。
- 前記中央ルーメンは0.5ミリメートルの公称内径を有し、前記ノズルは0.25ミリメートルの公称内径を有する、請求項10に記載のシステム。
- 前記ノズルシッパーの前記遠位端部は、前記ノズルシッパーの中心軸線に対してオフセットする頂点で交わる複数ファセットを含むくさび形状を有する、請求項10に記載のシステム。
- 前記ノズルは、前記ノズルシッパーの前記遠位端部の前記くさび形状と対応する形状である遠位端部を有する、請求項14に記載のシステム。
- (a)ポンプを作動させて、複数の試薬を対応する複数の試薬容器から1つずつ吸引するステップと、
(b)前記ポンプを作動させて、前記試薬を前記ポンプに流体連通するノズルシッパー経由で行先容器に排出するステップと、
(c)前記ポンプを作動させて、前記試薬を前記行先容器から前記ノズルシッパーを通じて吸引して、前記試薬を更に混合するステップと、
(d)前記ポンプを作動させて、前記試薬を前記ノズルシッパーから排出して前記行先容器に戻すステップと、
を含む方法であり、
前記ノズルシッパーは中央ルーメンとノズルとを有する細長い本体を含み、
前記中央ルーメンは前記細長い本体の端部間で延び、
前記ノズルは、前記細長い本体の遠位端部に配置され、
前記ノズルは前記中央ルーメンの公称内径を減少させる、方法。 - 前記ノズル及びルーメンは、前記ノズルシッパーから前記ノズルを通じて前記行先容器内に前記試薬を放出するときに前記行先容器で混合する渦度を高める寸法である、請求項16に記載の方法。
- 前記中央ルーメンは0.5ミリメートルの公称内径を有し、前記ノズルは前記中央ルーメンに挿入され0.25ミリメートルの公称内径を有する挿入部を含む、請求項16に記載の方法。
- 前記ノズルシッパーの前記遠位端部は、前記ノズルシッパーの中心軸線に対してオフセットする頂点で交わる複数ファセットを含むくさび形状を有する、請求項16に記載の方法。
- 前記試薬は、異なる特定の重さの少なくとも3つの試薬を含む、請求項16に記載の方法。
- (d)を実施する前に(b)及び(c)の繰り返しを1回以上実施することを更に含む、請求項16に記載の方法。
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Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP7292195B2 (ja) * | 2019-12-06 | 2023-06-16 | 株式会社日立ハイテク | 自動分析装置 |
US20220395784A1 (en) * | 2021-06-09 | 2022-12-15 | Perkinelmer Health Sciences, Inc. | Mixing liquids using an automated liquid handling system |
TWI804974B (zh) * | 2021-09-07 | 2023-06-11 | 博訊生物科技股份有限公司 | 吸液器的吸管尖連接裝置及連接方法 |
WO2023122589A2 (en) * | 2021-12-22 | 2023-06-29 | Nautilus Subsidiary, Inc. | Systems and methods for carrying out highly multiplexed bioanalyses |
CN114674612B (zh) * | 2022-03-25 | 2022-10-21 | 中煤浙江检测技术有限公司 | 一种水质在线取样方法 |
US20240001368A1 (en) * | 2022-06-30 | 2024-01-04 | Illumina, Inc. | Hydration and homogenization of lyophilized reagents |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2004535572A (ja) * | 2001-06-13 | 2004-11-25 | ケニス エフ. ウーヘンハイマー, | 自動化流体操作システムおよび方法 |
JP2007263857A (ja) * | 2006-03-29 | 2007-10-11 | Kurita Water Ind Ltd | 分析用試料調製装置及び分析装置 |
WO2011075075A1 (en) * | 2009-12-18 | 2011-06-23 | Zafena Ab | Micropipette |
JP2012173059A (ja) * | 2011-02-18 | 2012-09-10 | Hitachi High-Technologies Corp | 分析装置 |
JP2016508731A (ja) * | 2013-03-05 | 2016-03-24 | タッチライト ジェネティックス リミテッド | 合成装置及び合成方法 |
JP2016532111A (ja) * | 2013-08-08 | 2016-10-13 | イラミーナ インコーポレーテッド | フローセルへ試薬を送達するための流体システム |
Family Cites Families (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2588591A (en) | 1946-02-02 | 1952-03-11 | Automatic Canteen Company | Mixing device |
US3869068A (en) * | 1974-06-06 | 1975-03-04 | Hyperion Inc | Diluter probe assembly |
NL7915045A (nl) | 1978-05-25 | 1980-09-30 | Dynatech Ag | Geen |
JPH03170061A (ja) | 1989-12-30 | 1991-07-23 | Hitachi Nakaseiki Ltd | 二系列の液の戻し機能を共有するオートシッパー分光光度計 |
JPH087222B2 (ja) * | 1990-01-18 | 1996-01-29 | 持田製薬株式会社 | 自動分注希釈装置 |
EP0647161A1 (en) | 1992-06-17 | 1995-04-12 | KAARTINEN, Niilo | Method for mixing a quantity of liquid in a container for an analysis, a mixing and measuring needle and method for manufacturing the needle |
US5512248A (en) * | 1993-11-23 | 1996-04-30 | Van; Jack F. J. | Twin-probe blood sample diluting device |
US6641993B1 (en) * | 2000-02-22 | 2003-11-04 | Ortho Clinical Diagnostics, Inc. | Aspirating and mixing of liquids within a probe tip |
ATE370410T1 (de) | 2000-03-27 | 2007-09-15 | Arkray Inc | Verfahren zum rühren einer flüssigkeit |
US6764651B2 (en) | 2001-11-07 | 2004-07-20 | Varian, Inc. | Fiber-optic dissolution systems, devices, and methods |
US20050014284A1 (en) | 2003-07-18 | 2005-01-20 | Merrit Jacobs | Improved fluid mixing in a diagnostic analyzer |
TWI244594B (en) * | 2004-07-13 | 2005-12-01 | Quanta Comp Inc | Method for automatically assigning the address of communication ports and a blade server system |
US7651482B2 (en) | 2005-02-04 | 2010-01-26 | Boston Scientific Scimed, Inc. | Non-coring needles and methods of manufacturing same |
WO2006121789A2 (en) * | 2005-05-06 | 2006-11-16 | Instrumentation Laboratory Company | Telescoping closed-tube sampling assembly |
US9285297B2 (en) * | 2005-08-22 | 2016-03-15 | Applied Biosystems, Llc | Device, system, and method for depositing processed immiscible-fluid-discrete-volumes |
CN102803507B (zh) * | 2009-06-12 | 2016-05-25 | 精密公司 | 用于微流体装置中在板反应剂的脱水储存的组合物及方法 |
CN105973805B (zh) * | 2011-01-10 | 2019-06-18 | 伊鲁米那股份有限公司 | 用于生物或化学分析的样品的成像方法 |
KR101940833B1 (ko) | 2011-05-27 | 2019-01-21 | 제납시스 인크. | 유전자 및 생물학적 분석을 위한 시스템 및 방법 |
US9435765B2 (en) * | 2011-07-22 | 2016-09-06 | Tecan Trading Ag | Cartridge and system for manipulating samples in liquid droplets |
CN204832037U (zh) | 2012-04-03 | 2015-12-02 | 伊鲁米那股份有限公司 | 检测设备 |
AU2018366026B2 (en) * | 2017-11-08 | 2024-05-02 | Boston Scientific Scimed, Inc. | Capture devices and related methods of use |
KR102052568B1 (ko) | 2018-08-09 | 2019-12-05 | ㈜토니텍 | 유체의 정량 흡입 및 분배장치 |
WO2021146737A1 (en) * | 2020-01-18 | 2021-07-22 | Texas Scientific Products Llc | Analytical nebulizer |
US20220203352A1 (en) * | 2020-12-28 | 2022-06-30 | Canon Medical Systems Corporation | Reaction vessel and automatic analyzing device |
EP4151587A1 (en) * | 2021-09-16 | 2023-03-22 | Unito Smart Technologies Limited | Beverage mixing device and mixing tap system |
-
2017
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-
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- 2018-11-27 SA SA518400536A patent/SA518400536B1/ar unknown
-
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- 2021-05-19 US US17/303,043 patent/US20210270708A1/en active Pending
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2004535572A (ja) * | 2001-06-13 | 2004-11-25 | ケニス エフ. ウーヘンハイマー, | 自動化流体操作システムおよび方法 |
JP2007263857A (ja) * | 2006-03-29 | 2007-10-11 | Kurita Water Ind Ltd | 分析用試料調製装置及び分析装置 |
WO2011075075A1 (en) * | 2009-12-18 | 2011-06-23 | Zafena Ab | Micropipette |
JP2012173059A (ja) * | 2011-02-18 | 2012-09-10 | Hitachi High-Technologies Corp | 分析装置 |
JP2016508731A (ja) * | 2013-03-05 | 2016-03-24 | タッチライト ジェネティックス リミテッド | 合成装置及び合成方法 |
JP2016532111A (ja) * | 2013-08-08 | 2016-10-13 | イラミーナ インコーポレーテッド | フローセルへ試薬を送達するための流体システム |
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MY193187A (en) | 2022-09-26 |
EP3469379B1 (en) | 2023-08-09 |
IL262689B2 (en) | 2023-03-01 |
GB201704760D0 (en) | 2017-05-10 |
RU2713086C1 (ru) | 2020-02-03 |
US11016008B2 (en) | 2021-05-25 |
CN115598065A (zh) | 2023-01-13 |
BR112018076261A2 (pt) | 2019-03-26 |
CA3023126A1 (en) | 2018-07-12 |
TW201827587A (zh) | 2018-08-01 |
JP7097827B2 (ja) | 2022-07-08 |
AU2017390257A1 (en) | 2018-11-22 |
IL262689B (en) | 2022-11-01 |
CN109313211B (zh) | 2022-11-11 |
AU2017390257B2 (en) | 2022-07-28 |
ES2959289T3 (es) | 2024-02-22 |
TWI756331B (zh) | 2022-03-01 |
CA3023126C (en) | 2021-04-20 |
NZ747877A (en) | 2021-01-29 |
KR102472445B1 (ko) | 2022-11-29 |
SG11201811332YA (en) | 2019-01-30 |
US20210270708A1 (en) | 2021-09-02 |
BR112018076261B1 (pt) | 2022-10-18 |
EP3469379A4 (en) | 2020-02-12 |
EP3469379A1 (en) | 2019-04-17 |
US20180188141A1 (en) | 2018-07-05 |
IL262689A (en) | 2018-12-31 |
CN109313211A (zh) | 2019-02-05 |
SA518400536B1 (ar) | 2022-07-20 |
WO2018128842A1 (en) | 2018-07-12 |
KR20190095109A (ko) | 2019-08-14 |
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