SG11201811332YA - Reagent nozzle sipper mixing system and method - Google Patents

Reagent nozzle sipper mixing system and method

Info

Publication number
SG11201811332YA
SG11201811332YA SG11201811332YA SG11201811332YA SG11201811332YA SG 11201811332Y A SG11201811332Y A SG 11201811332YA SG 11201811332Y A SG11201811332Y A SG 11201811332YA SG 11201811332Y A SG11201811332Y A SG 11201811332YA SG 11201811332Y A SG11201811332Y A SG 11201811332YA
Authority
SG
Singapore
Prior art keywords
california
san diego
way
illumina
aspirate
Prior art date
Application number
SG11201811332YA
Inventor
Bradley Kent Drews
Michael Dai Wang
Umberto Ulmanella
James Michael Osmus
Stephen Wayne Clark
Johanna Lynn Whitacre
Steven Scott Phelps
Michelle L Alvarez
Michael Adalbert Niziolek
Debra Sue Bryan
Joshua Augustin Darland
Original Assignee
Illumina Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Illumina Inc filed Critical Illumina Inc
Publication of SG11201811332YA publication Critical patent/SG11201811332YA/en

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    • G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00465—Separating and mixing arrangements
    • G01N2035/00534—Mixing by a special element, e.g. stirrer
    • G01N2035/00544—Mixing by a special element, e.g. stirrer using fluid flow
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/04—Details of the conveyor system
    • G01N2035/0401—Sample carriers, cuvettes or reaction vessels
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N2035/1027—General features of the devices
    • G01N2035/1048—General features of the devices using the transfer device for another function
    • G01N2035/1058—General features of the devices using the transfer device for another function for mixing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
    • G01N35/1016—Control of the volume dispensed or introduced

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  • Chemical & Material Sciences (AREA)
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Abstract

INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 1111111111111111111111111111111111111111111111111111111111111111111111 Organization International Bureau (10) International Publication Number (43) International Publication Date ...... WO 2018/128842 Al 12 July 2018 (12.07.2018) WIP0 1 PCT (51) International Patent Classification: Stephen Wayne; 5200 Illumina Way, San Diego, Califor- GO/N 35/10 (2006.01) G01N 35/00 (2006.01) nia 92122 (US). WHITACRE, Johanna Lynn; 5200 Illu- BOIL 3/00 (2006.01) G01N 35/04 (2006.01) mina Way, San Diego, California 92122 (US). PHELPS, G01N 35/02 (2006.01) Steven Scott; 5200 Illumina Way, San Diego, California (21) International Application Number: 92122 (US). ALVAREZ, Michelle L.; 5200 Illumina Way, PCT/US2017/067836 San Diego, California 92122 (US). NIZIOLEK, Michael Adalbert; 5200 Illumina Way, San Diego, California 92122 (22) International Filing Date: (US). BRYAN, Debra Sue; 5200 Illumina Way, San Diego, 21 December 2017 (21.12.2017) California 92122 (US). DARLAND, Joshua Augustin; 5200 Illumina Way, San Diego, California 92122 (US). (25) Filing Language: English (26) Publication Language: English (74) Agent: SCHOLZ, Christian D. et al.; WEAVER AUSTIN VILLENEUVE & SAMPSON LLP, P.O. Box 70250, Oak- (30) Priority Data: land, California 94612-0250 (US). 62/442,765 05 January 2017 (05.01.2017) US (81) Designated States (unless otherwise indicated, for every 1704760.6 24 March 2017 (24.03.2017) GB kind of national protection available): AE, AG, AL, AM, 15/841,098 13 December 2017 (13.12.2017) US AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, (71) Applicant: ILLUMINA, INC. [US/US]; 5200 Illumina CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, Way, San Diego, California 92122 (US). DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, (72) Inventors: DREWS, Bradley Kent; 5200 Illumina Way, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, San Diego, California 92122 (US). WANG, Michael Dai; — MG, MK, MN, MW, MX, MY MZ, NA, NG, NI, NO, NZ, = 5200 Illumina Way, San Diego, California 92122 (US). UL- ego, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, MANELLA, Umberto; 5200 Illumina Way, San Diego, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, California 92122 (US). OSMUS, James Michael; 5200 Il-TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. = lumina Way, San Diego, California 92122 (US). CLARK, = (54) Title: REAGENT NOZZLE SIPPER MIXING SYSTEM AND METHOD (57) : An analysis instrument may perform analytical operations on an analyte that is combined with multiple reagents prior to being introduced = 206 ASPIRATE AIR into a flow cell. The instrument may include a nozzle sipper that aspirates = SHIFT VALVE(S) FFE ASPIRATE BU R __, 208 204 reagents from a recipient, along with an analyte. The reagents may be directed = 210 ) ..- SHIFT VALVES) ) to a volume and may be repeatedly moved into and out of the volume by cy- = ASPIRATE R1 cling of a pump. The reagents may be ejected into a destination recipient with 212) 2 ( 214 ...= SHIFT YAMS) the nozzle sipper promoting vorticity in the recipient to enhance mixing. The = ASPIRATE RN repeated aspiration and ejection through the nozzle sipper effectively mixes = SHIFT VALVE(S) the reagents and the template in an automated or semi-automated fashion. = SHIFT VALVES) = _ ASPIRATE R1 - 90 V.= SHIFT VALVE(S) = ASPIRATE RN 1- 232 - = 218 .._, (234 NO ASPIRATE To MIX -YES 1238 11 EXPEL INTO OHL TO MIX DESTINATION RECIMENT -... 6 L -238 N 7r 240 NO D ONE GC GC NO 242 130 , EL INTO N ASPIRATE AIR DESTINATION RECIPIENT 11 ,-.... - FIG. 11 O N O [Continued on next page] WO 2018/128842 Al MIDEDIMOMOIDEIREEMOMOHHHEIEDIREM (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3))
SG11201811332YA 2017-01-05 2017-12-21 Reagent nozzle sipper mixing system and method SG11201811332YA (en)

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Application Number Priority Date Filing Date Title
US201762442765P 2017-01-05 2017-01-05
GBGB1704760.6A GB201704760D0 (en) 2017-01-05 2017-03-24 Reagent nozzle sipper mixing system and method
US15/841,098 US11016008B2 (en) 2017-01-05 2017-12-13 Reagent nozzle sipper mixing system and method
PCT/US2017/067836 WO2018128842A1 (en) 2017-01-05 2017-12-21 Reagent nozzle sipper mixing system and method

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