JP2020503356A - ニトロキシル供与性化合物の投与方法 - Google Patents
ニトロキシル供与性化合物の投与方法 Download PDFInfo
- Publication number
- JP2020503356A JP2020503356A JP2019536215A JP2019536215A JP2020503356A JP 2020503356 A JP2020503356 A JP 2020503356A JP 2019536215 A JP2019536215 A JP 2019536215A JP 2019536215 A JP2019536215 A JP 2019536215A JP 2020503356 A JP2020503356 A JP 2020503356A
- Authority
- JP
- Japan
- Prior art keywords
- nitroxyl
- hours
- donating compound
- dose
- cyclodextrin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/40—Cyclodextrins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Inorganic Chemistry (AREA)
- Hospice & Palliative Care (AREA)
- Dermatology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762441803P | 2017-01-03 | 2017-01-03 | |
| US62/441,803 | 2017-01-03 | ||
| US201762549932P | 2017-08-24 | 2017-08-24 | |
| US62/549,932 | 2017-08-24 | ||
| PCT/US2018/012114 WO2018128999A1 (en) | 2017-01-03 | 2018-01-02 | Method of administering nitroxyl donating compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020503356A true JP2020503356A (ja) | 2020-01-30 |
| JP2020503356A5 JP2020503356A5 (https=) | 2021-04-08 |
Family
ID=61224497
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019536215A Pending JP2020503356A (ja) | 2017-01-03 | 2018-01-02 | ニトロキシル供与性化合物の投与方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US11083704B2 (https=) |
| EP (1) | EP3565544A1 (https=) |
| JP (1) | JP2020503356A (https=) |
| KR (1) | KR20190103281A (https=) |
| CN (1) | CN110520116A (https=) |
| AU (1) | AU2018205621B2 (https=) |
| BR (1) | BR112019013702A2 (https=) |
| CA (1) | CA3049003A1 (https=) |
| IL (1) | IL267728A (https=) |
| MX (1) | MX388684B (https=) |
| SG (2) | SG10202107533RA (https=) |
| WO (1) | WO2018128999A1 (https=) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002508766A (ja) * | 1997-06-25 | 2002-03-19 | ユニバーシティ テクノロジー コーポレイション | 心不全の治療方法 |
| JP2016505044A (ja) * | 2013-01-18 | 2016-02-18 | カルディオキシル ファーマシューティカルズ，インク． | ニトロキシル供与体を含む医薬組成物 |
| JP2016510040A (ja) * | 2013-02-28 | 2016-04-04 | アイレス ファーマシューティカルズ インコーポレイテッド | 心肺血行動態を改善するための無機亜硝酸塩 |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1024524A (en) | 1910-08-06 | 1912-04-30 | Lanston Monotype Machine Co | Type-casting machine. |
| US1058314A (en) | 1911-02-20 | 1913-04-08 | B F Cummins Company | Separating mechanism for mail-matter. |
| US1048704A (en) | 1911-04-29 | 1912-12-31 | King Construction Company | Clip for connecting rafters, purlins, and sash-bars of greenhouses. |
| US1017976A (en) | 1911-08-25 | 1912-02-20 | Rudolph Koch | Automatic mail-bag catcher and deliverer. |
| US1021340A (en) | 1911-10-14 | 1912-03-26 | William A Scott | Means for attaching binding-posts to dry batteries. |
| US1051784A (en) | 1912-02-16 | 1913-01-28 | Martin Trewhitt | Brooder. |
| US20040038947A1 (en) | 2002-06-14 | 2004-02-26 | The Gov. Of The U.S. Of America As Represented By The Sec. Of The Dept. Of Health & Human Services | Method of treating ischemia/reperfusion injury with nitroxyl donors |
| US6936639B2 (en) | 2002-08-21 | 2005-08-30 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Nitroxyl progenitors in the treatment of heart failure |
| WO2005074598A2 (en) | 2004-01-30 | 2005-08-18 | Johns Hopkins University | Nitroxyl progenitor compounds and methods of use |
| US20090298795A1 (en) | 2005-06-23 | 2009-12-03 | The Johns Hopins University | Thiol-Sensitive Positive Inotropes |
| US8030356B2 (en) | 2006-03-17 | 2011-10-04 | Cardioxyl Pharmaceuticals, Inc. | N-hydroxylsulfonamide derivatives as new physiologically useful nitroxyl donors |
| US7696373B2 (en) | 2006-04-13 | 2010-04-13 | Wake Forest University Health Sciences | C-nitroso-derived nitroxyl donors |
| CN104119310B (zh) | 2007-09-26 | 2017-04-12 | 约翰斯霍普金斯大学 | 作为新的在生理学上可用于硝酰基供体的n‑羟基磺酰胺衍生物及包含其的医药组合物 |
| EP3067352A3 (en) | 2008-05-07 | 2016-10-19 | Cardioxyl Pharmaceuticals Inc. | Novel nitroso compounds as nitroxyl donors and methods of use thereof |
| US20110160200A1 (en) | 2009-11-23 | 2011-06-30 | Cardioxyl Pharmaceuticals, Inc. | Nitroxyl Progenitors for the Treatment of Pulmonary Hypertension |
| CN105130855B (zh) | 2009-12-07 | 2018-05-25 | 约翰斯霍普金斯大学 | 二酰基化的羟基胺衍生物及其用途 |
| AU2010328234B2 (en) | 2009-12-07 | 2016-05-12 | Cardioxyl Pharmaceuticals, Inc. | N-acyloxysulfonamide and N-hydroxy-N-acylsulfonamide derivatives |
| JP6177246B2 (ja) | 2011-10-17 | 2017-08-09 | ザ・ジョンズ・ホプキンス・ユニバーシティ | ヒドロキシルアミンで置換された、ｈｎｏ供与体としてのメルドラム酸、バルビツール酸、及びピラゾロンの誘導体 |
| JP6306602B2 (ja) | 2012-11-01 | 2018-04-04 | ザ ジョンズ ホプキンス ユニバーシティ | 分子内環化−脱離による制御されたｈｎｏ放出 |
| EP2764868A1 (en) * | 2013-02-08 | 2014-08-13 | Friedrich-Alexander-Universität Erlangen-Nürnberg | Combination of nitroprusside and a sulfide salt as an HNO-releasing therapeutic for the treatment or prevention of cardiovascular diseases |
| EP2833611A1 (en) | 2013-07-31 | 2015-02-04 | Airbus Operations GmbH | Method of transmitting speech and digital data via an analog speech channel |
| ES2734060T3 (es) | 2014-01-17 | 2019-12-04 | Cardioxyl Pharmaceuticals Inc | Donadores de nitroxilo de N-hidroximetanosulfonamida |
| EP3148972B1 (en) | 2014-05-27 | 2019-08-21 | Cardioxyl Pharmaceuticals, Inc. | Pyrazolone derivatives as nitroxyl donors |
| US9464061B2 (en) | 2014-05-27 | 2016-10-11 | The Johns Hopkins University | N-hydroxylamino-barbituric acid derivatives |
| KR20180070672A (ko) | 2015-10-19 | 2018-06-26 | 카르디옥실 파마슈티칼스 인코포레이티드 | 니트록실 공여자로서의 n-히드록실술폰아미드 유도체 |
| US10723704B2 (en) | 2015-10-19 | 2020-07-28 | Cardioxyl Pharmaceuticals, Inc. | Pyrazolone derivatives as nitroxyl donors |
| EP3490975B1 (en) | 2016-07-28 | 2021-05-05 | The Johns Hopkins University | O-substituted hydroxamic acids |
-
2018
- 2018-01-02 WO PCT/US2018/012114 patent/WO2018128999A1/en not_active Ceased
- 2018-01-02 EP EP18705193.3A patent/EP3565544A1/en not_active Withdrawn
- 2018-01-02 SG SG10202107533RA patent/SG10202107533RA/en unknown
- 2018-01-02 CA CA3049003A patent/CA3049003A1/en active Pending
- 2018-01-02 CN CN201880014677.7A patent/CN110520116A/zh active Pending
- 2018-01-02 KR KR1020197022537A patent/KR20190103281A/ko not_active Ceased
- 2018-01-02 BR BR112019013702-5A patent/BR112019013702A2/pt not_active Application Discontinuation
- 2018-01-02 JP JP2019536215A patent/JP2020503356A/ja active Pending
- 2018-01-02 MX MX2019008000A patent/MX388684B/es unknown
- 2018-01-02 US US16/475,672 patent/US11083704B2/en active Active
- 2018-01-02 SG SG11201906145YA patent/SG11201906145YA/en unknown
- 2018-01-02 AU AU2018205621A patent/AU2018205621B2/en active Active
-
2019
- 2019-06-30 IL IL267728A patent/IL267728A/en unknown
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002508766A (ja) * | 1997-06-25 | 2002-03-19 | ユニバーシティ テクノロジー コーポレイション | 心不全の治療方法 |
| JP2016505044A (ja) * | 2013-01-18 | 2016-02-18 | カルディオキシル ファーマシューティカルズ，インク． | ニトロキシル供与体を含む医薬組成物 |
| JP2016510326A (ja) * | 2013-01-18 | 2016-04-07 | カルディオキシル ファーマシューティカルズ，インク． | 治療指数の改善されたニトロキシル供与体 |
| JP2016510040A (ja) * | 2013-02-28 | 2016-04-04 | アイレス ファーマシューティカルズ インコーポレイテッド | 心肺血行動態を改善するための無機亜硝酸塩 |
Non-Patent Citations (3)
| Title |
|---|
| CARDIOXYL PHARMACEUTICALS, INC, "CARDIOXYL PHARMACEUTICALS PRESENTS DATA ON ITS CLINICAL CANDIDATE, CXL-1020, AT THE 60TH ANNUAL AME, JPN6021038666, 2011, ISSN: 0004608503 * |
| CIRC HEART FAIL, vol. 6, JPN6021038664, 2013, pages 1250 - 1258, ISSN: 0004608502 * |
| JOURNAL OF AMERICAN COLLEGE OF CARDIOLOGY, vol. Vol.65, No.10S, JPN6021038662, 2015, pages 876, ISSN: 0004766922 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN110520116A (zh) | 2019-11-29 |
| US20190343790A1 (en) | 2019-11-14 |
| BR112019013702A2 (pt) | 2020-03-03 |
| AU2018205621B2 (en) | 2023-01-05 |
| KR20190103281A (ko) | 2019-09-04 |
| EP3565544A1 (en) | 2019-11-13 |
| MX2019008000A (es) | 2019-11-05 |
| CA3049003A1 (en) | 2018-07-12 |
| SG10202107533RA (en) | 2021-08-30 |
| AU2018205621A1 (en) | 2019-08-01 |
| MX388684B (es) | 2025-03-20 |
| SG11201906145YA (en) | 2019-08-27 |
| IL267728A (en) | 2019-08-29 |
| US11083704B2 (en) | 2021-08-10 |
| WO2018128999A1 (en) | 2018-07-12 |
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