JP2020503356A - ニトロキシル供与性化合物の投与方法 - Google Patents

ニトロキシル供与性化合物の投与方法 Download PDF

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Publication number
JP2020503356A
JP2020503356A JP2019536215A JP2019536215A JP2020503356A JP 2020503356 A JP2020503356 A JP 2020503356A JP 2019536215 A JP2019536215 A JP 2019536215A JP 2019536215 A JP2019536215 A JP 2019536215A JP 2020503356 A JP2020503356 A JP 2020503356A
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JP
Japan
Prior art keywords
nitroxyl
hours
donating compound
dose
cyclodextrin
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
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JP2019536215A
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English (en)
Japanese (ja)
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JP2020503356A5 (https=
Inventor
ポール・ディ・ケスラー
ウィリアム・アール・ユーイング
マリア・ボランタン
トゥーシャー・ガリメラ
エリス・ジー・ストック
Original Assignee
カルディオキシル ファーマシューティカルズ，インク．
カルディオキシル ファーマシューティカルズ，インク．
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Publication of JP2020503356A publication Critical patent/JP2020503356A/ja
Publication of JP2020503356A5 publication Critical patent/JP2020503356A5/ja
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/40—Cyclodextrins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Inorganic Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Dermatology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Hydrogenated Pyridines (AREA)
JP2019536215A 2017-01-03 2018-01-02 ニトロキシル供与性化合物の投与方法 Pending JP2020503356A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762441803P 2017-01-03 2017-01-03
US62/441,803 2017-01-03
US201762549932P 2017-08-24 2017-08-24
US62/549,932 2017-08-24
PCT/US2018/012114 WO2018128999A1 (en) 2017-01-03 2018-01-02 Method of administering nitroxyl donating compounds

Publications (2)

Publication Number Publication Date
JP2020503356A true JP2020503356A (ja) 2020-01-30
JP2020503356A5 JP2020503356A5 (https=) 2021-04-08

Family

ID=61224497

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2019536215A Pending JP2020503356A (ja) 2017-01-03 2018-01-02 ニトロキシル供与性化合物の投与方法

Country Status (12)

Country Link
US (1) US11083704B2 (https=)
EP (1) EP3565544A1 (https=)
JP (1) JP2020503356A (https=)
KR (1) KR20190103281A (https=)
CN (1) CN110520116A (https=)
AU (1) AU2018205621B2 (https=)
BR (1) BR112019013702A2 (https=)
CA (1) CA3049003A1 (https=)
IL (1) IL267728A (https=)
MX (1) MX388684B (https=)
SG (2) SG10202107533RA (https=)
WO (1) WO2018128999A1 (https=)

Citations (3)

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JP2002508766A (ja) * 1997-06-25 2002-03-19 ユニバーシティ テクノロジー コーポレイション 心不全の治療方法
JP2016505044A (ja) * 2013-01-18 2016-02-18 カルディオキシル ファーマシューティカルズ，インク． ニトロキシル供与体を含む医薬組成物
JP2016510040A (ja) * 2013-02-28 2016-04-04 アイレス ファーマシューティカルズ インコーポレイテッド 心肺血行動態を改善するための無機亜硝酸塩

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US1058314A (en) 1911-02-20 1913-04-08 B F Cummins Company Separating mechanism for mail-matter.
US1048704A (en) 1911-04-29 1912-12-31 King Construction Company Clip for connecting rafters, purlins, and sash-bars of greenhouses.
US1017976A (en) 1911-08-25 1912-02-20 Rudolph Koch Automatic mail-bag catcher and deliverer.
US1021340A (en) 1911-10-14 1912-03-26 William A Scott Means for attaching binding-posts to dry batteries.
US1051784A (en) 1912-02-16 1913-01-28 Martin Trewhitt Brooder.
US20040038947A1 (en) 2002-06-14 2004-02-26 The Gov. Of The U.S. Of America As Represented By The Sec. Of The Dept. Of Health & Human Services Method of treating ischemia/reperfusion injury with nitroxyl donors
US6936639B2 (en) 2002-08-21 2005-08-30 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Nitroxyl progenitors in the treatment of heart failure
CA2554771A1 (en) 2004-01-30 2005-08-18 Johns Hopkins University Nitroxyl progenitor compounds and methods of use
EP1909779A1 (en) 2005-06-23 2008-04-16 Johns Hopkins University Thiol-sensitive positive inotropes
BRPI0708804B8 (pt) 2006-03-17 2021-05-25 Cardioxyl Pharmaceuticals Inc compostos derivados de n-hidroxilsulfonamida como doadores de nitroxil, composição farmacêutica e kit
EP2010476A4 (en) 2006-04-13 2011-01-26 Univ Wake Forest Health Sciences NITROXYL DISPENSERS FROM C-NITROSO COMPOUNDS
NZ584036A (en) 2007-09-26 2012-06-29 Univ Johns Hopkins N-hydroxylsulfonamide derivatives as new physiologically useful nitroxyl donors
LT2278975T (lt) 2008-05-07 2016-11-25 Cardioxyl Pharmaceuticals Inc. Nauji nitrozo junginiai kaip nitroksilo donorai, ir jų panaudojimo būdas
WO2011063339A1 (en) 2009-11-23 2011-05-26 Cardioxyl Pharmaceuticals, Inc. Nitroxyl donors for the treatment of pulmonary hypertension
US20110144067A1 (en) 2009-12-07 2011-06-16 Toscano John P N-Acyloxysulfonamide and N-Hydroxy-N-Acylsulfonamide Derivatives
WO2011071947A2 (en) 2009-12-07 2011-06-16 Johns Hopkins University Bis-acylated hydroxylamine derivatives
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EP3148972B1 (en) 2014-05-27 2019-08-21 Cardioxyl Pharmaceuticals, Inc. Pyrazolone derivatives as nitroxyl donors
US10730828B2 (en) 2015-10-19 2020-08-04 Cardioxyl Pharmaceuticals, Inc. N-hydroxylsulfonamide derivatives as nitroxyl donors
KR20180063326A (ko) 2015-10-19 2018-06-11 카르디옥실 파마슈티칼스 인코포레이티드 니트록실 공여자로서의 피라졸론 유도체
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JP2002508766A (ja) * 1997-06-25 2002-03-19 ユニバーシティ テクノロジー コーポレイション 心不全の治療方法
JP2016505044A (ja) * 2013-01-18 2016-02-18 カルディオキシル ファーマシューティカルズ，インク． ニトロキシル供与体を含む医薬組成物
JP2016510326A (ja) * 2013-01-18 2016-04-07 カルディオキシル ファーマシューティカルズ，インク． 治療指数の改善されたニトロキシル供与体
JP2016510040A (ja) * 2013-02-28 2016-04-04 アイレス ファーマシューティカルズ インコーポレイテッド 心肺血行動態を改善するための無機亜硝酸塩

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Also Published As

Publication number Publication date
AU2018205621B2 (en) 2023-01-05
IL267728A (en) 2019-08-29
MX2019008000A (es) 2019-11-05
US20190343790A1 (en) 2019-11-14
US11083704B2 (en) 2021-08-10
AU2018205621A1 (en) 2019-08-01
WO2018128999A1 (en) 2018-07-12
BR112019013702A2 (pt) 2020-03-03
SG11201906145YA (en) 2019-08-27
CN110520116A (zh) 2019-11-29
SG10202107533RA (en) 2021-08-30
CA3049003A1 (en) 2018-07-12
MX388684B (es) 2025-03-20
KR20190103281A (ko) 2019-09-04
EP3565544A1 (en) 2019-11-13

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