CN110520116A - 供硝酰化合物的给予方法 - Google Patents

供硝酰化合物的给予方法 Download PDF

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Publication number
CN110520116A
CN110520116A CN201880014677.7A CN201880014677A CN110520116A CN 110520116 A CN110520116 A CN 110520116A CN 201880014677 A CN201880014677 A CN 201880014677A CN 110520116 A CN110520116 A CN 110520116A
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CN
China
Prior art keywords
hours
compound
nitryl
dose
another embodiment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201880014677.7A
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English (en)
Chinese (zh)
Inventor
P·D·凯斯勒
W·R·尤因
M·伯伦坦
T·加里梅拉
E·G·斯托克
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cardioxyl Pharmaceuticals Inc
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Cardioxyl Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cardioxyl Pharmaceuticals Inc filed Critical Cardioxyl Pharmaceuticals Inc
Publication of CN110520116A publication Critical patent/CN110520116A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/40—Cyclodextrins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Inorganic Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Dermatology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Hydrogenated Pyridines (AREA)
CN201880014677.7A 2017-01-03 2018-01-02 供硝酰化合物的给予方法 Pending CN110520116A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762441803P 2017-01-03 2017-01-03
US62/441,803 2017-01-03
US201762549932P 2017-08-24 2017-08-24
US62/549,932 2017-08-24
PCT/US2018/012114 WO2018128999A1 (en) 2017-01-03 2018-01-02 Method of administering nitroxyl donating compounds

Publications (1)

Publication Number Publication Date
CN110520116A true CN110520116A (zh) 2019-11-29

Family

ID=61224497

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201880014677.7A Pending CN110520116A (zh) 2017-01-03 2018-01-02 供硝酰化合物的给予方法

Country Status (12)

Country Link
US (1) US11083704B2 (https=)
EP (1) EP3565544A1 (https=)
JP (1) JP2020503356A (https=)
KR (1) KR20190103281A (https=)
CN (1) CN110520116A (https=)
AU (1) AU2018205621B2 (https=)
BR (1) BR112019013702A2 (https=)
CA (1) CA3049003A1 (https=)
IL (1) IL267728A (https=)
MX (1) MX388684B (https=)
SG (2) SG10202107533RA (https=)
WO (1) WO2018128999A1 (https=)

Citations (3)

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CN102753520A (zh) * 2009-12-07 2012-10-24 约翰斯霍普金斯大学 N-酰氧基磺酰胺和n-羟基-n-酰基磺酰胺衍生物
CN105142627A (zh) * 2013-01-18 2015-12-09 卡尔迪奥克斯尔制药公司 包含硝酰基供体的医药组合物
US20150374749A1 (en) * 2013-02-08 2015-12-31 Friedrich-Alexander-Universität Combination of nitroprusside and a sulfide salt as an hno-releasing therapeutic for the treatment or prevention of cardiovascular diseases

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US1058314A (en) 1911-02-20 1913-04-08 B F Cummins Company Separating mechanism for mail-matter.
US1048704A (en) 1911-04-29 1912-12-31 King Construction Company Clip for connecting rafters, purlins, and sash-bars of greenhouses.
US1017976A (en) 1911-08-25 1912-02-20 Rudolph Koch Automatic mail-bag catcher and deliverer.
US1021340A (en) 1911-10-14 1912-03-26 William A Scott Means for attaching binding-posts to dry batteries.
US1051784A (en) 1912-02-16 1913-01-28 Martin Trewhitt Brooder.
US5998458A (en) * 1997-06-25 1999-12-07 University Technology Corporation Method of treating heart failure
US20040038947A1 (en) 2002-06-14 2004-02-26 The Gov. Of The U.S. Of America As Represented By The Sec. Of The Dept. Of Health & Human Services Method of treating ischemia/reperfusion injury with nitroxyl donors
US6936639B2 (en) 2002-08-21 2005-08-30 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Nitroxyl progenitors in the treatment of heart failure
CA2554771A1 (en) 2004-01-30 2005-08-18 Johns Hopkins University Nitroxyl progenitor compounds and methods of use
EP1909779A1 (en) 2005-06-23 2008-04-16 Johns Hopkins University Thiol-sensitive positive inotropes
BRPI0708804B8 (pt) 2006-03-17 2021-05-25 Cardioxyl Pharmaceuticals Inc compostos derivados de n-hidroxilsulfonamida como doadores de nitroxil, composição farmacêutica e kit
EP2010476A4 (en) 2006-04-13 2011-01-26 Univ Wake Forest Health Sciences NITROXYL DISPENSERS FROM C-NITROSO COMPOUNDS
NZ584036A (en) 2007-09-26 2012-06-29 Univ Johns Hopkins N-hydroxylsulfonamide derivatives as new physiologically useful nitroxyl donors
LT2278975T (lt) 2008-05-07 2016-11-25 Cardioxyl Pharmaceuticals Inc. Nauji nitrozo junginiai kaip nitroksilo donorai, ir jų panaudojimo būdas
WO2011063339A1 (en) 2009-11-23 2011-05-26 Cardioxyl Pharmaceuticals, Inc. Nitroxyl donors for the treatment of pulmonary hypertension
WO2011071947A2 (en) 2009-12-07 2011-06-16 Johns Hopkins University Bis-acylated hydroxylamine derivatives
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US10730828B2 (en) 2015-10-19 2020-08-04 Cardioxyl Pharmaceuticals, Inc. N-hydroxylsulfonamide derivatives as nitroxyl donors
KR20180063326A (ko) 2015-10-19 2018-06-11 카르디옥실 파마슈티칼스 인코포레이티드 니트록실 공여자로서의 피라졸론 유도체
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Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102753520A (zh) * 2009-12-07 2012-10-24 约翰斯霍普金斯大学 N-酰氧基磺酰胺和n-羟基-n-酰基磺酰胺衍生物
CN105142627A (zh) * 2013-01-18 2015-12-09 卡尔迪奥克斯尔制药公司 包含硝酰基供体的医药组合物
US20150374749A1 (en) * 2013-02-08 2015-12-31 Friedrich-Alexander-Universität Combination of nitroprusside and a sulfide salt as an hno-releasing therapeutic for the treatment or prevention of cardiovascular diseases

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COWART, D., ET AL.: "A PHASE 1 STUDY OF THE SAFETY AND PHARMACOKINETICS OF THE INTRAVENOUS NITROXYL PRODRUG, CXL-1427.", 《JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY》 *
DEL RIO, C. L., ET AL.: "A NOVEL HNO DONOR, DECREASES MYOCARDIAL LOADING AND ENHANCES LOAD-INDEPENDENT LUSITROPY AND INOTROPY VIA A ?-AR/ACE INDEPENDENT MECHANISM", 《JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY》 *
YE TIAN, ET AL: "硝酰基(HNO),新一代心力衰竭治疗正性肌力药物", 《ENGINEERING》 *

Also Published As

Publication number Publication date
AU2018205621B2 (en) 2023-01-05
IL267728A (en) 2019-08-29
MX2019008000A (es) 2019-11-05
US20190343790A1 (en) 2019-11-14
US11083704B2 (en) 2021-08-10
AU2018205621A1 (en) 2019-08-01
WO2018128999A1 (en) 2018-07-12
BR112019013702A2 (pt) 2020-03-03
SG11201906145YA (en) 2019-08-27
SG10202107533RA (en) 2021-08-30
CA3049003A1 (en) 2018-07-12
MX388684B (es) 2025-03-20
JP2020503356A (ja) 2020-01-30
KR20190103281A (ko) 2019-09-04
EP3565544A1 (en) 2019-11-13

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Application publication date: 20191129