JP2020502280A - 置換ポルフィリン医薬化合物及び組成物を製造する方法 - Google Patents

置換ポルフィリン医薬化合物及び組成物を製造する方法 Download PDF

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Publication number
JP2020502280A
JP2020502280A JP2019554488A JP2019554488A JP2020502280A JP 2020502280 A JP2020502280 A JP 2020502280A JP 2019554488 A JP2019554488 A JP 2019554488A JP 2019554488 A JP2019554488 A JP 2019554488A JP 2020502280 A JP2020502280 A JP 2020502280A
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Japan
Prior art keywords
compound
formula
composition
pyridyl
anion
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Pending
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JP2019554488A
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English (en)
Japanese (ja)
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JP2020502280A5 (enExample
Inventor
バティニック−ハベルレ，イネス
トブマシャン，アルタック
ラジック ドゾリック，ズリンカ
ラジック ドゾリック，ズリンカ
スパソジェヴィック，アイヴァン
アレン リー，クリストファー
アレン リー，クリストファー
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Duke University
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Duke University
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Publication of JP2020502280A publication Critical patent/JP2020502280A/ja
Publication of JP2020502280A5 publication Critical patent/JP2020502280A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
    • C07F13/005—Compounds without a metal-carbon linkage
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B47/00—Formation or introduction of functional groups not provided for in groups C07B39/00 - C07B45/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
JP2019554488A 2016-12-20 2017-12-19 置換ポルフィリン医薬化合物及び組成物を製造する方法 Pending JP2020502280A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662436743P 2016-12-20 2016-12-20
US62/436,743 2016-12-20
PCT/US2017/067263 WO2018118891A1 (en) 2016-12-20 2017-12-19 Methods of making substituted porphyrin pharmaceutical compounds and compositions

Publications (2)

Publication Number Publication Date
JP2020502280A true JP2020502280A (ja) 2020-01-23
JP2020502280A5 JP2020502280A5 (enExample) 2021-02-04

Family

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Family Applications (1)

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JP2019554488A Pending JP2020502280A (ja) 2016-12-20 2017-12-19 置換ポルフィリン医薬化合物及び組成物を製造する方法

Country Status (8)

Country Link
US (1) US20190330220A1 (enExample)
EP (1) EP3558902A4 (enExample)
JP (1) JP2020502280A (enExample)
KR (1) KR20190098211A (enExample)
CN (1) CN110291060A (enExample)
CA (1) CA3046357A1 (enExample)
MX (1) MX2019007301A (enExample)
WO (1) WO2018118891A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2020536055A (ja) * 2017-09-29 2020-12-10 デューク ユニバーシティ フルオロ置換ポルフィリン化合物、該化合物を含む医薬組成物、並びに該化合物を調製及び使用する方法

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110621377A (zh) * 2017-04-04 2019-12-27 贝奥密美体合资有限公司 治疗和/或预防与放射和/或化疗暴露有关的副作用的方法、组合物以及试剂盒

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002535332A (ja) * 1999-01-25 2002-10-22 ナショナル・ジュウィッシュ・メディカル・アンド・リサーチ・センター 置換ポルフィリン
WO2005077269A1 (en) * 2004-02-09 2005-08-25 Duke University Substituted porphyrins
JP2006501163A (ja) * 2002-06-07 2006-01-12 デューク・ユニバーシティー 置換ポルフィリン
WO2010080881A1 (en) * 2009-01-07 2010-07-15 Duke University Substituted porphyrins
WO2010138633A1 (en) * 2009-05-26 2010-12-02 Duke University Method of providing neuroprotection using substituted porphyrins
WO2015112586A1 (en) * 2014-01-22 2015-07-30 Duke University Methods of treating pruritus

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6127356A (en) * 1993-10-15 2000-10-03 Duke University Oxidant scavengers

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002535332A (ja) * 1999-01-25 2002-10-22 ナショナル・ジュウィッシュ・メディカル・アンド・リサーチ・センター 置換ポルフィリン
JP2006501163A (ja) * 2002-06-07 2006-01-12 デューク・ユニバーシティー 置換ポルフィリン
WO2005077269A1 (en) * 2004-02-09 2005-08-25 Duke University Substituted porphyrins
WO2010080881A1 (en) * 2009-01-07 2010-07-15 Duke University Substituted porphyrins
WO2010138633A1 (en) * 2009-05-26 2010-12-02 Duke University Method of providing neuroprotection using substituted porphyrins
WO2015112586A1 (en) * 2014-01-22 2015-07-30 Duke University Methods of treating pruritus

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
ARTAK TOVMASYAN; ET AL: "RATIONAL DESIGN OF SUPEROXIDE DISMUTASE (SOD) MIMICS: THE EVALUATION OF THE THERAPEUTIC 以下備考", INORGANIC CHEMISTRY, vol. VOL:53, NR:21, JPN5020002148, 21 October 2014 (2014-10-21), pages 11467 - 11483, ISSN: 0004805975 *
RAJIC, ZRINKA; TOVMASYAN, ARTAK; SPASOJEVIC, IVAN; SHENG, HUAXIN; LU, MIAOMIAO; LI, ALICE M.; GRALLA: "A new SOD mimic, Mn(III) ortho N-butoxyethylpyridylporphyrin, combines superb potency and lipophi", FREE RADICAL BIOLOGY & MEDICINE, vol. 52(9),, JPN6021045193, 2012, pages 1828 - 1834, ISSN: 0004805974 *
TOVMASYAN, ARTAK ET. AL.: "Anticancer therapeutic potential of Mn porphyrin/ascorbate system", FREE RADICAL BIOLOGY & MEDICINE, vol. 89,, JPN6021045195, 2015, pages 1231 - 1247, ISSN: 0004805976 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2020536055A (ja) * 2017-09-29 2020-12-10 デューク ユニバーシティ フルオロ置換ポルフィリン化合物、該化合物を含む医薬組成物、並びに該化合物を調製及び使用する方法
JP7336805B2 (ja) 2017-09-29 2023-09-01 デューク ユニバーシティ フルオロ置換ポルフィリン化合物、該化合物を含む医薬組成物、並びに該化合物を調製及び使用する方法

Also Published As

Publication number Publication date
US20190330220A1 (en) 2019-10-31
EP3558902A1 (en) 2019-10-30
KR20190098211A (ko) 2019-08-21
CN110291060A (zh) 2019-09-27
WO2018118891A1 (en) 2018-06-28
MX2019007301A (es) 2019-10-30
EP3558902A4 (en) 2020-06-24
CA3046357A1 (en) 2018-06-28

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