JP2020502135A5 - - Google Patents
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- Publication number
- JP2020502135A5 JP2020502135A5 JP2019531812A JP2019531812A JP2020502135A5 JP 2020502135 A5 JP2020502135 A5 JP 2020502135A5 JP 2019531812 A JP2019531812 A JP 2019531812A JP 2019531812 A JP2019531812 A JP 2019531812A JP 2020502135 A5 JP2020502135 A5 JP 2020502135A5
- Authority
- JP
- Japan
- Prior art keywords
- drugs
- plasminogen
- composition according
- drug
- pharmaceutical composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 229940079593 drug Drugs 0.000 claims 15
- 239000003814 drug Substances 0.000 claims 15
- 102000013566 Plasminogen Human genes 0.000 claims 10
- 108010051456 Plasminogen Proteins 0.000 claims 10
- 239000008194 pharmaceutical composition Substances 0.000 claims 9
- 210000005084 renal tissue Anatomy 0.000 claims 8
- 239000000203 mixture Substances 0.000 claims 5
- 230000000451 tissue damage Effects 0.000 claims 4
- 231100000827 tissue damage Toxicity 0.000 claims 4
- 208000009304 Acute Kidney Injury Diseases 0.000 claims 3
- 239000002220 antihypertensive agent Substances 0.000 claims 3
- 229940127088 antihypertensive drug Drugs 0.000 claims 3
- 208000033626 Renal failure acute Diseases 0.000 claims 2
- 239000003472 antidiabetic agent Substances 0.000 claims 2
- 239000002246 antineoplastic agent Substances 0.000 claims 2
- 239000003443 antiviral agent Substances 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 210000003734 kidney Anatomy 0.000 claims 2
- 230000003907 kidney function Effects 0.000 claims 2
- 208000003918 Acute Kidney Tubular Necrosis Diseases 0.000 claims 1
- 201000003126 Anuria Diseases 0.000 claims 1
- 208000037157 Azotemia Diseases 0.000 claims 1
- 208000012639 Balance disease Diseases 0.000 claims 1
- XUIIKFGFIJCVMT-GFCCVEGCSA-N D-thyroxine Chemical compound IC1=CC(C[C@@H](N)C(O)=O)=CC(I)=C1OC1=CC(I)=C(O)C(I)=C1 XUIIKFGFIJCVMT-GFCCVEGCSA-N 0.000 claims 1
- 206010016654 Fibrosis Diseases 0.000 claims 1
- 206010018366 Glomerulonephritis acute Diseases 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 206010030302 Oliguria Diseases 0.000 claims 1
- 102000001938 Plasminogen Activators Human genes 0.000 claims 1
- 108010001014 Plasminogen Activators Proteins 0.000 claims 1
- 206010037597 Pyelonephritis acute Diseases 0.000 claims 1
- 208000001647 Renal Insufficiency Diseases 0.000 claims 1
- 206010038540 Renal tubular necrosis Diseases 0.000 claims 1
- PNNCWTXUWKENPE-UHFFFAOYSA-N [N].NC(N)=O Chemical compound [N].NC(N)=O PNNCWTXUWKENPE-UHFFFAOYSA-N 0.000 claims 1
- 230000001154 acute effect Effects 0.000 claims 1
- 231100000851 acute glomerulonephritis Toxicity 0.000 claims 1
- 201000011040 acute kidney failure Diseases 0.000 claims 1
- 201000001555 acute pyelonephritis Diseases 0.000 claims 1
- 208000012998 acute renal failure Diseases 0.000 claims 1
- 230000003276 anti-hypertensive effect Effects 0.000 claims 1
- 239000003416 antiarrhythmic agent Substances 0.000 claims 1
- 239000003146 anticoagulant agent Substances 0.000 claims 1
- 229940127219 anticoagulant drug Drugs 0.000 claims 1
- 239000003524 antilipemic agent Substances 0.000 claims 1
- 229940127218 antiplatelet drug Drugs 0.000 claims 1
- 229940121357 antivirals Drugs 0.000 claims 1
- 230000006907 apoptotic process Effects 0.000 claims 1
- 230000003115 biocidal effect Effects 0.000 claims 1
- 239000000496 cardiotonic agent Substances 0.000 claims 1
- 229940044683 chemotherapy drug Drugs 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 claims 1
- 229960004316 cisplatin Drugs 0.000 claims 1
- 229940109239 creatinine Drugs 0.000 claims 1
- 230000003247 decreasing effect Effects 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000002934 diuretic Substances 0.000 claims 1
- 229940030606 diuretics Drugs 0.000 claims 1
- 239000003792 electrolyte Substances 0.000 claims 1
- 230000008030 elimination Effects 0.000 claims 1
- 238000003379 elimination reaction Methods 0.000 claims 1
- 239000003527 fibrinolytic agent Substances 0.000 claims 1
- 230000004761 fibrosis Effects 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 230000024924 glomerular filtration Effects 0.000 claims 1
- 208000006750 hematuria Diseases 0.000 claims 1
- 229940088597 hormone Drugs 0.000 claims 1
- 239000002955 immunomodulating agent Substances 0.000 claims 1
- 229940121354 immunomodulator Drugs 0.000 claims 1
- 230000001524 infective effect Effects 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 201000006370 kidney failure Diseases 0.000 claims 1
- 150000002632 lipids Chemical class 0.000 claims 1
- 210000004185 liver Anatomy 0.000 claims 1
- 108010087750 lysyl-plasminogen Proteins 0.000 claims 1
- 239000002207 metabolite Substances 0.000 claims 1
- 108010049112 miniplasminogen Proteins 0.000 claims 1
- 230000003589 nefrotoxic effect Effects 0.000 claims 1
- 231100000381 nephrotoxic Toxicity 0.000 claims 1
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 claims 1
- 229940127126 plasminogen activator Drugs 0.000 claims 1
- 239000000106 platelet aggregation inhibitor Substances 0.000 claims 1
- 239000011251 protective drug Substances 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 201000001474 proteinuria Diseases 0.000 claims 1
- 238000011084 recovery Methods 0.000 claims 1
- 230000001105 regulatory effect Effects 0.000 claims 1
- 201000002793 renal fibrosis Diseases 0.000 claims 1
- 229940034208 thyroxine Drugs 0.000 claims 1
- XUIIKFGFIJCVMT-UHFFFAOYSA-N thyroxine-binding globulin Natural products IC1=CC(CC([NH3+])C([O-])=O)=CC(I)=C1OC1=CC(I)=C(O)C(I)=C1 XUIIKFGFIJCVMT-UHFFFAOYSA-N 0.000 claims 1
- 208000037816 tissue injury Diseases 0.000 claims 1
- 208000009852 uremia Diseases 0.000 claims 1
- 210000002700 urine Anatomy 0.000 claims 1
- 230000002792 vascular Effects 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2016110174 | 2016-12-15 | ||
| CN2016110169 | 2016-12-15 | ||
| CNPCT/CN2016/110174 | 2016-12-15 | ||
| CNPCT/CN2016/110169 | 2016-12-15 | ||
| PCT/CN2017/089059 WO2018107699A1 (zh) | 2016-12-15 | 2017-06-19 | 一种预防和治疗药物性肾损伤的方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020502135A JP2020502135A (ja) | 2020-01-23 |
| JP2020502135A5 true JP2020502135A5 (cg-RX-API-DMAC7.html) | 2020-07-30 |
| JP7242057B2 JP7242057B2 (ja) | 2023-03-20 |
Family
ID=62557856
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019531809A Active JP7182793B2 (ja) | 2016-12-15 | 2017-06-19 | 病理学的腎組織損傷を予防及び治療するための方法 |
| JP2019531812A Active JP7242057B2 (ja) | 2016-12-15 | 2017-06-19 | 薬物性腎損傷を予防及び治療するための方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019531809A Active JP7182793B2 (ja) | 2016-12-15 | 2017-06-19 | 病理学的腎組織損傷を予防及び治療するための方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US20190343930A1 (cg-RX-API-DMAC7.html) |
| EP (2) | EP3556386A4 (cg-RX-API-DMAC7.html) |
| JP (2) | JP7182793B2 (cg-RX-API-DMAC7.html) |
| CN (2) | CN110366427A (cg-RX-API-DMAC7.html) |
| CA (2) | CA3047171A1 (cg-RX-API-DMAC7.html) |
| TW (4) | TW201822797A (cg-RX-API-DMAC7.html) |
| WO (3) | WO2018107699A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018107697A1 (zh) * | 2016-12-15 | 2018-06-21 | 深圳瑞健生命科学研究院有限公司 | 一种预防和治疗肺纤维化的方法 |
| JP7335609B2 (ja) | 2017-06-19 | 2023-08-30 | タレンゲン インターナショナル リミテッド | Ｇｌｐ－１／ｇｌｐ－１ｒを調節制御する方法および薬剤 |
| TWI868051B (zh) * | 2017-06-23 | 2025-01-01 | 美商波麥堤克生物治療股份有限公司 | 與pai-1過表現相關之病狀的纖維蛋白溶酶原治療 |
| CN113456579B (zh) * | 2021-07-12 | 2023-04-25 | 南开大学 | 具有双靶点的hdac抑制剂的纳米胶束-水凝胶制剂在治疗急性肾损伤药物中的应用 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| IE52535B1 (en) | 1981-02-16 | 1987-12-09 | Ici Plc | Continuous release pharmaceutical compositions |
| CN87104683A (zh) * | 1986-05-15 | 1988-12-21 | 埃默里大学 | 改善血纤维蛋白溶解作用的组合物 |
| PT2275119E (pt) | 1995-07-27 | 2013-11-21 | Genentech Inc | Formulação de proteína liofilizada isotónica estável |
| US7202066B2 (en) | 2002-01-29 | 2007-04-10 | Carrington Laboratories, Inc. | Combination of a growth factor and a protease enzyme |
| EP1472346A2 (de) * | 2002-02-06 | 2004-11-03 | N-Zyme BioTec GmbH | Verfahren zur herstellung von rekombinanten proteinen in mikroorganismen |
| CN1668312A (zh) * | 2002-05-13 | 2005-09-14 | 洛杉矶儿童医院 | 疤痕疙瘩和其它的皮肤或内部的创伤或损伤中异常疤痕形成的处理和抑制 |
| JP2006514640A (ja) * | 2002-12-10 | 2006-05-11 | ワイス | プラスミノゲンアクティベータインヒビターのインヒビターとしての置換３−アルキル及び３−アリールアルキル１ｈ−イル酢酸誘導体 |
| US20050250694A1 (en) * | 2003-10-10 | 2005-11-10 | Ma Jian-Xing | Compounds useful in inhibiting vascular leakage, inflammation and fibrosis and methods of making and using same |
| AU2005277137A1 (en) * | 2004-08-23 | 2006-03-02 | Wyeth | Pyrrolo-naphthyl acids as PAI-1 inhibitors |
| US8741260B2 (en) | 2005-10-07 | 2014-06-03 | Armagen Technologies, Inc. | Fusion proteins for delivery of GDNF to the CNS |
| CN101563100B (zh) | 2006-08-28 | 2013-08-07 | 李季男 | 用于预防和治疗牙周病、改善牙周创伤愈合以及促进口腔健康的新药物靶标 |
| EP2435826B1 (en) * | 2009-05-26 | 2014-05-21 | Universidad De Salamanca | Urinary gm2 activator protein as a marker of acute renal failure or the risk of developing acute renal failure |
| JP5819293B2 (ja) * | 2009-07-10 | 2015-11-24 | スロンボジェニックス・ナムローゼ・フェンノートシャップＴｈｒｏｍｂｏＧｅｎｉｃｓ ＮＶ | プラスミノーゲンおよびプラスミンの変異体 |
| CN102121023B (zh) * | 2010-12-22 | 2012-07-04 | 中山大学 | 突变型人纤溶酶原kringle5及其制备方法及应用 |
| CN103384722B (zh) * | 2011-01-05 | 2016-11-16 | 斯路姆基因公司 | 纤溶酶原和纤溶酶变体 |
| CN102154253A (zh) | 2011-01-06 | 2011-08-17 | 郑州大学 | 具有抑制血小板凝集功能的微小纤溶酶原突变体及其制备方法和用途 |
| JP6157481B2 (ja) | 2011-09-29 | 2017-07-05 | メイヨ ファンデーション フォア メディカル エディケイション アンド リサーチ | 芳香族陽イオン性ペプチドおよびその使用方法 |
| UA118267C2 (uk) | 2013-08-13 | 2018-12-26 | Санофі | Антитіло до інгібітора активатора плазміногену 1 (раі-1) та його застосування |
| BR112016019332A2 (pt) * | 2014-02-21 | 2017-10-10 | Astellas Pharma Inc | anticorpo pai-1 anti-humano inovador |
-
2017
- 2017-06-19 JP JP2019531809A patent/JP7182793B2/ja active Active
- 2017-06-19 EP EP17880935.6A patent/EP3556386A4/en active Pending
- 2017-06-19 JP JP2019531812A patent/JP7242057B2/ja active Active
- 2017-06-19 US US16/469,991 patent/US20190343930A1/en not_active Abandoned
- 2017-06-19 CA CA3047171A patent/CA3047171A1/en not_active Abandoned
- 2017-06-19 EP EP17881449.7A patent/EP3556388A4/en active Pending
- 2017-06-19 TW TW106120455A patent/TW201822797A/zh unknown
- 2017-06-19 TW TW110102361A patent/TW202123962A/zh unknown
- 2017-06-19 US US16/469,960 patent/US20190328848A1/en not_active Abandoned
- 2017-06-19 WO PCT/CN2017/089059 patent/WO2018107699A1/zh not_active Ceased
- 2017-06-19 CA CA3047170A patent/CA3047170A1/en not_active Abandoned
- 2017-06-19 CN CN201780078167.1A patent/CN110366427A/zh active Pending
- 2017-06-19 CN CN201780078117.3A patent/CN110167582A/zh active Pending
- 2017-06-19 WO PCT/CN2017/089060 patent/WO2018107700A1/zh not_active Ceased
- 2017-06-19 WO PCT/CN2017/089055 patent/WO2018107695A1/zh not_active Ceased
- 2017-06-20 TW TW106120521A patent/TWI642441B/zh active
- 2017-06-20 TW TW106120523A patent/TWI661838B/zh active
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