CA3047171A1 - Method for preventing and treating pathological renal tissue injury - Google Patents
Method for preventing and treating pathological renal tissue injury Download PDFInfo
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- CA3047171A1 CA3047171A1 CA3047171A CA3047171A CA3047171A1 CA 3047171 A1 CA3047171 A1 CA 3047171A1 CA 3047171 A CA3047171 A CA 3047171A CA 3047171 A CA3047171 A CA 3047171A CA 3047171 A1 CA3047171 A1 CA 3047171A1
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- plasminogen
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- renal tissue
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- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/243—Platinum; Compounds thereof
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- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
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Landscapes
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2016110174 | 2016-12-15 | ||
| CN2016110169 | 2016-12-15 | ||
| CNPCT/CN2016/110174 | 2016-12-15 | ||
| CNPCT/CN2016/110169 | 2016-12-15 | ||
| PCT/CN2017/089060 WO2018107700A1 (zh) | 2016-12-15 | 2017-06-19 | 一种预防和治疗病理性肾组织损伤的方法 |
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| CA3047171A1 true CA3047171A1 (en) | 2018-06-21 |
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| CA3047170A Abandoned CA3047170A1 (en) | 2016-12-15 | 2017-06-19 | Method for preventing and treating drug-induced renal injury |
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| CA3047170A Abandoned CA3047170A1 (en) | 2016-12-15 | 2017-06-19 | Method for preventing and treating drug-induced renal injury |
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| WO2018107697A1 (zh) * | 2016-12-15 | 2018-06-21 | 深圳瑞健生命科学研究院有限公司 | 一种预防和治疗肺纤维化的方法 |
| JP7335609B2 (ja) | 2017-06-19 | 2023-08-30 | タレンゲン インターナショナル リミテッド | Ｇｌｐ－１／ｇｌｐ－１ｒを調節制御する方法および薬剤 |
| TWI868051B (zh) * | 2017-06-23 | 2025-01-01 | 美商波麥堤克生物治療股份有限公司 | 與pai-1過表現相關之病狀的纖維蛋白溶酶原治療 |
| CN113456579B (zh) * | 2021-07-12 | 2023-04-25 | 南开大学 | 具有双靶点的hdac抑制剂的纳米胶束-水凝胶制剂在治疗急性肾损伤药物中的应用 |
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| US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| IE52535B1 (en) | 1981-02-16 | 1987-12-09 | Ici Plc | Continuous release pharmaceutical compositions |
| CN87104683A (zh) * | 1986-05-15 | 1988-12-21 | 埃默里大学 | 改善血纤维蛋白溶解作用的组合物 |
| PT2275119E (pt) | 1995-07-27 | 2013-11-21 | Genentech Inc | Formulação de proteína liofilizada isotónica estável |
| US7202066B2 (en) | 2002-01-29 | 2007-04-10 | Carrington Laboratories, Inc. | Combination of a growth factor and a protease enzyme |
| EP1472346A2 (de) * | 2002-02-06 | 2004-11-03 | N-Zyme BioTec GmbH | Verfahren zur herstellung von rekombinanten proteinen in mikroorganismen |
| CN1668312A (zh) * | 2002-05-13 | 2005-09-14 | 洛杉矶儿童医院 | 疤痕疙瘩和其它的皮肤或内部的创伤或损伤中异常疤痕形成的处理和抑制 |
| JP2006514640A (ja) * | 2002-12-10 | 2006-05-11 | ワイス | プラスミノゲンアクティベータインヒビターのインヒビターとしての置換３−アルキル及び３−アリールアルキル１ｈ−イル酢酸誘導体 |
| US20050250694A1 (en) * | 2003-10-10 | 2005-11-10 | Ma Jian-Xing | Compounds useful in inhibiting vascular leakage, inflammation and fibrosis and methods of making and using same |
| AU2005277137A1 (en) * | 2004-08-23 | 2006-03-02 | Wyeth | Pyrrolo-naphthyl acids as PAI-1 inhibitors |
| US8741260B2 (en) | 2005-10-07 | 2014-06-03 | Armagen Technologies, Inc. | Fusion proteins for delivery of GDNF to the CNS |
| CN101563100B (zh) | 2006-08-28 | 2013-08-07 | 李季男 | 用于预防和治疗牙周病、改善牙周创伤愈合以及促进口腔健康的新药物靶标 |
| EP2435826B1 (en) * | 2009-05-26 | 2014-05-21 | Universidad De Salamanca | Urinary gm2 activator protein as a marker of acute renal failure or the risk of developing acute renal failure |
| JP5819293B2 (ja) * | 2009-07-10 | 2015-11-24 | スロンボジェニックス・ナムローゼ・フェンノートシャップＴｈｒｏｍｂｏＧｅｎｉｃｓ ＮＶ | プラスミノーゲンおよびプラスミンの変異体 |
| CN102121023B (zh) * | 2010-12-22 | 2012-07-04 | 中山大学 | 突变型人纤溶酶原kringle5及其制备方法及应用 |
| CN103384722B (zh) * | 2011-01-05 | 2016-11-16 | 斯路姆基因公司 | 纤溶酶原和纤溶酶变体 |
| CN102154253A (zh) | 2011-01-06 | 2011-08-17 | 郑州大学 | 具有抑制血小板凝集功能的微小纤溶酶原突变体及其制备方法和用途 |
| JP6157481B2 (ja) | 2011-09-29 | 2017-07-05 | メイヨ ファンデーション フォア メディカル エディケイション アンド リサーチ | 芳香族陽イオン性ペプチドおよびその使用方法 |
| UA118267C2 (uk) | 2013-08-13 | 2018-12-26 | Санофі | Антитіло до інгібітора активатора плазміногену 1 (раі-1) та його застосування |
| BR112016019332A2 (pt) * | 2014-02-21 | 2017-10-10 | Astellas Pharma Inc | anticorpo pai-1 anti-humano inovador |
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| US20190343930A1 (en) | 2019-11-14 |
| TW201822793A (zh) | 2018-07-01 |
| JP7242057B2 (ja) | 2023-03-20 |
| CN110366427A (zh) | 2019-10-22 |
| TWI661838B (zh) | 2019-06-11 |
| WO2018107699A1 (zh) | 2018-06-21 |
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| JP7182793B2 (ja) | 2022-12-05 |
| EP3556386A4 (en) | 2020-07-08 |
| TW201822797A (zh) | 2018-07-01 |
| TW202123962A (zh) | 2021-07-01 |
| CN110167582A (zh) | 2019-08-23 |
| EP3556386A1 (en) | 2019-10-23 |
| JP2020502134A (ja) | 2020-01-23 |
| EP3556388A4 (en) | 2020-07-08 |
| US20190328848A1 (en) | 2019-10-31 |
| EP3556388A1 (en) | 2019-10-23 |
| TWI642441B (zh) | 2018-12-01 |
| WO2018107695A1 (zh) | 2018-06-21 |
| JP2020502135A (ja) | 2020-01-23 |
| CA3047170A1 (en) | 2018-06-21 |
| WO2018107700A1 (zh) | 2018-06-21 |
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