JP2020502056A5 - - Google Patents

Info

Publication number

JP2020502056A5

JP2020502056A5 JP2019524445A JP2019524445A JP2020502056A5 JP 2020502056 A5 JP2020502056 A5 JP 2020502056A5 JP 2019524445 A JP2019524445 A JP 2019524445A JP 2019524445 A JP2019524445 A JP 2019524445A JP 2020502056 A5 JP2020502056 A5 JP 2020502056A5

Authority

JP

Japan

Prior art keywords

polypeptide

preparation

preparation according

rps2

seq

Prior art date

2017-11-13

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims description 10
• 206010020772 Hypertension Diseases 0.000 claims description 6
• 239000000203 mixture Substances 0.000 claims description 6
• 208000001072 type 2 diabetes mellitus Diseases 0.000 claims description 4
• 208000035150 Hypercholesterolemia Diseases 0.000 claims description 3
• 239000003814 drug Substances 0.000 claims description 3
• 229940079593 drug Drugs 0.000 claims description 3
• 201000001421 hyperglycemia Diseases 0.000 claims description 3
• 230000036772 blood pressure Effects 0.000 claims description 2
• 239000003795 chemical substances by application Substances 0.000 claims description 2
• 108090000765 processed proteins & peptides Proteins 0.000 claims 18
• 229920001184 polypeptide Polymers 0.000 claims 16
• 102000004196 processed proteins & peptides Human genes 0.000 claims 16
• 102000004339 Ribosomal protein S2 Human genes 0.000 claims 4
• 108090000904 Ribosomal protein S2 Proteins 0.000 claims 4
• 125000003275 alpha amino acid group Chemical group 0.000 claims 4
• 238000009472 formulation Methods 0.000 claims 4
• 239000012634 fragment Substances 0.000 claims 4
• 239000006172 buffering agent Substances 0.000 claims 3
• 239000000825 pharmaceutical preparation Substances 0.000 claims 3
• 208000001145 Metabolic Syndrome Diseases 0.000 claims 2
• 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 2
• 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 claims 2
• 238000000034 method Methods 0.000 claims 2
• 102100037563 40S ribosomal protein S2 Human genes 0.000 claims 1
• 101710107640 40S ribosomal protein S2 Proteins 0.000 claims 1
• 102400000321 Glucagon Human genes 0.000 claims 1
• 108060003199 Glucagon Proteins 0.000 claims 1
• 206010022489 Insulin Resistance Diseases 0.000 claims 1
• 239000003085 diluting agent Substances 0.000 claims 1
• LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical group P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 claims 1
• 201000010099 disease Diseases 0.000 claims 1
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• MASNOZXLGMXCHN-ZLPAWPGGSA-N glucagon Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 MASNOZXLGMXCHN-ZLPAWPGGSA-N 0.000 claims 1
• 229960004666 glucagon Drugs 0.000 claims 1
• 230000009229 glucose formation Effects 0.000 claims 1
• 230000002440 hepatic effect Effects 0.000 claims 1
• 239000008183 oral pharmaceutical preparation Substances 0.000 claims 1
• 239000000546 pharmaceutical excipient Substances 0.000 claims 1
• 239000002953 phosphate buffered saline Substances 0.000 claims 1
• 235000012000 cholesterol Nutrition 0.000 description 4
• 206010012601 diabetes mellitus Diseases 0.000 description 4
• 230000000694 effects Effects 0.000 description 2
• WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
• 239000008280 blood Substances 0.000 description 1
• 210000004369 blood Anatomy 0.000 description 1
• 239000008103 glucose Substances 0.000 description 1
• 208000010125 myocardial infarction Diseases 0.000 description 1
• 230000001225 therapeutic effect Effects 0.000 description 1