JP2020501512A - キメラ抗原受容体およびその組成物ならびにそれらの使用の方法 - Google Patents

キメラ抗原受容体およびその組成物ならびにそれらの使用の方法 Download PDF

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JP2020501512A
JP2020501512A JP2019515810A JP2019515810A JP2020501512A JP 2020501512 A JP2020501512 A JP 2020501512A JP 2019515810 A JP2019515810 A JP 2019515810A JP 2019515810 A JP2019515810 A JP 2019515810A JP 2020501512 A JP2020501512 A JP 2020501512A
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car
acid sequence
hla
antibody
amino acid
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JP2020501512A5 (enExample
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アラン エル． エプスタイン，
アラン エル． エプスタイン，
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ユニバーシティ オブ サザン カリフォルニア
ユニバーシティ オブ サザン カリフォルニア
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2869—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against hormone receptors
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • C07K16/2833—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules
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    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3076—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties
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JP2019515810A 2016-09-23 2017-09-22 キメラ抗原受容体およびその組成物ならびにそれらの使用の方法 Pending JP2020501512A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662399244P 2016-09-23 2016-09-23
US62/399,244 2016-09-23
PCT/US2017/052974 WO2018057904A1 (en) 2016-09-23 2017-09-22 Chimeric antigen receptors and compositions and methods of use thereof

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JP2020501512A true JP2020501512A (ja) 2020-01-23
JP2020501512A5 JP2020501512A5 (enExample) 2020-11-12

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US (1) US20200016201A1 (enExample)
EP (1) EP3515493A4 (enExample)
JP (1) JP2020501512A (enExample)
CN (1) CN110225766A (enExample)
AU (1) AU2017330423A1 (enExample)
CA (1) CA3037528A1 (enExample)
IL (1) IL265438B2 (enExample)
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WO2025220659A1 (ja) * 2024-04-16 2025-10-23 国立大学法人大阪大学 Ｎｋ前駆細胞及びそれを用いたｎｋ細胞の製造方法

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EP3568469A4 (en) * 2017-02-21 2020-11-11 Eutilex Co., Ltd. COMPOSITIONS OF CAR-T CELLS DIRECTED AGAINST HLA-DR AND THEIR MANUFACTURING AND USE PROCEDURES
CN109111525B (zh) * 2018-05-24 2021-10-29 卢英 一种hla-g嵌合抗原受体、编码序列和表达载体以及应用
JP7539161B2 (ja) 2018-08-10 2024-08-23 ユーティレックス カンパニー リミテッド Ｈｌａ－ｄｒに結合するキメラ抗原受容体およびｃａｒ－ｔ細胞
BR112021003757A2 (pt) 2018-08-31 2021-05-25 Invectys SA receptores de antígenos quiméricos contra múltiplas isoformas de hla-g
CN110903399B (zh) * 2018-09-17 2022-02-01 台湾中国医药大学附设医院 嵌合抗原受体、其核酸、表达质体、细胞、用途及组合物
TWI694083B (zh) * 2018-09-17 2020-05-21 中國醫藥大學附設醫院 嵌合抗原受體、核酸、嵌合抗原受體表達質體、表達嵌合抗原受體細胞、其用途以及用於治療癌症之醫藥組合物
CN111718957A (zh) * 2019-03-22 2020-09-29 南京安锐生物科技有限公司 一种嵌合抗原受体重组腺相关病毒颗粒及其应用
TWI717880B (zh) * 2019-10-24 2021-02-01 中國醫藥大學附設醫院 Hla-g特異性嵌合抗原受體、核酸、hla-g特異性嵌合抗原受體表達質體、表達hla-g特異性嵌合抗原受體細胞、其用途以及用於治療癌症之醫藥組合物

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