|
US4897355A
(en)
|
1985-01-07 |
1990-01-30 |
Syntex (U.S.A.) Inc. |
N[ω,(ω-1)-dialkyloxy]- and N-[ω,(ω-1)-dialkenyloxy]-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor
|
|
US4946787A
(en)
|
1985-01-07 |
1990-08-07 |
Syntex (U.S.A.) Inc. |
N-(ω,(ω-1)-dialkyloxy)- and N-(ω,(ω-1)-dialkenyloxy)-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor
|
|
US5049386A
(en)
|
1985-01-07 |
1991-09-17 |
Syntex (U.S.A.) Inc. |
N-ω,(ω-1)-dialkyloxy)- and N-(ω,(ω-1)-dialkenyloxy)Alk-1-YL-N,N,N-tetrasubstituted ammonium lipids and uses therefor
|
|
US6140466A
(en)
|
1994-01-18 |
2000-10-31 |
The Scripps Research Institute |
Zinc finger protein derivatives and methods therefor
|
|
DE69534629D1
(de)
|
1994-01-18 |
2005-12-29 |
Scripps Research Inst |
Derivate von zinkfingerproteinen und methoden
|
|
JP4285766B2
(ja)
|
1994-03-23 |
2009-06-24 |
オハイオ ユニバーシティ |
緻密にした核酸および細胞へのデリバリ
|
|
ATE524545T1
(de)
|
1994-08-20 |
2011-09-15 |
Gendaq Ltd |
Verbesserungen bei oder im zusammenhang mit bindeproteinen zur erkennung von dna
|
|
GB9824544D0
(en)
|
1998-11-09 |
1999-01-06 |
Medical Res Council |
Screening system
|
|
US5789538A
(en)
|
1995-02-03 |
1998-08-04 |
Massachusetts Institute Of Technology |
Zinc finger proteins with high affinity new DNA binding specificities
|
|
US5925523A
(en)
|
1996-08-23 |
1999-07-20 |
President & Fellows Of Harvard College |
Intraction trap assay, reagents and uses thereof
|
|
GB9710807D0
(en)
|
1997-05-23 |
1997-07-23 |
Medical Res Council |
Nucleic acid binding proteins
|
|
GB9710809D0
(en)
|
1997-05-23 |
1997-07-23 |
Medical Res Council |
Nucleic acid binding proteins
|
|
DE69942334D1
(de)
|
1998-03-02 |
2010-06-17 |
Massachusetts Inst Technology |
Poly-zinkfinger-proteine mit verbesserten linkern
|
|
DE69929600T2
(de)
|
1998-05-27 |
2006-09-07 |
Avigen Inc., Alameda |
Konvektion-erhöhte verabreichung aadc-kodierende aav vektoren
|
|
US6140081A
(en)
|
1998-10-16 |
2000-10-31 |
The Scripps Research Institute |
Zinc finger binding domains for GNN
|
|
US6534261B1
(en)
|
1999-01-12 |
2003-03-18 |
Sangamo Biosciences, Inc. |
Regulation of endogenous gene expression in cells using zinc finger proteins
|
|
US6453242B1
(en)
|
1999-01-12 |
2002-09-17 |
Sangamo Biosciences, Inc. |
Selection of sites for targeting by zinc finger proteins and methods of designing zinc finger proteins to bind to preselected sites
|
|
US6599692B1
(en)
|
1999-09-14 |
2003-07-29 |
Sangamo Bioscience, Inc. |
Functional genomics using zinc finger proteins
|
|
US7013219B2
(en)
|
1999-01-12 |
2006-03-14 |
Sangamo Biosciences, Inc. |
Regulation of endogenous gene expression in cells using zinc finger proteins
|
|
CA2394850C
(en)
|
1999-12-06 |
2012-02-07 |
Sangamo Biosciences, Inc. |
Methods of using randomized libraries of zinc finger proteins for the identification of gene function
|
|
KR20020086508A
(ko)
|
2000-02-08 |
2002-11-18 |
상가모 바이오사이언스 인코포레이티드 |
약물 발견용 세포
|
|
US20020061512A1
(en)
|
2000-02-18 |
2002-05-23 |
Kim Jin-Soo |
Zinc finger domains and methods of identifying same
|
|
US20030044787A1
(en)
|
2000-05-16 |
2003-03-06 |
Joung J. Keith |
Methods and compositions for interaction trap assays
|
|
JP2002060786A
(ja)
|
2000-08-23 |
2002-02-26 |
Kao Corp |
硬質表面用殺菌防汚剤
|
|
AU2002228841C1
(en)
|
2000-12-07 |
2006-11-23 |
Sangamo Biosciences, Inc |
Regulation of angiogenesis with zinc finger proteins
|
|
GB0108491D0
(en)
|
2001-04-04 |
2001-05-23 |
Gendaq Ltd |
Engineering zinc fingers
|
|
US7182944B2
(en)
|
2001-04-25 |
2007-02-27 |
The United States Of America As Represented By The Department Of Health And Human Services |
Methods of increasing distribution of nucleic acids
|
|
US20040224385A1
(en)
|
2001-08-20 |
2004-11-11 |
Barbas Carlos F |
Zinc finger binding domains for cnn
|
|
AU2002359284A1
(en)
|
2001-12-17 |
2003-06-30 |
The Trustees Of The University Of Pennsylvania |
Adeno-associated virus (aav) serotype 9 sequences, vectors containing same, and uses therefor
|
|
US7074596B2
(en)
|
2002-03-25 |
2006-07-11 |
Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College |
Synthesis and use of anti-reverse mRNA cap analogues
|
|
EP2508608A1
(en)
*
|
2003-06-09 |
2012-10-10 |
Alnylam Pharmaceuticals Inc. |
Method of treating neurodegenerative disease
|
|
US7888121B2
(en)
|
2003-08-08 |
2011-02-15 |
Sangamo Biosciences, Inc. |
Methods and compositions for targeted cleavage and recombination
|
|
US8409861B2
(en)
|
2003-08-08 |
2013-04-02 |
Sangamo Biosciences, Inc. |
Targeted deletion of cellular DNA sequences
|
|
JPWO2005030959A1
(ja)
*
|
2003-09-25 |
2006-12-07 |
千葉県 |
神経芽細胞腫予後診断のためのマイクロアレイと神経芽細胞腫予後診断方法
|
|
US20060239966A1
(en)
|
2003-10-20 |
2006-10-26 |
Tornoee Jens |
In vivo gene therapy of parkinson's disease
|
|
PT1807009E
(pt)
|
2004-10-05 |
2015-02-25 |
Univ California |
Cânula escalonada
|
|
EP1877583A2
(en)
|
2005-05-05 |
2008-01-16 |
Arizona Board of Regents on behalf of the Unversity of Arizona |
Sequence enabled reassembly (seer) - a novel method for visualizing specific dna sequences
|
|
AU2006283189B2
(en)
|
2005-08-23 |
2013-01-31 |
The Regents Of The University Of California |
Reflux resistant cannula and system for chronic delivery of therapeutic agents using convection-enhanced delivery
|
|
WO2007127803A2
(en)
|
2006-04-25 |
2007-11-08 |
The Regents Of The University Of California |
Administration of growth factors for the treatment of cns disorders
|
|
JP5266210B2
(ja)
|
2006-05-25 |
2013-08-21 |
サンガモ バイオサイエンシズ インコーポレイテッド |
改変開裂ハーフドメイン
|
|
US7837668B2
(en)
|
2006-10-10 |
2010-11-23 |
Ceregene, Inc. |
Needle assembly for use in delivering precise dosages of proteinaceous pharmaceutical compositions and methods for use of same
|
|
WO2008157688A2
(en)
|
2007-06-19 |
2008-12-24 |
Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College |
Synthesis and use of anti-reverse phosphorothioate analogs of the messenger rna cap
|
|
CA2700231C
(en)
|
2007-09-27 |
2018-09-18 |
Sangamo Biosciences, Inc. |
Rapid in vivo identification of biologically active nucleases
|
|
KR101802393B1
(ko)
|
2008-06-10 |
2017-11-28 |
상가모 테라퓨틱스, 인코포레이티드 |
Ｂａｘ- 및 ｂａｋ-결함 세포주들의 제조 방법 및 조성물
|
|
SG191561A1
(en)
|
2008-08-22 |
2013-07-31 |
Sangamo Biosciences Inc |
Methods and compositions for targeted single-stranded cleavage and targeted integration
|
|
US20110016539A1
(en)
|
2008-12-04 |
2011-01-20 |
Sigma-Aldrich Co. |
Genome editing of neurotransmission-related genes in animals
|
|
US20110023153A1
(en)
*
|
2008-12-04 |
2011-01-27 |
Sigma-Aldrich Co. |
Genomic editing of genes involved in alzheimer's disease
|
|
KR20100080068A
(ko)
*
|
2008-12-31 |
2010-07-08 |
주식회사 툴젠 |
신규한 징크 핑거 뉴클레아제 및 이의 용도
|
|
EP2206723A1
(en)
|
2009-01-12 |
2010-07-14 |
Bonas, Ulla |
Modular DNA-binding domains
|
|
UA107571C2
(xx)
|
2009-04-03 |
2015-01-26 |
|
Фармацевтична композиція
|
|
JP5866283B2
(ja)
|
2009-07-28 |
2016-02-17 |
サンガモ バイオサイエンシーズ， インコーポレイテッド |
トリヌクレオチド反復疾患を治療するための方法および組成物
|
|
BR112012002291A2
(pt)
|
2009-07-31 |
2016-11-29 |
Ethris Gmbh |
"polirribonucleotídeo com uma sequência que codifica uma proteína ou fragmento de proteína, implante, e, processo para a seleção de sequências de nucleotídeos"
|
|
US8956828B2
(en)
|
2009-11-10 |
2015-02-17 |
Sangamo Biosciences, Inc. |
Targeted disruption of T cell receptor genes using engineered zinc finger protein nucleases
|
|
US20110135613A1
(en)
*
|
2009-12-03 |
2011-06-09 |
The J. David Gladstone Institutes |
Methods for treating apolipoprotein e4-associated disorders
|
|
EP3594333B1
(en)
|
2010-02-08 |
2023-11-01 |
Sangamo Therapeutics, Inc. |
Engineered cleavage half-domains
|
|
PT2566972T
(pt)
|
2010-05-03 |
2020-03-02 |
Sangamo Biosciences Inc |
Composições para a ligação de módulos de dedo de zinco
|
|
JP6208580B2
(ja)
|
2010-05-17 |
2017-10-04 |
サンガモ セラピューティクス， インコーポレイテッド |
新規のｄｎａ結合タンパク質及びその使用
|
|
US9322023B2
(en)
|
2011-10-06 |
2016-04-26 |
Cornell University |
Constructs and methods for the assembly of biological pathways
|
|
AU2012340213B2
(en)
|
2011-11-16 |
2017-12-07 |
Sangamo Therapeutics, Inc. |
Modified DNA-binding proteins and uses thereof
|
|
CN108285491B
(zh)
|
2012-02-29 |
2021-08-10 |
桑格摩生物科学股份有限公司 |
治疗亨廷顿氏病的方法和组合物
|
|
EP2931899A1
(en)
|
2012-12-12 |
2015-10-21 |
The Broad Institute, Inc. |
Functional genomics using crispr-cas systems, compositions, methods, knock out libraries and applications thereof
|
|
ES2807379T3
(es)
*
|
2013-03-14 |
2021-02-22 |
Ionis Pharmaceuticals Inc |
Composiciones y métodos para regular la expresión de Tau
|
|
CN105683376A
(zh)
|
2013-05-15 |
2016-06-15 |
桑格摩生物科学股份有限公司 |
用于治疗遗传病状的方法和组合物
|
|
EP3004370B1
(en)
|
2013-06-05 |
2024-08-21 |
Duke University |
Rna-guided gene editing and gene regulation
|
|
TWI772856B
(zh)
|
2013-07-19 |
2022-08-01 |
美商百健Ｍａ公司 |
用於調節τ蛋白表現之組合物
|
|
US9359599B2
(en)
*
|
2013-08-22 |
2016-06-07 |
President And Fellows Of Harvard College |
Engineered transcription activator-like effector (TALE) domains and uses thereof
|
|
US9585971B2
(en)
|
2013-09-13 |
2017-03-07 |
California Institute Of Technology |
Recombinant AAV capsid protein
|
|
JP2017505756A
(ja)
*
|
2013-12-13 |
2017-02-23 |
ザ ジェネラル ホスピタル コーポレイション |
可溶性高分子量（ｈｍｗ）タウ種およびその用途
|
|
CN106459894B
(zh)
|
2014-03-18 |
2020-02-18 |
桑格摩生物科学股份有限公司 |
用于调控锌指蛋白表达的方法和组合物
|
|
WO2015153760A2
(en)
*
|
2014-04-01 |
2015-10-08 |
Sangamo Biosciences, Inc. |
Methods and compositions for prevention or treatment of a nervous system disorder
|
|
RU2691102C2
(ru)
|
2014-05-08 |
2019-06-11 |
Сангамо Байосайенсиз, Инк. |
Способы и композиции для лечения болезни хантингтона
|
|
EP3152319A4
(en)
*
|
2014-06-05 |
2017-12-27 |
Sangamo BioSciences, Inc. |
Methods and compositions for nuclease design
|
|
AU2016215155A1
(en)
*
|
2015-02-04 |
2017-08-17 |
F. Hoffmann-La Roche Ag |
Tau antisense oligomers and uses thereof
|
|
US20170035860A1
(en)
*
|
2015-04-02 |
2017-02-09 |
Alexander C. Flynn |
Compositions and methods for treatment of neurogenerative diseases
|
|
WO2017011556A1
(en)
|
2015-07-13 |
2017-01-19 |
The General Hospital Corporation |
Rare phosphorylated high molecular weight (hmw) tau species that are involved in neuronal uptake and propagation and applications thereof
|
|
CA3002524A1
(en)
|
2015-10-28 |
2017-05-04 |
Sangamo Therapeutics, Inc. |
Liver-specific constructs, factor viii expression cassettes and methods of use thereof
|
|
WO2017197141A2
(en)
|
2016-05-13 |
2017-11-16 |
Sangamo Therapeutics, Inc. |
Targeted treatment of androgenic alopecia
|
|
SG10201913948PA
(en)
|
2016-08-24 |
2020-03-30 |
Sangamo Therapeutics Inc |
Engineered target specific nucleases
|
|
LT3504229T
(lt)
*
|
2016-08-24 |
2021-12-10 |
Sangamo Therapeutics, Inc. |
Genų raiškos reguliavimas, panaudojant rekombinantines nukleazes
|
|
WO2018039471A2
(en)
|
2016-08-25 |
2018-03-01 |
Trustees Of Boston University |
Synthetic transcriptional and epigenetic regulators based on engineered, orthogonal zinc finger proteins
|
|
WO2018049009A2
(en)
|
2016-09-07 |
2018-03-15 |
Sangamo Therapeutics, Inc. |
Modulation of liver genes
|
|
US11371023B2
(en)
|
2016-11-22 |
2022-06-28 |
Wisconsin Alumni Research Foundation |
Artificial transcription factors and uses thereof
|
|
KR20210070344A
(ko)
|
2018-10-02 |
2021-06-14 |
상가모 테라퓨틱스, 인코포레이티드 |
타우 단백질의 조정을 위한 방법 및 조성물
|
|
CA3115158A1
(en)
|
2018-10-02 |
2020-04-09 |
Sangamo Therapeutics, Inc. |
Engineered genetic modulators
|
|
AU2021209699A1
(en)
|
2020-01-22 |
2022-07-21 |
Sangamo Therapeutics, Inc. |
Zinc finger protein transcription factors for repressing tau expression
|