JP2020203861A - 外用組成物 - Google Patents
外用組成物 Download PDFInfo
- Publication number
- JP2020203861A JP2020203861A JP2019113064A JP2019113064A JP2020203861A JP 2020203861 A JP2020203861 A JP 2020203861A JP 2019113064 A JP2019113064 A JP 2019113064A JP 2019113064 A JP2019113064 A JP 2019113064A JP 2020203861 A JP2020203861 A JP 2020203861A
- Authority
- JP
- Japan
- Prior art keywords
- ceramide
- external composition
- skin
- barrier function
- present
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 67
- 229940106189 ceramide Drugs 0.000 claims abstract description 35
- PHIQHXFUZVPYII-ZCFIWIBFSA-N (R)-carnitine Chemical compound C[N+](C)(C)C[C@H](O)CC([O-])=O PHIQHXFUZVPYII-ZCFIWIBFSA-N 0.000 claims abstract description 31
- YDNKGFDKKRUKPY-JHOUSYSJSA-N C16 ceramide Natural products CCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@H](O)C=CCCCCCCCCCCCCC YDNKGFDKKRUKPY-JHOUSYSJSA-N 0.000 claims abstract description 22
- CRJGESKKUOMBCT-VQTJNVASSA-N N-acetylsphinganine Chemical compound CCCCCCCCCCCCCCC[C@@H](O)[C@H](CO)NC(C)=O CRJGESKKUOMBCT-VQTJNVASSA-N 0.000 claims abstract description 22
- ZVEQCJWYRWKARO-UHFFFAOYSA-N ceramide Natural products CCCCCCCCCCCCCCC(O)C(=O)NC(CO)C(O)C=CCCC=C(C)CCCCCCCCC ZVEQCJWYRWKARO-UHFFFAOYSA-N 0.000 claims abstract description 22
- VVGIYYKRAMHVLU-UHFFFAOYSA-N newbouldiamide Natural products CCCCCCCCCCCCCCCCCCCC(O)C(O)C(O)C(CO)NC(=O)CCCCCCCCCCCCCCCCC VVGIYYKRAMHVLU-UHFFFAOYSA-N 0.000 claims abstract description 22
- 229960004203 carnitine Drugs 0.000 claims abstract description 13
- 150000003839 salts Chemical class 0.000 claims abstract description 11
- -1 ceramide 2 Chemical compound 0.000 claims description 29
- 239000004094 surface-active agent Substances 0.000 claims description 15
- 150000001783 ceramides Chemical class 0.000 claims description 13
- ATGQXSBKTQANOH-UWVGARPKSA-N N-oleoylphytosphingosine Chemical compound CCCCCCCCCCCCCC[C@@H](O)[C@@H](O)[C@H](CO)NC(=O)CCCCCCC\C=C/CCCCCCCC ATGQXSBKTQANOH-UWVGARPKSA-N 0.000 claims description 11
- MIUIRGGKIICMBP-NFOZDHADSA-N [27-oxo-27-[[(2s,3s,4r)-1,3,4-trihydroxyoctadecan-2-yl]amino]heptacosyl] octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCCCCCCCCCCCCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@H](O)[C@H](O)CCCCCCCCCCCCCC MIUIRGGKIICMBP-NFOZDHADSA-N 0.000 claims description 11
- 229940048864 ceramide 1 Drugs 0.000 claims description 11
- 229940099417 ceramide 2 Drugs 0.000 claims description 11
- 229940044176 ceramide 3 Drugs 0.000 claims description 11
- 230000008591 skin barrier function Effects 0.000 abstract description 35
- 230000035800 maturation Effects 0.000 abstract description 18
- 235000014113 dietary fatty acids Nutrition 0.000 description 16
- 229930195729 fatty acid Natural products 0.000 description 16
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- 230000000694 effects Effects 0.000 description 12
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- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 8
- 239000004615 ingredient Substances 0.000 description 8
- 230000001737 promoting effect Effects 0.000 description 8
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 7
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- KWIUHFFTVRNATP-UHFFFAOYSA-N glycine betaine Chemical compound C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 description 6
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- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 4
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- 150000002632 lipids Chemical class 0.000 description 3
- WWUZIQQURGPMPG-UHFFFAOYSA-N (-)-D-erythro-Sphingosine Natural products CCCCCCCCCCCCCC=CC(O)C(N)CO WWUZIQQURGPMPG-UHFFFAOYSA-N 0.000 description 2
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical class CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 2
- AERBNCYCJBRYDG-UHFFFAOYSA-N D-ribo-phytosphingosine Natural products CCCCCCCCCCCCCCC(O)C(O)C(N)CO AERBNCYCJBRYDG-UHFFFAOYSA-N 0.000 description 2
- 206010012438 Dermatitis atopic Diseases 0.000 description 2
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- 231100000960 LabCyte EPI-MODEL 24 Toxicity 0.000 description 2
- 206010048222 Xerosis Diseases 0.000 description 2
- 150000005215 alkyl ethers Chemical class 0.000 description 2
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- PHIQHXFUZVPYII-UHFFFAOYSA-N carnitine Chemical compound C[N+](C)(C)CC(O)CC([O-])=O PHIQHXFUZVPYII-UHFFFAOYSA-N 0.000 description 2
- 239000003093 cationic surfactant Substances 0.000 description 2
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- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
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- 125000005313 fatty acid group Chemical group 0.000 description 2
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- AERBNCYCJBRYDG-KSZLIROESA-N phytosphingosine Chemical compound CCCCCCCCCCCCCC[C@@H](O)[C@@H](O)[C@@H](N)CO AERBNCYCJBRYDG-KSZLIROESA-N 0.000 description 2
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- WWUZIQQURGPMPG-KRWOKUGFSA-N sphingosine Chemical compound CCCCCCCCCCCCC\C=C\[C@@H](O)[C@@H](N)CO WWUZIQQURGPMPG-KRWOKUGFSA-N 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 2
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- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 1
- GBGUSZWBYGKEBA-VBYMIUBRSA-N (2R)-2-hydroxy-N-[(E,2S,3R,6R)-1,3,6-trihydroxyoctadec-4-en-2-yl]tetracosanamide Chemical compound CCCCCCCCCCCCCCCCCCCCCC[C@@H](O)C(=O)N[C@@H](CO)[C@H](O)\C=C\[C@H](O)CCCCCCCCCCCC GBGUSZWBYGKEBA-VBYMIUBRSA-N 0.000 description 1
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 description 1
- PHIQHXFUZVPYII-LURJTMIESA-N (S)-carnitine Chemical compound C[N+](C)(C)C[C@@H](O)CC([O-])=O PHIQHXFUZVPYII-LURJTMIESA-N 0.000 description 1
- LDVVTQMJQSCDMK-UHFFFAOYSA-N 1,3-dihydroxypropan-2-yl formate Chemical compound OCC(CO)OC=O LDVVTQMJQSCDMK-UHFFFAOYSA-N 0.000 description 1
- XPALGXXLALUMLE-UHFFFAOYSA-N 2-(dimethylamino)tetradecanoic acid Chemical compound CCCCCCCCCCCCC(N(C)C)C(O)=O XPALGXXLALUMLE-UHFFFAOYSA-N 0.000 description 1
- WBIQQQGBSDOWNP-UHFFFAOYSA-N 2-dodecylbenzenesulfonic acid Chemical compound CCCCCCCCCCCCC1=CC=CC=C1S(O)(=O)=O WBIQQQGBSDOWNP-UHFFFAOYSA-N 0.000 description 1
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 description 1
- JOANURINNGZFDA-UHFFFAOYSA-N 3-hydroxy-3-[(trimethylazaniumyl)methyl]hexanoate Chemical compound C(CC)C(O)(C[N+](C)(C)C)CC([O-])=O JOANURINNGZFDA-UHFFFAOYSA-N 0.000 description 1
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- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
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- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
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- 239000003589 local anesthetic agent Substances 0.000 description 1
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- 108010079309 loricrin Proteins 0.000 description 1
- 159000000003 magnesium salts Chemical class 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 229930182817 methionine Natural products 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000002480 mineral oil Substances 0.000 description 1
- 239000011259 mixed solution Substances 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 230000037311 normal skin Effects 0.000 description 1
- HLERILKGMXJNBU-UHFFFAOYSA-N norvaline betaine Chemical compound CCCC(C([O-])=O)[N+](C)(C)C HLERILKGMXJNBU-UHFFFAOYSA-N 0.000 description 1
- 235000019198 oils Nutrition 0.000 description 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
- 239000006072 paste Substances 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920002503 polyoxyethylene-polyoxypropylene Polymers 0.000 description 1
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 150000004040 pyrrolidinones Chemical class 0.000 description 1
- 229940071089 sarcosinate Drugs 0.000 description 1
- 108700004121 sarkosyl Proteins 0.000 description 1
- 229920002545 silicone oil Polymers 0.000 description 1
- 229940075560 sodium lauryl sulfoacetate Drugs 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 229950005425 sodium myristyl sulfate Drugs 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- ZUFONQSOSYEWCN-UHFFFAOYSA-M sodium;2-(methylamino)acetate Chemical compound [Na+].CNCC([O-])=O ZUFONQSOSYEWCN-UHFFFAOYSA-M 0.000 description 1
- UAJTZZNRJCKXJN-UHFFFAOYSA-M sodium;2-dodecoxy-2-oxoethanesulfonate Chemical compound [Na+].CCCCCCCCCCCCOC(=O)CS([O-])(=O)=O UAJTZZNRJCKXJN-UHFFFAOYSA-M 0.000 description 1
- 230000007928 solubilization Effects 0.000 description 1
- 238000005063 solubilization Methods 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- SFVFIFLLYFPGHH-UHFFFAOYSA-M stearalkonium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 SFVFIFLLYFPGHH-UHFFFAOYSA-M 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 210000000498 stratum granulosum Anatomy 0.000 description 1
- 210000003902 stratum granulosum cell Anatomy 0.000 description 1
- 210000000437 stratum spinosum Anatomy 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 1
- 230000001502 supplementing effect Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
- 229960003080 taurine Drugs 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 102000003601 transglutaminase Human genes 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
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- 239000004711 α-olefin Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/68—Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Cosmetics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Description
項1. (A)セラミド、並びに(B)カルニチン、その塩、及びそれらの誘導体からなる群より選択される少なくとも1種を含有する、外用組成物。
項2. (A)成分として、2種以上のセラミドを含む、項1に記載の外用組成物。
項3. (A)成分が、セラミド1、セラミド2、及びセラミド3からなる群より選択される2種以上である、項1又は2に記載の外用組成物。
項4. (B)成分が、L−カルニチンである、項1〜3のいずれかに記載の外用組成物。
項5. 更に界面活性剤を含む、項1〜4のいずれかに記載の外用組成物。
本発明の外用組成物はセラミドを含有する。セラミドとは、スフィンゴシン又はフィトスフィンゴシンのアミノ基に脂肪酸がアミド結合により結合している化合物である。
本発明の外用組成物は、前記セラミドに加えて、カルニチン、その塩、及び/又はそれらの誘導体を含有する。このようにセラミドとカルニチン等とを併用することにより、CEの成熟を効果的に促進でき、優れた皮膚バリア機能の改善効果を奏することが可能になる。
本発明の外用組成物は、界面活性剤を含んでいてもよい。従来、外用組成物には、含有成分の乳化や可溶化のために界面活性剤が配合されることが多いが、外用組成物に配合された界面活性剤は、CEの成熟を遅延させたり、皮膚バリア機能を低下させたりする要因になっている。これに対して、本発明の外用組成物では、界面活性剤を含んでいても、前記(A)成分及び(B)成分による作用が、界面活性剤の前記欠点を凌駕して、優れた皮膚バリア機能の改善効果を奏することができる。
本発明の外用組成物は、前述する成分の他に、薬学的又は香粧学的な生理機能を発揮できる薬効成分が、必要に応じて、含まれていてもよい。このような薬効成分としては、例えば、ステロイド剤、抗ヒスタミン剤、局所麻酔剤、抗炎症剤、殺菌剤、抗菌剤、鎮痒剤、皮膚保護剤、血行促進成分、ビタミン類、ムコ多糖類等が挙げられる。これらの薬効成分は、1種単独で使用してもよく、また2種以上を組み合わせて使用してもよい。また、本発明の外用組成物において、これらの薬効成分を含有させる場合、その濃度については、使用する薬効成分の種類、期待する効果等に応じて適宜設定すればよい。
本発明の外用組成物の剤型については、経皮適用可能であることを限度として特に制限されず、液状、固形状、半固形状(クリーム状、ゲル状、軟膏状、ペースト状)等のいずれであってもよい。また、本発明の外用組成物は、水中油型乳化製剤、油中水型乳化製剤等の乳化製剤であってもよく、また可溶化型製剤、水性軟膏等の非乳化製剤であってもよい。
本発明の外用組成物は、皮膚バリア機能を改善できるので、低下した皮膚バリア機能の向上、健全な状態にある皮膚バリア機能の維持、皮膚バリア機能の低下抑制等の皮膚バリア機能の改善用途に使用される。
ヒト表皮モデルを使用して、TEWLの変化を測定することにより、皮膚バリア機能を評価した。なお、ヒト表皮モデルは、「LabCyte EPI-MODEL24 6D」(株式会社ジャパン・ティッシュ・エンジニアリング)を使用した。当該ヒト表皮モデルは、底部にメンブランフィルターを有する培養カップにヒト正常表皮細胞を6日間重層培養することにより形成され、初期状態(未熟な状態)の角層を有し、CEが成熟しておらず、TEWL値が高い表皮組織が形成されているヒト3次元培養表皮モデル(24ウェル)である。具体的な試験方法を以下に示す。
表2に示す水中油型乳化状の外用組成物を調製した。これらの外用組成物の使用によって、CEの成熟促進による皮膚バリア機能を改善効果が期待できる。
Claims (5)
- (A)セラミド、並びに(B)カルニチン、その塩、及びそれらの誘導体からなる群より選択される少なくとも1種を含有する、外用組成物。
- (A)成分として、2種以上のセラミドを含む、請求項1に記載の外用組成物。
- (A)成分が、セラミド1、セラミド2、及びセラミド3からなる群より選択される2種以上である、請求項1又は2に記載の外用組成物。
- (B)成分が、L−カルニチンである、請求項1〜3のいずれかに記載の外用組成物。
- 更に界面活性剤を含む、請求項1〜4のいずれかに記載の外用組成物。
Priority Applications (4)
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JP2019113064A JP2020203861A (ja) | 2019-06-18 | 2019-06-18 | 外用組成物 |
TW109119331A TW202100138A (zh) | 2019-06-18 | 2020-06-09 | 外用組成物 |
PCT/JP2020/023103 WO2020255866A1 (ja) | 2019-06-18 | 2020-06-11 | 外用組成物 |
JP2024037660A JP2024053124A (ja) | 2019-06-18 | 2024-03-11 | 外用組成物 |
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JP2019113064A JP2020203861A (ja) | 2019-06-18 | 2019-06-18 | 外用組成物 |
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JP2024037660A Division JP2024053124A (ja) | 2019-06-18 | 2024-03-11 | 外用組成物 |
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JP2019113064A Pending JP2020203861A (ja) | 2019-06-18 | 2019-06-18 | 外用組成物 |
JP2024037660A Pending JP2024053124A (ja) | 2019-06-18 | 2024-03-11 | 外用組成物 |
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WO (1) | WO2020255866A1 (ja) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
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WO2024028834A1 (en) * | 2022-08-05 | 2024-02-08 | Carbocode S.A. | Reduction of signs of skin aging |
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CN113512575B (zh) * | 2021-07-16 | 2023-06-20 | 中国科学院海洋研究所 | 一种促进雨生红球藻内虾青素积累的方法 |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2001220345A (ja) * | 2000-02-07 | 2001-08-14 | Noevir Co Ltd | 表皮セラミド生成促進剤、及びこれを含有する表皮保湿機能改善剤 |
WO2009084200A1 (ja) * | 2007-12-27 | 2009-07-09 | Kao Corporation | ニキビ肌用皮膚外用剤 |
JP2014114289A (ja) * | 2013-12-13 | 2014-06-26 | Showa Denko Kk | 化粧料または皮膚外用剤 |
CN104721129A (zh) * | 2015-04-13 | 2015-06-24 | 上海东晟源日化有限公司 | 微乳化生物科技护肤品 |
JP2015189723A (ja) * | 2014-03-28 | 2015-11-02 | 小林製薬株式会社 | セラミド配合外用剤組成物 |
JP2016190817A (ja) * | 2015-03-31 | 2016-11-10 | 小林製薬株式会社 | 外用組成物 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP7074647B2 (ja) * | 2018-10-19 | 2022-05-24 | 富士フイルム株式会社 | 水性ゲル状化粧料 |
-
2019
- 2019-06-18 JP JP2019113064A patent/JP2020203861A/ja active Pending
-
2020
- 2020-06-09 TW TW109119331A patent/TW202100138A/zh unknown
- 2020-06-11 WO PCT/JP2020/023103 patent/WO2020255866A1/ja active Application Filing
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2024
- 2024-03-11 JP JP2024037660A patent/JP2024053124A/ja active Pending
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2001220345A (ja) * | 2000-02-07 | 2001-08-14 | Noevir Co Ltd | 表皮セラミド生成促進剤、及びこれを含有する表皮保湿機能改善剤 |
WO2009084200A1 (ja) * | 2007-12-27 | 2009-07-09 | Kao Corporation | ニキビ肌用皮膚外用剤 |
JP2014114289A (ja) * | 2013-12-13 | 2014-06-26 | Showa Denko Kk | 化粧料または皮膚外用剤 |
JP2015189723A (ja) * | 2014-03-28 | 2015-11-02 | 小林製薬株式会社 | セラミド配合外用剤組成物 |
JP2016190817A (ja) * | 2015-03-31 | 2016-11-10 | 小林製薬株式会社 | 外用組成物 |
CN104721129A (zh) * | 2015-04-13 | 2015-06-24 | 上海东晟源日化有限公司 | 微乳化生物科技护肤品 |
Non-Patent Citations (4)
Title |
---|
"Contour Firming Gel", MINTELGNPD, JPN6023032081, January 2005 (2005-01-01), ISSN: 0005215986 * |
"Glam'Abdo Slimming Gel-Cream for a Flat Tummy", MINTELGNPD, JPN6023032083, March 2012 (2012-03-01), ISSN: 0005215988 * |
"Intensive Sun Cream for The Face", MINTELGNPD, JPN6023032080, June 2007 (2007-06-01), ISSN: 0005215985 * |
"Radiant Regenerating Gold Ampoule Mask", MINTELGNPD, JPN6023032082, December 2018 (2018-12-01), ISSN: 0005215987 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2024028834A1 (en) * | 2022-08-05 | 2024-02-08 | Carbocode S.A. | Reduction of signs of skin aging |
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TW202100138A (zh) | 2021-01-01 |
JP2024053124A (ja) | 2024-04-12 |
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