JP2020185004A5 - - Google Patents
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- Publication number
- JP2020185004A5 JP2020185004A5 JP2020124010A JP2020124010A JP2020185004A5 JP 2020185004 A5 JP2020185004 A5 JP 2020185004A5 JP 2020124010 A JP2020124010 A JP 2020124010A JP 2020124010 A JP2020124010 A JP 2020124010A JP 2020185004 A5 JP2020185004 A5 JP 2020185004A5
- Authority
- JP
- Japan
- Prior art keywords
- human
- progenitor cells
- cell
- pluripotent stem
- culturing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 15
- 210000000130 stem cell Anatomy 0.000 claims 9
- 210000004027 cell Anatomy 0.000 claims 5
- 210000001778 pluripotent stem cell Anatomy 0.000 claims 5
- 238000012258 culturing Methods 0.000 claims 4
- 239000003112 inhibitor Substances 0.000 claims 4
- 230000011664 signaling Effects 0.000 claims 4
- 101150008375 Pou4f1 gene Proteins 0.000 claims 3
- OHCQJHSOBUTRHG-KGGHGJDLSA-N FORSKOLIN Chemical compound O=C([C@@]12O)C[C@](C)(C=C)O[C@]1(C)[C@@H](OC(=O)C)[C@@H](O)[C@@H]1[C@]2(C)[C@@H](O)CCC1(C)C OHCQJHSOBUTRHG-KGGHGJDLSA-N 0.000 claims 2
- 101000701154 Homo sapiens Transcription factor ATOH7 Proteins 0.000 claims 2
- 102100029372 Transcription factor ATOH7 Human genes 0.000 claims 2
- 210000005044 neurofilament Anatomy 0.000 claims 2
- 102000045246 noggin Human genes 0.000 claims 2
- 108700007229 noggin Proteins 0.000 claims 2
- 229920001184 polypeptide Polymers 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims 2
- CDOVNWNANFFLFJ-UHFFFAOYSA-N 4-[6-[4-(1-piperazinyl)phenyl]-3-pyrazolo[1,5-a]pyrimidinyl]quinoline Chemical compound C1CNCCN1C1=CC=C(C2=CN3N=CC(=C3N=C2)C=2C3=CC=CC=C3N=CC=2)C=C1 CDOVNWNANFFLFJ-UHFFFAOYSA-N 0.000 claims 1
- 108090000715 Brain-derived neurotrophic factor Proteins 0.000 claims 1
- 102000004219 Brain-derived neurotrophic factor Human genes 0.000 claims 1
- 108010005939 Ciliary Neurotrophic Factor Proteins 0.000 claims 1
- 102100031614 Ciliary neurotrophic factor Human genes 0.000 claims 1
- SUZLHDUTVMZSEV-UHFFFAOYSA-N Deoxycoleonol Natural products C12C(=O)CC(C)(C=C)OC2(C)C(OC(=O)C)C(O)C2C1(C)C(O)CCC2(C)C SUZLHDUTVMZSEV-UHFFFAOYSA-N 0.000 claims 1
- 208000003098 Ganglion Cysts Diseases 0.000 claims 1
- 102100024392 Insulin gene enhancer protein ISL-1 Human genes 0.000 claims 1
- 101150070110 Isl1 gene Proteins 0.000 claims 1
- 102000008763 Neurofilament Proteins Human genes 0.000 claims 1
- 108010088373 Neurofilament Proteins Proteins 0.000 claims 1
- 102000007354 PAX6 Transcription Factor Human genes 0.000 claims 1
- 101150081664 PAX6 gene Proteins 0.000 claims 1
- 101150073614 POU4F2 gene Proteins 0.000 claims 1
- 208000005400 Synovial Cyst Diseases 0.000 claims 1
- 101150052863 THY1 gene Proteins 0.000 claims 1
- 230000001464 adherent effect Effects 0.000 claims 1
- 239000000853 adhesive Substances 0.000 claims 1
- 230000001070 adhesive effect Effects 0.000 claims 1
- 239000006143 cell culture medium Substances 0.000 claims 1
- OHCQJHSOBUTRHG-UHFFFAOYSA-N colforsin Natural products OC12C(=O)CC(C)(C=C)OC1(C)C(OC(=O)C)C(O)C1C2(C)C(O)CCC1(C)C OHCQJHSOBUTRHG-UHFFFAOYSA-N 0.000 claims 1
- 210000002242 embryoid body Anatomy 0.000 claims 1
- 210000001671 embryonic stem cell Anatomy 0.000 claims 1
- 210000004263 induced pluripotent stem cell Anatomy 0.000 claims 1
- 239000002609 medium Substances 0.000 claims 1
- 239000002243 precursor Substances 0.000 claims 1
- 230000002207 retinal effect Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462046165P | 2014-09-05 | 2014-09-05 | |
| US62/046,165 | 2014-09-05 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017512937A Division JP6778181B2 (ja) | 2014-09-05 | 2015-09-05 | 網膜神経節細胞およびその前駆体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020185004A JP2020185004A (ja) | 2020-11-19 |
| JP2020185004A5 true JP2020185004A5 (cg-RX-API-DMAC7.html) | 2021-02-25 |
| JP7263293B2 JP7263293B2 (ja) | 2023-04-24 |
Family
ID=55440432
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017512937A Active JP6778181B2 (ja) | 2014-09-05 | 2015-09-05 | 網膜神経節細胞およびその前駆体 |
| JP2020124010A Active JP7263293B2 (ja) | 2014-09-05 | 2020-07-20 | 網膜神経節細胞およびその前駆体 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017512937A Active JP6778181B2 (ja) | 2014-09-05 | 2015-09-05 | 網膜神経節細胞およびその前駆体 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20170274019A1 (cg-RX-API-DMAC7.html) |
| EP (2) | EP3922717A1 (cg-RX-API-DMAC7.html) |
| JP (2) | JP6778181B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR20170077117A (cg-RX-API-DMAC7.html) |
| CN (1) | CN107148276A (cg-RX-API-DMAC7.html) |
| AU (2) | AU2015311702A1 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2960211A1 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2883600T3 (cg-RX-API-DMAC7.html) |
| IL (3) | IL250924B (cg-RX-API-DMAC7.html) |
| PL (1) | PL3189135T3 (cg-RX-API-DMAC7.html) |
| PT (1) | PT3189135T (cg-RX-API-DMAC7.html) |
| SG (3) | SG10201912296RA (cg-RX-API-DMAC7.html) |
| WO (1) | WO2016037159A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUE044778T2 (hu) * | 2011-11-14 | 2019-11-28 | Astellas Inst For Regenerative Medicine | Humán RPE sejt gyógyászati készítmények és alkalmazásaik |
| IL303401A (en) | 2015-03-23 | 2023-08-01 | Astellas Inst For Regenerative Medicine | Improved assays for potency of human retinal pigment epithelium (rpe) cells and photoreceptor progenitors |
| SG10201913250SA (en) | 2015-08-18 | 2020-03-30 | Astellas Inst For Regenerative Medicine | Clinical formulations |
| EP3824906A1 (en) | 2016-12-21 | 2021-05-26 | Amgen Inc. | Anti-tnf alpha antibody formulations |
| WO2019078781A1 (en) * | 2017-10-17 | 2019-04-25 | National University Of Singapore | SYSTEMS AND METHODS FOR PRODUCING PHOTORECEPTOR PROGENITORS |
| US12213996B2 (en) | 2018-02-02 | 2025-02-04 | University Of Maryland, Baltimore | Methods of treating optic nerve diseases using neural progenitor cell growth factors |
| US11621058B2 (en) * | 2018-02-08 | 2023-04-04 | Ohio State Innovation Foundation | Synthetic IHC-stained digital sides generated using artificial neural networks |
| DK3810758T3 (da) * | 2018-06-20 | 2023-10-16 | Biolamina Ab | Metoder og sammensætninger til fremstilling af retina pigment epitelceller |
| KR102196069B1 (ko) | 2019-04-17 | 2020-12-29 | 경북대학교 산학협력단 | 망막신경절세포의 분리방법 및 그에 의해 분리된 세포의 용도 |
| CN112251408B (zh) * | 2020-09-14 | 2022-04-12 | 郑州大学 | 视网膜神经节细胞的制备方法 |
| CN114917367A (zh) * | 2021-06-02 | 2022-08-19 | 中国科学院动物研究所 | Lhx2在促进中枢系统神经元的损伤修复再生中的应用 |
| CN115404219B (zh) * | 2022-09-09 | 2023-10-27 | 中国医学科学院医学生物学研究所 | 一种树鼩视网膜神经节细胞的分离培养方法 |
| CN117821382A (zh) * | 2023-12-29 | 2024-04-05 | 广州赛莱拉干细胞科技股份有限公司 | 一种毛囊干细胞无血清培养基和培养方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2697363A1 (en) * | 2007-08-23 | 2009-03-05 | The Board Of Trustees Of The Leland Stanford Junior University | Modulation of synaptogenesis |
| CN101939417B (zh) * | 2007-12-04 | 2014-02-05 | 蛋白生物动力私人有限公司 | 祖细胞的保护和它们的分化的调节 |
| CA3066806C (en) * | 2009-08-24 | 2023-03-07 | David M. Gamm | Substantially pure human retinal progenitor, forebrain progenitor, and retinal pigment epithelium cell cultures and methods of making the same |
| EP2486126B1 (en) * | 2009-10-06 | 2017-12-06 | SNU R & DB Foundation | Method for differentiation into retinal cells from stem cells |
| KR101712556B1 (ko) * | 2014-08-27 | 2017-03-08 | 서울대학교산학협력단 | 줄기세포를 망막신경절세포로 분화시키는 방법 |
-
2015
- 2015-09-05 US US15/508,533 patent/US20170274019A1/en active Pending
- 2015-09-05 KR KR1020177008900A patent/KR20170077117A/ko not_active Ceased
- 2015-09-05 CA CA2960211A patent/CA2960211A1/en not_active Abandoned
- 2015-09-05 SG SG10201912296RA patent/SG10201912296RA/en unknown
- 2015-09-05 CN CN201580056489.7A patent/CN107148276A/zh active Pending
- 2015-09-05 PT PT158382630T patent/PT3189135T/pt unknown
- 2015-09-05 AU AU2015311702A patent/AU2015311702A1/en not_active Abandoned
- 2015-09-05 SG SG11201701709YA patent/SG11201701709YA/en unknown
- 2015-09-05 PL PL15838263T patent/PL3189135T3/pl unknown
- 2015-09-05 EP EP21168050.9A patent/EP3922717A1/en not_active Withdrawn
- 2015-09-05 WO PCT/US2015/048741 patent/WO2016037159A1/en not_active Ceased
- 2015-09-05 EP EP15838263.0A patent/EP3189135B1/en active Active
- 2015-09-05 JP JP2017512937A patent/JP6778181B2/ja active Active
- 2015-09-05 ES ES15838263T patent/ES2883600T3/es active Active
- 2015-09-05 SG SG10201901559SA patent/SG10201901559SA/en unknown
-
2017
- 2017-03-05 IL IL250924A patent/IL250924B/en active IP Right Grant
-
2020
- 2020-07-20 JP JP2020124010A patent/JP7263293B2/ja active Active
- 2020-10-04 IL IL277780A patent/IL277780B/en unknown
-
2021
- 2021-08-01 IL IL285258A patent/IL285258A/en unknown
- 2021-09-28 AU AU2021240145A patent/AU2021240145A1/en not_active Abandoned
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