JP2020176077A - Solubilization composition for water-soluble compound and oil-soluble compound - Google Patents
Solubilization composition for water-soluble compound and oil-soluble compound Download PDFInfo
- Publication number
- JP2020176077A JP2020176077A JP2019078087A JP2019078087A JP2020176077A JP 2020176077 A JP2020176077 A JP 2020176077A JP 2019078087 A JP2019078087 A JP 2019078087A JP 2019078087 A JP2019078087 A JP 2019078087A JP 2020176077 A JP2020176077 A JP 2020176077A
- Authority
- JP
- Japan
- Prior art keywords
- soluble compound
- water
- oil
- lower alcohol
- appropriate amount
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 title claims abstract description 46
- 239000000203 mixture Substances 0.000 title claims abstract description 35
- 238000005063 solubilization Methods 0.000 title abstract description 5
- 230000007928 solubilization Effects 0.000 title abstract description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 72
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 23
- 239000012046 mixed solvent Substances 0.000 claims abstract description 18
- 235000019441 ethanol Nutrition 0.000 claims description 40
- 239000002537 cosmetic Substances 0.000 claims description 5
- 230000003381 solubilizing effect Effects 0.000 abstract description 8
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 21
- -1 ethyl alcohol Chemical compound 0.000 description 20
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 15
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 10
- 238000002156 mixing Methods 0.000 description 10
- 238000009472 formulation Methods 0.000 description 9
- 239000003205 fragrance Substances 0.000 description 9
- 239000008213 purified water Substances 0.000 description 8
- NOOLISFMXDJSKH-KXUCPTDWSA-N (-)-Menthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@H]1O NOOLISFMXDJSKH-KXUCPTDWSA-N 0.000 description 7
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 7
- 229940101029 dipotassium glycyrrhizinate Drugs 0.000 description 6
- 235000011187 glycerol Nutrition 0.000 description 5
- 239000006210 lotion Substances 0.000 description 5
- 238000002360 preparation method Methods 0.000 description 5
- 239000001509 sodium citrate Substances 0.000 description 5
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 5
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 4
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- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 description 4
- 239000011626 DL-alpha-tocopherylacetate Substances 0.000 description 4
- 235000001809 DL-alpha-tocopherylacetate Nutrition 0.000 description 4
- BIVBRWYINDPWKA-VLQRKCJKSA-L Glycyrrhizinate dipotassium Chemical compound [K+].[K+].O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@H]1CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@](C)(CC[C@@]5(CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C)C)C(O)=O)C([O-])=O)[C@@H]1O[C@H](C([O-])=O)[C@@H](O)[C@H](O)[C@H]1O BIVBRWYINDPWKA-VLQRKCJKSA-L 0.000 description 4
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 description 4
- OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 4
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- 239000000843 powder Substances 0.000 description 4
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 4
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- 239000004909 Moisturizer Substances 0.000 description 2
- ILRKKHJEINIICQ-OOFFSTKBSA-N Monoammonium glycyrrhizinate Chemical compound N.O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@H]1CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@](C)(CC[C@@]5(CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C)C)C(O)=O)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O ILRKKHJEINIICQ-OOFFSTKBSA-N 0.000 description 2
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- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 description 2
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- 239000011570 nicotinamide Substances 0.000 description 2
- WNIFXKPDILJURQ-JKPOUOEOSA-N octadecyl (2s,4as,6ar,6as,6br,8ar,10s,12as,14br)-10-hydroxy-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-3,4,5,6,6a,7,8,8a,10,11,12,14b-dodecahydro-1h-picene-2-carboxylate Chemical compound C1C[C@H](O)C(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C)CC[C@@](C(=O)OCCCCCCCCCCCCCCCCCC)(C)C[C@H]5C4=CC(=O)[C@@H]3[C@]21C WNIFXKPDILJURQ-JKPOUOEOSA-N 0.000 description 2
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- ZUFQODAHGAHPFQ-UHFFFAOYSA-N pyridoxine hydrochloride Chemical compound Cl.CC1=NC=C(CO)C(CO)=C1O ZUFQODAHGAHPFQ-UHFFFAOYSA-N 0.000 description 2
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- 239000002904 solvent Substances 0.000 description 2
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- VZSRBBMJRBPUNF-UHFFFAOYSA-N 2-(2,3-dihydro-1H-inden-2-ylamino)-N-[3-oxo-3-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)propyl]pyrimidine-5-carboxamide Chemical compound C1C(CC2=CC=CC=C12)NC1=NC=C(C=N1)C(=O)NCCC(N1CC2=C(CC1)NN=N2)=O VZSRBBMJRBPUNF-UHFFFAOYSA-N 0.000 description 1
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- Cosmetics (AREA)
Abstract
Description
本発明は可溶化組成物、特に水溶性化合物及び油溶性化合物を水／低級アルコール溶媒に可溶化する可溶化組成物に関する。 The present invention relates to solubilizing compositions, particularly solubilizing compositions that solubilize water-soluble and oil-soluble compounds in water / lower alcohol solvents.
生体に対し各種の作用を有する水溶性ないし油溶性化合物が多種存在し、これらは通常、液状媒体に溶解して用いられる。
一方、水溶性化合物及び油溶性化合物を同時に液状媒体に可溶化すせることは困難であり、一般的には、いわゆる乳化組成物として、水性媒体中に油溶性化合物を乳化させるか、油性媒体中に水溶性化合物を乳化させて用いるのが一般的である（特許文献１、特許文献２）。
There are various water-soluble or oil-soluble compounds having various actions on a living body, and these are usually used by being dissolved in a liquid medium.
On the other hand, it is difficult to solubilize the water-soluble compound and the oil-soluble compound in the liquid medium at the same time. Generally, as a so-called emulsifying composition, the oil-soluble compound is emulsified in the aqueous medium or in the oil-based medium. It is common to emulsify and use a water-soluble compound in (Patent Document 1 and Patent Document 2).
しかしながら、いわゆる乳化組成物は通常白濁し、外観上の問題を生じるばかりでなく、適用された肌上で、微視的には水溶性化合物適用部位と油溶性化合物適用部位が存在することとなり、両化合物が同一適用部位で作用することを保証できない。
さらに、水溶性化合物及び油溶性化合物を同一媒体に均一に溶解するためには、各種の界面活性剤を用いることが必要となり、しかも長期保存、或いは温度変化により分離してしまうこともある。
However, the so-called emulsified composition usually becomes cloudy and causes not only an appearance problem, but also microscopically, there are a water-soluble compound application site and an oil-soluble compound application site on the applied skin. It cannot be guaranteed that both compounds will work at the same application site.
Further, in order to uniformly dissolve the water-soluble compound and the oil-soluble compound in the same medium, it is necessary to use various surfactants, and further, they may be separated by long-term storage or temperature change.
本発明は前記従来技術の課題に鑑みなされたものであり、その目的は水溶性化合物及び油溶性化合物を共に安定可溶化する可溶化組成物を提供することにある。
前記目的を達成するために本発明にかかる可溶化組成物は、水／低級アルコールの混合溶媒系に水溶性化合物および油溶性化合物が溶解された可溶化組成物であって、
混合溶媒中の低級アルコール比は、低級アルコール／（水＋低級アルコール）が０．４〜０．８５であり、
さらに、ＰＯＥフィトステロールを含むことを特徴とする。
また、前記組成物において、低級アルコールはエチルアルコールであることが好適である。
また、前記組成物において、ＰＯＥフィトステロールのＰＯＥ付加モル数は１０であることが好適である。
また、本発明にかかる可溶化組成物は、透明化粧料であることが好適である。
The present invention has been made in view of the above-mentioned problems of the prior art, and an object of the present invention is to provide a solubilized composition that stably solubilizes both a water-soluble compound and an oil-soluble compound.
The solubilizing composition according to the present invention for achieving the above object is a solubilizing composition in which a water-soluble compound and an oil-soluble compound are dissolved in a mixed solvent system of water / lower alcohol.
The lower alcohol ratio in the mixed solvent is 0.4 to 0.85 for lower alcohol / (water + lower alcohol).
Furthermore, it is characterized by containing POE phytosterols.
Further, in the above composition, the lower alcohol is preferably ethyl alcohol.
Further, in the above composition, the number of moles of POE phytosterol added is preferably 10.
Further, the solubilizing composition according to the present invention is preferably a transparent cosmetic.
以下、本発明の構成をさらに詳細に説明する。
本発明に用いられる低級アルコールは、炭素数が５以下のアルコールであり、低級一価アルコール、特にエチルアルコールが好ましい。
本発明において、混合溶媒は水／低級アルコール混合溶媒として定義され、混合溶媒（水＋低級アルコール）中の低級アルコールの質量比は、０．４〜０．８５である。
また、本発明に用いられるＰＯＥフィトステロールとしては、ＰＯＥβ−シトステロール、ＰＯＥスチグマステロール、ＰＯＥカンペステロールなどが例示される。
ＰＯＥ付加モル数は、５〜３０、好ましくは５〜２０、特に好ましくは１０である。
ＰＯＥフィトステロールの配合量は、組成物中０．１〜５質量％、好ましくは０．５〜２質量％であることが好ましい。
Hereinafter, the configuration of the present invention will be described in more detail.
The lower alcohol used in the present invention is an alcohol having 5 or less carbon atoms, and a lower monohydric alcohol, particularly ethyl alcohol, is preferable.
In the present invention, the mixed solvent is defined as a water / lower alcohol mixed solvent, and the mass ratio of the lower alcohol in the mixed solvent (water + lower alcohol) is 0.4 to 0.85.
Moreover, as POE phytosterol used in this invention, POEβ-sitosterol, POE stigmasterol, POE campesterol and the like are exemplified.
The number of moles with POE added is 5 to 30, preferably 5 to 20, and particularly preferably 10.
The blending amount of POE phytosterol is preferably 0.1 to 5% by mass, preferably 0.5 to 2% by mass in the composition.
また、本発明に用いられる水溶性化合物としては、塩化ベンザルコニウム、グリチルリチン酸ジカリウム、グリチルリチン酸モノアンモニウム、サリチル酸、アデノシン、アラントイン、レゾルシン、塩酸ピリドキシン、ニコチン酸アミドなどが例示される。
水溶性化合物の組成物中の添加量は、特に制限はないが、０．０１〜３質量％が好ましい。
また、本発明に用いられる油溶性化合物としては、ｌ−メントール、β−グリチルレチン酸、イソプロピルメチルフェノール、ｄｌ−カンフル、酢酸ｄｌ−α−トコフェロール、ｄ−カンフル、ハッカ油、グリチルレチン酸ステアリル、ｄ−パントテニルアルコール、ユーカリ油などが例示される。
油溶性化合物の組成物中の添加量は、特に制限はないが、０．０１〜２質量％程度が好ましい。
Examples of the water-soluble compound used in the present invention include benzalkonium chloride, dipotassium glycyrrhizinate, monoammonium glycyrrhizinate, salicylic acid, adenosine, allantin, resorcin, pyridoxine hydrochloride, and nicotinamide.
The amount of the water-soluble compound added to the composition is not particularly limited, but is preferably 0.01 to 3% by mass.
Examples of the oil-soluble compound used in the present invention include l-menthol, β-glycyrrhetinic acid, isopropylmethylphenol, dl-camphor, dl-α-tocopherol acetate, d-camphor, peppermint oil, stearyl glycyrrhetinate, and d-. Examples include pantothenyl alcohol and eucalyptus oil.
The amount of the oil-soluble compound added to the composition is not particularly limited, but is preferably about 0.01 to 2% by mass.
本発明にかかる可溶化組成物は、一種又は二種以上の添加剤と混合することによって、皮膚外用剤、頭皮用外用剤等を調製することができる。必要に応じて添加される添加剤としては、皮膚用化粧料や外用医薬品の製剤に一般的に用いられる、界面活性剤、金属セッケン、ゲル化剤、粉体、水溶性高分子、皮膜形成剤、樹脂、紫外線防御剤、包接化合物、抗菌剤、香料、消臭剤、塩類、ｐＨ調整剤、清涼剤、動物・微生物由来抽出物、植物抽出物、血行促進剤、収斂剤、抗脂漏剤、美白剤、抗炎症剤、本発明の一重項酸素消去剤以外の活性酸素消去剤、細胞賦活剤、保湿剤、キレート剤、角質溶解剤、酵素、ホルモン類、ビタミン類等が挙げられる。皮膚外用剤の調製は、常法に従って行うことができ、前記添加剤の配合量も本発明の効果を損なわない範囲で、常法に従って決定することができる。 The solubilized composition according to the present invention can be mixed with one or more kinds of additives to prepare an external preparation for skin, an external preparation for scalp, and the like. Additives that are added as needed include surfactants, metal keratins, gelling agents, powders, water-soluble polymers, and film-forming agents that are commonly used in the formulation of skin cosmetics and external medicines. , Resins, UV protection agents, inclusion compounds, antibacterial agents, fragrances, deodorants, salts, pH adjusters, refreshing agents, animal / microorganism-derived extracts, plant extracts, blood circulation promoters, astringents, anti-fat leaks Examples thereof include agents, whitening agents, anti-inflammatory agents, active oxygen scavengers other than the single-term oxygen scavenging agent of the present invention, cell activators, moisturizers, chelating agents, keratolytic agents, enzymes, hormones, vitamins and the like. The external preparation for skin can be prepared according to a conventional method, and the blending amount of the additive can also be determined according to a conventional method within a range that does not impair the effects of the present invention.
前記皮膚用外用剤の形態については限定されず、乳液、クリーム、化粧水、美容液、パック、洗顔料、メーキャップ化粧料等の皮膚用化粧料に属する形態；シャンプー、ヘアートリートメント、ヘアースタイリング剤、養毛剤、育毛剤等の頭髪化粧料に関する形態；及び分散液、軟膏、エアゾール、貼付剤、パップ剤等の外用医薬品の形態；のいずれであってもよい。
特に皮膚外用剤として用いる際には、保湿剤としてジプロピレングリコール、濃グリセリンなど用いることが好適である。
The form of the external preparation for skin is not limited, and forms belonging to skin cosmetics such as milky lotion, cream, lotion, beauty essence, pack, washing pigment, makeup cosmetic, etc .; shampoo, hair treatment, hair styling agent, It may be in any form relating to hair cosmetics such as hair restorer and hair restorer; and form of external medicine such as dispersion liquid, ointment, aerosol, patch and poultice.
In particular, when used as an external preparation for skin, it is preferable to use dipropylene glycol, concentrated glycerin or the like as a moisturizer.
本発明にかかる可溶化組成物は、水／低級アルコール混合溶媒系にＰＯＥフィトステロールを添加することにより、各種の水溶性化合物及び油溶性化合物を共に可溶化することが可能となる。 The solubilized composition according to the present invention can solubilize both various water-soluble compounds and oil-soluble compounds by adding POE phytosterol to a water / lower alcohol mixed solvent system.
以下、本発明の好適な実施形態について説明するが、本発明はこれらに限られるものではない。なお、配合量は質量％で示している。
当然のことながら水溶性化合物は水への溶解度が高く、一方、油溶性化合物は低級アルコールへの溶解度が高い。
そこで本発明者らは、目的とする水溶性化合物が均一に溶解するエチルアルコール濃度の水／エチルアルコール混合溶媒を調製し、これに油溶性化合物を溶解させる可溶化剤について検討を行った。
結果を表１に示す。
Hereinafter, preferred embodiments of the present invention will be described, but the present invention is not limited thereto. The blending amount is shown in% by mass.
As a matter of course, water-soluble compounds have high solubility in water, while oil-soluble compounds have high solubility in lower alcohols.
Therefore, the present inventors prepared a water / ethyl alcohol mixed solvent having an ethyl alcohol concentration that uniformly dissolves the target water-soluble compound, and investigated a solubilizer that dissolves the oil-soluble compound in the mixed solvent.
The results are shown in Table 1.
上記表１中、グリチルリチン酸ジカリウムは水溶性化合物に相当し、酢酸ｄｌ−α−トコフェロール、ｌ−メントール、香料は油溶性化合物に相当する。
In Table 1 above, dipotassium glycyrrhizinate corresponds to a water-soluble compound, and dl-α-tocopherol acetate, l-menthol, and fragrance correspond to oil-soluble compounds.
表１の結果より、水溶性化合物であるグリチルリチン酸ジカリウムが溶解する水／エチルアルコール混合溶媒（混合溶媒中、エチルアルコール比０．４６ないし０．８１）に、油溶性化合物である酢酸ｄｌ−α−トコフェロール及びポリオキシエチレンフィトステロールを加えた場合には、いずれの油溶性化合物も溶解が困難であり、また可溶化剤として汎用されるポリオキシエチレン硬化ひまし油（ＨＣＯ−６０）を加えた試験例１−３、ポリオキシエチレンオクチルドデシルエーテル（日本エマルジョン製 ＥＸＡＬＥＸセオドールＥ−２０１６）を加えた試験例１−４、さらにポリオキシエチレンポリオキシプロピレンデシルテトラデシルエーテル（日光ケミカルズ製 ＮＩＫＫＯＬ ＰＥＮ−４６１２）を加えた試験例１−５についても、いずれも可溶化の状態が不良であった。 From the results in Table 1, the oil-soluble compound dl-α acetate was dissolved in a water / ethyl alcohol mixed solvent (ethyl alcohol ratio 0.46 to 0.81 in the mixed solvent) in which the water-soluble compound dipotassium glycyrrhizinate was dissolved. -When tocopherol and polyoxyethylene phytosterol are added, it is difficult to dissolve any of the oil-soluble compounds, and Test Example 1 in which polyoxyethylene hydrogenated castor oil (HCO-60), which is widely used as a solubilizer, is added. -3, Test Example 1-4 to which polyoxyethylene octyldodecyl ether (EXALEX Theodor E-2016 manufactured by Nippon Emulsion) was added, and further added polyoxyethylene polyoxypropylene decyltetradecyl ether (NIKKOL PEN-4612 manufactured by Nikko Chemicals). In all of Test Examples 1-5, the solubilized state was poor.
これに対し、ポリオキシエチレン（１０）フィトステロール（日光ケミカルズ製 ＮＩＫＫＯＬ ＢＰＳ−１０）を加えた試験例１−１は、水溶性化合物及び油溶性化合物のいずれもが良好且つ安定に可溶化していた。また、ポリオキシエチレン（２０）フィトステロール（試験例１−６）、ポリオキシエチレン（３０）フィトステロール（試験例１−７）も、特にエタノールの比率の高い領域において好適に機能した。 On the other hand, in Test Example 1-1 to which polyoxyethylene (10) phytosterol (NIKKOL BPS-10 manufactured by Nikko Chemicals) was added, both the water-soluble compound and the oil-soluble compound were solubilized well and stably. .. In addition, polyoxyethylene (20) phytosterols (Test Example 1-6) and polyoxyethylene (30) phytosterols (Test Example 1-7) also functioned suitably in a region having a particularly high proportion of ethanol.
そこで本発明者らは、ポリオキシエチレンフィトステロールを用いた系で、水／エチルアルコール混合溶媒中のエチルアルコール濃度と、水溶性化合物及び油溶性化合物の可溶化能の相関について検討を行った。
結果を表２に示す。
Therefore, the present inventors investigated the correlation between the ethyl alcohol concentration in the water / ethyl alcohol mixed solvent and the solubilizing ability of the water-soluble compound and the oil-soluble compound in the system using polyoxyethylene phytosterol.
The results are shown in Table 2.
表２の結果より、混合溶媒中のエチルアルコール比が０．４〜０．８５、特に好ましくは０．４５〜０．８で、高い可溶化能が認められ、エチルアルコール比が0.4未満（試験例２−１）では油溶性化合物の可溶化能の低下のために白濁し、0.85を超える（試験例２−６）と水溶性化合物であるグリチルリチン酸ジカリウムが十分には溶解しない。
したがって、水／低級アルコール混合溶媒中の低級アルコール割合は、０．４〜０．８５であることが理解される。
From the results in Table 2, the ethyl alcohol ratio in the mixed solvent was 0.4 to 0.85, particularly preferably 0.4 to 0.8, and high solubilization ability was observed, and the ethyl alcohol ratio was less than 0.4 (test). In Example 2-1), it becomes cloudy due to a decrease in the solubilizing ability of the oil-soluble compound, and when it exceeds 0.85 (Test Example 2-6), the water-soluble compound dipotassium glycyrrhizinate is not sufficiently dissolved.
Therefore, it is understood that the lower alcohol ratio in the water / lower alcohol mixed solvent is 0.4 to 0.85.
さらに本発明者らは、混合溶媒中に可溶化可能な油溶性化合物量について検討を行った。
結果を表３に示す。
Furthermore, the present inventors investigated the amount of oil-soluble compound that can be solubilized in the mixed solvent.
The results are shown in Table 3.
表３の結果より、油溶性化合物量については、組成物中０．１〜１．４質量％で安定に配合可能であり、油溶性化合物の種類により０．０１〜２質量％程度までの配合が可能である。
From the results in Table 3, the amount of the oil-soluble compound can be stably blended at 0.1 to 1.4% by mass in the composition, and the blending can be up to about 0.01 to 2% by mass depending on the type of the oil-soluble compound. Is possible.
以下、本発明の好適な配合例について説明する。
配合例１ 粉末入りボディーローション 配合量（質量％）
エタノール ７０
１，３−ブチレングリコール ５
ポリオキシエチレンフィトステロール ０．３
塩化ナトリウム ０．１
ヒドロキシプロピル−β−シクロデキストリン ３
塩化ベンザルコニウム ０．０５
グリチルリチン酸ジカリウム ０．０５
ｌ−メントール ０．９
ベントナイト ０．５
ナイロン末 ５
乳酸 適量
乳酸ナトリウム液 適量
香料 適量
精製水 残余
Hereinafter, suitable compounding examples of the present invention will be described.
Formulation example 1 Body lotion containing powder Blending amount (mass%)
Ethanol 70
1,3-butylene glycol 5
Polyoxyethylene phytosterol 0.3
Sodium chloride 0.1
Hydroxypropyl-β-cyclodextrin 3
Benzalkonium chloride 0.05
Dipotassium glycyrrhizinate 0.05
l-menthol 0.9
Bentonite 0.5
Nylon powder 5
Lactic acid Appropriate amount Sodium lactate solution Appropriate amount Fragrance Appropriate amount Purified water Residual
配合例２ ヘアトニック 配合量（質量％）
エタノール ６５
ポリオキシエチレンフィトステロール ０．８
グリチルリチン酸モノアンモニウム ０．１
β−グリチルレチン酸 ０．１
ｌ−メントール ０．８
乳酸 適量
乳酸ナトリウム液 適量
香料 適量
精製水 残余
Formulation example 2 Hair tonic blending amount (mass%)
Ethanol 65
Polyoxyethylene phytosterol 0.8
Monoammonium glycyrrhizinate 0.1
β-Glycyrrhetinic acid 0.1
l-Menthol 0.8
Lactic acid Appropriate amount Sodium lactate solution Appropriate amount Fragrance Appropriate amount Purified water Residual
配合例３ デオドラントロールオン 配合量（質量％）
エタノール ６０
ポリオキシエチレンフィトステロール ０．２
アルミニウムハイドロキシクロライド １０
サリチル酸 ０．５
ｌ−メントール ０．５
ｌ−メンチルラクテート １
イソプロピルメチルフェノール ０．１
酸化亜鉛複合粉末 ０．０１
増粘剤 ０．０５
香料 適量
精製水 残余
Formulation example 3 Deodorant roll-on blending amount (mass%)
Ethanol 60
Polyoxyethylene phytosterol 0.2
Aluminum Hydrochicyclolide 10
Salicylic acid 0.5
l-menthol 0.5
l-Mentil Lactate 1
Isopropylmethylphenol 0.1
Zinc oxide composite powder 0.01
Thickener 0.05
Perfume Appropriate amount Purified water Residual
配合例４ 育毛剤 配合量（質量％）
エタノール ６０
１，３−ブチレングリコール ５
ポリオキシエチレンフィトステロール ０．５
デシルテトラデシルジメチルアミンオキシド １
酢酸ＤＬ−α−トコフェロール ０．１
アデノシン ０．５
ｄｌ−カンフル ０．５
クエン酸 適量
クエン酸ナトリウム 適量
香料 適量
精製水 残余
Formulation example 4 Hair restorer blending amount (mass%)
Ethanol 60
1,3-butylene glycol 5
Polyoxyethylene phytosterol 0.5
Decyltetradecyldimethylamine oxide 1
DL-α-tocopherol acetate 0.1
Adenosine 0.5
dl-camphor 0.5
Appropriate amount of citric acid Appropriate amount of sodium citrate Appropriate amount of fragrance Appropriate amount Purified water Residual
配合例５ アフターシェーブローション 配合量（質量％）
エタノール ５５
ジプロピレングリコール １
グリセリン １
ポリオキシエチレンフィトステロール ０．６
アラントイン ０．２
ｌ−メントール ０．２
ｄ−カンフル ０．１
ハッカ油 ０．４
クエン酸 適量
クエン酸ナトリウム 適量
香料 適量
精製水 残余
Formulation example 5 Aftershave lotion Blending amount (% by mass)
Ethanol 55
Dipropylene glycol 1
Glycerin 1
Polyoxyethylene phytosterol 0.6
Allantoin 0.2
l-menthol 0.2
d-camphor 0.1
Mint oil 0.4
Appropriate amount of citric acid Appropriate amount of sodium citrate Appropriate amount of fragrance Appropriate amount Purified water Residual
配合例６ 収斂化粧水
エタノール ５０
ジプロピレングリコール １
グリセリン ２
ポリオキシエチレンフィトステロール ０．４
グリチルリチン酸ジカリウム ０．５
グリチルレチン酸ステアリル ０．１
ｌ−メントール ０．２
クエン酸 適量
クエン酸ナトリウム 適量
香料 適量
精製水 残余
Formulation Example 6 Astringent Toner Ethanol 50
Dipropylene glycol 1
Glycerin 2
Polyoxyethylene phytosterol 0.4
Dipotassium glycyrrhizinate 0.5
Stearyl glycyrrhetinate 0.1
l-menthol 0.2
Appropriate amount of citric acid Appropriate amount of sodium citrate Appropriate amount of fragrance Appropriate amount Purified water Residual
配合例７ 粉末入り化粧水 配合量（質量％）
エタノール ４５
ジプロピレングリコール １
グリセリン ２
ポリオキシエチレンフィトステロール ０．１
レゾルシン ０．１
塩酸ピリドキシン ０．１
Ｄ−パントテニルアルコール ０．２
ポリエチレン末 ０．１
ベントナイト ０．３
カオリン １
硫酸亜鉛 ０．１
クエン酸 適量
クエン酸ナトリウム 適量
香料 適量
精製水 残余
Formulation example 7 Powdered lotion blending amount (mass%)
Ethanol 45
Dipropylene glycol 1
Glycerin 2
Polyoxyethylene phytosterol 0.1
Resorcin 0.1
Pyridoxine hydrochloride 0.1
D-pantothenyl alcohol 0.2
Polyethylene powder 0.1
Bentonite 0.3
Kaolin 1
Zinc sulfate 0.1
Appropriate amount of citric acid Appropriate amount of sodium citrate Appropriate amount of fragrance Appropriate amount Purified water Residual
配合例８ ボディミスト 配合量（質量％）
エタノール ４０
ジグリセリン ０．５
グリセリン １
ポリオキシエチレンフィトステロール ０．７
ニコチン酸アミド ０．２
ユーカリ油 ０．２
酢酸ＤＬ−α−トコフェロール ０．１５
クエン酸 適量
クエン酸ナトリウム 適量
香料 適量
精製水 残余
Formulation example 8 Body mist blending amount (mass%)
Ethanol 40
Diglycerin 0.5
Glycerin 1
Polyoxyethylene phytosterol 0.7
Nicotinamide 0.2
Eucalyptus oil 0.2
DL-α-tocopherol acetate 0.15
Appropriate amount of citric acid Appropriate amount of sodium citrate Appropriate amount of fragrance Appropriate amount Purified water Residual
Claims (4)
混合溶媒中の低級アルコール比は、低級アルコール／（水＋低級アルコール）が０．４〜０．８５であり、
さらに、ＰＯＥフィトステロールを含むことを特徴とする可溶化組成物。 A solubilized composition in which a water-soluble compound and an oil-soluble compound are dissolved in a mixed solvent system of water / lower alcohol.
The lower alcohol ratio in the mixed solvent is 0.4 to 0.85 for lower alcohol / (water + lower alcohol).
Further, a solubilized composition comprising POE phytosterol.
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009084588A1 (en) * | 2007-12-27 | 2009-07-09 | Shiseido Company, Ltd. | Water-containing composition which can be used as external composition |
| JP2010013375A (en) * | 2008-07-02 | 2010-01-21 | Shiseido Co Ltd | Water-containing composition |
| JP2013227294A (en) * | 2012-03-30 | 2013-11-07 | Kose Corp | Translucent to transparent composition |
| JP2015174838A (en) * | 2014-03-14 | 2015-10-05 | 日本メナード化粧品株式会社 | Solubilized cosmetic |
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2019
- 2019-04-16 JP JP2019078087A patent/JP7361488B2/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009084588A1 (en) * | 2007-12-27 | 2009-07-09 | Shiseido Company, Ltd. | Water-containing composition which can be used as external composition |
| JP2010013375A (en) * | 2008-07-02 | 2010-01-21 | Shiseido Co Ltd | Water-containing composition |
| JP2013227294A (en) * | 2012-03-30 | 2013-11-07 | Kose Corp | Translucent to transparent composition |
| JP2015174838A (en) * | 2014-03-14 | 2015-10-05 | 日本メナード化粧品株式会社 | Solubilized cosmetic |
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