JP2020121927A - Whitening external preparation for skin - Google Patents

Abstract

To provide a novel whitening external preparation for skin that exerts excellent whitening effect.SOLUTION: A whitening external preparation for skin containing gold foil.SELECTED DRAWING: None

Description

The present invention relates to a skin whitening external preparation containing gold leaf.

Various whitening agents for whitening the skin have been studied. Studies on the mechanism of whitening action have been actively conducted. For example, an agent that inhibits melanocyte-stimulating hormone (α-Melanocyte Stimulating Hormone: α-MSH) that acts on melanocytes in skin cells to promote melanin production is used. By using an agent that removes active oxygen species generated in the skin by ultraviolet rays, using an agent that inhibits tyrosinase that converts tyrosine, which is a raw material of melanin, to the intermediate dopaquinone, It is known that a whitening effect can be obtained by using an agent that inhibits a receptor involved in melanin uptake in epidermal cells when transporting melanin from melanocytes to epidermal cells. Further, it has been proposed to use gold foil and gold ions for cosmetics (Patent Documents 1 and 2). However, it is not known that the gold foil itself has a whitening effect and a melanin synthesis suppressing effect.

JP, 2016-202370, A JP2012-67026A

It is an object of the present invention to provide a new skin external preparation for whitening, which has an excellent whitening effect.

As a result of intensive studies to solve the above problems, the present inventors have found that gold foil has a whitening effect and a melanin synthesis suppressing effect, and by using this, an external skin preparation having an excellent whitening effect can be obtained. It was found that the present invention has been completed.

That is, the present invention is as follows.
[1]
Topical skin whitening agent containing gold leaf.
[2]
The whitening skin external preparation according to the above [1], wherein the gold foil has a thickness of 50 to 500 nm.
[3]
The whitening skin external preparation according to the above [1] or [2], wherein the content of the gold foil is 0.001 to 0.3% by mass.
[4]
The whitening skin external preparation according to any one of [1] to [3] above, which has a melanin synthesis inhibitory action.
[5]
The whitening skin according to the above [4], wherein the melanin synthesis inhibitory action is any one or more of the actions of inhibiting hormones that promote melanin synthesis, enzymes related to melanin synthesis, information mediators, and gene expression. Topical agent.
[6]
The above-mentioned [1] to [5], which is in the form of any one selected from the group consisting of emulsions, creams, lotions, beauty essences, gels, packs, face washes, soaps and makeup cosmetics. Topical skin whitening agent.
[7]
A whitening method using the external whitening agent for whitening according to any of [1] to [6] above.
[8]
Skin blackening inhibitor containing gold foil.

ADVANTAGE OF THE INVENTION According to this invention, the skin external preparation for whitening which exhibits the outstanding whitening effect can be provided.

The result of the skin blackening suppression test using the mouse in Example 1 is shown. The measurement result of the lightness (L value) in Example 2 is shown. The measurement result of the melanin index in Example 2 is shown.

Hereinafter, an embodiment of the present invention (hereinafter referred to as “the present embodiment”) will be described in detail, but the present invention is not limited to this, and various modifications can be made without departing from the gist thereof. Is.

The present embodiment relates to a whitening skin external preparation (hereinafter also simply referred to as “skin external preparation”) containing gold foil. Since the gold foil contained in the external preparation for skin of the present embodiment has a melanin synthesis inhibitory action, when applied to the skin, it suppresses the whitening agent for whitening the skin and pigmentation caused by irradiation of ultraviolet rays (particularly UVB). It exerts its effect as a pigmentation inhibitor. That is, the external preparation for skin containing the gold foil of the present embodiment can also be used as a melanin synthesis inhibitor.

The melanin synthesis-suppressing action of gold foil is not particularly limited, and examples thereof include any one or more of the actions of suppressing hormones that promote melanin synthesis, enzymes involved in melanin synthesis, information mediators, and gene expression.

In addition, the external preparation for skin containing the gold foil of the present embodiment can be used also as a skin blackening inhibitor, since it was also revealed this time that the gold foil has a skin blackening inhibitory action.

Gold leaf refers to a piece of gold that is beaten and rolled very thinly to form a foil. The gold foil may be a “pure gold foil” made only of gold or an “alloy foil” made of an alloy with silver, copper, platinum or the like.

The thickness of the gold foil is not particularly limited, but is preferably 50 to 500 nm, more preferably 50 to 200 nm, and further preferably 100 to 120 nm. If the thickness of the gold foil is too large, the weight per unit area becomes heavy, and the cost tends to increase. The thickness of the gold foil can be calculated from the weight/specific gravity of the raw material and the area.

Various methods for producing gold foil are known (for example, Japanese Patent Laid-Open No. 2016-202370), and those skilled in the art can easily produce gold foil by referring to these methods. For example, industrial foils and the like industrially produced by rolling with a roller or the like can be mentioned. In addition, there are green-coated gold foil, cut gold foil, and the like, which are produced by a handmade gold foil manufacturing method. As the external preparation for skin of the present embodiment, a gold foil prepared by any method may be used, but a cut gold foil is preferably used from the viewpoint of ease of production and quality.

The content of the gold foil contained in the external preparation for skin of the present embodiment is not particularly limited, but is preferably 0.001 to 0.3 mass% from the viewpoint of the balance between the effect of the present invention and the cost, and 0 It is more preferably 0.005 to 0.2% by mass, and further preferably 0.01 to 0.2% by mass.

The form of the external preparation for skin is not particularly limited as long as it is a form that belongs to skin cosmetics such as emulsion, cream, lotion, beauty essence, gel, pack, face wash, soap, makeup cosmetic.

The skin external preparation of the present embodiment, oils, powders (pigments, resin particles), surfactants, viscous agents, resins, water-based colorants, preservatives, fragrances, ultraviolet absorbers, which are usually used in cosmetics, Solvents, natural plant extract components, seaweed extract components, herbal medicine components, moisturizers such as polyhydric alcohols, salts, antioxidants, neutralizing agents, pH adjusters, insect repellents, and other components may be added as appropriate. it can.

Examples of the oil agent include volatile and non-volatile oil agents, solvents, resins and the like which are usually used in cosmetics, and may be liquid, paste or solid at room temperature. Examples of the oil agent include higher alcohols such as isostearyl alcohol, lauryl alcohol, hexadecyl alcohol, and octyldodecanol; fatty acids such as isostearic acid, undecylenic acid, and oleic acid; isononyl isononanoate, isotridecyl isononanoate, myristyl myristate, Esters such as hexyl laurate, decyl oleate, isopropyl myristate, hexyldecyl dimethyloctanoate, glyceryl monostearate, diethyl phthalate, ethylene glycol monostearate, octyl oxystearate, diisostearyl malate; liquid paraffin , Hydrocarbons such as paraffin, petrolatum and squalane; waxes such as lanolin, reduced lanolin, liquid lanolin, carnauba wax, candelilla wax, ceresin, ozokerite and microcrystalline wax; polyethylene wax, ethylene/α-olefin/co-oligomer, ethylene propylene Examples thereof include polymers.

Examples of the powder include pigments such as Red No. 104, Red No. 102, Red No. 226, Red No. 201, Red No. 202, Yellow No. 4, Black No. 401; Blue No. 1 Aluminum Lake, Yellow No. 4 Aluminum Lake, Lake dyes such as yellow No. 5 aluminum lake and yellow No. 203 barium lake; nylon powder, silk powder, urethane powder, Teflon (registered trademark) powder, silicone powder, polymethylmethacrylate powder, cellulose powder, silicone elastomer spherical powder, Colored pigments such as polyethylene powder, yellow iron oxide, red iron oxide, black iron oxide, chromium oxide, carbon black, ultramarine blue and dark blue; white pigments such as zinc oxide, titanium oxide and cerium oxide; talc, mica, sericite , Extenders such as kaolin and tabular barium sulfate; pearl pigments such as titanium mica; metal salts such as barium sulfate, calcium carbonate, magnesium carbonate, aluminum silicate and magnesium silicate; inorganic powders such as silica and alumina, bentonite, smectite , Boron nitride, fine particles of titanium oxide, fine particles of zinc oxide and the like, and these are conventionally known surface treatments such as N-acylated lysine treatment, amino acid treatment, hydrophilic polymer treatment, oil treatment, silicone treatment, metal treatment. It is also possible to use those which have been subjected to soap treatment, inorganic compound treatment, plasma treatment, mechanochemical treatment and the like. There is no particular limitation on the shape of these powders (spherical shape, rod shape, needle shape, plate shape, irregular shape, scaly shape, spindle shape, etc.). The size of the powder is preferably in the range of 5 nm to 100 μm, more preferably 10 nm to 25 μm. These powders may be treated alone or formed into a mixture and treated together. It is also possible to treat the mixture with the color adjusted to the skin color or the like. Further, it is possible to obtain a treated powder having an ultraviolet protection function by using an ultraviolet scattering component such as fine particle titanium oxide or fine particle zinc oxide.

As the surfactant, for example, an anionic surfactant, a cationic surfactant, a nonionic surfactant, or an amphoteric surfactant can be used. More specifically, fatty acid soap, α-acyl sulfonate, N-acyl amino acid salt, alkyl sulfonate, alkyl allyl sulfonate, alkyl naphthalene sulfonate, alkyl sulfate, alkyl ether sulfate, alkyl amide sulfate, Anionic surfactants such as alkyl phosphates, alkyl amide phosphates, alkyloyl alkyl taurine salts, sulfosuccinates, perfluoroalkyl phosphates, alkyl trimethyl ammonium chloride, stearyl trimethyl ammonium chloride, stearyl trimethyl ammonium bromide , Cationic surfactants such as cetostearyltrimethylammonium chloride, distearyldimethylammonium chloride, stearyldimethylbenzylammonium chloride and behenyltrimethylammonium bromide, alkanolamide lauric acid, POE (polyoxyethylene, the same applies hereinafter) sorbitan fatty acid ester, Nonionic surfactants such as POE glycerin fatty acid ester, POE fatty acid ester and polyether modified silicone, carboxybetaine type, amidobetaine type, sulfobetaine type, hydroxysulfobetaine type, amidosulfobetaine type, phosphobetaine type, aminocarboxylic acid Examples thereof include salt-type, imidazoline derivative-type and amidoamine-type amphoteric surfactants. Also, natural surfactants such as saponin and sugar-based surfactants can be used.

Examples of the preservatives include benzoic acid, sodium benzoate, undecylenic acid, salicylic acid, sorbic acid or a salt thereof, dehydroacetic acid or a salt thereof, methyl paraoxybenzoate, ethyl paraoxybenzoate, propyl paraoxybenzoate, isopropyl paraoxybenzoate, Butyl paraoxybenzoate, isobutyl paraoxybenzoate, benzyl paraoxybenzoate and other organic acids and their derivatives, isopropylmethylphenol, chlorhexidine gluconate, cresol, thymol, parachlorophenol, phenylethyl alcohol, phenylphenol, sodium phenylphenol, phenoxyethanol , Phenols such as phenoxydiglycol, phenol, benzyl alcohol, stearyltrimethylammonium chloride, cetyltrimethylammonium chloride, cetylpyridinium chloride, benzalkonium chloride, benzethonium chloride, methylbenzethonium chloride, lauryltrimethylammonium chloride, alkylisoquinobromide Examples thereof include quaternary ammonium salts such as lithium and domiphenone bromide, plant extracts such as tea extract, hinokitiol and apple extract, chloramine T, chlorhexidine and zinc pyrithione.

Examples of organic UV absorbers include 2-ethylhexyl paramethoxycinnamate, 2-ethylhexyl paradimethylaminobenzoate, 2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfuric acid. 2,2′-dihydroxy-4-methoxybenzophenone, p-methoxyhydrocinnamic acid diethanolamine salt, para-aminobenzoic acid (hereinafter abbreviated as PABA), homomenthyl salicylate, methyl-O-aminobenzoate, 2-ethylhexyl-2-cyano -3,3-diphenyl acrylate, octyl dimethyl PABA, octyl salicylate, 2-phenyl-benzimidazole-5-sulfate, triethanolamine salicylate, 3-(4-methylbenzylidene)camphor, 2,4-dihydroxybenzophenine, 2,2',4,4'-tetrahydroxybenzophenone, 2,2'-dihydroxy-4,4'-dimethoxybenzophenone, 2-hydroxy-4-N-octoxybenzophenone, 4-isopropyldibenzoylmethane, butylmethoxy Dibenzoylmethane, 4-(3,4-dimethoxyphenylmethylene)-2,5-dioxo-1-imidazolidine propionate 2-ethylhexyl and the like can be mentioned.

Examples of the solvent include purified water, cyclic silicone, ethanol, light liquid isoparaffin, lower alcohol, ethers, LPG, fluorocarbon, N-methylpyrrolidone, fluoroalcohol, and next-generation freon.

Examples of natural plant extract components, seaweed extract components, herbal medicine components include acitaba extract, avocado extract, armature extract, altea extract, arnica extract, aloe extract, apricot extract, apricot kernel extract, ginkgo extract, fennel extract, turmeric. Extract, oolong tea extract, ages extract, gardenia leaf extract, sardine extract, sorghum extract, sardine extract, barley extract, St. John's wort extract, sardine extract, Dutch mustard extract, orange extract, seawater dried product, seaweed extract, hydrolyzed elastin, hydrolyzed Wheat powder, hydrolyzed silk, chamomile extract, carrot extract, sagebrush extract, licorice extract, karkade extract, oyster extract, kiwi extract, kina extract, cucumber extract, guanosine, gardenia extract, kumazasa extract, clara extract, walnut extract, grapefruit extract, Clematis extract, chlorella extract, mulberry extract, gentian extract, black tea extract, yeast extract, burdock extract, rice bran extract, rice germ oil, comfrey extract, collagen, cowberry extract, saishin extract, psycho extract, saitai extract, salvia extract, Soaproot extract, Sasa extract, hawthorn extract, hawthorn extract, shiitake extract, dio extract, shikon extract, perilla extract, linden extract, spirea extract, peony extract, shobu root extract, birch extract, horsetail extract, honeysuckle extract, hawthorn extract, eucalyptus extract Elderberry extract, yarrow extract, mint extract, sage extract, mallow extract, senkyu extract, senburi extract, soybean extract, turmeric extract, thyme extract, tea extract, clove extract, chigaya extract, chimpanzee extract, touki extract, daffodil extract, tounin extract, Spruce extract, Dokudami extract, tomato extract, natto extract, carrot extract, garlic extract, Novara extract, hibiscus extract, bakumondou extract, lotus extract, parsley extract, honey, hamamelis extract, parietaria extract, Hikiokoshi extract, bisabolol, loquat extract, coltsfoot poppo Extract, Fukinotou Extract, Bukuryo Extract, Butcher Bloom Extract, Grape Extract, Propolis, Loofah Extract, Safflower Extract, Peppermint Extract, Bodaiju Extract, Button Extract, Hop Eki Su, pine extract, horse chestnut extract, sardine extract, sucrose extract, melissa extract, peach extract, cornflower extract, eucalyptus extract, yukinoshita extract, yuzu extract, yokuinin extract, wormwood extract, lavender extract, apple extract, lettuce extract, lemon extract, lotus root extract, Examples thereof include rose extract, rosemary extract, Roman chamomile extract, royal jelly extract and the like.

Examples of the water-based colorant include naturally-derived pigments such as Yellow No. 4, Yellow No. 5, Blue No. 1, Blue No. 2, Red No. 226, caramel, copper chlorophyll, gardenia, turmeric and safflower.

As the polyhydric alcohol, it is possible to use any component generally used as a material for cosmetics, for example, glycerin, diglycerin, ethylene glycol, diethylene glycol, triethylene glycol, propylene glycol, dipropylene glycol, polyethylene glycol. , Polypropylene glycol, 1,3-butylene glycol, 3-methyl-1,3-butanediol, 1,2-pentanediol, polyglycerin and its derivatives, polyoxyethylene glycerin (26EO), sorbitol, xylitol, inositol. , Sugar alcohols such as maltitol, lactitol, palatinit, and erythritol.

A thickener may be added to the external skin preparation of the present embodiment in order to adjust the viscosity. Examples of the thickener include water-soluble polymers. Examples of the water-soluble polymer include synthetic water-soluble polymers, semi-synthetic water-soluble polymers, natural water-soluble polymers and the like, which are generally used for external preparations.

Examples of the synthetic water-soluble polymer include long-chain alkyl methacrylic acid copolymers (having 10 to 30 carbon atoms) copolymer, ethylene oxide-propylene oxide block copolymer, carboxyvinyl polymer, polyvinyl alcohol, polyvinylpyrrolidone, polyvinyl methyl ether, Examples thereof include sodium polyacrylate and polyethylene oxide. Among these, from the viewpoint of usability and the like, long-chain alkyl acrylate (10-30 carbon atoms) copolymers (for example, "PEMULEN TR-1" manufactured by BF Goodrich Co., Ltd.), carboxyvinyl Polymers (for example, "Carbopol 934", "Carbopol 940", "Carbopol 941" and the like manufactured by BF Goodrich) are preferably used.

Examples of the semi-synthetic water-soluble polymer include carboxymethyl cellulose or salts thereof (eg, sodium salt, potassium salt, etc.), cellulosic polymers such as ethyl cellulose, methyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, methyl hydroxypropyl cellulose; soluble starch. , Starch-based water-soluble polymers such as carxymethyl starch and methyl starch; alginic acid-based water-soluble polymers such as propylene glycol alginate and alginate; polysaccharide-based water-soluble derivatives.

Examples of natural water-soluble polymers include guar gum, locust bingham, quince seed, carrageenan, galactan, gum arabic, tragacanth gum, pectin, mannan, starch, xanthan gum, dextran, succinoglucan, curdlan, hyaluronic acid, gelatin, casein, Examples thereof include albumin and collagen.

These water-soluble polymers may be used alone or in combination of two or more.

The method for producing the whitening skin external preparation of the present embodiment is not particularly limited, a conventional method for producing a skin external preparation can be used, and appropriately, a method of adding gold foil alone or after mixing is used. You can

This embodiment includes a whitening method using the above-mentioned whitening skin external preparation.

The present invention will be described more specifically with reference to Examples and Comparative Examples, but the present invention is not limited to these Examples and the like.

[Example 1]
[Skin blackening inhibition test using mouse]
The cosmetic containing gold foil was manufactured by weighing out 360 mg of gold foil having a thickness of about 100 nm, adding 5 mL of 5% arabic gum, homogenizing using a homogenizer, and further adding 5% arabic gum to make the total volume 10 mL. A cosmetic product containing no gold foil was produced by weighing 5 g of gum arabic powder with a precision electronic balance, placing it in a 100 mL flask, adding water for injection, making the total volume 100 mL, and thoroughly stirring with a stirrer.
The cosmetics obtained above were repeatedly transdermally applied for 14 days to a mouse in which atopic dermatitis was artificially generated by repeatedly applying the mite antigen (Biosta AD), and the effect on the black area of the skin was observed. did. As a result, when the cosmetic containing gold foil was applied, the skin black area was significantly improved even when the cosmetic was not applied. That is, it was found that the blackening of the skin that excited atopy was significantly improved by the action of the gold foil (see FIG. 1).
In addition, analysis of changes in mouse genes after 14 days using a DNA microarray revealed that genes involved in melanin synthesis were weakened, suggesting a mechanism in which gold leaf is involved in melanin synthesis and delivery to suppress blackening. It was Specifically, due to the action of gold foil, the endothelin gene involved in melanin synthesis was reduced 0.75-fold, and the gene of the receptor that receives the endothelin was reduced 0.68-fold. Further, the gene Mc5r, which is a receptor for hormones that stimulate melanocytes, was also reduced by 0.65 times. Furthermore, the genes Slc45a2 and Oca2, which are considered to influence the skin color involved in melanin synthesis, were reduced by 0.76 times and 0.49 times, respectively. In addition, the gene F2rl1, which is a substance that transports melanin to epidermal cells, was also reduced by 0.67 times.

[Example 2]
[Evaluation of whitening effect by humans]
A cosmetic gel containing gold foil was produced by mixing carbomer with gold foil having a thickness of about 100 nm so as to have a weight concentration of 0.15%. As the cosmetic gel containing no gold leaf, a gel containing only carbomer was used.
The cosmetic gel obtained above was applied to 9 white women aged 35 to 60 years, and L value, melanin concentration, and Hb amount were measured. As a control substance, a gel containing only carbomer was used as a placebo.
When the lightness (L value) of the skin surface was measured using a spectrophotometer, the group to which the cosmetic gel containing gold foil was applied showed a lightness improving effect in 4 weeks and 8 weeks compared with the start time. .. In addition, a significant improvement effect was observed as compared with the placebo-applied group (see FIG. 2).

Melanin level analysis When the melanin concentration and hemoglobin concentration were measured using the skin analysis system (Mexameter), the group to which the cosmetic gel containing gold foil was applied was compared with the group to which the placebo was applied for 8 weeks at the melanin index. After that, a significant improvement effect was observed (see FIG. 3).

In addition, when a photograph of a face was taken using VisioFace (manufactured by Courage & Khazaka) and a skin condition was evaluated by an expert, two people in the group to which the cosmetic gel containing gold foil had been applied showed stains (pigment spots). An improvement was observed.

Claims (8)

Topical skin whitening agent containing gold leaf. The whitening skin external preparation according to claim 1, wherein the gold foil has a thickness of 50 to 500 nm. The whitening skin external preparation according to claim 1 or 2, wherein the content of the gold foil is 0.001 to 0.3% by mass. The whitening skin external preparation according to any one of claims 1 to 3, which has a melanin synthesis inhibitory action. The whitening skin external use according to claim 4, wherein the melanin synthesis inhibitory action is any one or more of the actions of inhibiting hormones that promote melanin synthesis, enzymes involved in melanin synthesis, information mediators, and gene expression. Agent. The whitening according to any one of claims 1 to 5, which is in the form of any one selected from the group consisting of emulsion, cream, lotion, beauty essence, gel, pack, face wash, soap and makeup cosmetic. Skin external preparation. A whitening method using the whitening skin external preparation according to any one of claims 1 to 6. Skin blackening inhibitor containing gold foil.