JP2000063224A - Cosmetic - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a cosmetic having an increased physiological effect, a rough skin-improving effect, etc., and useful as a milky lotion, a cream, a lotion, etc., by adding raffinose and a specific physiologically active ingredient. SOLUTION: This cosmetic contains (A) raffinose obtained from the molasses of sugar beets, etc., and (B) a physiologically active ingredient (preferably an ascorbic acid compound such as ascorbic acid or ascorbic acid sulfate) excluding vitamin E or its derivatives. The components A and B are contained in amounts of preferably 0.1-15 wt.% and 0.05-90 wt.%, more preferably 0.3-5 wt.% and 0.1-50 wt.%, respectively, based on the total amount of the cosmetic. The cosmetic is useful as a calamine lotion, a sunscreen agent, a suntan agent, etc.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to cosmetics having an excellent effect of improving rough skin. More specifically, by containing raffinose, which is a natural component and has an excellent cytoprotective effect, and a physiologically active component other than vitamin E, the skin condition is improved and the effect of the physiologically active component is more effectively expressed. Regarding cosmetics that can be.

[0002]

2. Description of the Related Art Conventionally, raffinose is described in many published patent publications as a kind of polysaccharide, and it is known to be simply added to cosmetics.
Japanese Patent No. 412 proposes a cosmetic containing vitamin E and raffinose.

[0003]

However, none of these publications deals with raffinose in parallel with other sugars, and does not describe the unique physiological activity-enhancing effect of raffinose. On the other hand, cosmetics containing various physiologically active ingredients have been proposed, but sufficient physiologically active effects have not been obtained. That is, an object of the present invention is to provide a cosmetic having a physiologically active effect and a rough skin improving effect.

[0004]

SUMMARY OF THE INVENTION The present inventors have proposed that raffinose is used for the purpose of protecting its own cells when certain plants, for example, legumes, are placed in a harsh environment such as freezing. As a result of diligently examining cosmetics using this, when raffinose and a physiologically active ingredient are used in combination, raffinose improves the state of cells, and therefore, it is possible to more effectively I found that the effect can be obtained. Further, it was found that a cosmetic containing ascorbic acids and raffinose, which are one of the physiologically active ingredients, is suppressed in browning change of ascorbic acids over time.

That is, the first invention is a cosmetic containing (a) raffinose and (b) a physiologically active ingredient excluding vitamin E and its derivatives.

The second invention is (a) raffinose,
(B) ascorbic acid, ascorbic acid sulfate,
A cosmetic containing at least one ascorbic acid selected from the group consisting of ascorbic acid phosphoric acid ester, ascorbic acid higher fatty acid ester, and salts thereof.

[0007]

BEST MODE FOR CARRYING OUT THE INVENTION Raffinose used in the present invention is a type of trisaccharide, and is O-α-D-galactopyranosyl- (1,6) -O-α-D-glucopyranosyl- (1,
2) It has a structure of -β-D-fructofuranoside. It can be obtained from eucalyptus manna, sugar beet molasses, cottonseed, etc., but is most preferable because sugar beet molasses derived from molasses are stably supplied.

The blending ratio of raffinose in the cosmetic of the present invention is preferably 0.1 to 15% by weight, and more preferably 0.3 to 5% by weight, based on the total amount of the cosmetic. Within this range, both the enhancing effect of the physiologically active ingredient and the stabilizing effect of the ascorbic acid can be easily achieved.

Examples of the physiologically active ingredient excluding vitamin E and its derivatives used in the present invention include substances that give some physiological activity to the skin when applied to the skin. For example, whitening ingredients, anti-inflammatory agents, anti-aging agents, slimming agents, tightening agents, antioxidants, hair growth agents, hair growth agents, blood circulation promoters, moisturizing ingredients other than polyhydric alcohols or sugars, desiccants, cooling agents. , Warming agents, amino acids, wound healing promoters, stimulants, analgesics, cell activating agents, enzyme components and the like. Among them, animal and plant extract components, seaweed extract components, naturally derived components such as crude drug components, and ascorbic acids are preferable. In the present invention, it is preferable to blend one or more of these physiologically active ingredients.

These animal and plant extract components, seaweed extract components,
Examples of physiologically active ingredients such as naturally derived ingredients such as crude drug ingredients include acitaba extract, avocado extract, armature extract, altea extract, arnica extract, aloe extract,
Apricot extract, apricot kernel extract, ginkgo biloba extract, fennel extract, turmeric extract, oolong tea extract, ages extract, gardenia leaf extract, sardine extract, psyllium extract, laurel extract, barley extract, St. John's wort extract, scabbard extract, Dutch mustard extract, orange extract. , Dried seawater, seaweed extract, hydrolyzed elastin, hydrolyzed wheat powder, hydrolyzed silk,
Chamomile extract, carrot extract, wormwood extract, licorice extract, oil-soluble licorice extract, karkade extract,
Japanese oleander extract, kiwi extract, quinque extract, cucumber extract, guanosine, gardenia extract, kumazasa extract, clara extract, walnut extract, grapefruit extract, clematis extract, chlorella extract, mulberry extract, gentian extract, black tea extract, yeast extract,
Burdock extract, rice bran extract, rice germ oil, comfrey extract, collagen, cowberry extract, cinnamon extract, psychic extract, saitai extract, salvia extract, sapon extract, sasa extract, hawthorn extract,
Ginseng extract, shiitake extract, sardine extract, shikon extract, perilla extract, linden extract, spirea extract, peony extract, ginseng root extract, birch extract, horse mackerel extract, quince extract, hawthorn extract, sambucus nigra extract, yarrow millet extract, narwhal extract. Extract, sage extract, mallow extract, nematode extract, senburi extract, soybean extract, turmeric extract, thyme extract, tea extract, clove extract, chigaya extract, chimpi extract, touki extract, daffodil extract, tonin extract, spruce extract, dokudami extract, tomato extract, Natto extract, carrot extract, garlic extract,
Novara extract, Hibiscus extract, Bakumondo extract, Parsley extract, Honey, Hamamelis extract, Parietaria extract, Hikiokoshi extract, Bisabolol, Biwa extract, Fukitampo extract, Fukinoto extract, Bukurou extract, Butcher bloom extract, Grape extract, Placenta extract, Propolis, Propolis, Loofah Extract, Safflower Extract, Peppermint Extract, Bodaiju Extract, Button Extract, Hop Extract, Pine Extract, Horse Chestnut Extract, Citrus Unshiu Extract, Mukuroji Extract, Melissa Extract, Peach Extract, Cornflower Extract, Eucalyptus Extract, Yukinoshita Extract, Yuzu Extract, Yokuinin Extract, Mugwort Extract. , Lavender extract, apple extract, lettuce extract, lemon extract, astragalus extract,
Examples thereof include rose extract, rosemary extract, Roman chamomile extract, royal jelly extract and the like.

Specific examples of preferable physiologically active ingredients such as other naturally derived ingredients include deoxyribonucleic acid, mucopolysaccharide, sodium hyaluronate, sodium chondroitin sulfate, collagen, elastin, chitin, chitosan, hydrolyzed egg shell membrane and the like. Biopolymers of amino acids; amino acid derivatives of amino acids, sarcosine, N-methyl-L-serine and the like;
Moisturizing components other than polyhydric alcohols or sugars such as ethyl glucose, sodium lactate, urea, sodium pyrrolidonecarboxylate, betaine, whey; oily components such as sphingolipids, ceramides, cholesterol, cholesterol derivatives, phospholipids; ε-aminocaproic acid, Anti-inflammatory agents such as glycyrrhizinic acid, β-glycyrrhetinic acid, lysozyme chloride, guaiazulene and hydrocortisone; vitamins A, B ₂ , B ₆ , B, calcium pantothenate, biotin, vitamins other than vitamin E such as nicotinic acid amide; allantoin , Diisopropylamine dichloroacetic acid, 4-aminomethylcyclohexanecarboxylic acid and other active ingredients; carotenoids, flavonoids, tannins, lignans, saponins and other antioxidants; α-hydroxy acids, β-
Cell activating agents such as hydroxy acids and mevalonic acids, blood circulation promoting agents such as γ-oryzanol, wound healing agents such as retinol and retinol derivatives; ascorbic acids, arbutin,
Whitening agents such as kojic acid, placenta extract, sulfur, ellagic acid, linoleic acid, tranexamic acid, glutathione; cepharanthin, licorice extract, capsicum tincture, hinokitiol, garlic iodide extract, pyridoxine hydrochloride, nicotinic acid, nicotinic acid derivative, pantothene Calcium acid, D-pantothenyl alcohol, acetylpantothenyl ethyl ether, biotin, allantoin, isopropylmethylphenol, estradiol, ethinylesteradiol, capronium chloride, benzalkonium chloride, diphenhydramine hydrochloride, tacanal, camphor, salicylic acid, vanillylamide nonylate, Nonanoic acid vanillyl amide, piroctone olamine, glyceryl pentadecanoate, 1-menthol, mononitroguaiacol, resorcin, γ Aminobutyric acid, benzethonium chloride, mexiletine hydrochloride, auxin, female hormones, cantharis tincture, cyclosporine, zinc pyrithione,
Examples include hair-growing agents such as hydrocortisone, minoxidil, polyoxyethylene sorbitan monostearate, peppermint oil, and sasanishiki extract.

The above-mentioned ascorbic acids are ascorbic acid, ascorbic acid sulfuric acid ester, ascorbic acid phosphoric acid ester, ascorbic acid higher fatty acid ester, and salts thereof. Those salts are sodium salt, potassium salt, magnesium salt, calcium salt,
Barium salt, ammonium salt, monoethanolamine salt, diethanolamine salt, triethanolamine salt,
Examples include monoisopropanolamine salts, diisopropanolamine salts, triisopropanolamine salts and the like. Examples of the ascorbic acid sulfuric acid ester include ascorbic acid-2-sulfuric acid ester and ascorbic acid-3-sulfuric acid ester, and examples of the ascorbic acid phosphoric acid ester include ascorbic acid-2-phosphoric acid ester and ascorbic acid. -3-Phosphoric acid ester, which is a known substance and is disclosed in JP-B-44-3123.
No. 7 and Japanese Patent Publication No. 54-21415. Examples of higher fatty acid ascorbic acid ester include ascorbic acid-2-palmitic acid monoester, ascorbic acid-2,6-palmitic acid diester, and ascorbic acid-2-stearic acid ester.

The blending ratio of these physiologically active ingredients to the cosmetic depends on the concentration at which the active ingredient produces the effect, but when the extract and the like are taken into consideration, it is generally based on the total amount of the cosmetic,
The amount is preferably 0.05 to 90% by weight, more preferably 0.1 to 50% by weight.

In addition to the above-mentioned components, the cosmetic of the present invention contains an oil agent, powder (pigment, dye,
Resin), fluorine compounds, resins, surfactants, adhesives, preservatives, perfumes, antibacterial agents, bactericides, salts, solvents, chelating agents,
Ingredients such as a neutralizing agent, a pH adjusting agent and an insect repellent can be used.

As an example of the above powder, red No. 104,
Red 201, Yellow 4, Blue 1, Black 401 and other pigments, Yellow 4 Al lake, Yellow 203 Ba lake and other lake pigments; nylon powder, silk powder, urethane powder, Teflon powder, silicone powder, Polymers such as polymethylmethacrylate powder, cellulose powder, silicone elastomer spherical powder, polyethylene powder; colored pigments such as yellow iron oxide, red iron oxide, black iron oxide, chromium oxide, carbon black, ultramarine blue, and navy blue.
White pigments such as zinc oxide, titanium oxide and cerium oxide; extender pigments such as talc, mica, sericite, kaolin and plate barium sulfate; pearl pigments such as mica titanium; barium sulfate, calcium carbonate, magnesium carbonate, aluminum silicate, Metal salts such as magnesium silicate; inorganic powders such as silica and alumina; bentonite, smectite, boron nitride and the like. The shape of these powders is spherical, rod-shaped, needle-shaped, plate-shaped, irregularly-shaped, scaly, spindle-shaped or the like.

These powders are conventionally known surface treatments such as fluorine compound treatment, silicone treatment, silicone resin treatment, pendant treatment, silane coupling agent treatment, titanium coupling agent treatment, oil agent treatment, N-acylation. It may or may not be surface-treated in advance by lysine treatment, polyacrylic acid treatment, metal soap treatment, amino acid treatment, inorganic compound treatment, plasma treatment, mechanochemical treatment and the like.

Of these powders, silicone elastomer spherical powder, polyethylene powder, polypropylene powder, Teflon powder, silicone rubber, urethane powder, polyalkylsilsesquioxane, nylon, silica beads, alumina beads, apatite, allylation Spherical powders (including hollow resin powders) such as acrylic beads are preferably blended because they retain the physiologically active ingredient and are excellent in the effect of sustained release.

Examples of the oil agent include volatile and non-volatile oil agents and solvents and resins which are usually used in cosmetics, and may be liquid, paste or solid at room temperature, but a liquid excellent in handling is preferable. Examples of the oil agent include higher alcohols such as cetyl alcohol, isostearyl alcohol, lauryl alcohol, hexadecyl alcohol, and octyldodecanol; fatty acids such as isostearic acid, undecylenic acid, and oleic acid;
Polyhydric alcohols and sugars such as glycerin, sorbitol, ethylene glycol, propylene glycol, polyethylene glycol; myristyl myristate, hexyl laurate, decyl oleate, isopropyl myristate, hexyldecyl dimethyloctanoate, glyceryl monostearate, diethyl phthalate , Esters such as ethylene glycol monostearate and octyl oxystearate; hydrocarbons such as liquid paraffin, petrolatum and squalane; waxes such as lanolin, reduced lanolin and carnauba wax; mink oil, cocoa butter, coconut oil, palm kernel oil, Fats and oils such as camellia oil, sesame oil, castor oil, and olive oil; and ethylene / α-olefin / cooligomers.

Further, examples of the oil agent in another form include, for example, dimethylpolysiloxane, methylhydrogenpolysiloxane, methylphenylpolysiloxane, polyether-modified organopolysiloxane, fluoroalkyl / polyoxyalkylene co-modified organopolysiloxane. , Silicone compounds such as alkyl-modified organopolysiloxane, terminal-modified organopolysiloxane, fluorine-modified organopolysiloxane, amodimethicone, amino-modified organopolysiloxane, silicone gel, acrylic silicone, trimethylsiloxysilicic acid, silicone RTV rubber; perfluoropolyether , Fluorinated pitch, fluorocarbon, fluoroalcohol and other fluorine compounds.

Examples of the solvent include purified water, cyclic silicone, ethanol, light liquid isoparaffin, lower alcohol, ethers, LPG, fluorocarbon, N-methylpyrrolidone, fluoroalcohol, volatile linear silicone, next-generation CFC, etc. Is mentioned. However, although raffinose is easily soluble in water, it is insoluble in ethanol. Therefore, the cosmetic of the present invention preferably contains purified water.

As the surface active agent, for example, an anionic surface active agent, a cationic surface active agent, a nonionic surface active agent or a betaine surface active agent can be used.

Examples of the tackifier and resin are sodium polyacrylate, cellulose ether, calcium alginate, carboxyvinyl polymer, ethylene / acrylic acid copolymer, vinylpyrrolidone polymer, vinyl alcohol / vinylpyrrolidone copolymer, nitrogen. Substituted acrylamide polymer, polyacrylamide, cationic polymer such as cationized guar gum, dimethyl acrylic ammonium polymer, acrylic acid methacrylic acid acrylic copolymer, POE / POP copolymer, polyvinyl alcohol, pullulan, agar, gelatin, tamarind seed Polysaccharides, xanthan gum, carrageenan, high methoxyl pectin, low methoxyl pectin, guar gum, gum arabic, crystalline cellulose, arabinogalactan, karaya gum, tragacanth Arm, alginic acid, albumin, casein, curdlan, gellan gum, dextran, cellulose, polyethyleneimine, highly polymerized polyethylene glycol, cationized silicone polymer, synthetic latex, and the like.

It is also preferable to impart an ultraviolet protection effect to the cosmetic of the present invention. In this case, it is preferable to use an ultraviolet protective agent as shown below. The blending amount of the UV protection agent is 0.005 to 5 based on the total amount of the cosmetics.
0% by weight is preferable, and more preferably 0.01 to 40.
% By weight.

UV protection agent (including organic type and inorganic type. U
Examples of the inorganic UV-protecting agent include para-methoxycinnamic acid 2). -Ethylhexyl, 2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4
-Methoxybenzophenone-5-sulfuric acid, 2,2'-dihydroxy-4-methoxybenzophenone, p-methoxyhydrocinnamic acid diethanolamine salt, paraaminobenzoic acid (hereinafter abbreviated as PABA), ethyldihydroxypropyl PABA, glyceryl PABA, salicylic acid Homomenthyl, methyl-O-aminobenzoate, 2-ethylhexyl-2-cyano-3,3-diphenylacrylate, octyldimethyl PABA, octyl methoxycinnamate, octyl salicylate, 2-phenyl-benzimidazole-5-sulfate, trisalicylic acid. Ethanolamine, 3- (4-methylbenzylidene) camphor, 2,
4-dihydroxybenzophenine, 2,2 ', 4,4'
-Tetrahydroxybenzophenone, 2,2'-dihydroxy-4,4'-dimethoxybenzophenone, 2-hydroxy-4-N-octoxybenzophenone, 4-isopropyldibenzoylmethane, butylmethoxydibenzoylmethane, 4- (3, 4-dimethoxyphenylmethylene) -2,5-dioxo-1-imidazolidine propionate 2-ethylhexyl, polymer derivatives thereof, silane derivatives and the like. Further, among these, those obtained by sealing 4-tert-butyl-4′-methoxydibenzoylmethane in a polymer can be preferably used.

The cosmetics of the present invention include, for example, emulsions,
Cream, lotion, calamine lotion, sunscreen agent, tanning agent, aftershave lotion,
Pre-shave lotion, makeup base, pack, cleansing, facial cleanser, anti-acne cosmetic, basic cosmetics such as essence; foundation, white powder, eye shadow, eyeliner, eyebrow, cheek, lipstick, nail color, etc. Cosmetics: shampoo, rinse, conditioner, hair color, hair tonic, setting agent, body powder, deodorant, depilator, soap, body shampoo, hand soap, perfume and the like.

As the dosage form of the cosmetic of the present invention, there are two layers,
Conventionally known dosage forms such as water-in-oil emulsion, oil-in-water emulsion, gel, spray, mousse, oil, solid, and sheet can be used.

[0027]

EXAMPLES The present invention will be described in detail below with reference to examples and comparative examples. The evaluation methods of the rough skin improving effect of the cosmetics obtained in Examples and Comparative Examples are shown below.

Rough Skin Improvement Test A rough skin improvement test was carried out to evaluate the usefulness on the skin. The samples of Examples and Comparative Examples were applied to the faces of 30 adult women with rough skin, and the number of people who showed improvement of rough skin after 5 weeks was shown. Therefore, it is shown that the larger the number of people, the higher the improvement effect.

Examples 1 to 5 and Comparative Examples 1 to 3 (skin cream) Raffinose and physiologically active ingredients (cholesterol, aloe extract, urea, γ-oryzanol, ceramide, L-serine, glycine) were prepared in the compositions shown in Table 1, respectively. To prepare a skin cream.

(1) Composition

[0031]

[Table 1]

(2) Preparation method The components (A) and (B) are each melted by heating at 80 ° C., then mixed, cooled with stirring, cooled to 30 ° C., and then filled in a container to obtain a product. Obtained.

Examples 6 to 11 and Comparative Examples 4 to 6 (skin lotion) Raffinose and physiologically active ingredients (various extracts, hyaluronic acid, ethyl glucose, caffeine, N-methyl-L-).
Serine, peach leaf extract, and vitamin B ₆ hydrochloride) were blended in the composition shown in Table 2 to prepare a skin lotion.

(1) Composition

[0035]

[Table 2]

(2) Preparation method The components were mixed and dissolved, and then filled in a container to obtain a product.

Examples 12 to 17 and Comparative Examples 7 to 8 (lipophilic skin cream) Raffinose and physiologically active ingredients (diisopropylamine dichloroacetic acid, licorice extract, γ-aminobutyric acid, nicotinic acid amide, sodium ascorbyl phosphate ester) , Sodium ascorbate sulfate, placenta extract) were blended in the compositions shown in Table 3 to prepare a skin cream.

(1) Composition

[0039]

[Table 3]

(Note 1) BY by Toray Dow Corning, BY
22-008 (Note 2) ABI manufactured by Gold Schmidt-Taher
LE M90 (Note 3) Toray Dow Corning, trefill

(2) Preparation method The components (A) and (B) are each melted by heating at 60 ° C., then mixed, cooled with stirring, cooled to 30 ° C., and then filled in a container to obtain a product. Obtained.

Examples 18 to 23 (Beauty Solution) Raffinose and physiologically active ingredients (oil-soluble licorice extract, horsetail extract, dipotassium glycyrrhizinate, sarcosine,
N-methyl-L-serine, hibiscus extract, lactic acid,
Mevalonic acid) was blended in the composition shown in Table 4 to prepare a cream.

(1) Composition

[0044]

[Table 4]

(Note 4) YOFCO CL, manufactured by Nippon Seika Co., Ltd.
E-NH

(2) Preparation Method The components (A) and (B) are dissolved by heating at 60 ° C., then mixed, cooled with stirring, cooled to 30 ° C., and then filled in a container to obtain a product. Obtained.

Table 5 shows the evaluation results for rough skin improvement.

[0048]

[Table 5]

From the results of Table 5, Examples 1 to 11 of the present invention
In comparison with Comparative Examples 1 to 6, it was found that the effect of improving rough skin was excellent, and changes such as improvement of skin elasticity and improvement of fine wrinkles were observed. Also, in Examples 12 to 23, rough skin is improved and the skin's elasticity is improved.
Changes such as improved complexion and improved fine wrinkles were observed. Furthermore, the products of Examples 15 and 16 in which ascorbic acid and raffinose were mixed and the products of Comparative Examples 7 and 8 in which only ascorbic acid was mixed were subjected to a storage stability test at 40 ° C. for 1, 2 and 3 months. As a result, in Examples 15 and 16, no abnormality was found in appearance and feel,
Although it had a whitening effect, Comparative Examples 7 and 8 showed browning by visual observation.

[0050]

EFFECTS OF THE INVENTION From the above, the present invention improves the skin condition such as rough skin by containing raffinose and a physiologically active component which are natural components and are excellent in cell protection effect, and more effective. It is clear that a cosmetic material that can effectively exert the effect of the physiologically active ingredient can be obtained. Also,
The cosmetic containing ascorbic acids and raffinose, which are one of the physiologically active ingredients, can suppress the browning change of ascorbic acids over time.

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Claims (2)

[Claims] 1. A cosmetic containing (a) raffinose and (b) a physiologically active ingredient excluding vitamin E and its derivatives. 2. (a) Raffinose and (b) ascorbic acid, ascorbic acid sulfuric acid ester, ascorbic acid phosphoric acid ester, ascorbic acid higher fatty acid ester,
And a cosmetic containing at least one ascorbic acid selected from the group consisting of salts thereof.