JP2020111602A5 - - Google Patents
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- Publication number
- JP2020111602A5 JP2020111602A5 JP2020068792A JP2020068792A JP2020111602A5 JP 2020111602 A5 JP2020111602 A5 JP 2020111602A5 JP 2020068792 A JP2020068792 A JP 2020068792A JP 2020068792 A JP2020068792 A JP 2020068792A JP 2020111602 A5 JP2020111602 A5 JP 2020111602A5
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- pyridin
- oxy
- carbamoyl
- pyridine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 C*(C)(C)*C(C(N=C=O)=O)=* Chemical compound C*(C)(C)*C(C(N=C=O)=O)=* 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361789971P | 2013-03-15 | 2013-03-15 | |
| US61/789,971 | 2013-03-15 | ||
| JP2018126337A JP2018184416A (ja) | 2013-03-15 | 2018-07-02 | 抗がんおよび抗増殖活性を示すｎ−アシル−ｎ’−（ピリジン−２−イル）尿素および類似体 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018126337A Division JP2018184416A (ja) | 2013-03-15 | 2018-07-02 | 抗がんおよび抗増殖活性を示すｎ−アシル−ｎ’−（ピリジン−２−イル）尿素および類似体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020111602A JP2020111602A (ja) | 2020-07-27 |
| JP2020111602A5 true JP2020111602A5 (https=) | 2021-04-22 |
| JP6985448B2 JP6985448B2 (ja) | 2021-12-22 |
Family
ID=51529946
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016503187A Active JP6364472B2 (ja) | 2013-03-15 | 2014-03-14 | 抗がんおよび抗増殖活性を示すｎ−アシル−ｎ’−（ピリジン−２−イル）尿素および類似体 |
| JP2018126337A Pending JP2018184416A (ja) | 2013-03-15 | 2018-07-02 | 抗がんおよび抗増殖活性を示すｎ−アシル−ｎ’−（ピリジン−２−イル）尿素および類似体 |
| JP2020068792A Active JP6985448B2 (ja) | 2013-03-15 | 2020-04-07 | 抗がんおよび抗増殖活性を示すｎ−アシル−ｎ’−（ピリジン−２−イル）尿素および類似体 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016503187A Active JP6364472B2 (ja) | 2013-03-15 | 2014-03-14 | 抗がんおよび抗増殖活性を示すｎ−アシル−ｎ’−（ピリジン−２−イル）尿素および類似体 |
| JP2018126337A Pending JP2018184416A (ja) | 2013-03-15 | 2018-07-02 | 抗がんおよび抗増殖活性を示すｎ−アシル−ｎ’−（ピリジン−２−イル）尿素および類似体 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US9382228B2 (https=) |
| EP (1) | EP2968287B1 (https=) |
| JP (3) | JP6364472B2 (https=) |
| KR (2) | KR102386952B1 (https=) |
| CN (3) | CN110563700A (https=) |
| AU (2) | AU2014233414B2 (https=) |
| BR (1) | BR112015022263B1 (https=) |
| CA (1) | CA2903288C (https=) |
| ES (1) | ES2817902T3 (https=) |
| IL (2) | IL241523B (https=) |
| MX (2) | MX366429B (https=) |
| PH (2) | PH12015502336B1 (https=) |
| RU (1) | RU2769607C2 (https=) |
| SG (1) | SG11201508532VA (https=) |
| WO (1) | WO2014145028A2 (https=) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5335056B2 (ja) | 2011-11-16 | 2013-11-06 | 住友電気工業株式会社 | ボルト用アルミニウム合金線及びボルト並びにそれらの製造方法 |
| US8461179B1 (en) | 2012-06-07 | 2013-06-11 | Deciphera Pharmaceuticals, Llc | Dihydronaphthyridines and related compounds useful as kinase inhibitors for the treatment of proliferative diseases |
| JP6364472B2 (ja) * | 2013-03-15 | 2018-07-25 | デシフェラ ファーマシューティカルズ，エルエルシー | 抗がんおよび抗増殖活性を示すｎ−アシル−ｎ’−（ピリジン−２−イル）尿素および類似体 |
| TWI747873B (zh) * | 2016-02-01 | 2021-12-01 | 美商百歐克斯製藥公司 | 苯并吡唑化合物及其類似物 |
| KR101691954B1 (ko) | 2016-04-26 | 2017-01-02 | 고려대학교 산학협력단 | 신규 n-아실유레아 유도체 및 이를 함유하는 심혈관질환의 예방 또는 치료용 조성물 |
| EP3632907B1 (en) * | 2017-05-24 | 2024-02-28 | Abbisko Therapeutics Co., Ltd. | N-(azaaryl)cyclolactam-1-carboxamide derivative, preparation method therefor, and use thereof |
| WO2018233526A1 (zh) * | 2017-06-19 | 2018-12-27 | 上海和誉生物医药科技有限公司 | 一种csf1r抑制剂及其制备方法和应用 |
| US11274109B2 (en) * | 2017-08-24 | 2022-03-15 | Merck Patent Gmbh | Boronic acid derivatives |
| CN109776401A (zh) * | 2017-11-14 | 2019-05-21 | 成都博腾药业有限公司 | 一种制备6-氯-5-三氟甲基-2-氨基吡啶的方法 |
| IL276398B2 (en) | 2018-01-31 | 2026-03-01 | Deciphera Pharmaceuticals Llc | Combination therapy for mastocytosis |
| CN118416236A (zh) | 2018-01-31 | 2024-08-02 | 德西费拉制药有限责任公司 | 治疗胃肠道间质瘤的组合疗法 |
| CN110845476B (zh) * | 2018-08-21 | 2022-11-18 | 上海和誉生物医药科技有限公司 | 一种高选择性csf1r抑制剂、其制备方法和在药学上的应用 |
| BR112021012812A2 (pt) | 2018-12-28 | 2021-12-07 | Deciphera Pharmaceuticals Llc | Csf1r inhibitors para uso e tratamento de câncer |
| HRP20240012T1 (hr) * | 2019-02-06 | 2024-03-29 | Eli Lilly And Company | Derivati 1-((2-(2,2,2-trifluoroetoksi)piridin-4-il)metil)uree kao kcnq potencijatori |
| WO2020185812A1 (en) | 2019-03-11 | 2020-09-17 | Teva Pharmaceuticals International Gmbh | Solid state forms of ripretinib |
| PE20220597A1 (es) | 2019-05-10 | 2022-04-22 | Deciphera Pharmaceuticals Llc | Inhibidores de la autofagia de fenilaminopirimidina amida y metodos de uso de estos |
| US11518758B2 (en) | 2019-05-10 | 2022-12-06 | Deciphera Pharmaceuticals, Llc | Heteroarylaminopyrimidine amide autophagy inhibitors and methods of use thereof |
| PE20221083A1 (es) | 2019-06-17 | 2022-07-05 | Deciphera Pharmaceuticals Llc | Inhibidores de la autofagia de la amida aminopirimidina y sus metodos de uso |
| EP4013412B1 (en) | 2019-08-12 | 2026-01-28 | Deciphera Pharmaceuticals, LLC | Ripretinib for treating gastrointestinal stromal tumors |
| TWI878335B (zh) | 2019-08-12 | 2025-04-01 | 美商迪賽孚爾製藥有限公司 | 治療胃腸道基質瘤方法 |
| EP4084779B1 (en) | 2019-12-30 | 2024-10-09 | Deciphera Pharmaceuticals, LLC | Compositions of 1-(4-bromo-5-(1-ethyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluorophenyl)-3-phenylurea |
| MX2022008103A (es) | 2019-12-30 | 2022-09-19 | Deciphera Pharmaceuticals Llc | Formulaciones de inhibidores de la cinasa amorfa y metodos de estas. |
| IL302807A (en) | 2020-11-18 | 2023-07-01 | Deciphera Pharmaceuticals Llc | Gcn2 and perk kinase inhibitors and methods of use thereof |
| CN115385896B (zh) * | 2021-05-24 | 2024-11-15 | 上海和誉生物医药科技有限公司 | 一种csf-1r抑制剂中间体或其酸式盐的制备方法 |
| TWI912522B (zh) * | 2021-05-24 | 2026-01-21 | 大陸商上海和譽生物醫藥科技有限公司 | 一種結晶型csf-1r抑制劑酸式鹽及其製備方法和應用 |
| PE20250609A1 (es) | 2021-12-03 | 2025-02-26 | Deciphera Pharmaceuticals Llc | Inhibidores de gcn2 y perk quinasa y metodos de uso de los mismos |
| CA3240263A1 (en) | 2021-12-09 | 2023-06-15 | Daniel L. Flynn | Raf kinase inhibitors and methods of use thereof |
| US11779572B1 (en) | 2022-09-02 | 2023-10-10 | Deciphera Pharmaceuticals, Llc | Methods of treating gastrointestinal stromal tumors |
| WO2025122952A1 (en) | 2023-12-08 | 2025-06-12 | Deciphera Pharmaceuticals, Llc | Formulations of vimseltinib |
| US20250206720A1 (en) | 2023-12-08 | 2025-06-26 | Deciphera Pharmaceuticals, Llc | Solid forms of an ulk inhibitor |
| WO2025231106A1 (en) | 2024-05-01 | 2025-11-06 | Deciphera Pharmaceuticals, Llc | Csf-1r inhibitors and methods of use thereof |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE860511L (en) * | 1985-03-01 | 1986-09-01 | Alfa Farmaceutici Spa | "Benzoyl urea derivatives having anti-tumor activity" |
| AU2002313249B2 (en) * | 2001-06-22 | 2008-08-21 | Kirin Pharma Kabushiki Kaisha | Quinoline derivative and quinazoline derivate inhibiting self-phosphorylation of hepatocytus proliferator receptor, and medicinal composition containing the same |
| ATE446294T1 (de) * | 2005-11-15 | 2009-11-15 | Array Biopharma Inc | N4-phenyl-chinazolin-4-aminderivate und verwandte verbindungen als inhibitoren der erbb-typ-i- rezeptortyrosinkinase zur behandlung hyperproliferativer krankheiten |
| WO2008046216A1 (en) * | 2006-10-18 | 2008-04-24 | Methylgene, Inc. | Kinase inhibitors and uses thereof |
| AU2007338792B2 (en) * | 2006-12-20 | 2012-05-31 | Amgen Inc. | Substituted heterocycles and methods of use |
| CL2008002793A1 (es) * | 2007-09-20 | 2009-09-04 | Cgi Pharmaceuticals Inc | Compuestos derivados de amidas sustituidas, inhibidores de la actividad de btk; composicion farmaceutica que los comprende; utiles en el tratamiento del cancer, trastornos oseos, enfermedades autoinmunes, entre otras |
| JP5444365B2 (ja) * | 2008-10-29 | 2014-03-19 | デシフェラ ファーマシューティカルズ，エルエルシー | 抗癌活性および抗増殖活性を示すシクロプロパンアミドおよび類似物質 |
| JP6364472B2 (ja) * | 2013-03-15 | 2018-07-25 | デシフェラ ファーマシューティカルズ，エルエルシー | 抗がんおよび抗増殖活性を示すｎ−アシル−ｎ’−（ピリジン−２−イル）尿素および類似体 |
-
2014
- 2014-03-14 JP JP2016503187A patent/JP6364472B2/ja active Active
- 2014-03-14 WO PCT/US2014/029664 patent/WO2014145028A2/en not_active Ceased
- 2014-03-14 ES ES14764601T patent/ES2817902T3/es active Active
- 2014-03-14 CN CN201910586017.2A patent/CN110563700A/zh active Pending
- 2014-03-14 CA CA2903288A patent/CA2903288C/en active Active
- 2014-03-14 AU AU2014233414A patent/AU2014233414B2/en active Active
- 2014-03-14 KR KR1020217038874A patent/KR102386952B1/ko active Active
- 2014-03-14 US US14/214,185 patent/US9382228B2/en active Active
- 2014-03-14 BR BR112015022263-3A patent/BR112015022263B1/pt active IP Right Grant
- 2014-03-14 CN CN202010826889.4A patent/CN112047927A/zh active Pending
- 2014-03-14 PH PH1/2015/502336A patent/PH12015502336B1/en unknown
- 2014-03-14 SG SG11201508532VA patent/SG11201508532VA/en unknown
- 2014-03-14 MX MX2015013404A patent/MX366429B/es active IP Right Grant
- 2014-03-14 KR KR1020157029126A patent/KR102333718B1/ko active Active
- 2014-03-14 CN CN201480026796.6A patent/CN105228620B/zh active Active
- 2014-03-14 RU RU2015143718A patent/RU2769607C2/ru not_active Application Discontinuation
- 2014-03-14 EP EP14764601.2A patent/EP2968287B1/en active Active
- 2014-03-14 PH PH1/2020/550201A patent/PH12020550201A1/en unknown
-
2015
- 2015-09-10 IL IL24152315A patent/IL241523B/en active IP Right Grant
- 2015-09-17 MX MX2019008003A patent/MX2019008003A/es unknown
-
2018
- 2018-07-02 JP JP2018126337A patent/JP2018184416A/ja active Pending
- 2018-09-24 AU AU2018236691A patent/AU2018236691B2/en active Active
-
2019
- 2019-09-19 IL IL269451A patent/IL269451B/en unknown
-
2020
- 2020-04-07 JP JP2020068792A patent/JP6985448B2/ja active Active
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