ES2817902T3 - N-acil-N'-(piridin-2-il) ureas y análogos que presentan actividades anticancerosas y antiproliferativas - Google Patents

N-acil-N'-(piridin-2-il) ureas y análogos que presentan actividades anticancerosas y antiproliferativas Download PDF

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Publication number
ES2817902T3
ES2817902T3 ES14764601T ES14764601T ES2817902T3 ES 2817902 T3 ES2817902 T3 ES 2817902T3 ES 14764601 T ES14764601 T ES 14764601T ES 14764601 T ES14764601 T ES 14764601T ES 2817902 T3 ES2817902 T3 ES 2817902T3
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pyridin
methyl
oxy
carbamoyl
pyrazol
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Inventor
Timothy Malcolm Caldwell
William C Patt
Thiwanka Samarakoon
Lakshminarayana Vogeti
Karen M Yates
Daniel L Flynn
Michael D Kaufman
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Deciphera Pharmaceuticals LLC
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Deciphera Pharmaceuticals LLC
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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ES14764601T 2013-03-15 2014-03-14 N-acil-N'-(piridin-2-il) ureas y análogos que presentan actividades anticancerosas y antiproliferativas Active ES2817902T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361789971P 2013-03-15 2013-03-15
PCT/US2014/029664 WO2014145028A2 (en) 2013-03-15 2014-03-14 N-acyl-n'-(pyridin-2-yl) ureas and analogs exhibiting anti-cancer and anti-proliferative activities

Publications (1)

Publication Number Publication Date
ES2817902T3 true ES2817902T3 (es) 2021-04-08

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ES14764601T Active ES2817902T3 (es) 2013-03-15 2014-03-14 N-acil-N'-(piridin-2-il) ureas y análogos que presentan actividades anticancerosas y antiproliferativas

Country Status (15)

Country Link
US (1) US9382228B2 (https=)
EP (1) EP2968287B1 (https=)
JP (3) JP6364472B2 (https=)
KR (2) KR102333718B1 (https=)
CN (3) CN110563700A (https=)
AU (2) AU2014233414B2 (https=)
BR (1) BR112015022263B1 (https=)
CA (1) CA2903288C (https=)
ES (1) ES2817902T3 (https=)
IL (2) IL241523B (https=)
MX (2) MX366429B (https=)
PH (2) PH12015502336B1 (https=)
RU (1) RU2769607C2 (https=)
SG (1) SG11201508532VA (https=)
WO (1) WO2014145028A2 (https=)

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US8461179B1 (en) 2012-06-07 2013-06-11 Deciphera Pharmaceuticals, Llc Dihydronaphthyridines and related compounds useful as kinase inhibitors for the treatment of proliferative diseases
RU2769607C2 (ru) * 2013-03-15 2022-04-04 ДЕСИФЕРА ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи N-ацил-N'-(пиридин-2-ил) карбамиды и их аналоги, проявляющие противораковую и антипролиферативную активность
TWI854164B (zh) * 2016-02-01 2024-09-01 美商百歐克斯製藥公司 苯并吡唑化合物及其類似物
KR101691954B1 (ko) * 2016-04-26 2017-01-02 고려대학교 산학협력단 신규 n-아실유레아 유도체 및 이를 함유하는 심혈관질환의 예방 또는 치료용 조성물
EP3632907B1 (en) * 2017-05-24 2024-02-28 Abbisko Therapeutics Co., Ltd. N-(azaaryl)cyclolactam-1-carboxamide derivative, preparation method therefor, and use thereof
CN110461849B (zh) * 2017-06-19 2020-09-01 上海和誉生物医药科技有限公司 一种csf1r抑制剂及其制备方法和应用
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CN109776401A (zh) * 2017-11-14 2019-05-21 成都博腾药业有限公司 一种制备6-氯-5-三氟甲基-2-氨基吡啶的方法
IL276398B2 (en) 2018-01-31 2026-03-01 Deciphera Pharmaceuticals Llc Combination therapy for mastocytosis
KR102708177B1 (ko) 2018-01-31 2024-09-23 데시페라 파마슈티칼스, 엘엘씨. 위장관 기질 종양의 치료를 위한 병용 요법
CN110845476B (zh) * 2018-08-21 2022-11-18 上海和誉生物医药科技有限公司 一种高选择性csf1r抑制剂、其制备方法和在药学上的应用
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HUE064734T2 (hu) * 2019-02-06 2024-04-28 Lilly Co Eli 1-((2-(2,2,2-trifluoretoxi)piridin-4-il)metil)karbamid származékok mint KCNQ potenciátorok
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EP3966207B1 (en) 2019-05-10 2023-11-01 Deciphera Pharmaceuticals, LLC Phenylaminopyrimidine amide autophagy inhibitors and methods of use thereof
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IL325201A (en) 2019-06-17 2026-02-01 Deciphera Pharmaceuticals Llc Aminopyrimidine amide autophagy inhibitors and methods of using them
LT4013412T (lt) 2019-08-12 2026-03-25 Deciphera Pharmaceuticals, Llc Ripretinibas, skirtas virškinamojo trakto stromos navikų gydymui
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