JP2020029420A - 発毛促進、脱毛防止又はキューティクル改善用組成物及び創傷治癒剤 - Google Patents
発毛促進、脱毛防止又はキューティクル改善用組成物及び創傷治癒剤 Download PDFInfo
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Abstract
Description
項2.ヒシ属に属する植物の果皮の抽出物を有効成分とする、項1に記載の組成物。
項3.前記ヒシ属に属する植物がトウビシである、項1又は2に記載の組成物。
項4.ヒシ属に属する植物の抽出物を有効成分とする創傷治癒剤。
項5.ヒシ属に属する植物の果皮の抽出物を有効成分とする、項4に記載の創傷治癒剤。
項6.前記ヒシ属に属する植物がトウビシである、項4又は5に記載の創傷治癒剤。
ヒシ属に属する植物としては、特に制限されず、例えば、ヒシ(Trapa japonica)、オニビシ(Trapa natans L. ver. Japonica)、ヒメビシ(Trapa incisa)、トウビシ(Trapa bispinosa Roxb.)、ツノナシビシ(Trapa acornis)、トラパ・ナタンス(Trapa natans)
などが挙げられる。中でも、トウビシが好ましい。
本発明の発毛促進、脱毛防止又はキューティクル改善用組成物は、ヒシ属に属する植物の抽出物により発毛促進、脱毛防止及びキューティクル改善作用を発揮するため、発毛促進、脱毛防止又はキューティクル改善用外用剤、発毛促進、脱毛防止又はキューティクル改善用経口剤、頭髪用化粧料、飲食品、発毛促進、脱毛防止又はキューティクル改善作用を付与する添加剤等として、好適に使用することができる。本発明において、発毛には、育毛及び養毛の概念が含まれているものとする。
本発明の創傷治癒剤は、ヒシ属に属する植物の抽出物により創傷治癒効果を発揮するため、創傷治癒用外用剤、創傷治癒用経口剤、皮膚用化粧料、飲食品、創傷治癒効果を付与する添加剤等として、好適に使用することができる。
・ヒシエキス
林兼産業株式会社製のヒシエキス(トウビシ果皮熱水抽出物)を使用した。
0.4 mmolグリオキシル酸、1.2 mmolシアノ水素化ホウ素ナトリウム、及び400 mgウシ血清アルブミン(bovine serum albumin; BSA)をそれぞれ8 mlのpH7.4のリン酸緩衝液に溶かし、37℃で24時間インキュベートした。PD-10カラム(GE Healthcare Ltd., Osaka, Japan)をスタンドに固定し、pH7.4リン酸緩衝液を2 ml流してカラムを共洗いした後、2.5 mlのCMLをカラムに通した。カラム精製した試料を、ナノドロップ2000 (Thermo Fisher Scientific Inc., Ltd. Tokyo, Japan)にてOD280の吸光度測定により、フラクションを精製した。さらに、Slide-A-Lyzer 10,000 MWCO (Thermo Fisher Scientific Inc., Ltd)を使用して透析によりCMLを精製した。
8週齢、メスのC57BL/6マウスの背中の毛をセメダインバスコークN (セメダイン株式会社, Tokyo, Japan)を適量塗布し、24時間経過させ乾燥後に強制抜毛を行った。抜毛部位に27G×1/2注射針(NIPRO, Osaka, Japan)を用いて200 mg/ml CML 200μlを皮内に10か所程度注射した。2日後にマウスを安楽死させ、背部皮膚を摘出し試料とした。試料を4%パラホルムアルデヒド・リン酸緩衝液(Wako Pure Chemical Industries Ltd., Osaka, Japan)で組織固定を行い、パラフィン包埋を行い、5μmの薄切によりパラフィン切片を得た。
配合量(質量%)
モノイソステアリン酸デカグリセリル 1.0
モノミリスチン酸デカグリセリル 1.0
グリセリン 3.0
流動パラフィン 5.0
H20 89.5
ヒシエキス 0.5
100
8週齢、メスのC57BL/6マウスにストレプトゾトシンを投与後に、ヒシエキス2%を水に溶解した物又は水道水を自由引水させた。8週間後に背中の毛をセメダインバスコークNにより強制抜毛を行い、毛髪再生を観察した。
有意差の検定はstudent's unpaired t-testを用いて行った。P<0.05の場合は有意に異なるものと判定した。
・試験例1(外用試験)
マウス背部皮内にCMLを注射しヒシエキスを外用塗布することで、皮膚におけるヒシエキスによる毛包形成への影響を調べた。背部の毛を強制脱毛することで毛包形成周期をリセットし、成長期に強制的に移行させることで、毛包の形成初期におけるヒシエキスの影響を組織学的に観察した。結果を図1に示す。
マウスにストレプトゾトシンを投与したストレプトゾトシン誘発糖尿病モデルマウスにヒシエキスを自由引水させ、ヒシエキスの経口投与による効果を観察した。結果を図4に示す。
Claims (6)
- ヒシ属に属する植物の抽出物を有効成分とする、発毛促進、脱毛防止又はキューティクル改善用組成物。
- ヒシ属に属する植物の果皮の抽出物を有効成分とする、請求項1に記載の組成物。
- 前記ヒシ属に属する植物がトウビシである、請求項1又は2に記載の組成物。
- ヒシ属に属する植物の抽出物を有効成分とする創傷治癒剤。
- ヒシ属に属する植物の果皮の抽出物を有効成分とする、請求項4に記載の創傷治癒剤。
- 前記ヒシ属に属する植物がトウビシである、請求項4又は5に記載の創傷治癒剤。
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US20030021857A1 (en) * | 2001-07-24 | 2003-01-30 | Nitto Denko Corporation | Composition having physiological activity and production method thereof |
JP2003063976A (ja) * | 2001-08-28 | 2003-03-05 | Ichimaru Pharcos Co Ltd | ヒシ抽出物含有化粧料組成物 |
CN105233255A (zh) * | 2015-10-16 | 2016-01-13 | 郭艳 | 一种用于病理性脱发的中西药复方护理剂及其制备方法 |
JP2017141217A (ja) * | 2016-02-05 | 2017-08-17 | 参天製薬株式会社 | キサントフィルとヒシ属植物の加工物を含有する組成物 |
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US20030021857A1 (en) * | 2001-07-24 | 2003-01-30 | Nitto Denko Corporation | Composition having physiological activity and production method thereof |
JP2003063976A (ja) * | 2001-08-28 | 2003-03-05 | Ichimaru Pharcos Co Ltd | ヒシ抽出物含有化粧料組成物 |
CN105233255A (zh) * | 2015-10-16 | 2016-01-13 | 郭艳 | 一种用于病理性脱发的中西药复方护理剂及其制备方法 |
JP2017141217A (ja) * | 2016-02-05 | 2017-08-17 | 参天製薬株式会社 | キサントフィルとヒシ属植物の加工物を含有する組成物 |
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