JP2019537555A5 - - Google Patents
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- JP2019537555A5 JP2019537555A5 JP2019516389A JP2019516389A JP2019537555A5 JP 2019537555 A5 JP2019537555 A5 JP 2019537555A5 JP 2019516389 A JP2019516389 A JP 2019516389A JP 2019516389 A JP2019516389 A JP 2019516389A JP 2019537555 A5 JP2019537555 A5 JP 2019537555A5
- Authority
- JP
- Japan
- Prior art keywords
- vaccine
- herpes
- hsv
- vaccine formulation
- antiviral
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229960005486 vaccine Drugs 0.000 claims description 125
- 239000000203 mixture Substances 0.000 claims description 90
- 238000009472 formulation Methods 0.000 claims description 76
- 238000002560 therapeutic procedure Methods 0.000 claims description 69
- 230000000840 anti-viral effect Effects 0.000 claims description 63
- 238000000034 method Methods 0.000 claims description 63
- 208000001688 Herpes Genitalis Diseases 0.000 claims description 61
- 201000004946 genital herpes Diseases 0.000 claims description 61
- XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 claims description 57
- 241000701074 Human alphaherpesvirus 2 Species 0.000 claims description 52
- 238000002360 preparation method Methods 0.000 claims description 41
- 229920001184 polypeptide Polymers 0.000 claims description 33
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 33
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 33
- 230000003902 lesion Effects 0.000 claims description 30
- 101150027427 ICP4 gene Proteins 0.000 claims description 27
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- 230000007423 decrease Effects 0.000 claims description 17
- 210000004392 genitalia Anatomy 0.000 claims description 17
- 239000002671 adjuvant Substances 0.000 claims description 16
- 206010019973 Herpes virus infection Diseases 0.000 claims description 12
- 239000001397 quillaja saponaria molina bark Substances 0.000 claims description 12
- 229930182490 saponin Natural products 0.000 claims description 12
- 235000017709 saponins Nutrition 0.000 claims description 12
- 150000007949 saponins Chemical class 0.000 claims description 12
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- 239000003814 drug Substances 0.000 claims description 7
- 241000700588 Human alphaherpesvirus 1 Species 0.000 claims description 6
- HDOVUKNUBWVHOX-QMMMGPOBSA-N Valacyclovir Chemical compound N1C(N)=NC(=O)C2=C1N(COCCOC(=O)[C@@H](N)C(C)C)C=N2 HDOVUKNUBWVHOX-QMMMGPOBSA-N 0.000 claims description 6
- 210000003918 fraction a Anatomy 0.000 claims description 6
- 210000000540 fraction c Anatomy 0.000 claims description 6
- 239000002245 particle Substances 0.000 claims description 6
- 229940093257 valacyclovir Drugs 0.000 claims description 6
- 241000700605 Viruses Species 0.000 claims description 5
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- 229940079593 drug Drugs 0.000 claims description 5
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- 208000023275 Autoimmune disease Diseases 0.000 claims description 4
- 102000004190 Enzymes Human genes 0.000 claims description 4
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- 125000003275 alpha amino acid group Chemical group 0.000 claims description 4
- 239000000427 antigen Substances 0.000 claims description 4
- 102000036639 antigens Human genes 0.000 claims description 4
- 108091007433 antigens Proteins 0.000 claims description 4
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims description 4
- DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 claims description 4
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 2
- PIGTXFOGKFOFTO-PPEDVFHSSA-N CC1(C)CC[C@@]2([C@H](O)C[C@]3(C)C(=CC[C@@H]4[C@@]5(C)CCC(O[C@@H]6O[C@@H]([C@@H](O)[C@H](O)[C@H]6O)C(O)=O)[C@@](C)(C=O)[C@@H]5CC[C@@]34C)[C@@H]2C1)C(O)=O Chemical compound CC1(C)CC[C@@]2([C@H](O)C[C@]3(C)C(=CC[C@@H]4[C@@]5(C)CCC(O[C@@H]6O[C@@H]([C@@H](O)[C@H](O)[C@H]6O)C(O)=O)[C@@](C)(C=O)[C@@H]5CC[C@@]34C)[C@@H]2C1)C(O)=O PIGTXFOGKFOFTO-PPEDVFHSSA-N 0.000 claims description 2
- 208000009139 Gilbert Disease Diseases 0.000 claims description 2
- 208000022412 Gilbert syndrome Diseases 0.000 claims description 2
- 208000000903 Herpes simplex encephalitis Diseases 0.000 claims description 2
- 206010020751 Hypersensitivity Diseases 0.000 claims description 2
- 206010061598 Immunodeficiency Diseases 0.000 claims description 2
- 208000029462 Immunodeficiency disease Diseases 0.000 claims description 2
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims description 2
- 239000004472 Lysine Substances 0.000 claims description 2
- 201000009906 Meningitis Diseases 0.000 claims description 2
- 230000002159 abnormal effect Effects 0.000 claims description 2
- 229960004150 aciclovir Drugs 0.000 claims description 2
- MKUXAQIIEYXACX-UHFFFAOYSA-N aciclovir Chemical compound N1C(N)=NC(=O)C2=C1N(COCCO)C=N2 MKUXAQIIEYXACX-UHFFFAOYSA-N 0.000 claims description 2
- 208000026935 allergic disease Diseases 0.000 claims description 2
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- 210000004369 blood Anatomy 0.000 claims description 2
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- 229940000406 drug candidate Drugs 0.000 claims description 2
- 229960004396 famciclovir Drugs 0.000 claims description 2
- GGXKWVWZWMLJEH-UHFFFAOYSA-N famcyclovir Chemical compound N1=C(N)N=C2N(CCC(COC(=O)C)COC(C)=O)C=NC2=C1 GGXKWVWZWMLJEH-UHFFFAOYSA-N 0.000 claims description 2
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- 239000002547 new drug Substances 0.000 claims description 2
- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 claims description 2
- 230000035935 pregnancy Effects 0.000 claims description 2
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- 239000013589 supplement Substances 0.000 claims description 2
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- 238000001262 western blot Methods 0.000 claims description 2
- 239000003443 antiviral agent Substances 0.000 claims 26
- BPYKTIZUTYGOLE-IFADSCNNSA-N Bilirubin Chemical compound N1C(=O)C(C)=C(C=C)\C1=C\C1=C(C)C(CCC(O)=O)=C(CC2=C(C(C)=C(\C=C/3C(=C(C=C)C(=O)N\3)C)N2)CCC(O)=O)N1 BPYKTIZUTYGOLE-IFADSCNNSA-N 0.000 claims 2
- 206010015218 Erythema multiforme Diseases 0.000 claims 1
- 108091000080 Phosphotransferase Proteins 0.000 claims 1
- 229940124558 contraceptive agent Drugs 0.000 claims 1
- -1 for example Substances 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 102000020233 phosphotransferase Human genes 0.000 claims 1
- 229960004556 tenofovir Drugs 0.000 claims 1
- VCMJCVGFSROFHV-WZGZYPNHSA-N tenofovir disoproxil fumarate Chemical compound OC(=O)\C=C\C(O)=O.N1=CN=C2N(C[C@@H](C)OCP(=O)(OCOC(=O)OC(C)C)OCOC(=O)OC(C)C)C=NC2=C1N VCMJCVGFSROFHV-WZGZYPNHSA-N 0.000 claims 1
- 230000003247 decreasing effect Effects 0.000 description 59
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- 229940027941 immunoglobulin g Drugs 0.000 description 5
- 102000001398 Granzyme Human genes 0.000 description 4
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- 238000003752 polymerase chain reaction Methods 0.000 description 3
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- 206010015150 Erythema Diseases 0.000 description 1
- 102000001253 Protein Kinase Human genes 0.000 description 1
- 210000001744 T-lymphocyte Anatomy 0.000 description 1
- BPYKTIZUTYGOLE-UHFFFAOYSA-N billirubin-IXalpha Natural products N1C(=O)C(C)=C(C=C)C1=CC1=C(C)C(CCC(O)=O)=C(CC2=C(C(C)=C(C=C3C(=C(C=C)C(=O)N3)C)N2)CCC(O)=O)N1 BPYKTIZUTYGOLE-UHFFFAOYSA-N 0.000 description 1
- 230000002254 contraceptive effect Effects 0.000 description 1
- 231100000321 erythema Toxicity 0.000 description 1
- 108060006633 protein kinase Proteins 0.000 description 1
- 238000003753 real-time PCR Methods 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 238000000316 virotherapy Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662401148P | 2016-09-28 | 2016-09-28 | |
| US62/401,148 | 2016-09-28 | ||
| PCT/US2017/053835 WO2018064232A1 (en) | 2016-09-28 | 2017-09-27 | Methods and compositions for treating herpes |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019537555A JP2019537555A (ja) | 2019-12-26 |
| JP2019537555A5 true JP2019537555A5 (enExample) | 2020-11-12 |
| JPWO2018064232A5 JPWO2018064232A5 (enExample) | 2022-02-07 |
Family
ID=61763012
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019516389A Pending JP2019537555A (ja) | 2016-09-28 | 2017-09-27 | ヘルペスを処置するための方法および組成物 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US10350288B2 (enExample) |
| EP (1) | EP3519427A4 (enExample) |
| JP (1) | JP2019537555A (enExample) |
| WO (1) | WO2018064232A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2732815T3 (es) | 2009-05-22 | 2019-11-26 | Genocea Biosciences Inc | Vacunas frente al virus del herpes simple de tipo 2: composiciones y métodos para provocar una respuesta inmunitaria |
| US10350288B2 (en) | 2016-09-28 | 2019-07-16 | Genocea Biosciences, Inc. | Methods and compositions for treating herpes |
| US11690902B2 (en) | 2018-03-23 | 2023-07-04 | The General Hospital Corporation | Coxiella burnetii epitopes for T cell-targeted Q fever vaccines |
| CN110090228A (zh) * | 2018-04-18 | 2019-08-06 | 浙江大学 | 人羊膜上皮细胞在自身免疫性疾病中的治疗用途 |
| CN111620955B (zh) * | 2020-07-01 | 2022-11-08 | 北京康爱瑞浩细胞技术有限公司 | 一种多靶位复合抗原及其应用 |
| CN111986743A (zh) * | 2020-08-07 | 2020-11-24 | 上海神桥医药科技有限公司 | 一种医学审核方法及其应用 |
| CN116672614B (zh) * | 2023-06-15 | 2024-02-13 | 广州穗海新峰医疗设备制造股份有限公司 | 紫外线治疗系统、方法及装置 |
Family Cites Families (83)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4818694A (en) | 1982-07-20 | 1989-04-04 | American Cyanamid Company | Production of herpes simplex viral protein |
| NZ209308A (en) | 1983-08-30 | 1991-08-27 | Genentech Inc | Vaccine against hsv involving a truncated membrane-free derivative of a membrane-bound protein |
| US7264817B1 (en) | 1983-08-30 | 2007-09-04 | Genentech, Inc. | Immunogenic composition based on a truncated derivative of a membrane bound protein and process for making it |
| US5171568A (en) | 1984-04-06 | 1992-12-15 | Chiron Corporation | Recombinant herpes simplex gb-gd vaccine |
| US5244792A (en) | 1984-04-06 | 1993-09-14 | Chiron Corporation | Expression of recombinant glyoprotein B from herpes simplex virus |
| US5612041A (en) | 1984-07-17 | 1997-03-18 | Chiron Corporation | Recombinant herpes simplex gD vaccine |
| US5149529A (en) | 1988-04-08 | 1992-09-22 | Board Of Trustees Of Leland Chiron Corporation | Compositions and treatment for herpes simplex |
| WO1990013652A1 (en) | 1989-05-12 | 1990-11-15 | Triton Diagnostics, Inc. | Herpes simplex virus type 2-glycoprotein g proteins and polypeptides |
| DE69131200T2 (de) | 1990-08-02 | 1999-12-09 | Chiron Corp., Emeryville | Herpes simplex virus vp16 impfstoffe |
| DK31991D0 (da) | 1991-02-25 | 1991-02-25 | Carlbiotech Ltd As | Peptid og farmaceutisk praeparat indeholdende et saadant peptid |
| GB9105992D0 (en) | 1991-03-21 | 1991-05-08 | Smithkline Beecham Biolog | Vaccine |
| US5955088A (en) | 1992-02-03 | 1999-09-21 | Cedars-Sinai Medical Center | Pharmaceutical compsition of herpes simplex virus type-1 (HSV-1), glycoproteins |
| US5679348A (en) | 1992-02-03 | 1997-10-21 | Cedars-Sinai Medical Center | Immunotherapy for recurrent HSV infections |
| US5593972A (en) | 1993-01-26 | 1997-01-14 | The Wistar Institute | Genetic immunization |
| EP0708833A1 (en) | 1993-06-08 | 1996-05-01 | Abbott Laboratories | Herpes simplex virus type-2 protease |
| EP0714399A4 (en) | 1993-08-20 | 1999-01-27 | Smithkline Beecham Corp | HSV-2 UL26 GEN, ENVELOPE PROTEINS, IMMUNOASSAYS AND PROTEAS INHIBITORS |
| GB9325496D0 (en) | 1993-12-14 | 1994-02-16 | Smithkline Beecham Biolog | Vaccines |
| US7094767B2 (en) | 1994-07-22 | 2006-08-22 | Merck & Co., Inc. | Polynucleotide herpes virus vaccine |
| US6156319A (en) | 1994-07-25 | 2000-12-05 | The Trustees Of The University Of Pennsylvania | Soluble herpesvirus glycoprotein complex vaccine |
| US5807557A (en) | 1994-07-25 | 1998-09-15 | The Trustees Of The University Of Pennsylvania | Soluble herpesvirus glycoprotein complex |
| AUPM873294A0 (en) | 1994-10-12 | 1994-11-03 | Csl Limited | Saponin preparations and use thereof in iscoms |
| US5962428A (en) | 1995-03-30 | 1999-10-05 | Apollon, Inc. | Compositions and methods for delivery of genetic material |
| US6197497B1 (en) | 1995-04-21 | 2001-03-06 | University Of New Mexico | Immunoassay for herpes simplex virus |
| US5654174A (en) | 1995-07-07 | 1997-08-05 | Competitive Technologies, Inc. | Herpes simplex virus glycoprotein D variants |
| US5876923A (en) | 1996-07-26 | 1999-03-02 | Arch Development Corporation | Herpes simplex virus ICP4 as an inhibitor of apoptosis |
| US5958895A (en) | 1996-10-23 | 1999-09-28 | American Home Products Corporation | DNA vaccines for herpes simplex virus |
| WO1998020016A1 (en) | 1996-11-04 | 1998-05-14 | Smithkline Beecham Corporation | Novel coding sequences from herpes simplex virus type-2 |
| EP0984790A1 (en) | 1997-06-02 | 2000-03-15 | Chiron Corporation | Herpes simplex virus vp22 vaccines and methods of use |
| US6015832A (en) | 1997-12-31 | 2000-01-18 | The Regents Of The University Of Michigan | Methods of inactivating bacteria including bacterial spores |
| US6054131A (en) | 1998-01-16 | 2000-04-25 | University Of Maryland Baltimore | Vaccine composition for herpes simplex virus and method of using |
| ATE339223T1 (de) | 1998-03-09 | 2006-10-15 | Glaxosmithkline Biolog Sa | Kombinierte impfstoffzusammensetzungen |
| US6248558B1 (en) | 1998-03-31 | 2001-06-19 | Vanderbilt University | Sequence and method for genetic engineering of proteins with cell membrane translocating activity |
| BR9912671A (pt) | 1998-08-07 | 2001-05-02 | Univ Washington | Antìgenos imunológicos para o vìrus de herpes simples e métodos para sua utilização |
| US6692752B1 (en) | 1999-09-08 | 2004-02-17 | Smithkline Beecham Biologicals S.A. | Methods of treating human females susceptible to HSV infection |
| US6635676B2 (en) | 1999-04-28 | 2003-10-21 | Regents Of The University Of Michigan | Non-toxic antimicrobial compositions and methods of use |
| US6506803B1 (en) | 1999-04-28 | 2003-01-14 | Regents Of The University Of Michigan | Methods of preventing and treating microbial infections |
| US6559189B2 (en) | 1999-04-28 | 2003-05-06 | Regents Of The University Of Michigan | Non-toxic antimicrobial compositions and methods of use |
| PL210451B1 (pl) | 1999-06-10 | 2012-01-31 | Merial Sas | Szczepionka DNA przeciwko wirusowi nosówki psów (CDV) |
| GB9921146D0 (en) | 1999-09-07 | 1999-11-10 | Smithkline Beecham Biolog | Novel composition |
| ATE345389T1 (de) | 1999-09-30 | 2006-12-15 | Univ Washington | Immunologisch relevante antigene aus herpes simplexvirus |
| US7196066B1 (en) | 1999-11-03 | 2007-03-27 | Powderject Vaccines, Inc. | DNA-vaccines based on constructs derived from the genomes of human and animal pathogens |
| DE60026588T2 (de) | 1999-12-17 | 2007-01-18 | Wyeth Holdings Corp. | Impfstoffe zur erhöhung der immunantworten gegen herpes simplex virus |
| US7078388B2 (en) | 2000-01-21 | 2006-07-18 | Merial | DNA vaccines for farm animals, in particular bovines and porcines |
| US7157437B2 (en) | 2000-03-10 | 2007-01-02 | Dynavax Technologies Corporation | Methods of ameliorating symptoms of herpes infection using immunomodulatory polynucleotide sequences |
| US6821519B2 (en) | 2000-06-29 | 2004-11-23 | Corixa Corporation | Compositions and methods for the diagnosis and treatment of herpes simplex virus infection |
| US20030165819A1 (en) | 2000-06-29 | 2003-09-04 | Corixa Corporation | Compositions and methods for the diagnosis and treatment of herpes simplex virus infection |
| US6537555B2 (en) | 2000-06-29 | 2003-03-25 | Corixa Corporation | Compositions and methods for the diagnosis and treatment of herpes simplex virus infection |
| US6682892B2 (en) | 2000-07-13 | 2004-01-27 | Pharmacia & Upjohn Company | Method for treating herpes viruses |
| US7569218B2 (en) | 2000-07-27 | 2009-08-04 | The Trustees Of The University Of Pennsylvania | Compositions for and methods of using herpes simplex virus glycoprotein D to suppress immune responses |
| EP1178111A1 (en) | 2000-08-03 | 2002-02-06 | Lohmann Animal Health GmbH & Co. KG | Vaccination against host cell-associated herpesviruses |
| AU2002249764A1 (en) | 2000-11-16 | 2003-05-06 | Aurx, Inc. | Prevention of recurrent viral disease |
| US6867000B2 (en) | 2000-12-07 | 2005-03-15 | Wyeth Holdings Corporation | Method of enhancing immune responses to herpes |
| AU2002367976B2 (en) | 2001-06-05 | 2007-06-21 | The Regents Of The University Of Michigan | Nanoemulsion vaccines |
| WO2003011893A2 (en) | 2001-07-31 | 2003-02-13 | University Of Washington | Immunologically significant herpes simplex virus antigens and methods for using same |
| AU2002323443A1 (en) | 2001-09-04 | 2003-03-18 | Corixa Corporation | Compositions and methods for the diagnosis and treatment of herpes simplex virus infection |
| US20030219448A1 (en) | 2002-05-24 | 2003-11-27 | Cedars-Sinai Medical Center | Peptide epitope-based vaccine for treating herpes simplex virus infections and related diseases |
| US20080299140A1 (en) | 2002-05-24 | 2008-12-04 | The Regents Of The University Of California, | Immunogenic Composition and Peptide Sequences for Prevention and Treatment of an Hsv Condition |
| DE60324678D1 (de) | 2002-07-18 | 2008-12-24 | Univ Washington | N t-lymphozyten und damit identifizierte hsv-antigene |
| US7267940B2 (en) | 2003-03-04 | 2007-09-11 | Bio-Rad Laboratories, Inc. | HSV-2 type-specific immunoassays using glycoprotein G2 peptides |
| EP1670507A4 (en) | 2003-09-12 | 2007-10-17 | Antigenics Inc | VACCINE FOR THE TREATMENT AND PREVENTION OF HERPES SIMPLEX VIRUS INFECTION |
| GB0321615D0 (en) | 2003-09-15 | 2003-10-15 | Glaxo Group Ltd | Improvements in vaccination |
| WO2007097820A2 (en) | 2005-11-18 | 2007-08-30 | The Ohio State University Research Foundation | Viral gene products and methods for vaccination to prevent viral associated diseases |
| EP2001516A4 (en) | 2006-03-10 | 2010-04-28 | Univ California | VACCINATES AGAINST PERSISTENT OR LATENT INFECTIONS THREADING VIRUSES |
| US7628993B2 (en) | 2006-07-20 | 2009-12-08 | Vical Incorporated | Compositions and methods for vaccinating against HSV-2 |
| WO2008027394A2 (en) | 2006-08-28 | 2008-03-06 | The Wistar Institute Of Anatomy And Biology | Constructs for enhancing immune responses |
| WO2008030560A2 (en) | 2006-09-08 | 2008-03-13 | The Trustees Of The University Of Pennsyvania | Hsv-1 and hsv-2 vaccines and methods of use thereof |
| EP2087128A4 (en) | 2006-11-01 | 2009-11-04 | Immport Therapeutics Inc | COMPOSITIONS AND METHODS FOR IMMUNOMINANT ANTIGENES |
| US9284355B2 (en) | 2006-12-28 | 2016-03-15 | The Trustees Of The University Of Pennsylvania | Herpes simplex virus combined subunit vaccines and methods of use thereof |
| US8057804B2 (en) | 2006-12-28 | 2011-11-15 | The Trustees Of The University Of Pennsylvania | Herpes simplex virus combined subunit vaccines and methods of use thereof |
| WO2009006618A2 (en) | 2007-07-05 | 2009-01-08 | University Of Kansas | Herpes simplex virus mutant icp0 protein |
| WO2009006680A1 (en) | 2007-07-06 | 2009-01-15 | Sydney West Area Health Service | Epitopes of herpes simplex virus |
| SE532551C2 (sv) | 2008-06-30 | 2010-02-16 | Senseair Ab | Ett för spektralanalys anpassat arrangemang |
| EP3839512A1 (en) | 2008-07-01 | 2021-06-23 | Genocea Biosciences, Inc. | Methods of identifying infections and related conditions |
| EP2379106A4 (en) | 2008-12-17 | 2012-06-13 | Genocea Biosciences Inc | ANTIGENS OF CHLAMYDIAS AND USES THEREOF |
| US8460674B2 (en) | 2009-02-07 | 2013-06-11 | University Of Washington | HSV-1 epitopes and methods for using same |
| CA2754592A1 (en) | 2009-03-09 | 2010-09-16 | William Henry | Hapten-carrier conjugates with bacterial toxins having a signal peptide as carrier and their use in immunogenic compositions |
| ES2732815T3 (es) | 2009-05-22 | 2019-11-26 | Genocea Biosciences Inc | Vacunas frente al virus del herpes simple de tipo 2: composiciones y métodos para provocar una respuesta inmunitaria |
| US9089537B2 (en) | 2010-02-26 | 2015-07-28 | The Trustees Of The University Of Pennslyvania | Subunit vaccines for herpes viruses and methods of use |
| CA2792679C (en) | 2010-03-09 | 2019-11-12 | Biomedical Research Models, Inc. | A novel mucosal vaccination approach for herpes simplex virus type-2 |
| AU2011316924A1 (en) | 2010-10-20 | 2013-05-02 | Genocea Biosciences, Inc. | Chlamydia antigens and uses thereof |
| US9782474B2 (en) | 2010-11-24 | 2017-10-10 | Genocea Biosciences, Inc. | Vaccines against herpes simplex virus type 2: compositions and methods for eliciting an immune response |
| EP2782597B1 (en) * | 2011-11-23 | 2022-04-13 | Genocea Biosciences, Inc. | Nucleic acid vaccines against herpes simplex virus type 2: compositions and methods for eliciting an immune response |
| US10350288B2 (en) | 2016-09-28 | 2019-07-16 | Genocea Biosciences, Inc. | Methods and compositions for treating herpes |
-
2017
- 2017-09-27 US US15/717,849 patent/US10350288B2/en active Active - Reinstated
- 2017-09-27 EP EP17857372.1A patent/EP3519427A4/en not_active Withdrawn
- 2017-09-27 WO PCT/US2017/053835 patent/WO2018064232A1/en not_active Ceased
- 2017-09-27 JP JP2019516389A patent/JP2019537555A/ja active Pending
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