JP2019537555A5 - - Google Patents
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- JP2019537555A5 JP2019537555A5 JP2019516389A JP2019516389A JP2019537555A5 JP 2019537555 A5 JP2019537555 A5 JP 2019537555A5 JP 2019516389 A JP2019516389 A JP 2019516389A JP 2019516389 A JP2019516389 A JP 2019516389A JP 2019537555 A5 JP2019537555 A5 JP 2019537555A5
- Authority
- JP
- Japan
- Prior art keywords
- vaccine
- herpes
- hsv
- vaccine formulation
- antiviral
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229960005486 vaccine Drugs 0.000 claims description 125
- 239000000203 mixture Substances 0.000 claims description 90
- 238000009472 formulation Methods 0.000 claims description 76
- 238000002560 therapeutic procedure Methods 0.000 claims description 69
- 230000000840 anti-viral effect Effects 0.000 claims description 63
- 238000000034 method Methods 0.000 claims description 63
- 208000001688 Herpes Genitalis Diseases 0.000 claims description 61
- 201000004946 genital herpes Diseases 0.000 claims description 61
- XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 claims description 57
- 241000701074 Human alphaherpesvirus 2 Species 0.000 claims description 52
- 238000002360 preparation method Methods 0.000 claims description 41
- 229920001184 polypeptide Polymers 0.000 claims description 33
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 33
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 33
- 230000003902 lesion Effects 0.000 claims description 30
- 101150027427 ICP4 gene Proteins 0.000 claims description 27
- 230000009467 reduction Effects 0.000 claims description 20
- 208000024891 symptom Diseases 0.000 claims description 20
- 230000007423 decrease Effects 0.000 claims description 17
- 210000004392 genitalia Anatomy 0.000 claims description 17
- 239000002671 adjuvant Substances 0.000 claims description 16
- 206010019973 Herpes virus infection Diseases 0.000 claims description 12
- 239000001397 quillaja saponaria molina bark Substances 0.000 claims description 12
- 229930182490 saponin Natural products 0.000 claims description 12
- 235000017709 saponins Nutrition 0.000 claims description 12
- 150000007949 saponins Chemical class 0.000 claims description 12
- 150000001413 amino acids Chemical class 0.000 claims description 11
- 238000012217 deletion Methods 0.000 claims description 11
- 230000037430 deletion Effects 0.000 claims description 11
- 239000012634 fragment Substances 0.000 claims description 11
- 238000011282 treatment Methods 0.000 claims description 10
- 230000036039 immunity Effects 0.000 claims description 9
- 208000015181 infectious disease Diseases 0.000 claims description 8
- 239000003814 drug Substances 0.000 claims description 7
- 241000700588 Human alphaherpesvirus 1 Species 0.000 claims description 6
- HDOVUKNUBWVHOX-QMMMGPOBSA-N Valacyclovir Chemical compound N1C(N)=NC(=O)C2=C1N(COCCOC(=O)[C@@H](N)C(C)C)C=N2 HDOVUKNUBWVHOX-QMMMGPOBSA-N 0.000 claims description 6
- 210000003918 fraction a Anatomy 0.000 claims description 6
- 210000000540 fraction c Anatomy 0.000 claims description 6
- 239000002245 particle Substances 0.000 claims description 6
- 229940093257 valacyclovir Drugs 0.000 claims description 6
- 241000700605 Viruses Species 0.000 claims description 5
- 230000036755 cellular response Effects 0.000 claims description 5
- 229940079593 drug Drugs 0.000 claims description 5
- 230000008348 humoral response Effects 0.000 claims description 5
- 230000002163 immunogen Effects 0.000 claims description 5
- 230000007485 viral shedding Effects 0.000 claims description 5
- 208000023275 Autoimmune disease Diseases 0.000 claims description 4
- 102000004190 Enzymes Human genes 0.000 claims description 4
- 108090000790 Enzymes Proteins 0.000 claims description 4
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 4
- 239000000427 antigen Substances 0.000 claims description 4
- 102000036639 antigens Human genes 0.000 claims description 4
- 108091007433 antigens Proteins 0.000 claims description 4
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims description 4
- DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 claims description 4
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 2
- PIGTXFOGKFOFTO-PPEDVFHSSA-N CC1(C)CC[C@@]2([C@H](O)C[C@]3(C)C(=CC[C@@H]4[C@@]5(C)CCC(O[C@@H]6O[C@@H]([C@@H](O)[C@H](O)[C@H]6O)C(O)=O)[C@@](C)(C=O)[C@@H]5CC[C@@]34C)[C@@H]2C1)C(O)=O Chemical compound CC1(C)CC[C@@]2([C@H](O)C[C@]3(C)C(=CC[C@@H]4[C@@]5(C)CCC(O[C@@H]6O[C@@H]([C@@H](O)[C@H](O)[C@H]6O)C(O)=O)[C@@](C)(C=O)[C@@H]5CC[C@@]34C)[C@@H]2C1)C(O)=O PIGTXFOGKFOFTO-PPEDVFHSSA-N 0.000 claims description 2
- 208000009139 Gilbert Disease Diseases 0.000 claims description 2
- 208000022412 Gilbert syndrome Diseases 0.000 claims description 2
- 208000000903 Herpes simplex encephalitis Diseases 0.000 claims description 2
- 206010020751 Hypersensitivity Diseases 0.000 claims description 2
- 206010061598 Immunodeficiency Diseases 0.000 claims description 2
- 208000029462 Immunodeficiency disease Diseases 0.000 claims description 2
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims description 2
- 239000004472 Lysine Substances 0.000 claims description 2
- 201000009906 Meningitis Diseases 0.000 claims description 2
- 230000002159 abnormal effect Effects 0.000 claims description 2
- 229960004150 aciclovir Drugs 0.000 claims description 2
- MKUXAQIIEYXACX-UHFFFAOYSA-N aciclovir Chemical compound N1C(N)=NC(=O)C2=C1N(COCCO)C=N2 MKUXAQIIEYXACX-UHFFFAOYSA-N 0.000 claims description 2
- 208000026935 allergic disease Diseases 0.000 claims description 2
- 238000003556 assay Methods 0.000 claims description 2
- 210000004369 blood Anatomy 0.000 claims description 2
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- 235000012000 cholesterol Nutrition 0.000 claims description 2
- 239000003433 contraceptive agent Substances 0.000 claims description 2
- 229940109239 creatinine Drugs 0.000 claims description 2
- 238000003745 diagnosis Methods 0.000 claims description 2
- 229940000406 drug candidate Drugs 0.000 claims description 2
- 229960004396 famciclovir Drugs 0.000 claims description 2
- GGXKWVWZWMLJEH-UHFFFAOYSA-N famcyclovir Chemical compound N1=C(N)N=C2N(CCC(COC(=O)C)COC(C)=O)C=NC2=C1 GGXKWVWZWMLJEH-UHFFFAOYSA-N 0.000 claims description 2
- 230000009610 hypersensitivity Effects 0.000 claims description 2
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- 230000001506 immunosuppresive effect Effects 0.000 claims description 2
- 210000003734 kidney Anatomy 0.000 claims description 2
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- 238000002483 medication Methods 0.000 claims description 2
- 239000002547 new drug Substances 0.000 claims description 2
- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 claims description 2
- 230000035935 pregnancy Effects 0.000 claims description 2
- 230000001568 sexual effect Effects 0.000 claims description 2
- 239000013589 supplement Substances 0.000 claims description 2
- 230000009885 systemic effect Effects 0.000 claims description 2
- 238000001262 western blot Methods 0.000 claims description 2
- 239000003443 antiviral agent Substances 0.000 claims 26
- BPYKTIZUTYGOLE-IFADSCNNSA-N Bilirubin Chemical compound N1C(=O)C(C)=C(C=C)\C1=C\C1=C(C)C(CCC(O)=O)=C(CC2=C(C(C)=C(\C=C/3C(=C(C=C)C(=O)N\3)C)N2)CCC(O)=O)N1 BPYKTIZUTYGOLE-IFADSCNNSA-N 0.000 claims 2
- 206010015218 Erythema multiforme Diseases 0.000 claims 1
- 108091000080 Phosphotransferase Proteins 0.000 claims 1
- 229940124558 contraceptive agent Drugs 0.000 claims 1
- -1 for example Substances 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 102000020233 phosphotransferase Human genes 0.000 claims 1
- 229960004556 tenofovir Drugs 0.000 claims 1
- VCMJCVGFSROFHV-WZGZYPNHSA-N tenofovir disoproxil fumarate Chemical compound OC(=O)\C=C\C(O)=O.N1=CN=C2N(C[C@@H](C)OCP(=O)(OCOC(=O)OC(C)C)OCOC(=O)OC(C)C)C=NC2=C1N VCMJCVGFSROFHV-WZGZYPNHSA-N 0.000 claims 1
- 230000003247 decreasing effect Effects 0.000 description 59
- 230000029142 excretion Effects 0.000 description 16
- 229940027941 immunoglobulin g Drugs 0.000 description 5
- 102000001398 Granzyme Human genes 0.000 description 4
- 108060005986 Granzyme Proteins 0.000 description 4
- 230000035876 healing Effects 0.000 description 3
- 238000003752 polymerase chain reaction Methods 0.000 description 3
- 230000003472 neutralizing effect Effects 0.000 description 2
- 230000028327 secretion Effects 0.000 description 2
- 206010015150 Erythema Diseases 0.000 description 1
- 102000001253 Protein Kinase Human genes 0.000 description 1
- 210000001744 T-lymphocyte Anatomy 0.000 description 1
- BPYKTIZUTYGOLE-UHFFFAOYSA-N billirubin-IXalpha Natural products N1C(=O)C(C)=C(C=C)C1=CC1=C(C)C(CCC(O)=O)=C(CC2=C(C(C)=C(C=C3C(=C(C=C)C(=O)N3)C)N2)CCC(O)=O)N1 BPYKTIZUTYGOLE-UHFFFAOYSA-N 0.000 description 1
- 230000002254 contraceptive effect Effects 0.000 description 1
- 231100000321 erythema Toxicity 0.000 description 1
- 108060006633 protein kinase Proteins 0.000 description 1
- 238000003753 real-time PCR Methods 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 238000000316 virotherapy Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662401148P | 2016-09-28 | 2016-09-28 | |
| US62/401,148 | 2016-09-28 | ||
| PCT/US2017/053835 WO2018064232A1 (en) | 2016-09-28 | 2017-09-27 | Methods and compositions for treating herpes |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019537555A JP2019537555A (ja) | 2019-12-26 |
| JP2019537555A5 true JP2019537555A5 (enExample) | 2020-11-12 |
| JPWO2018064232A5 JPWO2018064232A5 (enExample) | 2022-02-07 |
Family
ID=61763012
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019516389A Pending JP2019537555A (ja) | 2016-09-28 | 2017-09-27 | ヘルペスを処置するための方法および組成物 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US10350288B2 (enExample) |
| EP (1) | EP3519427A4 (enExample) |
| JP (1) | JP2019537555A (enExample) |
| WO (1) | WO2018064232A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2432504B1 (en) | 2009-05-22 | 2019-05-01 | Genocea Biosciences, Inc. | Vaccines against herpes simplex virus type 2: compositions and methods for eliciting an immune response |
| US10350288B2 (en) | 2016-09-28 | 2019-07-16 | Genocea Biosciences, Inc. | Methods and compositions for treating herpes |
| AU2019238345A1 (en) | 2018-03-23 | 2020-10-15 | Epivax, Inc. | Coxiella burnetii epitopes for T cell-targeted Q fever vaccines |
| CN114470001A (zh) * | 2018-04-18 | 2022-05-13 | 浙江大学 | 人羊膜上皮细胞在自身免疫性疾病中的治疗用途 |
| CN111620955B (zh) * | 2020-07-01 | 2022-11-08 | 北京康爱瑞浩细胞技术有限公司 | 一种多靶位复合抗原及其应用 |
| CN111986743A (zh) * | 2020-08-07 | 2020-11-24 | 上海神桥医药科技有限公司 | 一种医学审核方法及其应用 |
| CN116672614B (zh) * | 2023-06-15 | 2024-02-13 | 广州穗海新峰医疗设备制造股份有限公司 | 紫外线治疗系统、方法及装置 |
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| JP6055776B2 (ja) | 2010-11-24 | 2016-12-27 | ジェノセア バイオサイエンシーズ， インコーポレイテッド | 単純ヘルペスウイルス２型に対するワクチン：免疫応答を誘発する組成物及び方法 |
| AU2012340712B2 (en) | 2011-11-23 | 2017-09-14 | Genocea Biosciences, Inc. | Nucleic acid vaccines against Herpes Simplex Virus type 2: compositions and methods for eliciting an immune response |
| US10350288B2 (en) | 2016-09-28 | 2019-07-16 | Genocea Biosciences, Inc. | Methods and compositions for treating herpes |
-
2017
- 2017-09-27 US US15/717,849 patent/US10350288B2/en active Active - Reinstated
- 2017-09-27 JP JP2019516389A patent/JP2019537555A/ja active Pending
- 2017-09-27 EP EP17857372.1A patent/EP3519427A4/en not_active Withdrawn
- 2017-09-27 WO PCT/US2017/053835 patent/WO2018064232A1/en not_active Ceased
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