JP2019537551A5 - - Google Patents
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- Publication number
- JP2019537551A5 JP2019537551A5 JP2019507936A JP2019507936A JP2019537551A5 JP 2019537551 A5 JP2019537551 A5 JP 2019537551A5 JP 2019507936 A JP2019507936 A JP 2019507936A JP 2019507936 A JP2019507936 A JP 2019507936A JP 2019537551 A5 JP2019537551 A5 JP 2019537551A5
- Authority
- JP
- Japan
- Prior art keywords
- water
- glatiramer acetate
- organic solvent
- fine particles
- double emulsion
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims 18
- 238000000034 method Methods 0.000 claims 15
- 108010072051 Glatiramer Acetate Proteins 0.000 claims 9
- FHEAIOHRHQGZPC-KIWGSFCNSA-N acetic acid;(2s)-2-amino-3-(4-hydroxyphenyl)propanoic acid;(2s)-2-aminopentanedioic acid;(2s)-2-aminopropanoic acid;(2s)-2,6-diaminohexanoic acid Chemical compound CC(O)=O.C[C@H](N)C(O)=O.NCCCC[C@H](N)C(O)=O.OC(=O)[C@@H](N)CCC(O)=O.OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 FHEAIOHRHQGZPC-KIWGSFCNSA-N 0.000 claims 9
- 229960003776 glatiramer acetate Drugs 0.000 claims 9
- 239000003960 organic solvent Substances 0.000 claims 7
- 239000010419 fine particle Substances 0.000 claims 6
- 239000008346 aqueous phase Substances 0.000 claims 5
- 239000000839 emulsion Substances 0.000 claims 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 5
- 239000004372 Polyvinyl alcohol Substances 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 229920002451 polyvinyl alcohol Polymers 0.000 claims 4
- 238000001035 drying Methods 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims 2
- 229920002988 biodegradable polymer Polymers 0.000 claims 2
- 239000004621 biodegradable polymer Substances 0.000 claims 2
- 238000004108 freeze drying Methods 0.000 claims 2
- 238000002513 implantation Methods 0.000 claims 2
- 238000007918 intramuscular administration Methods 0.000 claims 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims 2
- 239000012074 organic phase Substances 0.000 claims 2
- 229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 claims 2
- 238000007920 subcutaneous administration Methods 0.000 claims 2
- 239000004094 surface-active agent Substances 0.000 claims 2
- 238000013268 sustained release Methods 0.000 claims 2
- 239000012730 sustained-release form Substances 0.000 claims 2
- 239000007762 w/o emulsion Substances 0.000 claims 2
- 102000008186 Collagen Human genes 0.000 claims 1
- 108010035532 Collagen Proteins 0.000 claims 1
- 108010010803 Gelatin Proteins 0.000 claims 1
- 229920002201 Oxidized cellulose Polymers 0.000 claims 1
- 239000004698 Polyethylene Substances 0.000 claims 1
- 229920000331 Polyhydroxybutyrate Polymers 0.000 claims 1
- 150000008064 anhydrides Chemical class 0.000 claims 1
- 229920001400 block copolymer Polymers 0.000 claims 1
- 229920002678 cellulose Polymers 0.000 claims 1
- 229920001436 collagen Polymers 0.000 claims 1
- 238000004945 emulsification Methods 0.000 claims 1
- 238000001914 filtration Methods 0.000 claims 1
- 229920000159 gelatin Polymers 0.000 claims 1
- 239000008273 gelatin Substances 0.000 claims 1
- 235000019322 gelatine Nutrition 0.000 claims 1
- 235000011852 gelatine desserts Nutrition 0.000 claims 1
- 235000014655 lactic acid Nutrition 0.000 claims 1
- 239000004310 lactic acid Substances 0.000 claims 1
- 239000011859 microparticle Substances 0.000 claims 1
- 150000002905 orthoesters Chemical class 0.000 claims 1
- 229940107304 oxidized cellulose Drugs 0.000 claims 1
- 239000005015 poly(hydroxybutyrate) Substances 0.000 claims 1
- 229920002627 poly(phosphazenes) Polymers 0.000 claims 1
- 229920001610 polycaprolactone Polymers 0.000 claims 1
- 239000004632 polycaprolactone Substances 0.000 claims 1
- -1 polyethylene Polymers 0.000 claims 1
- 229920000573 polyethylene Polymers 0.000 claims 1
- 229920002643 polyglutamic acid Polymers 0.000 claims 1
- 229920001451 polypropylene glycol Polymers 0.000 claims 1
- 229920000136 polysorbate Polymers 0.000 claims 1
- 229950008882 polysorbate Drugs 0.000 claims 1
- 238000005406 washing Methods 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022189936A JP2023022199A (ja) | 2016-08-28 | 2022-11-29 | 酢酸グラチラマーを含有する微小粒子を調製する方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662380426P | 2016-08-28 | 2016-08-28 | |
| US62/380,426 | 2016-08-28 | ||
| PCT/IL2017/050954 WO2018042423A1 (en) | 2016-08-28 | 2017-08-28 | Process for preparing microparticles containing glatiramer acetate |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022189936A Division JP2023022199A (ja) | 2016-08-28 | 2022-11-29 | 酢酸グラチラマーを含有する微小粒子を調製する方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019537551A JP2019537551A (ja) | 2019-12-26 |
| JP2019537551A5 true JP2019537551A5 (https=) | 2020-10-08 |
| JP7232752B2 JP7232752B2 (ja) | 2023-03-03 |
Family
ID=61301634
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019507936A Active JP7232752B2 (ja) | 2016-08-28 | 2017-08-28 | 酢酸グラチラマーを含有する微小粒子を調製する方法 |
| JP2022189936A Pending JP2023022199A (ja) | 2016-08-28 | 2022-11-29 | 酢酸グラチラマーを含有する微小粒子を調製する方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022189936A Pending JP2023022199A (ja) | 2016-08-28 | 2022-11-29 | 酢酸グラチラマーを含有する微小粒子を調製する方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US11471421B2 (https=) |
| EP (1) | EP3503907B1 (https=) |
| JP (2) | JP7232752B2 (https=) |
| CN (1) | CN109689082A (https=) |
| AU (1) | AU2017319781B2 (https=) |
| BR (1) | BR112019003131A2 (https=) |
| ES (1) | ES2979169T3 (https=) |
| IL (1) | IL264824B (https=) |
| MX (1) | MX2019001999A (https=) |
| WO (1) | WO2018042423A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12097292B2 (en) | 2016-08-28 | 2024-09-24 | Mapi Pharma Ltd. | Process for preparing microparticles containing glatiramer acetate |
| HUE071047T2 (hu) | 2016-08-31 | 2025-07-28 | Mapi Pharma Ltd | Glatiramer-acetátot tartalmazó depórendszerek |
| CN110382052A (zh) * | 2017-03-26 | 2019-10-25 | Mapi医药公司 | 用于治疗进展型形式的多发性硬化症的格拉替雷储库系统 |
| CN111249524B (zh) * | 2020-01-18 | 2020-12-08 | 南京医科大学附属口腔医院 | 用于骨组织再生的高孔隙率聚己内酯多孔微球支架及其制备方法 |
| WO2023170493A1 (en) * | 2022-03-07 | 2023-09-14 | Hadidi Naghmeh | Drug delivery using a parenteral pharmaceutical composition |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL113812A (en) | 1994-05-24 | 2000-06-29 | Yeda Res & Dev | Copolymer-1 pharmaceutical compositions containing it and its use |
| US5945126A (en) * | 1997-02-13 | 1999-08-31 | Oakwood Laboratories L.L.C. | Continuous microsphere process |
| US8871241B2 (en) | 2002-05-07 | 2014-10-28 | Psivida Us, Inc. | Injectable sustained release delivery devices |
| CN1398584A (zh) | 2002-07-15 | 2003-02-26 | 裴福兴 | 一种bFGF－PLGA缓释微球及其制备方法和用途 |
| US20060276390A1 (en) | 2003-07-31 | 2006-12-07 | Yeda Research And Development Co. Ltd. | Combined treatments comprising synthetic peptide copolymers for preventing graft rejection |
| US8377885B2 (en) | 2010-01-04 | 2013-02-19 | Mapi Pharma Ltd. | Depot systems comprising glatiramer or pharmacologically acceptable salt thereof |
| JP5916622B2 (ja) * | 2010-01-04 | 2016-05-11 | マピ ファーマ リミテッド | グラチラマーまたはその薬理学的に許容される塩を含むデポーシステム |
| ES2601892T3 (es) | 2011-04-21 | 2017-02-16 | Mapi Pharma Limited | Pentapolímero aleatorio para el tratamiento de enfermedades autoinmunes |
| CN103169670B (zh) | 2013-03-22 | 2016-07-06 | 深圳翰宇药业股份有限公司 | 一种醋酸格拉替雷微球及其制备方法 |
| HUE071047T2 (hu) | 2016-08-31 | 2025-07-28 | Mapi Pharma Ltd | Glatiramer-acetátot tartalmazó depórendszerek |
| CN110382052A (zh) | 2017-03-26 | 2019-10-25 | Mapi医药公司 | 用于治疗进展型形式的多发性硬化症的格拉替雷储库系统 |
-
2017
- 2017-08-28 US US16/328,572 patent/US11471421B2/en active Active
- 2017-08-28 MX MX2019001999A patent/MX2019001999A/es unknown
- 2017-08-28 BR BR112019003131-6A patent/BR112019003131A2/pt unknown
- 2017-08-28 JP JP2019507936A patent/JP7232752B2/ja active Active
- 2017-08-28 CN CN201780053557.3A patent/CN109689082A/zh active Pending
- 2017-08-28 ES ES17845665T patent/ES2979169T3/es active Active
- 2017-08-28 WO PCT/IL2017/050954 patent/WO2018042423A1/en not_active Ceased
- 2017-08-28 AU AU2017319781A patent/AU2017319781B2/en active Active
- 2017-08-28 EP EP17845665.3A patent/EP3503907B1/en active Active
-
2019
- 2019-02-13 IL IL264824A patent/IL264824B/en unknown
-
2022
- 2022-11-29 JP JP2022189936A patent/JP2023022199A/ja active Pending
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