JP2019536805A5 - - Google Patents
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- JP2019536805A5 JP2019536805A5 JP2019530011A JP2019530011A JP2019536805A5 JP 2019536805 A5 JP2019536805 A5 JP 2019536805A5 JP 2019530011 A JP2019530011 A JP 2019530011A JP 2019530011 A JP2019530011 A JP 2019530011A JP 2019536805 A5 JP2019536805 A5 JP 2019536805A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- composition according
- inhibitor
- administered
- cdk4
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000008194 pharmaceutical composition Substances 0.000 claims 68
- 229940124297 CDK 4/6 inhibitor Drugs 0.000 claims 26
- 239000002246 antineoplastic agent Substances 0.000 claims 26
- VSRXQHXAPYXROS-UHFFFAOYSA-N azanide;cyclobutane-1,1-dicarboxylic acid;platinum(2+) Chemical compound [NH2-].[NH2-].[Pt+2].OC(=O)C1(C(O)=O)CCC1 VSRXQHXAPYXROS-UHFFFAOYSA-N 0.000 claims 25
- 229960004562 carboplatin Drugs 0.000 claims 25
- 229960005420 etoposide Drugs 0.000 claims 24
- VJJPUSNTGOMMGY-MRVIYFEKSA-N etoposide Chemical compound COC1=C(O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H]4O[C@H](C)OC[C@H]4O3)O)[C@@H]3[C@@H]2C(OC3)=O)=C1 VJJPUSNTGOMMGY-MRVIYFEKSA-N 0.000 claims 24
- 229940127089 cytotoxic agent Drugs 0.000 claims 23
- 206010006187 Breast cancer Diseases 0.000 claims 12
- 208000026310 Breast neoplasm Diseases 0.000 claims 12
- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 claims 12
- 229960003852 atezolizumab Drugs 0.000 claims 12
- 229940121656 pd-l1 inhibitor Drugs 0.000 claims 12
- 229940076838 Immune checkpoint inhibitor Drugs 0.000 claims 11
- 102000037984 Inhibitory immune checkpoint proteins Human genes 0.000 claims 11
- 108091008026 Inhibitory immune checkpoint proteins Proteins 0.000 claims 11
- 239000012271 PD-L1 inhibitor Substances 0.000 claims 11
- 239000012274 immune-checkpoint protein inhibitor Substances 0.000 claims 11
- 238000011282 treatment Methods 0.000 claims 11
- 206010028980 Neoplasm Diseases 0.000 claims 10
- 201000011510 cancer Diseases 0.000 claims 10
- 238000012423 maintenance Methods 0.000 claims 9
- 206010041067 Small cell lung cancer Diseases 0.000 claims 7
- 208000000587 small cell lung carcinoma Diseases 0.000 claims 7
- 229930012538 Paclitaxel Natural products 0.000 claims 6
- 229960004679 doxorubicin Drugs 0.000 claims 6
- 230000006698 induction Effects 0.000 claims 6
- 229960001592 paclitaxel Drugs 0.000 claims 6
- 229940121655 pd-1 inhibitor Drugs 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 6
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 6
- 102000013701 Cyclin-Dependent Kinase 4 Human genes 0.000 claims 4
- 108010025464 Cyclin-Dependent Kinase 4 Proteins 0.000 claims 4
- 239000012270 PD-1 inhibitor Substances 0.000 claims 4
- 239000012668 PD-1-inhibitor Substances 0.000 claims 4
- DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 claims 4
- 229960004316 cisplatin Drugs 0.000 claims 4
- CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 claims 3
- GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 claims 3
- 208000003721 Triple Negative Breast Neoplasms Diseases 0.000 claims 3
- 229940044683 chemotherapy drug Drugs 0.000 claims 3
- 229960004397 cyclophosphamide Drugs 0.000 claims 3
- 229960002949 fluorouracil Drugs 0.000 claims 3
- SDUQYLNIPVEERB-QPPQHZFASA-N gemcitabine Chemical compound O=C1N=C(N)C=CN1[C@H]1C(F)(F)[C@H](O)[C@@H](CO)O1 SDUQYLNIPVEERB-QPPQHZFASA-N 0.000 claims 3
- 229960005277 gemcitabine Drugs 0.000 claims 3
- DWAFYCQODLXJNR-BNTLRKBRSA-L oxaliplatin Chemical compound O1C(=O)C(=O)O[Pt]11N[C@@H]2CCCC[C@H]2N1 DWAFYCQODLXJNR-BNTLRKBRSA-L 0.000 claims 3
- 229960001756 oxaliplatin Drugs 0.000 claims 3
- 238000011287 therapeutic dose Methods 0.000 claims 3
- 208000022679 triple-negative breast carcinoma Diseases 0.000 claims 3
- 102000003903 Cyclin-dependent kinases Human genes 0.000 claims 2
- 108090000266 Cyclin-dependent kinases Proteins 0.000 claims 2
- 229950002916 avelumab Drugs 0.000 claims 2
- 229950009791 durvalumab Drugs 0.000 claims 2
- 102000015694 estrogen receptors Human genes 0.000 claims 2
- 108010038795 estrogen receptors Proteins 0.000 claims 2
- 239000003112 inhibitor Substances 0.000 claims 2
- 229960002621 pembrolizumab Drugs 0.000 claims 2
- 230000010076 replication Effects 0.000 claims 2
- 230000001419 dependent effect Effects 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 238000011269 treatment regimen Methods 0.000 claims 1
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022091214A JP7483791B2 (ja) | 2016-12-05 | 2022-06-03 | 化学療法計画中の免疫応答の保護 |
| JP2023143202A JP7710496B2 (ja) | 2016-12-05 | 2023-09-04 | 化学療法計画中の免疫応答の保護 |
| JP2025115144A JP2025148426A (ja) | 2016-12-05 | 2025-07-08 | 化学療法計画中の免疫応答の保護 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662430302P | 2016-12-05 | 2016-12-05 | |
| US62/430,302 | 2016-12-05 | ||
| US201762479605P | 2017-03-31 | 2017-03-31 | |
| US62/479,605 | 2017-03-31 | ||
| PCT/US2017/064775 WO2018106729A1 (en) | 2016-12-05 | 2017-12-05 | Preservation of immune response during chemotherapy regimens |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022091214A Division JP7483791B2 (ja) | 2016-12-05 | 2022-06-03 | 化学療法計画中の免疫応答の保護 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019536805A JP2019536805A (ja) | 2019-12-19 |
| JP2019536805A5 true JP2019536805A5 (https=) | 2021-01-21 |
Family
ID=62491342
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019530011A Pending JP2019536805A (ja) | 2016-12-05 | 2017-12-05 | 化学療法計画中の免疫応答の保護 |
| JP2022091214A Active JP7483791B2 (ja) | 2016-12-05 | 2022-06-03 | 化学療法計画中の免疫応答の保護 |
| JP2023143202A Active JP7710496B2 (ja) | 2016-12-05 | 2023-09-04 | 化学療法計画中の免疫応答の保護 |
| JP2025115144A Pending JP2025148426A (ja) | 2016-12-05 | 2025-07-08 | 化学療法計画中の免疫応答の保護 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022091214A Active JP7483791B2 (ja) | 2016-12-05 | 2022-06-03 | 化学療法計画中の免疫応答の保護 |
| JP2023143202A Active JP7710496B2 (ja) | 2016-12-05 | 2023-09-04 | 化学療法計画中の免疫応答の保護 |
| JP2025115144A Pending JP2025148426A (ja) | 2016-12-05 | 2025-07-08 | 化学療法計画中の免疫応答の保護 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US11529352B2 (https=) |
| EP (1) | EP3548030A4 (https=) |
| JP (4) | JP2019536805A (https=) |
| KR (4) | KR20190092478A (https=) |
| CN (3) | CN117530948A (https=) |
| AU (4) | AU2017372856B9 (https=) |
| BR (1) | BR112019011410A2 (https=) |
| CA (1) | CA3045465A1 (https=) |
| IL (4) | IL317919A (https=) |
| MX (2) | MX2019006523A (https=) |
| NZ (1) | NZ753631A (https=) |
| WO (1) | WO2018106729A1 (https=) |
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| ES2984147T3 (es) | 2018-06-20 | 2024-10-29 | Fujifilm Corp | Medicamento combinado que comprende una composición liposómica de gemcitabina encapsulada y bloqueo de punto de control inmunitario |
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| WO2019199883A1 (en) | 2018-04-09 | 2019-10-17 | G1 Therapeutics, Inc. | Treatment of cancers having driving oncogenic mutations |
| AU2019325685B2 (en) | 2018-08-24 | 2025-07-24 | Pharmacosmos Holding A/S | Improved synthesis of 1,4-diazaspiro(5.5)undecan-3-one |
| CN113271977A (zh) | 2018-11-09 | 2021-08-17 | G1治疗公司 | 使用艾日布林和选择性cdk4/6抑制剂组合治疗癌症的治疗方案 |
| TW202114684A (zh) | 2019-06-18 | 2021-04-16 | 美商G1治療公司 | 增強癌症病患之抗腫瘤免疫之方法 |
| TW202128174A (zh) | 2019-10-09 | 2021-08-01 | 美商G1治療公司 | 失調之纖維母細胞生長因子受體訊息傳遞的癌症之標靶性治療 |
| US10988479B1 (en) | 2020-06-15 | 2021-04-27 | G1 Therapeutics, Inc. | Morphic forms of trilaciclib and methods of manufacture thereof |
| EP4362948A4 (en) | 2021-07-01 | 2025-05-07 | Pharmacosmos Holding A/S | Combination treatments in patients with advanced and/or metastatic trop-2 overexpressed cancers |
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2017
- 2017-12-05 KR KR1020197019110A patent/KR20190092478A/ko not_active Ceased
- 2017-12-05 EP EP17878506.9A patent/EP3548030A4/en active Pending
- 2017-12-05 KR KR1020247004108A patent/KR20240023676A/ko active Pending
- 2017-12-05 BR BR112019011410-6A patent/BR112019011410A2/pt not_active Application Discontinuation
- 2017-12-05 KR KR1020247004112A patent/KR20240024296A/ko active Pending
- 2017-12-05 WO PCT/US2017/064775 patent/WO2018106729A1/en not_active Ceased
- 2017-12-05 NZ NZ753631A patent/NZ753631A/en unknown
- 2017-12-05 CN CN202311165935.0A patent/CN117530948A/zh active Pending
- 2017-12-05 AU AU2017372856A patent/AU2017372856B9/en active Active
- 2017-12-05 MX MX2019006523A patent/MX2019006523A/es unknown
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- 2017-12-05 KR KR1020247004113A patent/KR20240023677A/ko not_active Withdrawn
- 2017-12-05 CA CA3045465A patent/CA3045465A1/en active Pending
- 2017-12-05 IL IL311265A patent/IL311265A/en unknown
- 2017-12-05 CN CN201780075215.1A patent/CN110035759A/zh active Pending
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2019
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2022
- 2022-06-03 JP JP2022091214A patent/JP7483791B2/ja active Active
- 2022-12-01 US US18/072,963 patent/US12527798B2/en active Active
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2023
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2025
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