JP2019536764A5 - - Google Patents
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- Publication number
- JP2019536764A5 JP2019536764A5 JP2019523090A JP2019523090A JP2019536764A5 JP 2019536764 A5 JP2019536764 A5 JP 2019536764A5 JP 2019523090 A JP2019523090 A JP 2019523090A JP 2019523090 A JP2019523090 A JP 2019523090A JP 2019536764 A5 JP2019536764 A5 JP 2019536764A5
- Authority
- JP
- Japan
- Prior art keywords
- benzenesulfonamide
- chloro
- fluoro
- amino
- thiazole
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- -1 bicyclic amine Chemical class 0.000 claims 46
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 33
- 125000000217 alkyl group Chemical group 0.000 claims 27
- 125000000753 cycloalkyl group Chemical group 0.000 claims 14
- 125000001475 halogen functional group Chemical group 0.000 claims 12
- 150000001875 compounds Chemical class 0.000 claims 10
- 125000003545 alkoxy group Chemical group 0.000 claims 7
- 125000001424 substituent group Chemical group 0.000 claims 7
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 5
- 125000004093 cyano group Chemical group *C#N 0.000 claims 4
- 125000004438 haloalkoxy group Chemical group 0.000 claims 4
- 125000001188 haloalkyl group Chemical group 0.000 claims 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 229910052739 hydrogen Inorganic materials 0.000 claims 3
- 239000001257 hydrogen Substances 0.000 claims 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 3
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 3
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 claims 3
- 125000001412 tetrahydropyranyl group Chemical group 0.000 claims 3
- KHBQMWCZKVMBLN-UHFFFAOYSA-N Benzenesulfonamide Chemical compound NS(=O)(=O)C1=CC=CC=C1 KHBQMWCZKVMBLN-UHFFFAOYSA-N 0.000 claims 2
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 2
- 125000002393 azetidinyl group Chemical group 0.000 claims 2
- 150000002431 hydrogen Chemical class 0.000 claims 2
- 125000002757 morpholinyl group Chemical group 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 125000004193 piperazinyl group Chemical group 0.000 claims 2
- 125000003386 piperidinyl group Chemical group 0.000 claims 2
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 2
- 125000001113 thiadiazolyl group Chemical group 0.000 claims 2
- 125000000335 thiazolyl group Chemical group 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 125000000532 dioxanyl group Chemical group 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662413555P | 2016-10-27 | 2016-10-27 | |
| US62/413,555 | 2016-10-27 | ||
| PCT/US2017/058472 WO2018081384A1 (en) | 2016-10-27 | 2017-10-26 | Acyl sulfonamide nav1.7 inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019536764A JP2019536764A (ja) | 2019-12-19 |
| JP2019536764A5 true JP2019536764A5 (en:Method) | 2020-11-19 |
| JP7072569B2 JP7072569B2 (ja) | 2022-05-20 |
Family
ID=60245256
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019523090A Active JP7072569B2 (ja) | 2016-10-27 | 2017-10-26 | アシルスルホンアミドＮａＶ１．７阻害剤 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US10836758B2 (en:Method) |
| EP (1) | EP3532462B1 (en:Method) |
| JP (1) | JP7072569B2 (en:Method) |
| KR (1) | KR102561076B1 (en:Method) |
| CN (1) | CN110088093B (en:Method) |
| ES (1) | ES2897998T3 (en:Method) |
| MA (1) | MA46615A (en:Method) |
| WO (1) | WO2018081384A1 (en:Method) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG10201912372XA (en) * | 2016-12-09 | 2020-02-27 | Xenon Pharmaceuticals Inc | Benzenesulfonamide compounds and their use as therapeutic agents |
| EP3807281A1 (en) | 2018-06-13 | 2021-04-21 | Xenon Pharmaceuticals Inc. | Benzenesulfonamide compounds and their use as therapeutic agents |
| US12246008B2 (en) | 2018-12-05 | 2025-03-11 | Merck Sharp & Dohme Llc | 4-amino or 4-alkoxy-substituted aryl sulfonamide compounds with selective activity in voltage-gated sodium channels |
| CN111285825B (zh) * | 2018-12-10 | 2023-02-17 | 中国科学院上海药物研究所 | 一类苯磺酰胺取代的衍生物，其制法及其用途 |
| WO2020199683A1 (zh) * | 2019-04-04 | 2020-10-08 | 上海海雁医药科技有限公司 | 氮杂环取代的磺酰基苯甲酰胺衍生物、其制法与医药上的用途 |
| WO2020248123A1 (en) | 2019-06-11 | 2020-12-17 | Merck Sharp & Dohme Corp. | Hydroxypyrrolidine-substituted arylsulfonamide compounds with selective activity in voltage-gated sodium channels |
| EP4402276A1 (en) | 2021-09-15 | 2024-07-24 | Richter Gedeon Nyrt. | Process to produce (1 r, 4 r)-4-substituted cyclohexane-1-amines |
| WO2025096637A1 (en) * | 2023-10-31 | 2025-05-08 | Xenon Pharmaceuticals Inc. | Substituted aryl sulfonamides for use as sodium channel inhibitors |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103209960A (zh) * | 2010-07-26 | 2013-07-17 | 百时美施贵宝公司 | 用作cyp17抑制剂的磺酰胺化合物 |
| BR112014010271A2 (pt) * | 2011-10-31 | 2017-04-18 | Xenon Pharmaceuticals Inc | compostos de benzenossulfonamida e seu uso como agentes terapêuticos |
| US8889741B2 (en) * | 2012-02-09 | 2014-11-18 | Daiichi Sankyo Company, Limited | Cycloalkane derivatives |
| WO2015077905A1 (en) * | 2013-11-29 | 2015-06-04 | Merck Sharp & Dohme Corp. | Bicycloamine-substituted-n-benzenesulfonamide compounds with selective activity in voltage-gated sodium channels |
| EP3126360A1 (en) * | 2014-03-29 | 2017-02-08 | Lupin Limited | Sulfonamide compounds as voltage gated sodium channel modulators |
| TW201718629A (zh) * | 2015-09-25 | 2017-06-01 | 韓美藥品股份有限公司 | 包含多個生理多肽及免疫球蛋白Ｆｃ區之蛋白質接合物 |
| GB201518888D0 (en) * | 2015-10-24 | 2015-12-09 | Smiths Medical Int Ltd | Medico-surgical tubes and their manufacture |
| AU2016370554B2 (en) | 2015-12-18 | 2018-11-29 | Merck Sharp & Dohme Corp. | Hydroxyalkylamine- and hydroxycycloalkylamine-substituted diamine-arylsulfonamide compounds with selective activity in voltage-gated sodium channels |
| EP3389654B1 (en) * | 2015-12-18 | 2023-08-16 | Merck Sharp & Dohme LLC | Diamino-alkylamino-linked arylsulfonamide compounds with selective activity in voltage-gated sodium channels |
-
2017
- 2017-10-26 EP EP17794203.4A patent/EP3532462B1/en active Active
- 2017-10-26 JP JP2019523090A patent/JP7072569B2/ja active Active
- 2017-10-26 ES ES17794203T patent/ES2897998T3/es active Active
- 2017-10-26 US US16/344,414 patent/US10836758B2/en active Active
- 2017-10-26 CN CN201780079199.3A patent/CN110088093B/zh active Active
- 2017-10-26 WO PCT/US2017/058472 patent/WO2018081384A1/en not_active Ceased
- 2017-10-26 KR KR1020197014690A patent/KR102561076B1/ko active Active
- 2017-10-26 MA MA046615A patent/MA46615A/fr unknown
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