JP2019536764A5 - - Google Patents
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- Publication number
- JP2019536764A5 JP2019536764A5 JP2019523090A JP2019523090A JP2019536764A5 JP 2019536764 A5 JP2019536764 A5 JP 2019536764A5 JP 2019523090 A JP2019523090 A JP 2019523090A JP 2019523090 A JP2019523090 A JP 2019523090A JP 2019536764 A5 JP2019536764 A5 JP 2019536764A5
- Authority
- JP
- Japan
- Prior art keywords
- benzenesulfonamide
- chloro
- fluoro
- amino
- thiazole
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- -1 bicyclic amine Chemical class 0.000 claims 46
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 33
- 125000000217 alkyl group Chemical group 0.000 claims 27
- 125000000753 cycloalkyl group Chemical group 0.000 claims 14
- 125000001475 halogen functional group Chemical group 0.000 claims 12
- 150000001875 compounds Chemical class 0.000 claims 10
- 125000003545 alkoxy group Chemical group 0.000 claims 7
- 125000001424 substituent group Chemical group 0.000 claims 7
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 5
- 125000004093 cyano group Chemical group *C#N 0.000 claims 4
- 125000004438 haloalkoxy group Chemical group 0.000 claims 4
- 125000001188 haloalkyl group Chemical group 0.000 claims 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 229910052739 hydrogen Inorganic materials 0.000 claims 3
- 239000001257 hydrogen Substances 0.000 claims 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 3
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 3
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 claims 3
- 125000001412 tetrahydropyranyl group Chemical group 0.000 claims 3
- KHBQMWCZKVMBLN-UHFFFAOYSA-N Benzenesulfonamide Chemical compound NS(=O)(=O)C1=CC=CC=C1 KHBQMWCZKVMBLN-UHFFFAOYSA-N 0.000 claims 2
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 2
- 125000002393 azetidinyl group Chemical group 0.000 claims 2
- 150000002431 hydrogen Chemical class 0.000 claims 2
- 125000002757 morpholinyl group Chemical group 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 125000004193 piperazinyl group Chemical group 0.000 claims 2
- 125000003386 piperidinyl group Chemical group 0.000 claims 2
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 2
- 125000001113 thiadiazolyl group Chemical group 0.000 claims 2
- 125000000335 thiazolyl group Chemical group 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 125000000532 dioxanyl group Chemical group 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662413555P | 2016-10-27 | 2016-10-27 | |
| US62/413,555 | 2016-10-27 | ||
| PCT/US2017/058472 WO2018081384A1 (en) | 2016-10-27 | 2017-10-26 | Acyl sulfonamide nav1.7 inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019536764A JP2019536764A (ja) | 2019-12-19 |
| JP2019536764A5 true JP2019536764A5 (OSRAM) | 2020-11-19 |
| JP7072569B2 JP7072569B2 (ja) | 2022-05-20 |
Family
ID=60245256
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019523090A Active JP7072569B2 (ja) | 2016-10-27 | 2017-10-26 | アシルスルホンアミドＮａＶ１．７阻害剤 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US10836758B2 (OSRAM) |
| EP (1) | EP3532462B1 (OSRAM) |
| JP (1) | JP7072569B2 (OSRAM) |
| KR (1) | KR102561076B1 (OSRAM) |
| CN (1) | CN110088093B (OSRAM) |
| ES (1) | ES2897998T3 (OSRAM) |
| MA (1) | MA46615A (OSRAM) |
| WO (1) | WO2018081384A1 (OSRAM) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7022751B2 (ja) | 2016-12-09 | 2022-02-18 | ゼノン・ファーマシューティカルズ・インコーポレイテッド | ベンゼンスルホンアミド化合物および治療剤としてのそれらの使用 |
| SG11202011862PA (en) | 2018-06-13 | 2020-12-30 | Xenon Pharmaceuticals Inc | Benzenesulfonamide compounds and their use as therapeutic agents |
| WO2020117626A1 (en) | 2018-12-05 | 2020-06-11 | Merck Sharp & Dohme Corp. | 4-amino or 4-alkoxy-substituted aryl sulfonamide compounds with selective activity in voltage-gated sodium channels |
| CN111285825B (zh) * | 2018-12-10 | 2023-02-17 | 中国科学院上海药物研究所 | 一类苯磺酰胺取代的衍生物，其制法及其用途 |
| WO2020199683A1 (zh) * | 2019-04-04 | 2020-10-08 | 上海海雁医药科技有限公司 | 氮杂环取代的磺酰基苯甲酰胺衍生物、其制法与医药上的用途 |
| WO2020248123A1 (en) * | 2019-06-11 | 2020-12-17 | Merck Sharp & Dohme Corp. | Hydroxypyrrolidine-substituted arylsulfonamide compounds with selective activity in voltage-gated sodium channels |
| EP4402276A1 (en) | 2021-09-15 | 2024-07-24 | Richter Gedeon Nyrt. | Process to produce (1 r, 4 r)-4-substituted cyclohexane-1-amines |
| WO2025096637A1 (en) * | 2023-10-31 | 2025-05-08 | Xenon Pharmaceuticals Inc. | Substituted aryl sulfonamides for use as sodium channel inhibitors |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012015723A1 (en) * | 2010-07-26 | 2012-02-02 | Bristol-Myers Squibb Company | Sulfonamide compounds useful as cyp17 inhibitors |
| US9630929B2 (en) | 2011-10-31 | 2017-04-25 | Xenon Pharmaceuticals Inc. | Benzenesulfonamide compounds and their use as therapeutic agents |
| US8889741B2 (en) * | 2012-02-09 | 2014-11-18 | Daiichi Sankyo Company, Limited | Cycloalkane derivatives |
| WO2015077905A1 (en) | 2013-11-29 | 2015-06-04 | Merck Sharp & Dohme Corp. | Bicycloamine-substituted-n-benzenesulfonamide compounds with selective activity in voltage-gated sodium channels |
| TW201623264A (zh) * | 2014-03-29 | 2016-07-01 | 魯賓有限公司 | 作為電位閘控鈉通道調節劑之磺胺化合物 |
| TW201718629A (zh) * | 2015-09-25 | 2017-06-01 | 韓美藥品股份有限公司 | 包含多個生理多肽及免疫球蛋白Ｆｃ區之蛋白質接合物 |
| GB201518888D0 (en) * | 2015-10-24 | 2015-12-09 | Smiths Medical Int Ltd | Medico-surgical tubes and their manufacture |
| JP2019502688A (ja) | 2015-12-18 | 2019-01-31 | メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． | 電位作動型ナトリウムチャネルにおいて選択的活性を有するジアミノ−アルキルアミノ結合アリールスルホンアミド化合物 |
| CN108699015A (zh) | 2015-12-18 | 2018-10-23 | 默沙东公司 | 对电压门控性钠通道具有选择性活性的羟基烷基胺-和羟基环烷基胺-取代的二胺-芳基磺胺化合物 |
-
2017
- 2017-10-26 MA MA046615A patent/MA46615A/fr unknown
- 2017-10-26 US US16/344,414 patent/US10836758B2/en active Active
- 2017-10-26 CN CN201780079199.3A patent/CN110088093B/zh active Active
- 2017-10-26 KR KR1020197014690A patent/KR102561076B1/ko active Active
- 2017-10-26 JP JP2019523090A patent/JP7072569B2/ja active Active
- 2017-10-26 ES ES17794203T patent/ES2897998T3/es active Active
- 2017-10-26 WO PCT/US2017/058472 patent/WO2018081384A1/en not_active Ceased
- 2017-10-26 EP EP17794203.4A patent/EP3532462B1/en active Active
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