JP2019535779A5 - - Google Patents

Info

Publication number

JP2019535779A5

JP2019535779A5 JP2019528118A JP2019528118A JP2019535779A5 JP 2019535779 A5 JP2019535779 A5 JP 2019535779A5 JP 2019528118 A JP2019528118 A JP 2019528118A JP 2019528118 A JP2019528118 A JP 2019528118A JP 2019535779 A5 JP2019535779 A5 JP 2019535779A5

Authority

JP

Japan

Prior art keywords

composition

composition according

concentration

present

fruit extract

Prior art date

2017-11-24

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 239000000203 mixture Substances 0.000 claims 17
• 241001444063 Aronia Species 0.000 claims 7
• 235000013399 edible fruits Nutrition 0.000 claims 6
• AXNVHPCVMSNXNP-IVKVKCDBSA-N (2s,3s,4s,5r,6r)-6-[[(3s,4s,4ar,6ar,6bs,8r,8ar,9r,10r,12as,14ar,14br)-9-acetyloxy-8-hydroxy-4,8a-bis(hydroxymethyl)-4,6a,6b,11,11,14b-hexamethyl-10-[(e)-2-methylbut-2-enoyl]oxy-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicen-3-yl]oxy]-4-hydroxy-3, Chemical compound O([C@@H]1[C@H](O[C@H]([C@@H]([C@H]1O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)O[C@H]1CC[C@]2(C)[C@H]3CC=C4[C@@]([C@@]3(CC[C@H]2[C@]1(CO)C)C)(C)C[C@@H](O)[C@@]1(CO)[C@@H](OC(C)=O)[C@@H](C(C[C@H]14)(C)C)OC(=O)C(/C)=C/C)C(O)=O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O AXNVHPCVMSNXNP-IVKVKCDBSA-N 0.000 claims 4
• AXNVHPCVMSNXNP-GKTCLTPXSA-N Aescin Natural products O=C(O[C@H]1[C@@H](OC(=O)C)[C@]2(CO)[C@@H](O)C[C@@]3(C)[C@@]4(C)[C@@H]([C@]5(C)[C@H]([C@](CO)(C)[C@@H](O[C@@H]6[C@@H](O[C@H]7[C@@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O7)[C@@H](O)[C@H](O[C@H]7[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O7)[C@@H](C(=O)O)O6)CC5)CC4)CC=C3[C@@H]2CC1(C)C)/C(=C/C)/C AXNVHPCVMSNXNP-GKTCLTPXSA-N 0.000 claims 4
• 229940093314 beta-escin Drugs 0.000 claims 4
• AXNVHPCVMSNXNP-BEJCRFBNSA-N beta-escin Natural products CC=C(/C)C(=O)O[C@H]1[C@H](OC(=O)C)[C@]2(CO)[C@H](O)C[C@@]3(C)C(=CC[C@@H]4[C@@]5(C)CC[C@H](O[C@H]6O[C@@H]([C@H](O[C@H]7O[C@H](CO)[C@@H](O)[C@H](O)[C@H]7O)[C@H](O)[C@@H]6O[C@@H]8O[C@H](CO)[C@@H](O)[C@H](O)[C@H]8O)C(=O)O)[C@](C)(CO)[C@@H]5CC[C@@]34C)[C@@H]2CC1(C)C AXNVHPCVMSNXNP-BEJCRFBNSA-N 0.000 claims 4
• 230000002503 metabolic effect Effects 0.000 claims 3
• 239000001397 quillaja saponaria molina bark Substances 0.000 claims 3
• 229930182490 saponin Natural products 0.000 claims 3
• 150000007949 saponins Chemical class 0.000 claims 3
• IKHGUXGNUITLKF-UHFFFAOYSA-N Acetaldehyde Chemical compound CC=O IKHGUXGNUITLKF-UHFFFAOYSA-N 0.000 claims 2
• 108020002663 Aldehyde Dehydrogenase Proteins 0.000 claims 2
• LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 2
• 208000007848 Alcoholism Diseases 0.000 claims 1
• 102000005369 Aldehyde Dehydrogenase Human genes 0.000 claims 1
• 208000000461 Esophageal Neoplasms Diseases 0.000 claims 1
• 206010064571 Gene mutation Diseases 0.000 claims 1
• 206010019133 Hangover Diseases 0.000 claims 1
• 102000009645 Mitochondrial Aldehyde Dehydrogenase Human genes 0.000 claims 1
• 108010009513 Mitochondrial Aldehyde Dehydrogenase Proteins 0.000 claims 1
• 206010030155 Oesophageal carcinoma Diseases 0.000 claims 1
• 206010031096 Oropharyngeal cancer Diseases 0.000 claims 1
• 206010057444 Oropharyngeal neoplasm Diseases 0.000 claims 1
• 201000007930 alcohol dependence Diseases 0.000 claims 1
• 230000002255 enzymatic effect Effects 0.000 claims 1
• 201000004101 esophageal cancer Diseases 0.000 claims 1
• 238000011010 flushing procedure Methods 0.000 claims 1
• 235000021579 juice concentrates Nutrition 0.000 claims 1
• 239000007788 liquid Substances 0.000 claims 1
• 201000006958 oropharynx cancer Diseases 0.000 claims 1
• 230000002265 prevention Effects 0.000 claims 1
• 230000000241 respiratory effect Effects 0.000 claims 1
• 230000001988 toxicity Effects 0.000 claims 1
• 231100000419 toxicity Toxicity 0.000 claims 1