JP2019535709A5 - - Google Patents

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Publication number

JP2019535709A5

JP2019535709A5 JP2019524895A JP2019524895A JP2019535709A5 JP 2019535709 A5 JP2019535709 A5 JP 2019535709A5 JP 2019524895 A JP2019524895 A JP 2019524895A JP 2019524895 A JP2019524895 A JP 2019524895A JP 2019535709 A5 JP2019535709 A5 JP 2019535709A5

Authority

JP

Japan

Prior art keywords

alkoxy

halogen

alkyl

atom

atoms

Prior art date

2017-11-14

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 125000003545 alkoxy group Chemical group 0.000 claims 63
• 229910052736 halogen Inorganic materials 0.000 claims 59
• 229910052794 bromium Inorganic materials 0.000 claims 55
• 229910052801 chlorine Inorganic materials 0.000 claims 55
• 229910052731 fluorine Inorganic materials 0.000 claims 55
• 150000002367 halogens Chemical class 0.000 claims 53
• 125000004432 carbon atom Chemical group C* 0.000 claims 29
• 125000004433 nitrogen atom Chemical group N* 0.000 claims 29
• 125000004430 oxygen atom Chemical group O* 0.000 claims 29
• 150000001412 amines Chemical class 0.000 claims 26
• 125000000217 alkyl group Chemical group 0.000 claims 22
• 150000001875 compounds Chemical class 0.000 claims 22
• 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 22
• 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 21
• 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 20
• 125000000304 alkynyl group Chemical group 0.000 claims 20
• 125000003118 aryl group Chemical group 0.000 claims 19
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 19
• 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 16
• 125000003187 heptyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 15
• 229910052757 nitrogen Inorganic materials 0.000 claims 15
• 125000005842 heteroatom Chemical group 0.000 claims 14
• 125000005262 alkoxyamine group Chemical group 0.000 claims 13
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 13
• 125000001424 substituent group Chemical group 0.000 claims 12
• 239000003795 chemical substances by application Substances 0.000 claims 11
• 125000003342 alkenyl group Chemical group 0.000 claims 10
• 229910052760 oxygen Inorganic materials 0.000 claims 10
• -1 pyridadyl Chemical group 0.000 claims 7
• 125000005843 halogen group Chemical group 0.000 claims 6
• 239000003814 drug Substances 0.000 claims 5
• 125000002883 imidazolyl group Chemical group 0.000 claims 5
• 125000003226 pyrazolyl group Chemical group 0.000 claims 5
• 125000006701 (C1-C7) alkyl group Chemical group 0.000 claims 4
• 108010057466 NF-kappa B Proteins 0.000 claims 4
• 102100023050 Nuclear factor NF-kappa-B p105 subunit Human genes 0.000 claims 4
• 125000006615 aromatic heterocyclic group Chemical group 0.000 claims 4
• 229940079593 drug Drugs 0.000 claims 4
• 229910052739 hydrogen Inorganic materials 0.000 claims 4
• 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 4
• 125000003373 pyrazinyl group Chemical group 0.000 claims 4
• 125000004076 pyridyl group Chemical group 0.000 claims 4
• 125000000714 pyrimidinyl group Chemical group 0.000 claims 4
• 206010028980 Neoplasm Diseases 0.000 claims 3
• 201000011510 cancer Diseases 0.000 claims 3
• 230000011664 signaling Effects 0.000 claims 3
• 238000011282 treatment Methods 0.000 claims 3
• 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims 2
• 229910052799 carbon Inorganic materials 0.000 claims 2
• 230000007674 genetic toxicity Effects 0.000 claims 2
• 231100000025 genetic toxicology Toxicity 0.000 claims 2
• 231100000024 genotoxic Toxicity 0.000 claims 2
• 230000001738 genotoxic effect Effects 0.000 claims 2
• 230000001939 inductive effect Effects 0.000 claims 2
• 230000005764 inhibitory process Effects 0.000 claims 2
• 238000000034 method Methods 0.000 claims 2
• MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 claims 1
• 125000006527 (C1-C5) alkyl group Chemical group 0.000 claims 1
• 230000005778 DNA damage Effects 0.000 claims 1
• 231100000277 DNA damage Toxicity 0.000 claims 1
• 230000008265 DNA repair mechanism Effects 0.000 claims 1
• 208000031448 Genomic Instability Diseases 0.000 claims 1
• 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 1
• 102100040247 Tumor necrosis factor Human genes 0.000 claims 1
• 230000006907 apoptotic process Effects 0.000 claims 1
• 125000004429 atom Chemical group 0.000 claims 1
• 238000000423 cell based assay Methods 0.000 claims 1
• 238000002512 chemotherapy Methods 0.000 claims 1
• 125000004122 cyclic group Chemical group 0.000 claims 1
• 230000002950 deficient Effects 0.000 claims 1
• 201000010099 disease Diseases 0.000 claims 1
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
• 230000001747 exhibiting effect Effects 0.000 claims 1
• 238000000338 in vitro Methods 0.000 claims 1
• 230000002401 inhibitory effect Effects 0.000 claims 1
• 230000007246 mechanism Effects 0.000 claims 1
• 230000001404 mediated effect Effects 0.000 claims 1
• 230000032147 negative regulation of DNA repair Effects 0.000 claims 1
• 230000034190 positive regulation of NF-kappaB transcription factor activity Effects 0.000 claims 1
• 238000001959 radiotherapy Methods 0.000 claims 1
• 231100000331 toxic Toxicity 0.000 claims 1
• 230000002588 toxic effect Effects 0.000 claims 1
• 210000004881 tumor cell Anatomy 0.000 claims 1