JP7307677B2 - 遺伝毒性ストレスにより誘導されるＩＫＫ／ＮＦ－κＢ経路の選択的阻害剤 - Google Patents

遺伝毒性ストレスにより誘導されるＩＫＫ／ＮＦ－κＢ経路の選択的阻害剤 Download PDF

Info

Publication number
JP7307677B2
JP7307677B2 JP2019524895A JP2019524895A JP7307677B2 JP 7307677 B2 JP7307677 B2 JP 7307677B2 JP 2019524895 A JP2019524895 A JP 2019524895A JP 2019524895 A JP2019524895 A JP 2019524895A JP 7307677 B2 JP7307677 B2 JP 7307677B2
Authority
JP
Japan
Prior art keywords
alkyl
cells
activation
halogen
alkoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2019524895A
Other languages
English (en)
Japanese (ja)
Other versions
JP2019535709A (ja
JP2019535709A5 (enExample
Inventor
シェイデライト クラウス
ビレンブロック ミヒャエル
リンデマン ペーター
ラデツキー ジルケ
ペーター フォンクリーズ イェンス
ナザレ マルク
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Forschungsverbund Berlin FVB eV
Original Assignee
Forschungsverbund Berlin FVB eV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Forschungsverbund Berlin FVB eV filed Critical Forschungsverbund Berlin FVB eV
Publication of JP2019535709A publication Critical patent/JP2019535709A/ja
Publication of JP2019535709A5 publication Critical patent/JP2019535709A5/ja
Priority to JP2023075706A priority Critical patent/JP7701403B2/ja
Application granted granted Critical
Publication of JP7307677B2 publication Critical patent/JP7307677B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/16—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
JP2019524895A 2016-11-14 2017-11-14 遺伝毒性ストレスにより誘導されるＩＫＫ／ＮＦ－κＢ経路の選択的阻害剤 Active JP7307677B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2023075706A JP7701403B2 (ja) 2016-11-14 2023-05-01 遺伝毒性ストレスにより誘導されるＩＫＫ／ＮＦ－κＢ経路の選択的阻害剤

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP16198731.8 2016-11-14
EP16198731.8A EP3321264A1 (en) 2016-11-14 2016-11-14 Selective inhibitors of genotoxic stress-induced ikk/nf-kb pathways
PCT/EP2017/079181 WO2018087389A1 (en) 2016-11-14 2017-11-14 SELECTIVE INHIBITORS OF GENOTOXIC STRESS-INDUCED IKK/NF-kB PATHWAYS

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2023075706A Division JP7701403B2 (ja) 2016-11-14 2023-05-01 遺伝毒性ストレスにより誘導されるＩＫＫ／ＮＦ－κＢ経路の選択的阻害剤

Publications (3)

Publication Number Publication Date
JP2019535709A JP2019535709A (ja) 2019-12-12
JP2019535709A5 JP2019535709A5 (enExample) 2020-12-24
JP7307677B2 true JP7307677B2 (ja) 2023-07-12

Family

ID=57288311

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2019524895A Active JP7307677B2 (ja) 2016-11-14 2017-11-14 遺伝毒性ストレスにより誘導されるＩＫＫ／ＮＦ－κＢ経路の選択的阻害剤
JP2023075706A Active JP7701403B2 (ja) 2016-11-14 2023-05-01 遺伝毒性ストレスにより誘導されるＩＫＫ／ＮＦ－κＢ経路の選択的阻害剤

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2023075706A Active JP7701403B2 (ja) 2016-11-14 2023-05-01 遺伝毒性ストレスにより誘導されるＩＫＫ／ＮＦ－κＢ経路の選択的阻害剤

Country Status (7)

Country Link
US (1) US11028084B2 (enExample)
EP (2) EP3321264A1 (enExample)
JP (2) JP7307677B2 (enExample)
CN (1) CN109963850A (enExample)
AU (1) AU2017359276B2 (enExample)
CA (1) CA3041832A1 (enExample)
WO (1) WO2018087389A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023101521A (ja) * 2016-11-14 2023-07-21 マックス－デルブリュック－セントルム フュール モレキュラー メディツィン イン デア ヘルムホルツ－ゲマインシャフト 遺伝毒性ストレスにより誘導されるＩＫＫ／ＮＦ－κＢ経路の選択的阻害剤

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113913515A (zh) * 2020-07-10 2022-01-11 上海吉凯基因医学科技股份有限公司 人eme1基因的用途及相关产品
CN111781358A (zh) * 2020-07-13 2020-10-16 张瑜 Xab2蛋白作为卵巢癌预后和/或预测铂类耐药标志物
CN116829560A (zh) * 2020-12-14 2023-09-29 金奥克斯治疗有限公司 催产素受体调节剂
AU2023397973A1 (en) * 2022-12-13 2025-07-03 Flare Therapeutics Inc. Compounds and composition for targeting tp53-y220c mutants
EP4467141A1 (en) 2023-05-24 2024-11-27 Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft Pyrazolo-quinolines as selective inhibitors of genotoxic stress-induced ikk/nf- kb pathways for cancer therapy

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006526580A (ja) 2003-06-02 2006-11-24 新疆華世丹薬物研究有限責任公司 ハルミン誘導体、これらの調製において使用する中間体、調製過程およびこれらの使用
JP2009526855A (ja) 2006-02-16 2009-07-23 ミレニアム・ファーマシューティカルズ・インコーポレイテッド アルファカルボリンおよびその使用
JP2012533623A (ja) 2009-07-22 2012-12-27 ザ・ボード・オブ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・イリノイ Ｈｄａｃ阻害剤およびそれを用いる治療法
WO2014041125A1 (en) 2012-09-13 2014-03-20 Baden-Württemberg Stiftung Gmbh Specific inhibitors of protein p21 as therapeutic agents

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3663559A (en) * 1969-12-03 1972-05-16 Union Carbide Corp Preparation of oxo-furo-pyridines from furylvinyl isocyanates
TW200800978A (en) * 2006-03-23 2008-01-01 Otsuka Pharma Co Ltd Carbazole compound
CA2932121A1 (en) * 2007-11-30 2009-06-11 Newlink Genetics Corporation Ido inhibitors
CN102015717A (zh) * 2008-03-28 2011-04-13 奥蒂瑞斯治疗公司 趋化因子受体调节剂
CA2785233C (en) * 2009-12-28 2018-10-09 Audiocure Pharma Gmbh .beta.-carbolines for treatment of hearing damages and vertigo
CN102146080B (zh) * 2010-02-10 2013-01-30 新疆华世丹药业股份有限公司 β-咔啉碱衍生物类化合物及其应用
US20120039804A1 (en) * 2010-06-04 2012-02-16 Philippe Diaz Novel Tricyclic Modulators of Cannabinoid Receptors
CN111012779A (zh) * 2011-10-25 2020-04-17 新疆华世丹药物研究有限责任公司 去氢骆驼蓬碱衍生物在制备抗菌药物中的应用
RU2608217C2 (ru) * 2011-11-02 2017-01-17 Байер Интеллектуэль Проперти Гмбх Соединения с нематоцидной активностью
EP3321264A1 (en) 2016-11-14 2018-05-16 Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft Selective inhibitors of genotoxic stress-induced ikk/nf-kb pathways

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006526580A (ja) 2003-06-02 2006-11-24 新疆華世丹薬物研究有限責任公司 ハルミン誘導体、これらの調製において使用する中間体、調製過程およびこれらの使用
JP2009526855A (ja) 2006-02-16 2009-07-23 ミレニアム・ファーマシューティカルズ・インコーポレイテッド アルファカルボリンおよびその使用
JP2012533623A (ja) 2009-07-22 2012-12-27 ザ・ボード・オブ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・イリノイ Ｈｄａｃ阻害剤およびそれを用いる治療法
WO2014041125A1 (en) 2012-09-13 2014-03-20 Baden-Württemberg Stiftung Gmbh Specific inhibitors of protein p21 as therapeutic agents

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
Biochemical Pharmacology，70(1)，2005年，pp.102-112
Bioorganic & Medicinal Chemistry Letters，2016年，26(16)，pp.4015-4019
Chemical and Pharmaceutical Bulletin，2012年，pp.1372-1379
ChemMedChem，2016年，11(16)，pp.1721-1733
European Journal of Medicinal Chemistry，2016年，110，pp.98-114
Journal of Molecular Graphics and Modelling，2013年，42，pp.62-72

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023101521A (ja) * 2016-11-14 2023-07-21 マックス－デルブリュック－セントルム フュール モレキュラー メディツィン イン デア ヘルムホルツ－ゲマインシャフト 遺伝毒性ストレスにより誘導されるＩＫＫ／ＮＦ－κＢ経路の選択的阻害剤
JP7701403B2 (ja) 2016-11-14 2025-07-01 マックス－デルブリュック－セントルム フュール モレキュラー メディツィン イン デア ヘルムホルツ－ゲマインシャフト 遺伝毒性ストレスにより誘導されるＩＫＫ／ＮＦ－κＢ経路の選択的阻害剤

Also Published As

Publication number Publication date
JP2019535709A (ja) 2019-12-12
EP3538529B1 (en) 2022-01-19
JP7701403B2 (ja) 2025-07-01
CA3041832A1 (en) 2018-05-17
EP3538529A1 (en) 2019-09-18
AU2017359276A1 (en) 2019-05-16
US11028084B2 (en) 2021-06-08
US20190276452A1 (en) 2019-09-12
WO2018087389A1 (en) 2018-05-17
JP2023101521A (ja) 2023-07-21
CN109963850A (zh) 2019-07-02
EP3321264A1 (en) 2018-05-16
AU2017359276B2 (en) 2022-02-17

Similar Documents

Publication Publication Date Title
JP7701403B2 (ja) 遺伝毒性ストレスにより誘導されるＩＫＫ／ＮＦ－κＢ経路の選択的阻害剤
Michels et al. Predictive biomarkers for cancer therapy with PARP inhibitors
JP6919977B2 (ja) メニン−ｍｌｌの置換された阻害剤及びその使用方法
CN103237799B (zh) 杂环衍生物、制备方法及其药学用途
TWI659021B (zh) Ｋｒａｓ ｇ１２ｃ之抑制劑
Zhang et al. Discovery of 4-hydroxyquinazoline derivatives as small molecular BET/PARP1 inhibitors that induce defective homologous recombination and lead to synthetic lethality for triple-negative breast cancer therapy
KR20160076519A (ko) Kras g12c 억제제
CN101981013A (zh) 作为parp和微管蛋白聚合抑制剂的四氢菲啶酮和四氢环戊二烯并喹啉酮
EA009875B1 (ru) 6-алкенил и 6-фенилалкил замещенные 2-хинолиноны и 2-хиноксалиноны в качестве ингибиторов поли(адф-рибоза) полимеразы
AU2023239344A1 (en) Piperazine substituted indazole compounds as inhibitors of parg
CA3172987A1 (en) Small molecule inhibitors of oncogenic chd1l with preclinical activity against colorectal cancer
KR20180035905A (ko) Bet 브로모도메인 억제제에 대한 저항성의 메카니즘
CN110603256A (zh) 可用作wee-1激酶抑制剂的嘧啶并嘧啶酮
Sayed et al. Design, synthesis, anticancer evaluation, and in silico studies of some thieno [2, 3‐d] pyrimidine derivatives as EGFR inhibitors
WO2010075372A1 (en) Inhibitors of mre11, rad50 and/or nbs1
US9750742B2 (en) Small molecular inhibitors of RAD51 recombinase and methods thereof
WO2024240877A1 (en) Pyrazolo-quinolines as selective inhibitors of genotoxic stress-induced ikk/nf- kb pathways for cancer therapy
HK40015060B (en) SELECTIVE INHIBITORS OF GENOTOXIC STRESS-INDUCED IKK/NF-kB PATHWAYS
HK40015060A (en) SELECTIVE INHIBITORS OF GENOTOXIC STRESS-INDUCED IKK/NF-kB PATHWAYS
WO2022032224A1 (en) Compositions and methods for the treatment and diagnosis of cancer
Vasiljeva et al. Development of prospective non-toxic inhibitors of ABCB1 activity and expression in a series of selenophenoquinolinones
El-Rashedy Comprehensive Highlights of Some Novel Small-Molecule Inhibitors of Checkpoint Kinase for Cancer Therapy
Harnor et al. Modulation of the DNA-Damage Response by Inhibitors of the Phosphatidylinositol 3-Kinase Related Kinase (PIKK) Family
Steffen Design, development, and evaluation of tools to study cellular ADP-ribose polymer metabolism
Shuck Identification of novel small molecule inhibitors of proteins required for genomic maintenance and stability

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20201113

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20201113

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20211130

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20220228

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20220531

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20220614

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20220914

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20221207

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20230117

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20230501

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20230502

A911 Transfer to examiner for re-examination before appeal (zenchi)

Free format text: JAPANESE INTERMEDIATE CODE: A911

Effective date: 20230523

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20230613

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20230630

R150 Certificate of patent or registration of utility model

Ref document number: 7307677

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150