CN109963850A - 基因毒性应激诱导性IKK/NF-κB途径的选择性抑制剂 - Google Patents

基因毒性应激诱导性IKK/NF-κB途径的选择性抑制剂 Download PDF

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Publication number
CN109963850A
CN109963850A CN201780071520.3A CN201780071520A CN109963850A CN 109963850 A CN109963850 A CN 109963850A CN 201780071520 A CN201780071520 A CN 201780071520A CN 109963850 A CN109963850 A CN 109963850A
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China
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alkyl
halogen
alkoxy
ring
amine
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Chinese (zh)
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克劳斯·沙伊德尔雷特
米夏埃尔·威伦布罗克
彼得·林德曼
西尔克·拉德茨基
延斯·彼得·冯克里斯
马克·纳扎雷
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Marx - Helmholtz - Ladbrok Center For Molecular Medicine Association
Forschungsverbund Berlin FVB eV
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Marx - Helmholtz - Ladbrok Center For Molecular Medicine Association
Forschungsverbund Berlin FVB eV
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Publication of CN109963850A publication Critical patent/CN109963850A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/16—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CN201780071520.3A 2016-11-14 2017-11-14 基因毒性应激诱导性IKK/NF-κB途径的选择性抑制剂 Pending CN109963850A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP16198731.8 2016-11-14
EP16198731.8A EP3321264A1 (en) 2016-11-14 2016-11-14 Selective inhibitors of genotoxic stress-induced ikk/nf-kb pathways
PCT/EP2017/079181 WO2018087389A1 (en) 2016-11-14 2017-11-14 SELECTIVE INHIBITORS OF GENOTOXIC STRESS-INDUCED IKK/NF-kB PATHWAYS

Publications (1)

Publication Number Publication Date
CN109963850A true CN109963850A (zh) 2019-07-02

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CN201780071520.3A Pending CN109963850A (zh) 2016-11-14 2017-11-14 基因毒性应激诱导性IKK/NF-κB途径的选择性抑制剂

Country Status (7)

Country Link
US (1) US11028084B2 (enExample)
EP (2) EP3321264A1 (enExample)
JP (2) JP7307677B2 (enExample)
CN (1) CN109963850A (enExample)
AU (1) AU2017359276B2 (enExample)
CA (1) CA3041832A1 (enExample)
WO (1) WO2018087389A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111781358A (zh) * 2020-07-13 2020-10-16 张瑜 Xab2蛋白作为卵巢癌预后和/或预测铂类耐药标志物
CN113913515A (zh) * 2020-07-10 2022-01-11 上海吉凯基因医学科技股份有限公司 人eme1基因的用途及相关产品

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3321264A1 (en) * 2016-11-14 2018-05-16 Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft Selective inhibitors of genotoxic stress-induced ikk/nf-kb pathways
CN116829560A (zh) * 2020-12-14 2023-09-29 金奥克斯治疗有限公司 催产素受体调节剂
AU2023397973A1 (en) * 2022-12-13 2025-07-03 Flare Therapeutics Inc. Compounds and composition for targeting tp53-y220c mutants
EP4467141A1 (en) 2023-05-24 2024-11-27 Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft Pyrazolo-quinolines as selective inhibitors of genotoxic stress-induced ikk/nf- kb pathways for cancer therapy

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US20120039804A1 (en) * 2010-06-04 2012-02-16 Philippe Diaz Novel Tricyclic Modulators of Cannabinoid Receptors
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113913515A (zh) * 2020-07-10 2022-01-11 上海吉凯基因医学科技股份有限公司 人eme1基因的用途及相关产品
CN111781358A (zh) * 2020-07-13 2020-10-16 张瑜 Xab2蛋白作为卵巢癌预后和/或预测铂类耐药标志物

Also Published As

Publication number Publication date
JP2019535709A (ja) 2019-12-12
EP3538529B1 (en) 2022-01-19
JP7701403B2 (ja) 2025-07-01
CA3041832A1 (en) 2018-05-17
EP3538529A1 (en) 2019-09-18
AU2017359276A1 (en) 2019-05-16
US11028084B2 (en) 2021-06-08
US20190276452A1 (en) 2019-09-12
WO2018087389A1 (en) 2018-05-17
JP2023101521A (ja) 2023-07-21
JP7307677B2 (ja) 2023-07-12
EP3321264A1 (en) 2018-05-16
AU2017359276B2 (en) 2022-02-17

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